Gene expression profiling reveals insights into infant immunological and febrile responses to group B meningococcal vaccine by Daniel O’Connor, Marta Valente Pinto, Dylan Sheerin, Adriana Tomic, Ruth E Drury, Samuel Channon‐Wells, Ushma Galal, Christina Dold, Hannah Robinson, Simon Kerridge, Emma Plested, Harri Hughes, Lisa Stockdale, Manish Sadarangani, Matthew D Snape, Christine S Rollier, Michael Levin, Andrew J Pollard

“…Finally, we present transcriptomic profiles predictive of immunological and febrile responses following 4CMenB vaccine.…”
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Spatial transcriptomics highlights B cells as key contributors to a complete and durable response to chemo-immunotherapy in a patient with resectable NSCLC by Paola Nisticò, Federico Cappuzzo, Francesca Fusco, Francesca De Nicola, Lorenza Landi, Paolo Visca, Lorenzo D’Ambrosio, Nicla Porciello, Filippo Gallina, Giuseppe Frisullo, Vittoria Balzano

“…Notably, the formation of several tertiary lymphoid structures in the regression bed of post-treatment primary tumor was observed, suggesting the in situ generation of high-affinity antibody and specific immune memory response. …”
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Integrated transcriptomic and immune enzymatic analyses uncover coordinated immunometabolic responses in large yellow croaker (Larimichthys crocea) to Metanophrys sp. infection by Ruiling Zhou, Kangshuai Sun, Xiao Xie, Fei Yin, Jorge Galindo-Villegas

“…To elucidate the host response, we conducted an experimental infection followed by an integrated analysis combining immune enzymatic profiling and transcriptome sequencing. …”
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Shared molecular profiles of post-laser vision correction ectasia and keratoconus with key differences in CADPS, CPT1B, CIITA, and TBC1D4 by Katarzyna Jaskiewicz-Rajewicz, Alicja Wysocka, Magdalena Maleszka-Kurpiel, Magdalena Maleszka-Kurpiel, Eliza Matuszewska-Mach, Jakub Wozniak, Jakub Wozniak, Rafal Ploski, Jan Matysiak, Malgorzata Rydzanicz, Marzena Gajecka, Marzena Gajecka

“…We hypothesize that although the mechanistic aspects of post-LVC ectasia and KTCN are distinct, there are notable similarities in the epithelial responses, including shared molecular features.MethodsA total of 11 post-LVC ectasia, 8 mild myopia (controls), and 28 KTCN patients were included in a retrospective multiomics case–control study. …”
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Identification of genes in response to cucurbit aphid-borne yellows virus infection in melon by YANG Siyu, GONG Zihui, HU Zhongyuan, ZHANG Mingfang, YANG Jinghua

“…A total of 1 654 differentially expressed genes (DEGs) in response to CABYV infection were identified by transcriptome sequencing analysis, including 677 up-regulated genes and 977 down-regulated genes. …”
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Transcriptomic analysis of non-leukemic cell subsets in azacytidine-responsive AML highlights pathways associated with adhesion, platelet aggregation, and angiogenesis in mice and... by Nancy D. Ebelt, Suvithanandhini Loganathan, Lara C. Avsharian, Edwin R. Manuel

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Evaluating two live-attenuated vaccines against Salmonella enterica serovar Reading in turkeys: reduced tissue colonization and cecal tonsil transcriptome responses by Melissa S. Monson, Manoj Gurung, Manoj Gurung, Bradley L. Bearson, Samuel J. Whelan, Samuel J. Whelan, Julian M. Trachsel, Torey Looft, Matthew J. Sylte, Shawn M.D. Bearson

“…Gene expression of intestinal transporters (such as SCNN1B and SLC10A2) and tight junction proteins was significantly decreased in the turkey cecal tonsil transcriptome at 2 DPI with S. Reading. Vaccination with either vaccine mitigated most cecal tonsil gene expression responses to S. …”
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Comparative transcriptomics in B73-teosinte near-isogenic maize lines reveals key defense signaling and phytoalexins in response to Cercospora zeina infection by Xiaomeng Sun, Xiaomeng Sun, Ruiyu Zhang, Ruiyu Zhang, Zongping Wang, Zongping Wang, Haotian Zhang, Haotian Zhang, Hairun Wen, Hairun Wen, Junli Zhang, Naibin Yu, Naibin Yu, Zhe Wang, Zhe Wang, Huanhuan Tai, Huanhuan Tai, Qin Yang, Qin Yang

“…Here we conducted transcriptome analyses on leaves from a pair of B73-teosinte near-isogenic lines (NILs) with contrasting Qgls8 alleles infected with C. zeina at 0, 4, 8, and 12 hours post inoculation (hpi). …”
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Exploring the Inter-Individual Variability in Response to Food in Seniors Living at Home: The MetabotypAGE Project by Claudine Manach, Cécile Gladine, Christine Morand, Laurent Mosoni, Estelle Pujos-Guillot, Didier Rémond, Sergio Polakof

“…Previous studies demonstrated the possibility to predict the postprandial glycemic response to food in healthy adults based on deep phenotyping. …”
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Insights of Phaseolus vulgaris’ response to infection by Uromyces appendiculatus using an RNA-seq approach by Penny Makhumbila, Molemi Rauwane, Hangwani Muedi, Sandiswa Figlan

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Examination of the lung and lymphoid tissue mRNA transcriptome response in dairy calves following experimental challenge with bovine alphaherpesvirus one (BoHV-1). by Stephanie O'Donoghue, Bernadette Earley, Dayle Johnston, Matthew S Finnie, S Louise Cosby, Ken Lemon, Michael J McMenamy, Jeremy F Taylor, Jae Woo Kim, Derek W Morris, Sinéad M Waters

“…Bovine alphaherpesvirus one (BoHV-1) is a primary cause of bovine respiratory disease (BRD), and a leading cause of morbidity and mortality in cattle. The transcriptomic responses of key respiratory and immune associated tissues of dairy calves following experimental challenge with BoHV-1 are unknown. …”
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Transcriptional regulation of hormone signalling genes in black pepper in response to Phytophthora capsici by Chidambareswaren Mahadevan, K. Mohamed Shafi, B Nagarathnam, Manjula Sakuntala, Ramanathan Sowdhamini

“…Conclusions This comprehensive transcriptome analysis of P. nigrum response to P. capsici attack provides valuable insights into the plant defense mechanisms. …”
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Embryonic thermal conditioning and post-hatch heat challenge alter hypothalamic expression of genes related to appetite, thermoregulation, and stress modulation in broiler chicks by Reagan Vaughan, Usman Sulaiman, Annalise Flynn, Fernando Biase, Noam Meiri, Dongmin Liu, Paul Siegel, Mark Cline, Elizabeth Gilbert

“…The objective of this study was to determine the effects of an acute heat challenge on day 4 post-hatch on the transcriptome of several brain nuclei associated with thermal regulation, stress, and appetite. …”
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Transcriptome Analysis of Potato (<i>Solanum tuberosum</i> L.) Seedlings with Varying Resistance Levels Reveals Diverse Molecular Pathways in Early Blight Resistance by Jiangtao Li, Jie Li, Hongfei Shen, Rehemutula Gulimila, Yinghong Jiang, Hui Sun, Yan Wu, Binde Xing, Ruwei Yang, Yi Liu

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Insights to microsporidia Nosema bombycis congenital infection and host immune responses in the embryo and larva stages of silkworms by Tangxin Li, Yue Song, Quan Sun, Qiong Yang, Yunlin Tang, Zigang Shen, Zhangshuai He, Yabin Dou, Junzheng Zhang, Sheng Li, Tian Li, Xianzhi Meng, Zeyang Zhou, Jie Chen, Guoqing Pan

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Revealing the Immune Response of <i>Sitona callosus</i> Gyllenhal to Entomopathogenic Fungi <i>Beauveria bassiana</i> Infection Through Integrative Analyses of Transcriptomics and... by Nan Li, Xin Gu, Ming Xin, Xinpu Wang

“…The transcriptomic analysis unveiled that <i>B. bassiana</i> infection boosted immune responses in tubercula, affecting carbohydrate metabolism, cytochrome P450 activity, lysosome function, apoptosis regulation, phagosome formation, glutathione metabolism, amino acid metabolism, and pathogen response pathways. …”
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Longitudinal profiling of host response and oropharyngeal respiratory microbiome reveals dynamic alterations during recovery from community-acquired pneumonia by Lizhe Hong, Lijun Suo, Kang Chang, Hongyun Cao, Jiahui Luan, Fuxin Zhang, Xiaofeng Yu, Xiaohui Zou, Bo Liu, Bin Cao

“…To address this gap, we longitudinally collected CAP patients’ peripheral blood for transcriptome and oropharyngeal swabs for microbiome analysis from admission to 4 months post infection. …”
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Clinical assessment and transcriptome analysis of host immune responses in a vaccination-challenge study using a glycoprotein G deletion mutant vaccine strain of infectious laryngo... by Gayathri Gopakumar, Mauricio J. C. Coppo, Mauricio J. C. Coppo, Andrés Diaz-Méndez, Carol A. Hartley, Joanne M. Devlin

“…In the current study, the transcriptome of peripheral blood mononuclear cells (PBMCs) of the ΔgG-ILTV-vaccinated group of specific-pathogen-free chickens were compared to those of the nonvaccinated group at 7 days post-vaccination. …”
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Transcriptome analysis of maize resistance to Fusarium verticillioides by Hui Zeng, Hongyu Cai, Tianhang Bai, Xuejiao Ren, Jiabin Ci, Wei Yang

“…The study revealed that inbred line J1259 exhibited resistance to Fusarium verticillioides by increasing the activities of POD and CAT enzymes. Transcriptome analysis at 48 and 96 hours post-infection with Fusarium verticillioides revealed a large number of DEGs involved in plant-pathogen interactions, MAPK signaling pathways-plants and plant hormone signaling were significant up-regulated. …”
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Unraveling metabolic signatures in SARS-CoV-2 variant infections using multiomics analysis by Sunho Lee, Sunho Lee, Jueun Lee, Kwang-Soo Lyoo, Yourim Shin, Yourim Shin, Dong-Min Shin, Jun-Won Kim, Jeong-Sun Yang, Kyung-Chang Kim, Joo-Yeon Lee, Geum-Sook Hwang, Geum-Sook Hwang

“…Principal component analysis uncovered the delta variant significantly altered lung metabolite levels between the pre- and post-infection states. Additionally, metabolic pathways determined by assessment of metabolites and genes in lung revealed significant alterations in arginine biosynthesis, glutathione metabolism, and tryptophan metabolism upon infection with both variants and closely linked to inflammatory cytokines, indicating immune activation and oxidative stress in response to both variants. …”
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