Exploring the mechanism of triptolide inhibiting the motility of fibroblast-like synoviocytes in rheumatoid arthritis via RhoA/Rho-associated kinase axis, based on network pharmaco... by Jiacheng Shen, Jiacheng Shen, Jiacheng Shen, Yuxuan Fang, Yuxuan Fang, Nan Xu, Nan Xu, Hongyi Chen, Hongyi Chen, Miao Zhu, Miao Zhu, Dan Li, Dan Li, Zewen Chu, Masataka Sunagawa, Yanqing Liu, Yanqing Liu, Haibo Wang, Haibo Wang, Guoqing Li, Guoqing Li

“…Background and objectiveRheumatoid arthritis (RA) is a chronic autoimmune disease characterized by the hyperproliferation and invasive behavior of rheumatoid arthritis fibroblast-like synoviocytes (RA-FLS), which contributes to the degradation of articular cartilage and bone. …”
Get full text

新編中學生考試焦慮因應量表：以潛在類別分析取向探究學生因應組型及預測因子 Coping Scale With Test Anxiety (COSTA) for Adolescent Students: Exploring Coping Profiles and Predictors Through a Latent Class Analysis Approa... by 趙子揚 Tzu-Yang Chao

“…In the formal phase, confirmatory factor analysis (CFA), reliability analysis, correlation analysis with external criteria, LPA, and three-step LCR were conducted to assess the quality of COSTA, identify the number of coping patterns among students, and determine whether individual attributes could predict specific coping pattern categories. Results Through the pretest phase, the study finalized a formal COSTA scale comprising 63 items across 12 dimensions: “Seeking Improvement,” “Positive Cognition,” “Abandoning Preparation,” “Emotional Venting,” “Relaxation Behavior,” “Mood Shifting,” “Support for Improvement,” “Accepting Results,” “Gathering with Friends,” “Consoling Thoughts,” “Self-Reward,” and “Writing for Emotional Release.” …”
Get full text

Gene Editing Anxiety by Angelo Osofsky

“…Many individual genes impact various aspects of physiology or behavior. For example, the CCR5 gene encodes a macrophage receptor targeted by certain HIV strains. …”
Get full text

Pyruvate and related energetic metabolites modulate resilience against high genetic risk for glaucoma by Keva Li, Nicholas Tolman, Ayellet V Segrè, Kelsey V Stuart, Oana A Zeleznik, Neeru A Vallabh, Kuang Hu, Nazlee Zebardast, Akiko Hanyuda, Yoshihiko Raita, Christa Montgomery, Chi Zhang, Pirro G Hysi, Ron Do, Anthony P Khawaja, Janey L Wiggs, Jae H Kang, Simon WM John, Louis R Pasquale, UK Biobank Eye and Vision Consortium

Get full text

Observations of Uranus at High Phase Angle as Seen by New Horizons by Samantha N. Hasler, L. C. Mayorga, William M. Grundy, Amy A. Simon, Susan D. Benecchi, Carly J. A. Howett, Silvia Protopapa, Heidi B. Hammel, Daniel D. Wenkert, S. Alan Stern, Kelsi N. Singer, Simon B. Porter, Pontus C. Brandt, Joel W. Parker, Anne J. Verbiscer, John R. Spencer, The New Horizons Planetary Science Theme Team

“…The photometry suggests that Uranus may be darker than predicted by a Lambertian phase curve in the blue and red filters. …”
Get full text

Spatio-Temporal Characteristics and Driving Forces of Landscape Ecological Risks in Highly Urbanized Areas: A Case Study of Suzhou City by Lingyue LU, Dawei SHAO, Dianming WU

“…Landscape ecological risk (LER), a critical subset of ecological risk assessment, focuses on the coupling of ecological processes and spatial patterns, emphasizing the changes in regional ecological risk under the combined influence of human behavior and natural activities. A large amount of research has concentrated on risk evolution, the identification of influencing factors or drivers, and the simulation and prediction of risks in natural areas such as watersheds, coastal zones, wetlands, and ecological reserves. …”
Get full text

In its very early phases, COVID-19 shifts the associations between alcohol consumption and psychological symptoms in young adults by Karina Janson, Arun L.W. Bokde, Sylvane Desrivières, Hugh Garavan, Penny Gowland, Antoine Grigis, Andreas Heinz, Jean-Luc Martinot, Marie-Laure Paillère Martinot, Eric Artiges, Dimitri Papadopoulos Orfanos, Tomáš Paus, Luise Poustka, Michael N. Smolka, Nathalie E. Holz, Nilakshi Vaidya, Henrik Walter, Robert Whelan, Gunter Schumann, Herta Flor, Olaf Reis, Emanuel Schwarz, Tobias Banaschewski, Frauke Nees, IMAGEN Consortium, CoviDrug Consortium

“…Changes in anxiety may contribute to riskier alcohol use behaviors following the pandemic, while depression appears to be one of the most critical factors influencing alcohol use during such crisis situations. …”
Get full text

Young Stellar Objects in the Carina Nebula: Near-infrared Variability and Spectroscopy by Jura Borissova, Radostin Kurtev, Josemanuel Escobar, Javier Alonso-García, Nicolas Medina, Javier Osses, Zhen Guo, Philip W. Lucas, Michael Kuhn, Dante Minniti, Kevin R. Covey, Roberto K. Saito, Francisco Förster

“…This well-characterized catalog also offers a robust training data set for machine learning applications aimed at predicting YSO behavior.…”
Get full text

An in vivo systemic massively parallel platform for deciphering animal tissue-specific regulatory function by Ashley R. Brown, Ashley R. Brown, Grant A. Fox, Grant A. Fox, Irene M. Kaplow, Irene M. Kaplow, Irene M. Kaplow, Alyssa J. Lawler, Alyssa J. Lawler, BaDoi N. Phan, BaDoi N. Phan, BaDoi N. Phan, Lahari Gadey, Lahari Gadey, Morgan E. Wirthlin, Morgan E. Wirthlin, Easwaran Ramamurthy, Easwaran Ramamurthy, Gemma E. May, Ziheng Chen, Qiao Su, Qiao Su, C. Joel McManus, Robert van de Weerd, Robert van de Weerd, Andreas R. Pfenning, Andreas R. Pfenning, Andreas R. Pfenning

“…In neural tissue, these gene regulatory processes are crucial for coordinating a plethora of interconnected and regionally specialized cell types, ensuring their synchronized activity in generating behavior. Recognizing the intricate interplay of gene regulatory processes in the brain is imperative, as mounting evidence links neurodevelopment and neurological disorders to non-coding genome regions. …”
Get full text

Liquid biopsy in gynecological cancers: a translational framework from molecular insights to precision oncology and clinical practice by Canio Martinelli, Alfredo Ercoli, Giuseppe Vizzielli, Sharon Raffaella Burk, Maria Cuomo, Vrunda Satasiya, Housem Kacem, Simone Braccia, Giulio Mazzarotti, Irene Miriello, Manuela Nana Tchamou, Stefano Restaino, Martina Arcieri, Alice Poli, Veronica Tius, Silvana Parisi, Stefano Pergolizzi, Giuseppe Iatì, Chiara Conti Nibali, Cristina Pizzimenti, Ludovica Pepe, Antonio Ieni, Salvatore Cortellino, Antonio Giordano

“…Abstract Liquid biopsy offers a noninvasive method to identify and monitor tumor-derived biomarkers, including circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), exosomes, microRNAs, and tumor-educated platelets, that provide real-time insights into the biological behavior of gynecological cancers. The detection of these markers has the potential to revolutionize cancer management by enabling earlier detection, providing novel data to personalize treatments, and predicting disease recurrence before clinical imaging can confirm progression, thereby also guiding complex clinical decision-making. …”
Get full text

A Semiempirical Estimate of Solar Extreme-ultraviolet Evolution from 10 Myr to 10 Gyr by Kevin France, Girish Duvvuri, Cynthia S. Froning, Alexander Brown, P. Christian Schneider, J. Sebastian Pineda, David Wilson, Allison Youngblood, Vladimir S. Airapetian, Kosuke Namekata, Yuta Notsu, Tristen Sextro

“…We find that the EUV activity evolution for solar-type stars follows a two-component behavior: a saturated L (EUV)/ L _bol plateau (at a level of about 10 ^−4 ) followed by a power-law decay ( α ≈ −1.1) after ages of ≈50–100 Myr. …”
Get full text

The Modal Particle "-ā", a New Member of Modal Elements in Persian Language by Morteza Dastlan

“…Epistemic Concepts Modal particle '-ā' introduces epistemic modal meanings like predicting unfavorable circumstances and assessing a situation with astonishment.   3.2.1. …”
Get full text

Caveolin-1 inhibits the proliferation and invasion of lung adenocarcinoma via EGFR degradation by Jiahui Dong, Ruiping Du, Yani Zhang, Bo Hong, Gengyun Sun

“…Abstract Lung adenocarcinoma (LUAD) has become the most common pathological pattern of lung cancer in recent decades. Prediction of biological behavior of LUAD is crucial for disease management and treatment options. …”
Get full text

THE ANALYSIS OF THE STRAIN STATE OF SHEAR ZONES IN TERMS OF  TYPES OF SECONDARY FRACTURES: STATEMENT OF PROBLEM by Fyodor L. Yakovlev

“…Shear cracks of X and P types (which are also paired) demonstrate similar behavior: X cracks occur with lengthening of the zone, while P cracks occur with its shortening. …”
Get full text

Experimental Study on the Influence Patterns of Buildings Displaced and Buried by Debris Flow by FENG Lei, SONG Dongri, CHEN Xiaoqing, LIU Jia, CHEN Qian, LIU Yunhui

“…Further research was required to quantitatively analyze the impact of each physical parameter on relative position, enabling theoretical prediction of the positions of building blocks in debris flow debris-flow deposition. …”
Get full text

Research on entity recognition and alignment of APT attack based on Bert and BiLSTM-CRF by Xiuzhang YANG, Guojun PENG, Zichuan LI, Yangqi LYU, Side LIU, Chenguang LI

“…Moreover, the proposed model has the best prediction effect on the "attack method" entity category, whose F1-score is 0.927 5. …”
Get full text

The Pathology of Insistence on Indirect Disclosure of Operating Cash Flows by Esmail Farzaneh Kargar, Mehdi Bahar Moghadam

“…Findings The findings showed that most investors use the cash flow statement in their economic decision-making, and this use is mainly to assess the liquidity and predict the future cash flows of the company. Supplementary findings showed that while investors consider the cash flow statement to be the most useful part of the financial statements in assessing a company's liquidity; however, this financial statement is in third place in terms of usefulness in predicting future cash flows. …”
Get full text

Research on entity recognition and alignment of APT attack based on Bert and BiLSTM-CRF by Xiuzhang YANG, Guojun PENG, Zichuan LI, Yangqi LYU, Side LIU, Chenguang LI

“…Moreover, the proposed model has the best prediction effect on the "attack method" entity category, whose F1-score is 0.927 5. …”
Get full text

The Milky Way Radial Metallicity Gradient as an Equilibrium Phenomenon: Why Old Stars Are Metal Rich by James W. Johnson, David H. Weinberg, Guillermo A. Blanc, Ana Bonaca, Gwen C. Rudie, Yuxi (Lucy) Lu, Bronwyn Reichardt Chu, Emily J. Griffith, Tawny Sit, Jennifer A. Johnson, Liam O. Dubay, Miqaela K. Weller, Daniel A. Boyea, Jonathan C. Bird

“…This constancy challenges current models of Galactic chemical evolution, which typically predict lower metallicities for older stellar populations. …”
Get full text

Environmental phenol mixture during pregnancy and child sleep quality in the ECHO cohort by Sarah D. Geiger, Sarah D. Geiger, Xiaoshuang Xun, Cai Zhang, Cai Zhang, Aruna Chandran, Kritika Madan, Grace Kim, Fatima Naveed, Megan Woodbury, Dana E. Goin, Stephanie M. Eick, Courtney K. Blackwell, Maxwell Mansolf, Max Aung, Akram Alshawabkeh, Dana Dabelea, Anne L. Dunlop, Assiamira Ferrara, Jonika B. Hash, Monique Hedderson, Erica Jansen, Monique LeBourgeois, Louise O’Brien, Yeyi Zhu, Susan L. Schantz, Susan L. Schantz

“…IntroductionPoor sleep quality in childhood can predict sleep quality throughout the lifecourse and other health outcomes. …”
Get full text