Plasma metabolomics of immune-related adverse events for patients with lung cancer treated with PD-1/PD-L1 inhibitors by Juan Chen, Jun-yan Liu, Fan Yang, Ting Zou, Zhan Wang, Jia-Si Liu, Lei She, Xiang-Ping Li, Zhaoqian Liu

“…Background Metabolomics has the characteristics of terminal effects and reflects the physiological state of biological diseases more directly. Several current biomarkers of multiple omics were revealed to be associated with immune-related adverse events (irAEs) occurrence. …”
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The impact of family environment on social avoidance in adolescents with depressive disorders: a chain mediation model involving basic psychological needs and core self-evaluations by Xin Tian, Xin Tian, Liqi Gu, Xinrong Ma, Yuelan Zhang, Ling Dang, Furong Gou, Mengyuan Zhang, Wenjun Wang, Hao Duan

“…Mediation analysis was conducted using SPSS 27.0 with PROCESS Macro Model 6.ResultsFamily environment was significantly associated with social avoidance (β = –0.4682, p < 0.001). …”
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Maternal exposure to dim light at night induces behavioral alterations in the adolescent and adult offspring Wistar rat by Shellye González-González, Mariana Gutiérrez-Pérez, Mara A. Guzmán-Ruiz, Estefania Espitia-Bautista, Rosa María Pavón, Karla P. Estrada-Rodríguez, Alejandro Díaz-Infante R., Cecilia G. Guadarrama Gándara, Carolina Escobar, Natalí N. Guerrero-Vargas

“…In contrast, DLAN male offspring exhibited a significant decrease in social play behavior compared to LD animals, which was associated with higher numbers of microglia in the NAc that had more ramified morphology. Importantly, at PN90, DLAN offspring presented increased anxiety-like behaviors. …”
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Content validity testing of the INTERMED Self‐Assessment in a sample of adults with rheumatoid arthritis and rheumatology healthcare providers by Kiran Dhiman, Marc Hall, Trafford Crump, Alison M. Hoens, Diane Lacaille, James A. Rankin, Karen L. Then, Glen Hazlewood, Cheryl Barnabe, Steven Katz, Jason Sutherland, Erika Dempsey, Claire E. H. Barber

“…Future instrument development requires an iterative cognitive debriefing and repair process with the population of interest in the early stages to ensure content validity and comprehension. …”
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Use of a pathogen X tabletop exercise to assess the operational response preparedness of an emerging infectious diseases research network by Rachael Lee, Jennifer Hemingway-Foday, Nefer Batsuli, L. Danielle Wagner, Aaron Macoubray, Robert F. Garry, Christine K. Johnson, Kathryn A. Hanley, Nikos Vasilakis, Souleymane Mboup, Hongying Li, Cecilia A. Sánchez, Peter M. Rabinowitz, Robert F. Breiman, Nathan Vandergrift, Eric J. Earley, Hilary Bouton-Verville, E. Candice Beaubien, E. Megan Davidson, Gretchen Van Vliet, Sara Woodson, M. Anthony Moody, Gregory D. Sempowski, Richard Reithinger

“…By the end of 2021, the Network leadership realized that it had a blind spot with regards to research centers and their sites’ overall capacities and stakeholder connections. To foster more meaningful and deeper levels of coordination and collaboration across research centers, as well as stress-test its capacity and readiness for rapid research during an EID outbreak. …”
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Optimization and management practice of specialist nurses in outpatient nursing of integrated Traditional Chinese and western medicine (中西医结合门诊护理专科护士管理模式优化实践)... by NIU Liqiang (牛丽强), TIAN Li (田丽), YANG Zhe (杨喆), GUAN Yingzhi (管迎芝), WANG Jian (王健), CAO Yanchen (曹艳晨), GUO Haifeng (果海凤), CHEN Bo (陈博), LI Xuejian (李雪健), PEI Xiaolu (裴晓璐)

“…In order to make the outpatient nursing of integrated Traditional Chinese and western medicine more effective, medical institutions should optimize the management mode of specialist nurses around the following nine aspects: strictly employing specialized nurses, setting up standardized posts of specialized nurses, formulating and perfecting the work and assessment system, establishing specialist nursing team, strengthening humanized management, optimizing outpatient layout, strengthening patient education, optimizing the process of seeing a doctor, and establishing outpatient nursing supervision group. …”
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A bottom-up approach to find lead compounds in expansive chemical spaces by Álvaro Serrano-Morrás, Andrea Bertran-Mostazo, Marina Miñarro-Lleonar, Arnau Comajuncosa-Creus, Adrià Cabello, Carme Labranya, Carmen Escudero, Tian V. Tian, Inna Khutorianska, Dmytro S. Radchenko, Yurii S. Moroz, Lucas Defelipe, David Ruiz-Carrillo, Maria Garcia-Alai, Robert Schmidt, Matthias Rarey, Patrick Aloy, Carles Galdeano, Jordi Juárez-Jiménez, Xavier Barril

“…Abstract Drug discovery starts with the identification of a “hit” compound that, following a long and expensive optimization process, evolves into a drug candidate. Bigger screening collections increase the odds of finding more and better hits. …”
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Cortical Morphometric Similarity Remodeling in Traumatic Brain Injury Links Cognitive Impairments with Transcriptional Changes and Type‐Specific Cells by Yizhen Pan, Zhuonan Wang, Xiang Zhang, Wenpu Zhao, Haonan Zhang, Xuan Li, Xiaoyan Jia, Qiuyu Ji, Bo Yin, Guanghui Bai, Tingting Wu, Zhiqi Lee, Jierui Ding, Lei Shi, Jie Zhang, David H. Salat, Lijun Bai

“…Subsequently, cortical MS remodeling patterns are identified involving mostly MS increases in the frontal modules with typical high MS and decreases in the occipital module with typical low MS, with more pronounced changes observed in the developing brain with mTBI. …”
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Evaluating the ecological and social targeting of a compensation scheme in Bangladesh. by Annabelle Jade Bladon, Essam Yassin Mohammed, Belayet Hossain, Golam Kibria, Liaquat Ali, E J Milner-Gulland

“…This study highlights a challenge for conservation payment schemes that aim to achieve the dual objectives of poverty reduction and ecological sustainability, particularly large-scale public schemes, and suggests that more effective targeting and transparency about the basis of payment distribution are prerequisites for schemes to be both cost-effective and socially acceptable.…”
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Development of Thermosensitive Hydrogels with Tailor-Made Geometries to Modulate Cell Harvesting of Non-Flat Cell Cultures by Rubén García-Sobrino, Enrique Martínez-Campos, Daniel Marcos-Ríos, Zenen Zepeda-Rodríguez, Juan L. Valentín, Raúl Sanz-Horta, Marina León-Calero, Helmut Reinecke, Carlos Elvira, Alberto Gallardo, Juan Rodríguez-Hernández

“…The fabrication process is based on the use as a mold of two-layer thick water-soluble polyvinyl alcohol (PVA) previously printed by Extrusion Material (MatEx). …”
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Blood immunophenotyping of multiple sclerosis patients at diagnosis identifies a classical monocyte subset associated to disease evolution by Stéphane Rodriguez, Stéphane Rodriguez, Laura Couloume, Juliette Ferrant, Juliette Ferrant, Nicolas Vince, Marion Mandon, Marion Mandon, Rachel Jean, Rachel Jean, Celine Monvoisin, Simon Leonard, Simon Le Gallou, Simon Le Gallou, Nayane S. B. Silva, Nayane S. B. Silva, Sonia Bourguiba-Hachemi, David Laplaud, David Laplaud, Alexandra Garcia, Romain Casey, Romain Casey, Romain Casey, Romain Casey, Helene Zephir, Anne Kerbrat, Gilles Edan, Emmanuelle Lepage, Eric Thouvenot, Eric Thouvenot, Aurelie Ruet, Aurelie Ruet, Guillaume Mathey, Guillaume Mathey, Pierre-Antoine Gourraud, Pierre-Antoine Gourraud, Karin Tarte, Karin Tarte, Celine Delaloy, Patricia Amé, Patricia Amé, Mikael Roussel, Mikael Roussel, Laure Michel, Laure Michel, Laure Michel

“…Notably, this patients’ subgroup exhibited a more aggressive disease phenotype two years post-diagnosis. …”
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Job characteristics model-based study of the intrinsic motivations for primary care practitioners by Shichao Zhao, Jing Ping, Hong Zhu, Wanting Ji, Yuyan Wang, Ying Wang

“…Conclusion: The influence of intrinsic motivations stemming from of job characteristics is more significant in explaining job performance among primary care practitioners than extrinsic motivational factors. …”
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Mass Spectrometry Identification and Computational Chemistry Study of Fluoromethcathinone Isomers by Xiao-wei LI, Xiang-li LIN, Xuan-yu ZHOU, Xing KE, Yi-lei FAN, Yu XU, Jia-wei XU

“…In addition, the fragmentation mechanisms of 3-FMC and 4-FMC were investigated by applying density functional theory calculation, which can more accurately elucidate the mass spectral behavior and structure characteristics of compounds as reflected by mass spectrometric data. …”
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Compactação do solo na cultura do feijoeiro. I: efeitos nas propriedades físico-hídricas do solo Soil compaction in a bean crop. I: effects on soil physical and water properties... by Luís F. Stone, Cleber M. Guimarães, José A. A. Moreira

“…The flow-weighted mean pore size was reduced too decreasing soil hydraulic conductivity. This reduction was more pronounced at higher pressure heads. The reduction in pore size was partially compensated with the increase in the number of pores, at a pressure head of -2.0 cm of water. …”
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Effects of wilting extent on the concentration of phytoestrogens, nutritional value, microbial populations, and in vitro ruminal methane emissions of red clover hay and silage acro... by D. Zamudio, R.A. De Castro, A.P. Jimenez-Lagos, M.V.S.B. Cardoso, M.A. Killerby, G. Pereira, M.R.M. Lima, C. Knight, J.J. Romero

“…Measurements were taken at the start of storage (STRT), after 14 d (early stage of storage), and once storage processes had stabilized for hay and silage (50 and 78 d, respectively; late stage). …”
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KMS (Knowledge Management System) Obat Ibu Hamil Berbasis Android by Halimah Tus Sadiah, Muhamad Saad Nurul Ishlah, Nyayu Siti Aminah Lily Elfrieda, Mauladani Adi Gasbara

“…The development of KMS has been equipped with features under the results of the process of capturing knowledge from experts. The KMS for Pregnant Women is 72% more complete than the existing application, namely MomsMed. …”
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GNSS Precipitable Water Vapor Prediction for Hong Kong Based on ICEEMDAN-SE-LSTM-ARIMA Hybrid Model by Jie Zhao, Xu Lin, Zhengdao Yuan, Nage Du, Xiaolong Cai, Cong Yang, Jun Zhao, Yashi Xu, Lunwei Zhao

“…Enhanced by local mean optimization and adaptive noise regulation, the ICEEMDAN algorithm effectively suppresses pseudo-modes and minimizes residual noise, enabling its decomposed intrinsic mode functions (IMFs) to more accurately capture the multi-scale features of GNSS-PWV. …”
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Success and Failure in Foreign Policy: Narrative Analysis of JCPOA by Heidarali Masoudi, Masoud Hamiani

“…Supporters of the Intermediate narrative initially portrayed the JCPOA as a win-win scenario but gradually developed a narrative, suggesting that Iran should have secured more concessions from the opposing side (setting of the story). …”
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Exploring the Effects of Light–Water Interaction in Plant Factory to Improve the Yield and Quality of <i>Panax notoginseng</i> (Burkill) F. H. Chen by Jing Wang, Zhe Han, Junjie He, Hongwei Kang, Qinghua Li, Haomin Chen, Xuan Zhang, Wanying Miao, Xiaojian Shang, Wenting Chen, Zhiyong Gao

“…Chen, as a traditional Chinese medicinal herb with significant therapeutic effects, is highly sensitive to environmental factors during its growth process, particularly light and water conditions. …”
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Development and study of mucoadhesive microcapsules for the nasal levodopa delivery by D. S. Gordeeva, V. V. Khutoryanskiy, R. I. Moustafine

“…ImageJ 1.53e software (ImageJ, USA) was used to process the obtained macroscopic images and plot graphs. …”
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