Engineered circular RNA-based DLL3-targeted CAR-T therapy for small cell lung cancer by Jingsheng Cai, Zheng Liu, Shaoyi Chen, Jingwei Zhang, Haoran Li, Xun Wang, Feng Yang, Shaodong Wang, Xiao Li, Yun Li, Kezhong Chen, Jun Wang, Ming Sun, Mantang Qiu

“…Electroporation conditions were then optimized for the efficient delivery of circRNA into human primary T cells. Subsequently, a circRNA encoding the anti-Delta-like Ligand 3 (DLL3) CAR was constructed, and CAR-T cells were generated via electroporation. …”
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Evaluation of the application of wild yeasts in inhibiting germination of ochratoxin-producing Fungi during coffee fermentation process by Tsung-Yu Liu, Wei-Hsuan Hsu, Bao-Hong Lee

“…High-performance liquid chromatography (HPLC) analysis indicated that citric acid is likely the primary organic acid responsible for inhibiting A. niger spore germination. …”
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Transkingdom mechanism of MAMP generation by chitotriosidase feeds oligomeric chitin from fungal pathogens and allergens into TLR2-mediated innate immune sensing by Tzu-Hsuan Chang, Yamel Cardona Gloria, Margareta J. Hellmann, Timmy Richardo, Carsten Leo Greve, Didier Le Roy, Thierry Roger, Francesca Bork, Stefanie Bugl, Johanna Jakob, Johannes Sonnberger, Lydia Kasper, Bernhard Hube, Bernhard Hube, Stefan Pusch, Neil A. R. Gow, Morten Sørlie, Anne Tøndervik, Bruno M. Moerschbacher, Alexander N. R. Weber, Alexander N. R. Weber, Alexander N. R. Weber, Alexander N. R. Weber

“…In human and murine immune cells, a similar enzymatic activity was shown for human chitotriosidase (CHIT1), and oligomeric chitin is sensed via an innate immune receptor, Toll-like receptor (TLR) 2. However, a complete system of generating MAMPs from chitin and feeding them into a specific receptor/co-receptor-aided sensing mechanism has remained unknown in mammals.MethodsThe effect of the secreted chitinolytic host enzyme, CHIT1, on the TLR2 activity of polymeric chitin preparations from shrimps, house dust mites and the fungal pathogen Candida albicans was assessed in vitro using cell lines and primary immune cells. …”
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Composition and Provenance of the Chang′e-6 Lunar Samples: Insights from the Simulation of the Impact Gardening Process by Yanze Su, Luyuan Xu, Meng-Hua Zhu, Xing-Li Cui

“…The foreign materials in the CE-6 drilled samples likely constitute a minor portion, with an abundance of ∼3.0%. …”
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Medical school admission processes to target rural applicants: an international scoping review and mapping of Australian practices by Jordan Fox, Jessica Beattie, Janelle McGrail, Diann Eley, Lara Fuller, Wendy Hu, Catherine Keniry, Srinivas Kondalsamy Chennakesavan, Lyndal Parker-Newlyn, Katharine Reid, Lucie Walters, Matthew McGrail

“…The primary aim of this study was to identify admission and selection processes utilised by Australian medical schools to target rural applicants and evaluate whether they are evidence-based against international literature. …”
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Perdagangan Saham di Pasar Modal Syariah (Studi Kasus Bursa Efek Indonesia) by Gusniarti Gusniarti

“…The question of “what for” is what is the purpose of stock trading in capital market and the question word of “how” is  how  is the process of transaction in capital market especially secondary market.  …”
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Feasibility and acceptability of a pilot randomized trial of a single session of imagery rescripting targeting the primary consequences of negative experiences with eating and appe... by Nichole R. Kelly, Kelly Jean Doty, Bonnie H. C. Schrag, Shaylah Bryant, Sammy Plezia, Nicholas J. Parr, Elizabeth L. Budd

“…Imagery rescripting (IR) is a therapeutic process during which individuals are guided through recalling and bringing support into distressing memories, like NEREAs. …”
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Growth factors IGF-1 and KGF and adipose-derived stem cells promote migration and viability of primary human keratinocytes in an in vitro wound model by Nina Stadelmann, Raymund E. Horch, Rafael Schmid, David Ostendorf, Ajay Peddi, Theresa Promny, Anja M. Boos, Annika Kengelbach-Weigand

“…For optimum translation into the clinical setting, primary human keratinocytes and patient-matched ADSCs were isolated and used in an in vitro wound model.ResultsThe keratinocyte migration and viability increased after treatment with the growth factors insulin-like growth factor 1 (IGF-1) and keratinocyte growth factor (KGF). …”
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Cyclin-dependent kinase 5 negatively regulates antiviral immune response by disrupting myeloid differentiation primary response protein 88 self-association by Jian-Ping Ren, Hao-Long Cong, Li-Jie Gao, Dong-Fang Jiang, Xin-Tong Li, Yun Wang, Jiu-Qiang Wang, Tie-Shan Tang

“…As a member of the pattern recognition receptors (PRRs) involving in the innate immune system, Toll-like receptors (TLRs) can sense a wide range of microbial pathogens and combat infections by producing antimicrobial products, inflammatory cytokines, and chemokines. …”
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Illustrating the influence of anodic/cathodic second-phases on dissolution mode via Mg–Ca–Sn alloy anodes for primary Mg-air cells by Bowen Yu, Haitao Jiang

“…Two second-phases with an opposite potential difference to the α-Mg matrix may affect the discharge mechanism of magnesium (Mg) anodes for primary Mg-air cells through different micro-galvanic behaviors. …”
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Identification of Nicotinic Acetylcholine Receptor for N‐Acetylcysteine to Rescue Nicotine‐induced Injury Using Beating Cilia in Primary Tissue Derived Airway Organoids by Yichao Zheng, Qinyong Tian, Haowei Yang, Yongde Cai, Jiaxin Zhang, Yifen Wu, Shuo Zhu, Zuocheng Qiu, Yimin Lin, Jiangquan Hong, Yi Zhang, David Dockrell, Shaohua Ma

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Comparing traditional natural language processing and large language models for mental health status classification: a multi-model evaluation by Thomas Kallstenius, Andrea Johansson Capusan, Gerhard Andersson, Adam Williamson

“…Additional metrics like precision, recall, and F1-score were analyzed. …”
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Health Catch-UP!: a realist evaluation of an innovative multi-disease screening and vaccination tool in UK primary care for at-risk migrant patients by Jessica Carter, Lucy P. Goldsmith, Felicity Knights, Anna Deal, Subash Jayakumar, Alison F. Crawshaw, Farah Seedat, Nathaniel Aspray, Dominik Zenner, Philippa Harris, Yusuf Ciftci, Fatima Wurie, Azeem Majeed, Tess Harris, Philippa Matthews, Rebecca Hall, Ana Requena-Mendez, Sally Hargreaves

“…Methods We carried out a mixed-methods process evaluation of Health Catch-UP! in two urban primary healthcare practices to integrate Health Catch-UP! …”
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Genesis of feudalism in Western Europe and its influence to the globai process of history: The conceptions of L. Vasilyev and E. Gudavičius by Nerijus Babinskas

“…The structural heritage of Antiquity was a primary stimulus during the process of the genesis of feudalism. …”
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Bone density may affect primary stability of anterior cruciate ligament reconstruction when organic core bone plug fixation technique used by Pouya Dehestani, Farzam Farahmand, Amirhossein Borjali, Kaveh Bashti, Mahmoud Chizari

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How, why and when are delayed (back-up) antibiotic prescriptions used in primary care? A realist review integrating concepts of uncertainty in healthcare by Monsey Mcleod, Anne Campbell, Benedict Hayhoe, Aleksandra J. Borek, Sarah Tonkin-Crine, Michael V. Moore, Christopher C. Butler, A. Sarah Walker, Alison Holmes, Geoff Wong, on behalf of the STEP-UP study team

“…Conclusion This review explains how, why and in what contexts GPs are more or less likely to use DP, as well as various uncertainties GPs face which DP may mitigate or provoke. …”
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Is screening for microalbuminuria in patients with type 2 diabetes feasible in the Cape Town public sector primary care context? A cost and consequence study by H.O. Ibrahim, D. Stapar, B. Mash

“…Of the eligible patients, 69.9% completed the screening process which led to a diagnosis of microalbuminuria in another 11.7%. …”
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Sociodemographic characteristics and prevalence of otitis media among children under five years of age attending selected primary healthcare facilities in Calabar, Nigeria by Nse O. Umoh1*, Aniekan Eyo1, Mfoniso Udonkang2, Glory Bebia1, Justin Mbah1, Samuel Akpan3

“…Due diligence for care and protection of children from overcrowding, dust and poor hygienic conditions often associated with substandard daycare centers would likely reduce the burden of OM in the population.…”
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Breast Cancer Detection Using Infrared Thermography: A Survey of Texture Analysis and Machine Learning Approaches by Larry Ryan, Sos Agaian

“…It comprehensively reviews the entire processing pipeline, from image preprocessing and feature extraction to classification and performance assessment. …”
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A case of early gastric cancer with a single giant lymph node metastasis by Masato Yoshikawa, Misaki Tamario, Masayoshi Obatake, Koichi Sato, Shigehiko Yagi, Hiromi Otani, Katsumi Kito

“…Cancer often becomes more malignant in metastatic lesions than in primary lesions, and retrodifferentiation to the fetal gastrointestinal tract during the metastatic process has been reported in gastric cancer. …”
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