Context dependent role of miR-486 promoting neuroregeneration of primary sensory neurons downstream of interleukin-6 signal transducer by Theodora Kalpachidou, Kai Kummer, Valentina Handle, David Zimmermann, Maria Peteinareli, Serena Quarta, Natalia Mach, Laura Castaldi, Paul A. Heppenstall, Rainer V. Haberberger, Hermona Soreq, Michaela Kress

“…On the other hand, DRG neurons derived from mice with a conditional deletion of IL6ST/gp130 in Nav1.8-expressing primary afferent nociceptors (SNS-gp130−/−) show strongly compromised neuro-regeneration, which was significantly rescued by overexpressing miR-486, indicative of a specific role of miR-486 in IL-6/gp130-dependent neuro-regenerative processes. …”
Get full text

Natural Language Processing framework for identifying abdominal aortic aneurysm repairs using unstructured electronic health records by Daniel C. Thompson, Reza Mofidi

“…This study aimed to develop NLP models for identifying and classifying abdominal aortic aneurysm (AAA) repairs from unstructured EHRs, demonstrating a proof-of-concept for automated patient identification in registries like the National Vascular Registry. Using the MIMIC-IV-Note dataset, a multi-tiered approach was developed to identify vascular patients (Task 1), AAA repairs (Task 2), and classify repairs as primary or revision (Task 3). …”
Get full text

A qualitative process evaluation of group problem management plus for distressed Syrian refugees in Türkiye by Ayşenur Coşkun-Toker, Zeynep İlkkurşun, Daniela Fuhr, Bayard Roberts, Pim Cuijpers, Marit Sijbrandij, Ceren Acarturk

“…Adapting gPM+ to address social determinants like poverty may be beneficial. The need for booster sessions was emphasized to maintain long-term change and provide deeper learning of the strategies. …”
Get full text

GROUNDWATER POTENTIAL MAPPING (GWPM) USING ANALYTICAL HIERARCHY PROCESS (AHP) IN BENGKULU CITY, INDONESIA by Citra Febiola Ariska, Darmawan Ikhlas Fadli, Muhammad Afif Nabhan, Rahma Alshenta Nugraha, Belliya Hafiza, Isra Amalia, Erlan Sumanjaya, Arif Ismul Hadi, Refrizon Refrizon, Ayu Maulidiyah

“…This research seeks to assess groundwater potential in Bengkulu City, Indonesia, employing the Analytical Hierarchy Process (AHP). The study incorporates eight primary factors: lineament density, drainage density, precipitation, geomorphology, geology, slope, land cover, and elevation. …”
Get full text

Cessation of smoking in people attending UK emergency departments: the COSTED RCT with economic and process evaluation by Ian Pope, Lucy V Clark, Allan Clark, Emma Ward, Pippa Belderson, Susan Stirling, Steve Parrott, Jinshuo Li, Timothy Coats, Linda Bauld, Richard Holland, Sarah Gentry, Sanjay Agrawal, Benjamin M Bloom, Adrian Boyle, Alasdair Gray, M Geraint Morris, Caitlin Notley

“…Main outcome measures The primary outcome was biochemically validated sustained abstinence at 6 months. …”
Get full text

Analysis of physicochemical properties, trihalomethane levels, and trihalomethane formation potential in Cagayan de Oro city's primary drinking water source by Ronnie L. Besagas, Romeo M. Del Rosario, Angelo Mark P. Walag

Get full text

Implementation outcomes from a randomized, controlled trial of a strategy to improve integration of behavioral health and primary care services by Constance van Eeghen, Jeni Soucie, Jessica Clifton, Juvena Hitt, Brenda Mollis, Gail L. Rose, Sarah Hudson Scholle, Kari A. Stephens, Xiaofei Zhou, Laura-Mae Baldwin

“…Results Regarding acceptability, 74% (14) of practices had high scores for willingness of providers and staff to use the Toolkit and 68% (13) for quality improvement teams liking the Toolkit. For appropriateness, 95% (19) of practices had high scores for the structured process being a good match and 63% (12) for the Toolkit being a good match. …”
Get full text

Sustaining forest biodiversity: Exploring the effect of long-term natural disturbance dynamics on contemporary lichen communities in primary forest ecosystems by Rhiannon Gloor, Marek Svitok, Martin Mikoláš, Jeňýk Hofmeister, Josef Halda, Pavel Janda, Francesco Maria Sabatini, Lucie Zemanová, Arne Buechling, Daniel Kozák, Matej Ferenčík, Michal Frankovič, Martin Dušátko, Miroslav Svoboda

“…Using a dendrochronological approach, this study investigates how natural disturbance dynamics indirectly influence various lichen community metrics in some of Europe's best-preserved primary mixed-beech forests. Mixed modelling revealed that natural historical disturbance processes have decades-long effects on forest structural attributes, which had both congruent and divergent impacts on lichen community richness and composition. …”
Get full text

Internet and telephone intervention to support patients discontinuing long-term antidepressants in primary care: the REDUCE research programme including RCT by Tony Kendrick, Beth Stuart, Hannah Bowers, Mahboobeh Haji Sadeghi, Helen Page, Christopher Dowrick, Michael Moore, Mark Gabbay, Geraldine Leydon, Guiqing Lily Yao, Shihua Zhu, Paul Little, Gareth Griffiths, Glyn Lewis, Carl May, Joanna Moncrieff, Chris F Johnson, Una Macleod, Simon Gilbody, Rachel Dewar-Haggart, Samantha Williams, Wendy O’Brien, Riya Tiwari, Catherine Woods, Tasneem Patel, Naila Khan, Emma Maund, Nadja van Ginneken, Amy Din, Claire Reidy, Rebecca Lucier, Bryan Palmer, Taeko Becque, Yumna Masood, Natalie Thompson, Ellen van Leeuwen, Marta Glowacka, Adam WA Geraghty

“…Adverse events from attempting discontinuation are likely to be few, and usually not serious, so this is a relatively safe thing to do in primary care, where relapse of depression is likely to occur in a minority of patients, and treatment can be quickly restarted if patients are monitored. …”
Get full text

Increasing uptake of self-management education programmes for type 2 diabetes in primary care: the Embedding research programme including an RCT by Melanie J Davies, Shona Agarwal, Danielle H Bodicoat, Alan Brennan, Simon Dixon, Helen Eborall, Agnieszka Glab, Laura J Gray, Michelle Hadjiconstantinou, Lisa Huddlestone, Nicky Hudson, Anju Keetharuth, Kamlesh Khunti, Caroline Kristunas, Graham Martin, Alison Northern, Mike Patterson, Daniel Pollard, Rebecca Pritchard, Sally Schreder, Jane Speight, Bernie Stribling, Jackie Sturt, Jess Turner, Christina Weis

“…This limited uptake of the Embedding Package likely contributed to it having no overall effect on the primary or main secondary outcomes. …”
Get full text

LL37 complexed to double-stranded RNA induces RIG-I-like receptor signalling and Gasdermin E activation facilitating IL-36γ release from keratinocytes by Jennifer Keller, Judit Danis, Isabella Krehl, Eleftheria Girousi, Takashi K. Satoh, Barbara Meier-Schiesser, Lajos Kemény, Márta Széll, W. Wei-Lynn Wong, Steve Pascolo, Lars E. French, Thomas M. Kündig, Mark Mellett

“…Here, we demonstrate that LL37 binds to dsRNA and induces IL-36γ release from human primary keratinocytes. LL37/dsRNA complexes activate RIG-I-like Receptor signalling, resulting in Caspase-3 and Gasdermin E (GSDME) cleavage. …”
Get full text

Sanse Powder Essential Oil Nanoemulsion Negatively Regulates TRPA1 by AMPK/mTOR Signaling in Synovitis: Knee Osteoarthritis Rat Model and Fibroblast-Like Synoviocyte Isolates by Mingchao Li, Li Zhang, Zixiu Liu, Li Zhang, Runlin Xing, Songjiang Yin, Xiaochen Li, Nongshan Zhang, Peimin Wang

“…Synovitis is the primary driving factor for the occurrence and development of knee osteoarthritis (KOA) and fibroblast-like synoviocytes (FLSs) and plays a crucial role during this process. …”
Get full text

Exploring the barriers to accessing antenatal care at the primary health care center level of a tertiary hospital in Lebanon: a qualitative study by Carla El Alam, Linda Abou-Abbas, Mohamad Shafic Ramadan, Michèle Kosremelli Asmar

“…This study examines the barriers pregnant women in Lebanon face when accessing ANC at a primary healthcare center (PHCC) in a public tertiary hospital located in Beirut, Lebanon. …”
Get full text

OPC-UA in artificial intelligence: a systematic review of the integration of data mining and NLP in industrial processes by Velesaca Henry O., Holgado-Terriza Juan A.

“…The review evaluates current methodologies and applications aimed at addressing these challenges, particularly in areas like predictive maintenance, anomaly detection, process optimization, and others. …”
Get full text

CHARACTERISTICS OF BIOMASS RESULTING FROM AGRO-INDUSTRIAL PROCESSES AND POSSIBILITIES OF ITS EVALUATION IN THE CONTEXT OF THE CIRCULAR BIOECONOMY by TAȘCA, Corina

“…Present-day methods for handling solid organic waste often include its application in agriculture, incineration, anaerobic digestion, composting, and related processes. Liquid waste from the agro-industrial sector can be treated through processes like sedimentation, settling, and anaerobic fermentation.…”
Get full text

Quality of the diagnostic process in patients presenting with symptoms suggestive of bladder or kidney cancer: a systematic review by Georgios Lyratzopoulos, Fiona M Walter, Willie Hamilton, Yin Zhou, Marije van Melle

“…Urinary tract infections, nephrolithiasis and benign prostatic conditions before cancer diagnosis were associated with diagnostic delay. Women were more likely to experience diagnostic delay than men. Patients who first saw a urologist were less likely to experience delayed evaluation and cancer diagnosis.Conclusions Women, and patients with non-cancerous urological diagnoses just prior to their cancer diagnosis, were more likely to experience lower quality diagnostic processes. …”
Get full text

Patient–physician relationship and use of gut feeling in cancer diagnosis in primary care: a cross-sectional survey of patients and their general practitioners by Peter Vedsted, Anette Fischer Pedersen, Christina Maar Andersen, Mads Lind Ingeman

“…The named GP subsequently received a questionnaire.Primary and secondary outcome measures GPs’ use of GF in the diagnostic process for the particular patient. …”
Get full text

What do children, parents and staff think about a healthy lifestyles intervention delivered in primary schools? a qualitative study by Joanna Goldthorpe, Tracy Epton, Chris Keyworth, Rachel Calam, Joanna Brooks, Chris Armitage

“…Objective Primary schools are crucial settings for early weight management interventions but effects on children’s weight are small and evidence shows that deficiencies in intervention implementation may be responsible. …”
Get full text

Development of a clinical decision support tool for Primary care Management of lower Urinary tract Symptoms in men: the PriMUS study by Adrian Edwards, Ridhi Agarwal, Janine Bates, Alison Bray, Sarah Milosevic, Emma Thomas-Jones, Michael Drinnan, Marcus Drake, Peter Michell, Bethan Pell, Haroon Ahmed, Natalie Joseph-Williams, Kerenza Hood, Yemisi Takwoingi, Chris Harding

“…As with all models currently used in practice, continued external validation of the models is important, and in populations with greater ethnic diversity. As above, the primary outcome is likely to be that of referral rates as these are the driver of resource use (secondary care investigations, clinic time etc). …”
Get full text

Current experience and future potential of facilitating access to digital NHS primary care services in England: the Di-Facto mixed-methods study by Gary Abel, Helen Atherton, Jon Sussex, Nurunnahar Akter, Abodunrin Q Aminu, Wiktoria Bak, Carol Bryce, Christopher E Clark, Emma Cockcroft, Hamish Evans, Evangelos Gkousis, Georgia Jenkins, Caroline Jenkinson, Nada Khan, Jeffrey Lambert, Brandi Leach, Christine Marriott, Jennifer Newbould, Sarah Parkinson, Jo Parsons, Emma Pitchforth, Laura Sheard, Stephanie Stockwell, Chloe Thomas, Bethan Treadgold, Rachel Winder, John L Campbell

“…Background Current National Health Service policy in England encourages enhanced digital access in primary care service provision. In this study, we investigate ‘digital facilitation’ – that range of processes, procedures and personnel which seeks to support National Health Service primary care patients in their uptake and use of online services. …”
Get full text