DICER-LIKE2 plays a primary role in transitive silencing of transgenes in Arabidopsis. by Sizolwenkosi Mlotshwa, Gail J Pruss, Angela Peragine, Matthew W Endres, Junjie Li, Xuemei Chen, R Scott Poethig, Lewis H Bowman, Vicki Vance

“…Dicer-like (DCL) enzymes play a pivotal role in RNA silencing in plants, processing the long double-stranded RNA (dsRNA) that triggers silencing into the primary short interfering RNAs (siRNAs) that mediate it. …”
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Mechanism and target treatment of primary immunodeficiency diseases with systemic lupus erythematosus‐like phenotype by Shan Liu, Zhiyong Zhang, Xuemei Tang, Xiaodong Zhao, Yunfei An

“…In recent years, the increasing identification of monogenic causes of SLE and PIDs discloses the partially shared genetic background and common pathogenic process. The study of PIDs with SLE‐like phenotype paves the way for the exploration of lupus pathogenesis and new perspectives in targeted therapies concurrently.…”
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Senescence-like Phenotype After Chronic Exposure to Isoproterenol in Primary Quiescent Immune Cells by Michael Laumann, Philipp Palombo, Judy Fieres, Mara Thomas, Gabriele Saretzki, Alexander Bürkle, Maria Moreno-Villanueva

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A two year observation of the process of applying recombinant IGF-1 to treat short stature in children with primary IGF-1 deficiency - case reports of 3 patients by Elżbieta Petriczko, Beata Wikiera, Anita Horodnicka-Józwa, Katarzyna Marcinkiewicz, Justyna Szmit-Domagalska, Andrzej Kędzia, Julia Durzyńska, Justyna Broniarczyk, Bartosz Gabryelczyk

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Role of hormonal factor in development of primary and secondary tumorous process in the brain by O. I. Kit, V. A. Bandovkina, E. M. Frantsiyants, E. E. Rostorguev, I. V. Balyazin-Parfenov, N. D. Cheryarina

“…Causes of the development onset of primary malignant cerebral neoplasms have not yet been determined. …”
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Characterization of Key Odorants During Processing of Minty-like Aroma ‘Rucheng Baimaocha’ Black Tea by Jian Ouyang, Ronggang Jiang, Qi Liu, Hongyu Chen, Xiaoqin Yi, Yuzi Yang, Fangfang Huang, Juan Li, Haitao Wen, Ligui Xiong, Jianan Huang, Zhonghua Liu

“…Aroma analysis revealed that 28 compounds with odor activity values (OAV) > 1 were the primary contributors during RCBT processing. Notably, minty-like odorants in RCBT were primarily derived from the metabolic pathways of the methylerythritol phosphate (MEP) and mevalonic acid (MVA), lipid oxidation, and phenylalanine. …”
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Association of polymorphic markers in innate immunity receptor genes with the risk of primary adrenal insufficiency by N. D. Rasskazova, E. A. Meremyanina, N. O. Kalyuzhnaya, N. D. Abramova, E. V. Budanova, I. N. Diakov

“…Thus, the purpose of our work was to study polymorphic markers in the genes of interferon, NOD- and RIG-like receptors and their association with the risk of developing primary adrenal insufficiency. …”
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Optimizing the early-stage of composting process emissions – artificial intelligence primary tests by Joanna Rosik, Maciej Karczewski, Sylwia Stegenta-Dąbrowska

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Photon-likeness of Hadron Showers and Impact of Lorentz Boosting by Jannis Pawlowsky, Karl-Heinz Kampert, Julian Rautenberg

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Like a Complete Unknown: An Audit of the Quality of the Referrals to the Cancer of Unknown Primary Clinic at a Tertiary Care Centre by Ian Hirsch, Jonah Teich, Khaled Abdulalem, Samuel D. Saibil

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Synergistic strengthening and toughening in β titanium alloy via enhanced micron-sized primary α with the fiber-like β grains by Leliang Liu, Qiaoyan Sun, Jixiong Liu, Xiaoxiang Wang, Jun Sun

“…During the thermomechanical process, the microscale primary α phase (αp) hindered the migration of β grain boundaries and coordinated the deformation, forming fiber-like β grains. …”
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From fibrosis to granuloma: drug induced systemic sarcoidosis-like reaction after rituximab in a patient with primary Sjögren’s syndrome by Rui Rua Coelho, Sara Xavier Pires, José Ricardo Brandão, Inês Furtado

“…Drug induced sarcoidosis-like reaction (DISR) is a systemic granulomatous reaction, which is histopathologically identical to primary sarcoidosis - mostly described after the use of biologics like tumour necrosis factor alpha antagonists but also anti-CD20 (rituximab). …”
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The Manifestation of the Dual ROS-Processing and Redox Signaling Roles of Glutathione Peroxidase-like Enzymes in Development of <i>Arabidopsis</i> Seedlings by Krisztina Bela, Bernát Tompa, Riyazuddin Riyazuddin, Edit Horváth, Krisztián Jász, Ádám Hajnal, Sajid Ali Khan Bangash, Ágnes Gallé, Jolán Csiszár

“…Plant glutathione peroxidase-like (GPXL) enzymes are thiol-based peroxidases that reduce H₂O₂ or hydroperoxides to water or alcohols using electrons principally from thioredoxin. …”
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Integrated care teams in primary care improve clinical outcomes and care processes in patients with non-communicable diseases by Pei Lin Hu, Cynthia Yan-Ling Tan, Ngoc Hoang Long Nguyen, Rebekah Ryanne Wu, Juliana Bahadin, Nivedita Vikas Nadkarni, Ngiap Chuan Tan

“…Introduction: Primary care physicians face the increasing burden of managing multimorbidities in an ageing population. …”
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TL-532, a novel specific Toll-like receptor 3 agonist rationally designed for targeting cancers: discovery process and biological characterization by Sylvain Thierry, Sarah Maadadi, Aurore Berton, Laura Dimier, Clémence Perret, Nelly Vey, Saïd Ourfali, Mathilde Saccas, Solène Caron, Mathilde Boucard-Jourdin, Marc Colombel, Bettina Werle, Marc Bonnin

“…Toll-like receptor 3 (TLR3) is an innate immune receptor that recognizes double-stranded RNA (dsRNA) and induces inflammation in immune and normal cells to initiate anti-microbial responses. …”
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Structural convergence and membrane interactions of Aβ1-42 along the primary nucleation process studied by solid state NMR by Maurine K. Kengwerere, June M. Kenyaga, Peng Xiao, Shubha S. Gunaga, Faith J. Scott, Xyomara Wutoh-Hughes, James Wang, Brian Lum, Yan Sun, Frederic Mentink-Vigier, Tuo Wang, Wei Qiang

“…Overall, our results provide a molecular-level understanding of the Aβ1-42 nucleation process in a membrane-like environment and its membrane-disrupting intermediates. …”
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Primary saltmarsh succession on a tropical coral island in the South China Sea: Human influences initiate and accelerate the process of succession by Deyi Yin, Shuguang Jian, Hongfang Lu, Qianmei Zhang, Hai Ren

“…Abstract Saltmarsh represents a classic model of primary succession, yet the processes underlying its initiation and development, especially in response to human influences, remain poorly understood. …”
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Wear of End Mills with Carbon Coatings When Aluminum Alloy A97075 High-Speed Processing by Evgeny E. Ashkinazi, Sergey V. Fedorov, Artem K. Martyanov, Dmitry N. Sovyk, Victor G. Ralchenko, Artem P. Litvinov, Artem A. Ershov, Vitaly I. Konov

“…It was revealed that at a forced cutting mode of about 1000 m/min, cutters made of CTS12D alloy with a nanocrystalline diamond coating with a “cauliflower” structure and with a diamond-like film showed 10% higher resistance. The primary wear mechanism was adhesive. …”
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Application of machine learning and temporal response function modeling of EEG data for differential diagnosis in primary progressive aphasia by Heather Dial, Lokesha S. Pugalenthi, G. Nike Gnanateja, Junyi Jessy Li, Maya L. Henry

“…Abstract Primary progressive aphasia (PPA) is a neurodegenerative syndrome characterized by progressive decline in speech and/or language. …”
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The Impact of Protein Intake on Insulin-Like Growth Factor-1 (IGF-1) Levels and Its Implications for Metabolic Health and Aging Processes– a literature review by Marlena Jankowska, Karolina Baran, Natalia Jańczyk, Karolina Mędrysa, Jakub Jan Pokrzepa, Michał Presak, Gabriela Blecharz, Julia Szwech, Mikołaj Pograniczny, Adrianna Mielżyńska

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