Targeting the cGAS-STING pathway: emerging strategies and challenges for the treatment of inflammatory skin diseases by Haoyun Luo, Tian Tian, Chenmin Hu, Fei Hao

“…Nevertheless, there are problems in both this pathway and drug research still left to be solved: inhibitors are not generally specific enough, drugs are not generally bioavailable enough, and there is an imbalance between the two—immunosuppression and the immune response. …”
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Locality-Preserving Multiprojection Discriminant Analysis by Jiajun Ma

“…However, its discriminative performance is still severely limited by the following factors. …”
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Readiness for Perception and Action: Towards a More Mechanistic Understanding of Phasic Alertness by Christian H. Poth

“…Here, we identify key problems that have to be solved for this to be possible and delineate concrete ways to achieve this. …”
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Research progress of catalyst for hydrogen precipitation reaction (HER) in hydrogen production by electrolytic water by Song Yiming

“…With the transformation of the global energy structure to low- carbon, the development of efficient and sustainable clean energy technology has become the key to solve the depletion of fossil energy and environmental problems. …”
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Blockchain data access control scheme based on CP-ABE algorithm by Yunxiang QIU, Hongxia ZHANG, Qi CAO, Jiancong ZHANG, Xingshu CHEN, Hongjian JIN

“…Different from the public chain,the consortium blockchain Hyperledger Fabric integrates the additional member management service(MSP) mechanism to provide channel-based data isolation protection.However,the data isolation protection mechanism still synchronizes the plaintext data within a channel,so there is a risk of data leakage.Besides,the channel-based data access control mechanism does not apply to some fine-grained privacy protection scenarios.To solve the problems of data privacy and security involved in the consortium chain Hyperledger mentioned above,a blockchain data access control scheme based on the CP-ABE algorithm was proposed.Based on the original existing Fabric-CA module in the Hyperledger,our scheme can realize the secure distribution of user attribute keys in the CP-ABE scheme while implementing the fine-grained security access control of blockchain data at the user level.The security analysis shows that the scheme achieves the security goals of ABE user attribute private key security distribution and data privacy protection.The performance analysis also shows that the proposed scheme has good usability.…”
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Incorporating Transformers and Attention Networks for Stock Movement Prediction by Yawei Li, Shuqi Lv, Xinghua Liu, Qiuyue Zhang

“…Therefore, to solve the above problems, we propose a transformer-based attention network framework that uses historical text and stock prices to capture the temporal dependence of financial data. …”
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Intent-driven cloud-network convergence on-demand orchestration by Lulu ZHANG, Chungang YANG, Dong WANG, Ying OUYANG, Tong LI, Junjie GUO, Ru DONG

“…With the rapid development of cloud computing and Internet technology, user service demands show a diversified development trend, and cloud-network convergence has become an important choice for the development of the current information and communication industry.At present, cloud-network convergence only achieves simple cloud-network interconnection, which can not overcome the heavy problems of diversified service demands and massive heterogeneous resource supply.Therefore, promoting cloud-network convergence still requires strengthening the on-demand delivery capability of cloud services.Intent-driven network, as a new networking paradigm, becomes a viable option to solve this dilemma.The research status of cloud-network convergence was sorted out, and the research necessity of intention-driven cloud-network convergence business on-demand orchestration was summarized.Furthermore, the intent-driven cloud-network convergence architecture and its key technologies were proposed and analyzed, and on this basis, an on-demand orchestration model of cloud business was proposed.Finally, in the hybrid cloud interconnection and industrial Internet scenarios, the intent-driven on-demand orchestration model of cloud business was analyzed, and the future prospects were introduced.…”
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Enhanced YOLOv8-based pavement crack detection: A high-precision approach. by ZuXuan Zhang, HongLi Zhang, TongJia Zhang

“…At present, the repair of cracks is still implemented manually, which has the problems of low identification efficiency and high labor cost. …”
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Adversarial example generation method for SAR images based on mask extraction by ZHANG Jianwu, NAI Hao, LI Jie, QIAN Jianhua, FANG Yinfeng

“…To solve the above problems, a SAR image adversarial sample generation model was proposed. …”
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PENGEMBANGAN SISTEM INFORMASI SELEKSI BEASISWA UNGGULAN P3SWOT KEMDIKNAS ONLINE MENGGUNAKAN UNIFIED PROCESS by Khadijah Khadijah, Priyo Sidik Sasongko, Edy Suharto, A.B. Susanto

“…The selection mechanism of P3SWOT excellence scholarship still has some problems. Recently there are ineffective registration and unintegrated scholarship registration data. …”
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Phonetics Applied to English for Specific Purposes in 5th year-medicine Students. by Elizabeth Mercedes Monagas Alvarez

“…<strong><br />Conclusions:</strong> The methodological strategy elaborated for the 5th year students of the medicine specialty highly contributed to solve great part of the pronunciation problems developing pronunciation skills. …”
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A blockchain searchable encryption scheme for legal data shared by multiple parties by Zemin Wang

“…The national judicial system has put forward higher requirements for the sharing of legal data, but existing legal data sharing schemes still have some problems, such as weak data security, unrestricted user access. …”
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Research and Design of Flood Discharge and Energy Dissipation Structures of Datengxia Hydro Project by TAN Zhijun, PAN Minghong

“…The design of flood discharge and energy dissipation structures is important and is the primary research problem in the layout of hydro projects,which involves the problems of discharge capacity,cavitation of flow surface,water aeration,and sediment abrasion and scouring of downstream riverbeds.For the Datengxia hydro project,its maximum discharge capacity of flood discharge structures reaches 66,200 m³/s,and the Froude number of energy dissipation structures is low.Therefore,the scheme of bottom outlets for flood discharge and surface outlets for drift discharge is adopted for flood discharge structures,and the underflow energy dissipation mode of the secondary stilling basin is adopted for energy dissipation structures.As flood discharge structures mainly adopt the bottom outlets for flood discharge,and the radial gate bears huge water thrust,the steel beam is selected as the radial gate support,which solves the difficulties in engineering design and provides a reference for similar projects.…”
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Identifying and Prioritization the Factors Affective the Development of Industrial Clusters With Knowledge-based Companies by Javadj Mir, Hassan Dehghan dehnavi, Mozhde Rabbani

“…This, in turn, emphasizes localization and underlying factors in the development of new clusters.This research is also an applied research that seeks to identify the factors affecting the establishment of knowledge-based companies and the development of industrial clusters in Sistan and Baluchestan province, which help entrepreneurs in this regard. Therefore, to solve the problem, the method of hierarchical data analysis is used, based on which the importance of our subject is the study and development of industrial clusters. …”
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Involution and governance reform in professional football club–school integration: a case study of S City’s youth training base by Lin Wang, Chuanfang Zhu, Yuyuan Zhang, Lan Wang

“…The integrated development of Chinese professional football clubs and campus football has achieved good development. However, there are still many problems in terms of training methods and depth of integration. …”
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ANALYSIS OF INTERPRETATION ABILITY AND MATHEMATICAL DISPOSITION BASED ON STUDENTS' LEARNING MOTIVATION by Silmi Nursyahidah, Supratman Supratman, Sinta Verawati Dewi

“…Students with medium motivation showed varied achievements, generally possessing sufficient self-confidence, perseverance, interest, and curiosity, capable of understanding problems, representing information, and drawing conclusions, although the accuracy of their writing and the scope of problems solved were still limited. …”
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Dynamic decomposition and hyper-distance based many-objective evolutionary algorithm by Xujian Wang, Fenggan Zhang, Minli Yao

“…Abstract Nowadays many algorithms have appeared to solve many-objective optimization problems (MaOPs), yet the balance between convergence and diversity is still an open issue. …”
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Scope of Using Autonomous Trucks and Lorries for Parcel Deliveries in Urban Settings by Evelyne Tina Kassai, Muhammad Azmat, Sebastian Kummer

“…Despite that, there are still some difficulties that need to be solved before actual implementation. …”
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Coverage of the Neurovascular Unit of the Fingertip Using a Reverse Homodigital Dorsal Flap by Rosario E. Perrotta, Alessio Stivala, Dario Virzì, Roberto Grella, Domenico Pagliara, Sergio Brongo

“…The exposure of bone, tendons, vessels, and nerves in a digital defect is one of the most frequent and severe problems to solve in hand surgery and current approaches are still disappointing. …”
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Printed and Digital Media: Printed and Digital Textbooks by Ivan Ivić

“…The production of digital textbooks also faces a significant number of challenges that the current production has not yet solved. Empirical research on the process of digital reading and understanding what has been read, indicate all the problems that still exist in digital textbook creation.…”
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