The IMPART (IMproving PAlliative care in Residential aged care using Telehealth) trial: a stepped-wedge cluster-randomised controlled trial protocol by Anita M. Y. Goh, Katrin Gerber, Kayla Lock, Ellen Gaffy, Kerry Hwang, Anna Lane, Kirsten J. Moore, Barbara Hayes, Lidia Engel, Mark Tacey, Brian Le, Paul Yates, Melissa J. Bloomer, Len Gray, Dimity Constance Pond, Danny Hills, Frances Batchelor, Ross Bicknell, Debra Nestel, Christina Johnson, Steven Savvas, Karen Bodna, Penny Harvey, Aaron B. Wong, Bonnie Lui, Wen Kwang Lim

“…Secondary outcomes include reduction of emergency department presentations and length of stay of unplanned hospital admissions, and improvement in residents’ quality of life, comfort, satisfaction, and quality of EOLC. …”
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Preclinical data and design of a phase I clinical trial of neoantigen-reactive TILs for advanced epithelial or ICB-resistant solid cancers by J. Palomero, V. Galvao, I. Creus, J. Lostes, M. Aylagas, A. Marín-Bayo, M. Rotxés, M. Sanz, M. Lozano-Rabella, A. Garcia-Garijo, A. Yuste-Estevanez, D. Grases, J. Díaz-Gómez, J. González, J.F. Navarro, J.J. Gartner, I. Braña, X. Villalobos, N. Bayó-Puxan, J. Jiménez, A.N. Palazón, S. Muñoz, G. Villacampa, A. Piris-Giménez, P. Barba, M. Codinach, L. Rodríguez, S. Querol, E. Muñoz-Couselo, J. Tabernero, S. Martín-Lluesma, A. Gros, E. Garralda

“…Six good manufacturing practice (GMP)-grade validations of pre-REP TIL expansion were carried out and TIL cultures from these six intermediate products were selected to carry out the clinical-scale GMP validation of the REP. …”
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Utility of a Novel High‐Sensitivity Multiplex Companion Diagnostic Test Using Formalin‐Fixed Paraffin‐Embedded Cell Block Materials of Non‐small Cell Lung Cancer by Yoshiki Shinomiya, Yuko Ishida, Kanako C. Hatanaka, Mamiko Yamamoto, Ayae Nange, Asami Okumura, Yumi Wada, Mitsuharu Abiko, Tomohiro Shimizu, Ryoko Watanabe, Yamato Hashimoto, Yoshiharu Sato, Jun Sakakibara‐Konishi, Tatsuya Kato, Shinya Tanaka, Yutaka Hatanaka

“…This approach enables the detection of mutations even when they are present in only small amounts within the sample. This study aimed to evaluate the utility of cPANEL using FFPE cell block (CB) with a low TC. …”
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Diagnostic value of sonographic signs in acute injury of anterior talofibular ligament by Meijun Zhou, Jialin Ye, Sushu Li, Wenhong Yi, Yu Wang, Jiangting Ji, Tianyue Wang, Yi Yin, Yanni He, Hongmei Liu

“…Objectives: The present study aimed to determine the diagnostic value of sonographic signs in patients who have experienced an acute injury of the anterior talofibular ligament (ATFL), and provide diagnostic evidence for improving the classification of ATFL injuries. …”
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The COMPLETE trial: HolistiC early respOnse assessMent for oroPharyngeaL cancEr paTiEnts; Protocol for an observational study by Aad van der Lugt, Dik C van Gent, Gerda M Verduijn, Marta E Capala, Nienke D Sijtsema, Iris Lauwers, Juan A Hernandez Tamames, Wilma D Heemsbergen, Aniel Sewnaik, Jose A Hardillo, Hetty Mast, Yvette van Norden, Maurice P H M Jansen, Mischa S Hoogeman, Bianca Mostert, Steven F Petit

“…The main results of the trial will be presented in international meetings and medical journals.Trial registration number NL8458.…”
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A novel way to understand and communicate the burden of AntiPsycHotic prescribing for adults across specialist Intellectual Disability services in England and Wales: the APHID feas... by Emily Stanyard, Helen Neilens, Victoria Allgar, Victoria Allgar, Matthew Bailey, Crispin Musicha, Kiran Purandare, Bhathika Perera, Ashok Roy, Indermeet Sawhney, Lance Watkins, Lance Watkins, Sujeet Jaydeokar, Sujeet Jaydeokar, Sarah Lennard, Sarah Lennard, Sarah Mitchell, Sarah Mitchell, Paula McGowan, Richard Laugharne, Richard Laugharne, Samuel J. Tromans, Samuel J. Tromans, Rohit Shankar, Rohit Shankar

“…It could be that cumulative service level antipsychotic treatment converted and presented as chlorpromazine units could allow for comparison of services on how antipsychotic treatment is being utilised and allow for comparing of practices between services in different regions. …”
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Suitability of the Amazonas region for beekeeping and its future distribution under climate change scenarios by Darwin Gómez-Fernández, Ligia García, Jhonsy O. Silva-López, Jaris Veneros Guevara, Erick Arellanos Carrión, Rolando Salas-Lopez, Malluri Goñas, Nilton Atalaya-Marin, Manuel Oliva-Cruz, Nilton B. Rojas-Briceño

“…This study modeled and mapped areas with present conditions suitable for beekeeping and future climate behavior. …”
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Stepped wedge cluster randomised controlled trial to assess the impact of a decision support tool for physical restraint use in intensive care units (ARBORea Study): a study protoc... by Bruno Pereira, Christine Rolhion, Dominique Morand, J Boyer, E David, Thomas Godet, Ruben Martinez, Lynda Araujo, Céline Lambert, Périne Vidal, Mohamad Yakhni, Sylvie Cosserant, Isabelle Genès, Angelina Barage, J Bourenne, H Antoine, S L’hotellier, M Berrahal, S Piot, F Degivry, F Moitron, N Revel, M Bonnefoy, C Fazilleau, N Himer, I Roure, S Cluse, M Bothorel, C Riehl

“…Findings will be published in peer-reviewed journals and presented at local, national and international meetings and conferences to publicise and explain the research to clinicians, commissioners and service users. …”
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Integrated deep vertical rotary tillage and subsurface pipe drainage techniques for sustainable soil salinization management and cotton production in arid regions by Zhijie Li, Qiang Meng, Ling Li, Zhentao Bai, Yanjie Li, Hongguang Liu, Pengfei Li, Tangang Wang

“…Soil salinization impacts over 6 % of the world’s arable land, presenting an even greater challenge to agriculture in arid regions. …”
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Serial casting for contractures in SMA: consensus derived guidelines for treatment by Laurey Brown, Katie Hoffman, Chiara Corbo-Galli, Carolyn Kelley, Terri Carry, Matt Civitello, Giorgia Coratti, Roberto DeSanctis, Tina Duong, Brigid Driscoll, Jean Flickinger, Allan M. Glanzman, Jennifer Jones, Elizabeth Maczek, Dionne Moat, Jacqueline Montes, Robert Muni-Lofra, Leslie Nelson, Leslie Nelson, Amy Pasternak, Melanie Valle, Kristin J. Krosschell, Kristin J. Krosschell

“…BackgroundIndividuals with Spinal Muscular Atrophy (SMA) often present with muscle contractures. Serial casting has been used in a variety of other peripheral nerve, muscle, and central nervous system disorders to improve knee and ankle range of motion limitations and functional performance in both ambulatory and non-ambulatory individuals.ObjectiveThe goal of this study was to reach a consensus about the parameters, considerations and general guidelines that should inform practice when serial casting to improve flexibility in individuals with SMA.MethodsThis international effort was conducted between August 2020 and May 2023. …”
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Lower respiratory tract microbiome dysbiosis impairs clinical responses to immune checkpoint blockade in advanced non‐small‐cell lung cancer by Yong Zhang, Xiang‐Xiang Chen, Ruo Chen, Ling Li, Qing Ju, Dan Qiu, Yuan Wang, Peng‐Yu Jing, Ning Chang, Min Wang, Jian Zhang, Zhi‐Nan Chen, Ke Wang

“…Conclusions This study provided a microecological landscape of the lower respiratory tract with advanced NSCLC to ICI interventions and presented a multidimensional perspective with favoured outcomes that may improve the predictive capacity of the localized microbiome in clinical practices. …”
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Protektem pikinini blong yu trial: protocol for a single arm field trial to assess the effectiveness of treating-all pregnant women with hepatitis B infection with tenofovir prophy... by Leila Bell, Aleesha Kalulu, Kali Ameara, Nicole Allard, Sereana Natuman, Zeshi Fisher, Caroline SE Homer, Annie Taissets, Kathy Jackson, Navin Karan, Kaylene Kalmos, Emily Deed, Leiwia Dick, Leias Obed, Florita Toa, Harriet Obed, Ben John Taura, Philippe Guyant, Jessica Howell, Jason Iopa, Junior George Pakoa, Minado Paul, Harriet Sam, Tim Spelman, Jenny Stephens, Sale Vurobaravu, Margaret Hellard, Caroline van Gemert

“…Adjusted analyses will be performed, as needed, and presented in addition to unadjusted comparisons. Discussion This study will provide evidence of acceptability, effectiveness and cost-effectiveness of prophylaxis for all women with hepatitis B during pregnancy, as per the updated WHO guidelines, compared with current practice. …”
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Psilocybin-Assisted suppoRtive psychoTherapy IN the treatment of prolonged Grief (PARTING) trial: protocol for an open-label pilot trial for cancer-related bereavement by Jerome Sarris, Rachel E Neale, Jörg Strobel, Stephen Parker, Fiona Maccallum, Margaret Ross, Vanessa L Beesley, Susan L Rossell, Tom J Kennedy, Renee Harvey, Daniel Perkins, James Bennett-Levy, Shevaugn Johnson, Hanna Beebe, Natalie Roset

“…Introduction Prolonged grief disorder (PGD) represents a substantial public health issue, especially in oncology settings where it affects up to 30% of bereaved carers. Current best-practice treatments are lengthy, and up to 50% of participants have persistent PGD. …”
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18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in Large-Vessel Vasculitis During Active and Inactive Disease Stages Is Associated with the Metabolic Profil... by Dimitris Anastasios Palamidas, Georgios Kalykakis, Dimitra Benaki, Loukas Chatzis, Ourania D. Argyropoulou, Panagiota Palla, Antonia Kollia, Pavlos Kafouris, Marinos Metaxas, Andreas V. Goules, Emmanuel Mikros, Konstantinos Kambas, Constantinos D. Anagnostopoulos, Athanasios G. Tzioufas

“…These preliminary results could pave the way for more extensive studies integrating serum metabolomic parameters with PET/CT imaging data to extract sensitive composite disease indexes useful for everyday clinical practice.…”
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Implementation of a novel stratified PAthway of CarE for common musculoskeletal (MSK) conditions in primary care: protocol for a multicentre pragmatic randomised controlled trial (... by Michele Sterling, Ian Cameron, Lyndal Trevena, Manuela Ferreira, Kim L Bennell, Paul Hodges, Luke Connelly, Kathryn Refshauge, Kerrie Evans, Trudy Rebbeck, Julia Treleaven, Gwen Jull, Tim J Shaw, Milena Simic, Paulo Ferreira, Darren Beales, Carrie Ritchie, Nadine Foster, Deborah Black

“…Dissemination of findings will occur via peer-reviewed publications, conference presentations and social media.Trial registration number ACTRN12619000871145.…”
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Systematic method for developing tailored strategies for implementing point-of-care procalcitonin testing to guide antibiotic prescribing in Swiss primary care: a protocol for a mi... by Lauren Clack, Joachim Marti, Byron J Powell, Yolanda Mueller, Noémie Boillat-Blanco, Anna Nicolet, Rahel Naef, Aline Wolfensberger, Sophie CL Gendolla, Jelena Dunaiceva, Catherine Plüss-Suard, Anne Niquille

“…The results of our study will be shared among the Antimicrobial Stewardship in Ambulatory Care Platform network, published in peer-reviewed scientific journals, and will be presented at international and national conferences.…”
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Exploring Treatment Protocol Adherence and Variations in Paroxysmal Supraventricular Tachycardia in the Emergency Department: A Multi-Center Cohort Study by Kevin Ku, Jack Healy, Christian A. Lee, Maha Khan, Kevin D. Chao, Saleh Hassan, Ching-Fang Tiffany Tzeng, Yu-Lin Hsieh, Andrew Shedd, Toral Bhakta, Dahlia Hassani, Eric H. Chou

“…Despite evidence-based guidelines recommending a stepwise approach, significant variability in clinical practice persists, particularly in adenosine dosing strategies. …”
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HpFBH3 transactivates HpCO7 via binding to the E-boxes in the promoter and may accelerate flower formation in pitaya by Xiaowei Cai, Ling Xiao, Xiangmei Nie, Qiandong Hou, Sulin Wen, Kun Yang, Xiaopeng Wen

“…Previously, FLOWERING BHLHs (FBHs) have been identified as positive regulators of flower formation. In the present work, a total of eight FBHs were identified in pitaya. …”
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International Alliance of Urolithiasis (IAU) consensus on miniaturized percutaneous nephrolithotomy by Guo-Hua Zeng, Wen Zhong, Giorgio Mazzon, Wei Zhu, Sven Lahme, Sanjay Khadgi, Janak Desai, Madhu Agrawal, David Schulsinger, Mantu Gupta, Emanuele Montanari, Juan Manuel Lopez Martinez, Shabir Almousawi, Vincent Emanuel F. Malonzo, Seshadri Sriprasad, Chu Ann Chai, Vimoshan Arumuham, Stefania Ferretti, Wissam Kamal, Ke-Wei Xu, Fan Cheng, Xiao-Feng Gao, Ji-Wen Cheng, Bhaskar Somani, Mordechai Duvdevani, Kah Ann Git, Christian Seitz, Norberto Bernardo, Tarek Ahmed Amin Ibrahim, Albert Aquino, Takahiro Yasui, Cristian Fiori, Thomas Knoll, Athanasios Papatsoris, Nariman Gadzhiev, Ulanbek Zhanbyrbekuly, Oriol Angerri, Hugo Lopez Ramos, Iliya Saltirov, Mohamad Moussa, Guido Giusti, Fabio Vicentini, Edgar Beltran Suarez, Margaret Pearle, Glenn M. Preminger, Qing-Hui Wu, Otas Durutovic, Khurshid Ghani, Marcus Maroccolo, Marianne Brehmer, Palle J. Osther, Marek Zawadzki, Azimdjon Tursunkulov, Monolov Nurbek Kytaibekovich, Abdusamad Abdukakhorovich Abuvohidov, Cesar Antonio Recalde Lara, Zamari Noori, Stefano Paolo Zanetti, Sunil Shrestha, Jean de la Rosette, John Denstedt, Zhang-Qun Ye, Kemal Sarica, Simon Choong

“…The series of detailed techniques presented here serve as a comprehensive guide for urologists, aiming to improve their procedural understanding and optimize patient outcomes.…”
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Incidence and risk factors for delayed intracranial hemorrhage after mild brain injury in anticoagulated patients: a multicenter retrospective study by Nicolò Capsoni, Giovanni Carpani, Francesca Tarantino, Silvia Gheda, Jean Marc Cugnod, Sabrina Lanfranchi, Jhe Lee, Simone Lizza, Sara Marchesani, Enrica Meloni, Annalisa Rigamonti, Irene Serrai, Silvia Vergani, Elisa Ginevra Zuddio, Bruno Gherardo Zumbo, Daniele Privitera, Francesco Salinaro, Davide Bernasconi, Gianmarco Secco, Filippo Galbiati, Stefano Perlini, Michele Bombelli

“…However, the utility of this practice is controversial, with recent evidence suggesting that the risk of delayed ICH in these patients is low. …”
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