Methodological and regulatory aspects of pharmaceutical development of biological products by D. V. Kurkin, E. I. Morkovin, D. A. Bakulin, A. V. Zaborovsky, I. E. Makarenko, R. V. Drai, A. G. Solodovnikov, V. I. Petrov, K. N. Koryanova, N. A. Lycheva, S. A. Voskresensky, A. V. Strygin, Yu. A. Kolosov, Yu. V. Gorbunova, O. V. Ivanova

“…Significant advances have been made in gene, immune and cell therapies, resulting in the approval of such drugs more than doubling over the past ten years. …”
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Testing the effectiveness of a new type of spacers for local antibiotic therapy by Ildar F. Akhtyamov, Oskar A. Sachenkov, Rashid A. Shafigulin, Alina E. Galyautdinova, Nikita V. Kharin, Igor A. Bespalov, Sergey V. Boychuk

“…Discussion Antibiotic release is a superficial process and is not dependent on the total volume of bone cement. …”

Development of a rapid LFA test based on direct RT-LAMP for diagnosis of SARS-CoV-2 by Negar Sadeghi, Neda Shirazi, Moein Dehbashi, Bahareh Maleki, William C. Cho, Zohreh Hojati

“…The RT-LAMP method was also carried out directly on heat-treated swab samples. The strip tests were made using gold nanoparticles and combined with the RT-LAMP for further analysis. …”
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New insights on physicochemical features and toxicological outcome provided from incineration of nanocomposites by Claire Longuet, Carine Chivas-Joly, Nora Lambeng, Valérie Forest, Lara Leclerc, Gwendoline Sarry, Jérémie Pourchez, José-Marie Lopez-Cuesta

“…As highlighted in the ECHA report (November 2021) and although substantial progress have been made in the characterization and measurement of nanomaterials, some challenges remain, particularly the characterization of nanomaterials in complex media. …”
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Enhancing grapevine viability and pathogen control through optimised hot water treatment by Margarida Lourenço, Cláudia Sofia Batalha Neto, Justino Sobreiro, Jorge Sofia

“…Nurseries need tailor-made and effective methods for guaranteeing the supply of GTD-free material. …”
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T7 DNA polymerase treatment improves quantitative sequencing of both double-stranded and single-stranded DNA viruses by Billaud, Maud, Theodorou, Ilias, Lamy-Besnier, Quentin, Shah, Shiraz A., Lecointe, François, De Sordi, Luisa, De Paepe, Marianne, Petit, Marie-Agnès

“…Using a synthetic mix of viral particles, we made use of the T7 DNA polymerase (T7pol) to convert viral circular ssDNA molecules to dsDNA, while preventing over-replication of such molecules, as is the case with the Phi29 DNA polymerase. …”
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Effect of Thermal Oxidation on the Structure, Surface Texturing, and Microstructure Evolution in Nanocrystalline Ga─O─N Films by Debabrata Das, Francelia Sanchez, Paul Gaurav Nalam, Nolan Herbort, Felicia S. Manciu, V. Shutthanandan, C.V. Ramana

“…The structure‐phase‐chemical composition correlation, which will be useful for nanocrystalline materials for selective optoelectronic applications, is established in Ga─O─N films made by thermal treatment of GaN.…”
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The effect of fabrication methods on the physical properties of Sumberejo kenaf fiber - Polyurethane foam core sandwich composite for sustainable building construction by Ilva Zahrotin, Ariadne L. Juwono, Januar P. Siregar, Seto Roseno, Saeful Rohman, Eryanti Kalembang

“…Sandwich composites made of natural fibers are currently being investigated for use in buildings. …”
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Sustainable innovation for fermented cassava roasting: Examining the potential of parabolic dish solar collectors and thermal energy storage by O.G. Sobarasua, I.F. Onuche, A.O. Kuye, E.O. Diemuodeke, I.K. Muritala, E.G. Saturday, K.E. Okedu, A. Kalam

“…Fermented cassava roasting is an energy-intensive process that is commonly used to produce gari, a popular food in Nigeria made from cassava. …”
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Transcriptomic Analysis Reveals the Role of Long Non-Coding RNAs in Response to Drought Stress in Tibetan Hulless Barley by Zitao Wang, Yue Fang, Qinyue Min, Kaifeng Zheng, Yanrong Pang, Jinyuan Chen, Feng Qiao, Shengcheng Han

“…LncRNAs, a type of RNAs exceeding 200 nucleotides (nt) and lacking representative open reading frames (ORFs), have emerged as crucial regulatory molecules that modulate numerous growth and development processes in plants. While substantial progress has been made in interpreting the functions and regulatory mechanisms of coding RNAs, the study of lncRNAs in Tibetan hulless barley remains incomplete. …”
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Farmer-veterinarian communication during herd health visits on dairy farms in Flanders, Belgium by Linda Dorrestein, Caroline Ritter, Ellen de Jong, Jannet de Jonge, Jolanda Jansen, Sarne De Vliegher, Geert Vertenten, Herman W. Barkema

“…The CCG communication processes “History taking,” “Presenting information,” and “Safety net and follow-up” were most prevalent. …”
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Thermophysiological Comfort Behaviour of Cut Protective Workwear Consisting of Filament Twisted Multicomponent Hybrid Yarn by Zayedul Hasan, Rochak Rathour, Apurba Das, Ramasamy Alagirusamy, Nandan Kumar

“… Current cut protective gear is subject to several difficulties, such as the use of heavy fabric, complicated donning processes, lack of comfort and limited movement. When selecting the most comfortable cut protective fabric, it is important to consider the end users' specific needs. …”
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Hereditary alpha-tryptasemia and monoclonal mast cell disorders by Yannick Chantran, Yannick Chantran, Yannick Chantran, Michel Arock, Michel Arock

“…Although both HαT and mMCD induce increased bST levels, their overlap in laboratory features, and potentially in associated clinical manifestations, have made the diagnostic process of mMCD more accurate but more complicated. …”
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Review of Post-registration Changes in the Life Cycle of Сholera Bivalent Chemical Vaccine (Review) by I. V. Shulgina, O. A. Lobovikova, O. A. Voloh, O. V. Gromova, A. K. Nikiforov, A. V. Komissarov, V. A. Demchenko, A. S. Fes’kova, S. S. Galetova, N. P. Mironova, V. I. Pavlova

“…First of all, the changes made to the registration documentation for IMP concerned the updating of the dossier in accordance with the adopted Federal laws and Resolutions of the government of the Russian Federation. …”
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DISYNCRO: Perceived roles of clinical study coordinators and data managers: results from a web-based survey of professionals from contract research organizations by Susanna Yedro, Elena Tinari, Daniele Napolitano, Giulia Wlderk, Eleonora Ribaudi, Luciana Giannone, Gianluca Ianiro, Mattia Bozzetti, Antonio Gasbarrini, Vincenzina Mora

“…Introduction: The evolution of clinical trials has made it essential to introduce specific roles, such as Clinical Study Coordinator (CSC) and Data Manager (DM), into the research process. …”
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Echo Intima-Media Thickness (IMT) in the Evaluation of Early Atherosclerosis in Inflammatory Bowel Disease (IBD) Patients – a Prospective Study by Ana Maria NEGREANU, Simona BADIU, Eugenia PANAITESCU, Monica IONITA, Lucian NEGREANU

“…Introduction: Inflammatory bowel diseases (IBD) are accompanied by an early and accelerated atherosclerotic process. Previous studies showed that Doppler ultrasonography and intima media thickness (IMT) is a reliable marker for early atherosclerosis diagnosis. …”
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ANTIHISTAMINES: RESEARCH AND ANALYSIS OF THE REGIONAL RETAIL MARKET by V. V. Prokopenko, T. I. Kabakova, M. V. Chernikov, A. B. Goryachev, S. A. Mikhailova, O. I. Knysh

“…Focused on optimizing the assortment portfolio of pharmacy organizations and improving the process of drug supply to end-consumers, the aim of the study was to analyze the regional pharmaceutical market for antihistamines.Materials and methods. …”
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Detection of IgM, IgG and IgA against pertussis in pregnant women in I - II - III trimesters by T. A. Skirda, O. Yu. Borisova, N. T. Gadua, A. S. Pimenova, I. I. Mekhant'ev, Yu. I. Stepkin, I. M. Degtyareva, S. V. Bredihin, M. S. Petrova, A. B. Borisova, A. V. Safronova, S. Yu. Kombarova

“…The detection of IgM, IgG and IgA made it possible to detect the active infection process in 11 (3,9%) pregnant women by elevated level of IgA. …”
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A Digital Twin of the Trondheim Fjord for Environmental Monitoring—A Pilot Case by Antonio Vasilijevic, Ute Brönner, Muriel Dunn, Gonzalo García-Valle, Jacopo Fabrini, Ralph Stevenson-Jones, Bente Lilja Bye, Igor Mayer, Arne Berre, Martin Ludvigsen, Raymond Nepstad

“…Data ingested into an InfluxDB are made available to users via an API or an interface for interacting with the DTO and setting up alerts or events to support ’what-if’ scenarios. …”
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Retrospective analysis and modern spatiotemporal characteristics of tularemia in the territory of the West Kazakhstan and North Kazakhstan regions by U. A. Izbanova, L. Yu. Lukhnova, T. V. Meka-Mechenko, N. S. Maykanov, V. P. Sadovskaya, V. G. Meka-Mechenko, A. A. Yusupov, A. B. Makulova

“…An analysis of long-term data on the epizootic and epidemic activity of tularemia natural foci, processed using descriptive statistics and GIS technology, made it possible to identify places of long-term persistence of the tularemia agent in the natural focus of the North Kazakhstan and West Kazakhstan regions and to create an electronic map of the territories endemic for tularemia to determine the scope of preventive measures.…”
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