Gut microbial metabolism of bile acids modifies the effect of Mediterranean diet interventions on cardiometabolic risk in a randomized controlled trial by Peipei Gao, Ehud Rinott, Danyue Dong, Zhendong Mei, Fenglei Wang, Yuxi Liu, Omer Kamer, Anat Yaskolka Meir, Kieran M. Tuohy, Matthias Blüher, Michael Stumvoll, Meir J. Stampfer, Iris Shai, Dong D. Wang

“…Baseline fecal BA levels significantly modified the beneficial effects of the MedDiet; for example, BMI reduction induced by MedDiet interventions was more pronounced in individuals with lower 12-dehydrocholic acid levels (q-interaction <0.001). …”
Get full text

Current challenges and future directions of ATMPs in regenerative medicine by Fatemeh Abbasi Kakroodi, Elaheh Khodadoust, Marzieh Alizadeh, Reyhaneh Sadat Hayaei Tehrani, Pedram Asadi Sarabi, Mohammad Rahmanian, Massoud Vosough

“…Organoid technology holds a significant promise in overcoming the challenges associated with preclinical and modeling of ATMPs by providing more accurate models for diseases, drug screening, and personalized medicine. …”
Get full text

Rationale and Design of the ORCCA (Outcomes Registry for Cardiac Conditions in Athletes) Study by Nathaniel Moulson, Bradley J. Petek, Michael J. Ackerman, Timothy W. Churchill, Sharlene M. Day, Jonathan H. Kim, Stephanie A. Kliethermes, Rachel Lampert, Benjamin D. Levine, Matthew W. Martinez, Manesh R. Patel, Dermot Phelan, Kimberly G. Harmon, Aaron L. Baggish, Jonathan A. Drezner

“…Recent guidelines have taken a more permissive approach, using a shared decision‐making model. …”
Get full text

An analytical approach to explore prospects and limits of nutrition-sensitive fisheries governance under climate change by Abigail Bennett, Julia G Mason, Willow Battista, Christopher M Free, Jessica A Gephart, Kristin M Kleisner, Emma D Rice, Kelly F Robinson, John Virdin

“…Yet governing fisheries for nutrition objectives is complicated by the multiple overlapping processes that shape availability and access to nutrients over time, including fishing sustainability, climate change, trade dynamics, and consumer preferences. …”
Get full text

An International Study Exploring the Experience of Survivors of Critical Illness as Volunteers Within ICU Recovery Services by Carly Robinson, BN, Elizabeth Hibbert, B.Physiotherapy, Anthony J. Bastin, MBBS, PhD, Joel Meyer, BM, BCh, DM, Ashley Montgomery-Yates, MD, Tara Quasim, MBChB, MD, Andrew Slack, MBBS, MRCP, EDIC, MD (Res), Mark E. Mikkelsen, MD, MSCE, Theodore J. Iwashyna, MD, PhD, Kimberley J. Haines, PhD, BHSc (Physiotherapy), Carla M. Sevin, MD, Joanne McPeake, PhD, MSc, BN (Hons), RGN, Leanne M. Boehm, PhD, RN, ACNS-BC

“…Peer volunteers undertake a variety of roles in ICU recovery services and during recovery more generally. These roles appear to be of direct benefit to those in these roles. …”
Get full text

Interactive chirality transfer between chiral phosphor and achiral polyacetylene for constructing multi-color circularly polarized room temperature phosphorescence by Kai Yang, Xinhui Gao, Xujie Wang, Biao Zhao, Youping Wu, Jianping Deng

“…The present work offers more insights into chirality transfer between the chiral-luminescent molecule and helical polymers, and establishes a universal platform for constructing CPRTP materials with large glum.…”
Get full text

A glyco-engineering approach for site-specific conjugation to Fab glycans by Maria L. Jaramillo, Traian Sulea, Yves Durocher, Mauro Acchione, Melissa J. Schur, Anna Robotham, John F. Kelly, Marie-France Goneau, Alma Robert, Yuneivy Cepero-Donates, Michel Gilbert

“…In conventional ADCs, the drug molecules are chemically attached randomly to antibody surface residues (typically Lys or Cys), which can interfere with epitope binding and targeting, and lead to overall product heterogeneity, long-term colloidal instability and unfavorable pharmacokinetics. Here, we present a more controlled process for generating ADCs where drug is specifically conjugated to only Fab N-linked glycans in a narrow ratio range through functionalized sialic acids. …”
Get full text

Femtosecond X-ray cross-correlation analysis of disordered crystals forming in a supercooled atomic liquid by Johannes Möller, Michele Caresana, Alexander Schottelius, Felix Lehmkühler, Ulrike Boesenberg, Frédéric Caupin, Francesco Dallari, Tiberio A. Ezquerra, José M. Fernández, Luca Gelisio, Claudia Goy, Jörg Hallmann, Anton Kalinin, Chan Kim, Ruslan P. Kurta, Dmitry Lapkin, Francesco Mambretti, Markus Scholz, Roman Shayduk, René Steinbrügge, Florian Trinter, Ivan A. Vartanyants, Alexey Zozulya, Davide E. Galli, Gerhard Grübel, Anders Madsen, Robert E. Grisenti

“…The preservation of angular information from the scattering signal allows probing the structure factor along selected directions in reciprocal space and identifying signatures undetectable in azimuthally integrated scattering curves. Therefore, more information from serial diffraction experiments on stochastic crystallization processes can be retrieved despite the inherent variation of the crystal orientation and morphology for each single probe. …”
Get full text

CO2 reforming of benzene into syngas by plasma-enhanced packed-bed dielectric barrier discharge with different packing materials by Yafeng Guo, Yafeng Guo, Shiye Cheng, Shiye Cheng, Shiye Cheng, Yu Du, Yu Du, Na Lu, Chao Li, Chao Li, Hanchun Bao, Hanchun Bao, Xiao Zhu, Xiao Zhu, Shi-Ya Tang, Shi-Ya Tang

“…Emission spectroscopy (Method 3) corroborated the presence of active hydroxyl radical (·OH) particle during the discharge process. It suggests that the SiC-packed ED-DBD reactor more efficiently generates active OH particles during the discharge compared to the SiO2-packed ED-DBD reactor (Results and Discussion 3). …”
Get full text

Luffa Cylindrica: Sustainable industrial innovations by Angisenit Reyes-Prezas, Marieli Lavoignet-Ruiz, Gregorio Fernández-Lambert, Luis Enrique García-Santamaría, Eduardo Fernández-Echeverría, Juan Manuel Carrión-Delgado, Yair Romero-Romero

“…The research contributes significantly to the development of cleaner, more sustainable industrial processes.…”
Get full text

Nucleosynthesis Conditions in Outflows of White Dwarfs Collapsing to Neutron Stars by Eirini Batziou, Robert Glas, H.-Thomas Janka, Jakob Ehring, Ernazar Abdikamalov, Oliver Just

“…AIC and MIC events are thus potential sites of r -process element production, which may imply constraints on their occurrence rates. …”
Get full text

Exploiting <i>Brassica rapa</i> L. subsp. <i>pekinensis</i> Genome Research by Faujiah Nurhasanah Ritonga, Zeyu Gong, Yihui Zhang, Fengde Wang, Jianwei Gao, Cheng Li, Jingjuan Li

“…To comprehend the molecular process of these characteristics, it is necessary to have a prior understanding of molecular breeding for the objective of enhancing quality. …”
Get full text

First report on the physicochemical and proteomic characterization of Proteus mirabilis outer membrane vesicles under urine-mimicking growth conditions: comparative analysis with E... by María José González, Nicolás Navarro, Erlen Cruz, Sofía Sánchez, Sofía Sánchez, Javier O. Morales, Javier O. Morales, Pablo Zunino, Luciana Robino, Analía Lima, Paola Scavone

“…Notably, the protein composition of OMVs varied depending on the growth medium, and proteins associated with zinc and iron uptake being more prominent in artificial urine, suggesting their importance in the urinary environment. …”
Get full text

Targeted temperature management at 33 versus 36 degrees after out-of-hospital cardiac arrest: A follow-up study by Robert Doerning, Kyle R. Danielson, Jane Hall, Catherine R. Counts, Michael R. Sayre, Sarah Wahlster, James A. Town, Sue Scruggs, David J. Carlbom, Nicholas J. Johnson

“…Results: Of 1,469 OCHA patients meeting inclusion criteria, 800 (54%) received TTM. TTM was initiated more frequently during TTM33-1 (60%) than TTM36 (52%) or TTM33-2 (52%). …”
Get full text

Development and assessment of an online communication skills course to optimise antibiotic prescribing for children in primary care by Lucía Arias-Alonso, Nieves Barragán-Brun, Usue Elizondo-Alzola, Andrea Boldu-Minguell, Claudio Alfonso Rocha-Calderón, Ena Niño-de-Guzmán, Francisca María Santandreu, Fermín Quesada-Carrasco, Ignacio Ricci-Cabello, Pedro Jesús Gorrotxategi-Gorrotxategi, Mariam de la Poza-Abad, Gemma Mas-Dalmau, Anna Gibert-Agulló, Jesús González-Lama, Pablo Alonso-Coello

“…Suggestions for improvement included incorporating a workshop, and featuring more representation of other professionals. The majority of professionals (93%) expressed interest in completing the course. …”
Get full text

A framework for disentangling ecological mechanisms underlying the island species–area relationship by Jonathan M. Chase, Leana Gooriah, Felix May, Wade A. Ryberg, Matthew S. Schuler, Dylan Craven, Tiffany M. Knight

“…This approach will offer insight into the role of sampling and other processes that underpin the ISAR, providing a more complete understanding of how, and some indication of why, patterns of biodiversity respond to gradients in island area.…”
Get full text

Genetics in the Ocean's Twilight Zone: Population Structure of the Glacier Lanternfish Across Its Distribution Range by María Quintela, Eva García‐Seoane, Geir Dahle, Thor A. Klevjer, Webjørn Melle, Roger Lille‐Langøy, François Besnier, Konstantinos Tsagarakis, Maxime Geoffroy, Naiara Rodríguez‐Ezpeleta, Eugenie Jacobsen, David Côté, Sofie Knutar, Laila Unneland, Espen Strand, Kevin Glover

“…The arrangement of this putative inversion showed frequency differences between open‐ocean and more confined water bodies such as the fjords and the Mediterranean, as it was fixed in the latter for the second most common arrangement of the fjord's samples. …”
Get full text

Tailoring the number of lines for IGO-channel 2T0C DRAM comparable to conventional 2-line operation 1T1C structure for highly scaled cell volume by Jae-Hyeok Kwag, Su-Hwan Choi, Daejung Kim, Jun-Yeoub Lee, Taewon Hwang, Hye-Jin Oh, Chang-Kyun Park, Jin-Seong Park

“…Furthermore, for stored voltage intervals of 0.1 V and 0.5 V, the refresh time was 10 s and 1 000 s in multi-bit operation; these values were more than 150 and 15 000 times longer than those of the conventional Si channel 1T1C DRAM, respectively. …”
Get full text

Electrochemical modulation of tau protein phosphorylation levels with biomimetic polyaniline membranes by Shang-Chi Chien, Chia-Hsuan Chang, Hung-Ju Wang, Chien-Chih Hsu, Yu-Lin Wang, Ching-Cheng Chuang, Jung-Chih Chen

“…Reversing tau hyperphosphorylation provides a groundbreaking therapeutic strategy for AD, opening new avenues for more effective treatment modalities and improving patient outcomes.The research demonstrates that phosphorylated tau peptides and proteins adhere effectively to PANI membranes under electrostatic stimulation. …”
Get full text

First Application of a New Rapid Method of Age Determination in European Anchovy (<i>Engraulis encrasicolus</i>) by Fourier Transform Near-Infrared Spectroscopy by Gualtiero Basilone, Miryam Fortuna, Gabriella Lo Cicero, Simona Genovese, Giovanni Giacalone, Ignazio Fontana, Angelo Bonanno, Salvatore Aronica, Rosalia Ferreri

“…The calibration model developed for all regions combined proved more robust than the models for each area, demonstrating its efficacy for the entire study area. …”
Get full text