Notch1 blockade by a novel, selective anti-Notch1 neutralizing antibody improves immunotherapy efficacy in melanoma by promoting an inflamed TME by Juliano Tiburcio de Freitas, Varsha Thakur, Kathryn M. LaPorte, Vijay S. Thakur, Brian Flores, Valentina Caicedo, Chioma G. E. Ajaegbu, Giuseppe Ingrasci, Zoe M. Lipman, Keman Zhang, Hong Qiu, Thomas R. Malek, Barbara Bedogni

“…Tumors were measured and processed for flow cytometry using antibodies against major immune cell populations. …”
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Uncertainty in the projected Antarctic contribution to sea level due to internal climate variability by J. Caillet, N. C. Jourdain, P. Mathiot, F. Gillet-Chaulet, B. Urruty, C. Burgard, C. Burgard, C. Amory, C. Amory, M. Chekki, C. Kittel, C. Kittel, C. Kittel

“…However, the impact of the irreducible internal climate variability, resulting from processes intrinsic to the climate system, remains poorly understood and quantified. …”
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Seed-based resting-state connectivity as a neurosignature in fibromyalgia and depression: a narrative systematic review by Betina Franceschini Tocchetto, Betina Franceschini Tocchetto, Andrea Cristiane Janz Moreira, Andrea Cristiane Janz Moreira, Álvaro de Oliveira Franco, Álvaro de Oliveira Franco, Iraci L. S. Torres, Felipe Fregni, Wolnei Caumo, Wolnei Caumo, Wolnei Caumo

“…Unique patterns of rs-FC were also observed: FM-specific changes involved the periaqueductal gray, hypothalamus, and thalamus, indicating impaired pain modulation and emotional processing. In contrast, MDD-specific changes were primarily observed in the reward, salience, and default mode networks, reflecting impaired emotional regulation. …”
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Oxidative genomic damage in pediatric patients exposed to mercury released by dental amalgam by Guadalupe Nalleli Macías-Lamas, Yveth Marlene Ortiz-García, Blanca Patricia Lazalde-Ramos, Guillermo Moisés Zúñiga-González, Belinda Claudia Gómez-Meda, Cristina Hermila Martínez-Bugarín, Susana Vanessa Sánchez-De-La-Rosa, Saulo Oswaldo Sánchez-Rivera, Gabriela Morales-Velazquez, Celia Guerrero-Velázquez, Ana Lourdes Zamora-Perez

“…Hg from dental amalgam fillings has been shown to be released into the buccal cavity due to processes such as abrasion and corrosion, and which could represent a continuous source of oxidative damage to mouth tissues. …”
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Antibiofilm Power of Basil Essential Oil Against Fish-Originated Multidrug-Resistant <i>Salmonella</i> and <i>Bacillus</i> spp.: Targeting Biofilms on Food Contact Surfaces by Valentina Pavone, Francisco Emilio Argote-Vega, Waleed Butt, Junior Bernardo Molina-Hernandez, Domenico Paludi, Johannes Delgado-Ospina, Luca Valbonetti, José Ángel Pérez-Álvarez, Clemencia Chaves-López

“…Our findings highlight BEOI’s potential as a natural anti-biofilm agent in food processing environments, offering a promising strategy to combat multidrug-resistant bacteria biofilm-related challenges in the food industry.…”
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Elevated Galectin-3 levels in the tumor microenvironment of ovarian cancer – implication of ROS mediated suppression of NK cell antitumor response via tumor-associated neutrophils... by Veronika Karlsson, Veronika Karlsson, Ebba Stål, Emma Stoopendahl, Anton Ivarsson, Hakon Leffler, Maria Lycke, Martina Sundqvist, Karin Sundfeldt, Karin Sundfeldt, Karin Christenson, Elin Bernson, Elin Bernson

“…The β-galactoside-binding lectin, Galectin-3, is involved in different immune processes and has been associated with poor outcome in various cancer diagnoses. …”
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Comprehensive field investigation of a large botulism outbreak, Saudi Arabia, 2024 by Saad Nasser Al Zuayr, Shady Abdelrahman Kamel, Abdulaziz Saad Almutairi, Yahya Abdullah AlAsseri, Musa alfaifi, Bader Alyahya, Mohammad Al Deeb, Hussein Ayaed Albogami, Hamoud Marzouq Alrougi, Rayyan Mohammad Saqah, Abdulmohsen Mohammed Alahmad, Abd Elelah Hamoud Almutairi, Eman Elsayed Abd-Ellatif

“…Food-borne botulism typically results from consuming homemade canned, preserved, or fermented food. This paper presents the first documented occurrence of a commercially prepared food-borne botulism outbreak in Saudi Arabia. …”
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A General Framework for Closed Loop Negative Feedback Multivariable Physiological Control Systems: Existence, Uniqueness, and Stability of Homeostatic Equilibrium Points by Anna Procopio, Annarita Tedesco, Fabrizio Lo Regio, Giuseppe Cesarelli, Leandro Donisi, Carlo Ricciardi, Alessio Merola, Alfonso Maria Ponsiglione, Maria Romano, Francesco Montefusco, Carlo Cosentino, Francesco Amato

“…Control theory approaches can provide effective strategies to model physiological control systems, helping in understanding the dynamics of bio- and physio-logical regulation processes. However, the intrinsic complexity of living systems makes it difficult to identify unified biomodels that can represent a wide variety of physiological systems. …”
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MiceDEGdb: a knowledge base on differentially expressed mouse genes as a model object in biomedical research by O. A. Podkolodnaya, I. V. Chadaeva, S. V. Filonov, N. L. Podkolodnyy, D. A. Rasskazov, N. N. Tverdokhleb, K. A. Zolotareva, A. G. Bogomolov, E. Yu. Kondratyuk, D. Yu. Oshchepkov, M. P. Ponomarenko

“…The fundamental understanding of many biological processes that unfold in a human body has become possible due to experimental studies on animal models. …”
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Decreased basal thermogenesis is associated with the downregulation of cellular metabolic activity of organs and serum thyroid hormones in fasting Eurasian Tree Sparrows (Passer mo... by Hong Jin, Qi Xia, Ziqing Gao, Yujie XuanYuan, Beibei Dong, Ming Li, Qingjian Liang, Jinsong Liu

“…Basal metabolic rate (BMR) reflects the energy expended by endothermic animals for basic physiological processes and constitutes a major part of their daily energy budget. …”
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Regional and aging-specific cellular architecture of non-human primate brains by Yun-Mei Wang, Wen-Chao Wang, Yongzhang Pan, Lin Zeng, Jing Wu, Zheng-Bo Wang, Xiao-Lin Zhuang, Ming-Li Li, David N. Cooper, Sheng Wang, Yong Shao, Li-Min Wang, Ying-Yin Fan, Yonghan He, Xin-Tian Hu, Dong-Dong Wu

“…Abstract Background Deciphering the functionality and dynamics of brain networks across different regions and age groups in non-human primates (NHPs) is crucial for understanding the evolution of human cognition as well as the processes underlying brain pathogenesis. However, systemic delineation of the cellular composition and molecular connections among multiple brain regions and their alterations induced by aging in NHPs remain largely unresolved. …”
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Candidate Phyla Radiation (CPR) bacteria from hyperalkaline ecosystems provide novel insight into their symbiotic lifestyle and ecological implications by Yu He, Shiyan Zhuo, Meng Li, Jie Pan, Yongguang Jiang, Yidan Hu, Robert A. Sanford, Qin Lin, Weimin Sun, Na Wei, Shuming Peng, Zhou Jiang, Shuyi Li, Yongzhe Li, Yiran Dong, Liang Shi

“…Our observations suggest that CPR bacteria may contribute to auxotrophic organisms and indirectly influence biogeochemical processes. Video Abstract…”
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Vibration, current, torque, RPM dataset for multiple fault conditions in industrial-scale electric motors under randomized speed and load variationsMendeley DataMendeley DataMendel... by Wonho Jung, Junho Kim, Kangmin Jang, Sung-Hyun Yun, Daeguen Lim, Minje Jin, Yong-Hwa Park

“…This article presents a comprehensive dataset acquired from two fault diagnosis environments: (1) industrial AC motors operating under various real-world conditions, and (2) belt-loosening scenarios in HVAC air handling units. …”
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Hippo-YAP/TAZ-ROS signaling axis regulates metaflammation induced by SelenoM deficiency in high-fat diet-derived obesity by Jingzeng Cai, Jiaqiang Huang, Di Li, Xintong Zhang, Bendong Shi, Qiaohan Liu, Cheng Fang, Shiwen Xu, Ziwei Zhang

“…SelenoM contributes to the modulation of antioxidative stress and inflammation in multiple pathological processes; however, its roles in metaflammation and the proinflammatory macrophage (M1)-like state in adipose tissue have not been determined. …”
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Prevalence and clinical characteristics of patients with rheumatoid arthritis with interstitial lung disease using unstructured healthcare data and machine learning by Raul Castellanos-Moreira, Diego Benavent, Alejandra López Robles, Ernesto Trallero-Araguás, Lucía Silva-Fernández, Juliana Restrepo, Jose A Román Ivorra, Maria Lopez Lasanta, Laura Cebrián, Leticia Lojo, Belén López-Muñíz, Julia Fernández-Melon, Belén Núñez, Raúl Veiga Cabello, Pilar Ahijado, Isabel De la Morena Barrio, Nerea Costas Torrijo, Belén Safont, Enrique Ornilla, Arantxa Campo, Jose L Andreu, Elvira Díez, Elena Bollo, David Vilanova, Sara Luján Valdés

“…This study aimed to estimate the prevalence of RA and ILD in patients with RA (RAILD) in Spain, and to compare clinical characteristics of patients with RA with and without ILD using natural language processing (NLP) on electronic health records (EHR).Methods Observational case–control, retrospective and multicentre study based on the secondary use of unstructured clinical data from patients with adult RA and RAILD from nine hospitals between 2014 and 2019. …”
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Patient and public involvement in international research: Perspectives of a team of researchers from six countries on collaborating with people with lived experiences of dementia a... by Shirin Vellani, Marie‐Lee Yous, Vanessa Maradiaga Rivas, Stephanie Lucchese, Julia Kruizinga, Tamara Sussman, Julia Abelson, Noori Akhtar‐Danesh, Gina Bravo, Kevin Brazil, Rebecca Ganann, Sharon Kaasalainen

“…Discussion and Implications International projects that involve PPI can present many sources of challenges. The findings in this study highlight important considerations for foundational work for incorporating PPI in international projects. …”
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The cAMP responsive element modulator (CREM) transcription factor influences susceptibility to undernutrition and infection by Audrey C. Brown, Md. Jashim Uddin, Rebecca M. Munday, Farha Naz, G. Brett Moreau, Girija Ramakrishnan, Stephen S. Rich, Rashidul Haque, Genevieve L. Wojcik, Priya Duggal, Chelsea Marie, William A. Petri

“…DEGs related to mitochondrial function were upregulated in the small intestine of children with the rs2148483 reference allele, while adaptive immune response processes were enriched among downregulated genes. …”
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Clinical-grade extracellular vesicles derived from umbilical cord mesenchymal stromal cells: preclinical development and first-in-human intra-articular validation as therapeutics f... by Aliosha I. Figueroa-Valdés, Patricia Luz-Crawford, Yeimi Herrera-Luna, Nicolás Georges-Calderón, Cynthia García, Hugo E. Tobar, María Jesús Araya, José Matas, Darío Donoso-Meneses, Catalina de la Fuente, Jimena Cuenca, Eliseo Parra, Fernando Lillo, Cristóbal Varela, María Ignacia Cádiz, Rolando Vernal, Alexander Ortloff, Gino Nardocci, Verónica Castañeda, Catalina Adasme-Vidal, Maximiliano Kunze-Küllmer, Yessia Hidalgo, Francisco Espinoza, Maroun Khoury, Francisca Alcayaga-Miranda

“…The product development of UC-MSC-sEV involved refining, standardizing, and validating processes in compliance with GMP standards. The initial assessment of the safety of the clinical-grade product via IA administration in a first-in-human study showed no adverse effects after a 12 month follow-up period. …”
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Evaluating Dietary Red Lentil Screenings on Performance, Antioxidant Status, Caecal Environment, and Intestinal Morphometric Features in Rabbits by Gianluca Pugliese, Caterina Losacco, Letizia Passantino, Giovanni Lentini, Maria M. Cavalluzzi, Michele Schiavitto, Simona Tarricone, Vito Laudadio, Vincenzo Tufarelli

“…Lentils are widespread worldwide and are consumed as part of traditional dishes, and their health-promoting benefits are currently well recognized. Their industrial processing for human consumption implies the generation of different by-products which can be used as promising alternative feedstuff. …”
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Fecal galectin-1 as a potential marker for colorectal cancer and disease severity by Jovanović Milan, Gajović Nevena, Zdravković Nataša, Jovanović Marina, Jurišević Milena, Vojvodić Danilo, Mirković Darko, Milev Boško, Marić Veljko, Arsenijević Nebojša

“…The fecal values of gal-1 higher than 13,708.29 pg/g presented a highly sensitive and specific marker for histological differentiation of tumor tissue. …”
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