Integrative identification of key genes governing Verticillium wilt resistance in Gossypium hirsutum using machine learning and WGCNA by Yufeng Lei, Jing Zhao, Siyuan Hou, Fufeng Xu, Chongbo Zhang, Dongchen Cai, Xiaolei Cao, Zhaoqun Yao, Sifeng Zhao

“…In this study, we aimed to dissect the temporal transcriptional dynamics and regulatory mechanisms underlying Gossypium hirsutum response to V. dahliae infection.MethodsWe employed a time-course RNA-Seq approach using the susceptible upland cotton cultivar Jimian 11 to profile transcriptomic responses in root and leaf tissues post-V. dahliae inoculation. …”
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Whole‐Blood RNA Sequencing Profiling of Patients With Rheumatoid Arthritis Treated With Tofacitinib by Chiara Bellocchi, Ennio Giulio Favalli, Gabriella Maioli, Elena Agape, Marzia Rossato, Matteo Paini, Adriana Severino, Barbara Vigone, Martina Biggioggero, Elena Trombetta, Roberto Caporali, Lorenzo Beretta

“…Linear models were used to determine differentially expressed genes (DEGs) (1) at baseline according to clinical responses and (2) in the pre‐post comparison after tofacitinib treatment and in relation to EULAR responses. …”
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Biophysical and biochemical signatures of pancreatic stellate cell activation: insights into mechano-metabolic signalling from atomic force microscopy and Raman spectroscopy by Jacek J. Litewka, Monika A. Jakubowska, Marta Targosz-Korecka, Ewelina Wiercigroch, Jakub Dybas, Natalia Cisak, Zbigniew Madeja, Pawel E. Ferdek

“…These data were complemented by transcriptomic analyses to evaluate gene expression profiles related to lipid metabolism and autophagy. …”
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The histone methyltransferase SETD2 regulates HIV expression and latency. by Cameron R Bussey-Sutton, Airlie Ward, Joshua A Fox, Anne-Marie W Turner, Jackson J Peterson, Ann Emery, Arturo R Longoria, Ismael Gomez-Martinez, Corbin Jones, Austin Hepperla, David M Margolis, Brian D Strahl, Edward P Browne

“…We show that prevention of H3K36me3 by a potent and selective inhibitor of SETD2 (EPZ-719) leads to reduced post-integration viral gene expression and accelerated emergence of latently infected cells. …”
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STAT1 regulates immune-mediated intestinal stem cell proliferation and epithelial regeneration by Shuichiro Takashima, Roshan Sharma, Winston Chang, Marco Calafiore, Ya-Yuan Fu, Suze A. Jansen, Takahiro Ito, Anastasiya Egorova, Jason Kuttiyara, Viktor Arnhold, Jessica Sharrock, Endi Santosa, Ojasvi Chaudhary, Heather Geiger, Hiromi Iwasaki, Chen Liu, Joseph Sun, Nicolas Robine, Linas Mazutis, Caroline A. Lindemans, Alan M. Hanash

“…Intestinal stem cells (ISCs) from GVHD mice have exhibited global transcriptomic changes associated with a substantial Interferon-γ response and upregulation of STAT1. …”
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Light-induced epigenetic modifications in the hypothalamus during avian embryonic development enhance phenotypic plasticity by Joanna Bartman, Tali Rosenberg, Hadar Parnas, Ronit Yosofov, Natalie Avital-Cohen, Ron Weiss, Gal Harmatz, Israel Rozenboim, Asaf Marco

“…In G3D, cFOS immunostaining revealed heightened hypothalamic responsiveness to a post-hatch green light pulse, indicating that in-ovo GMI primed the brain’s circuitry for future stimuli. …”
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The Maltase Involved in Starch Metabolism in Barley Endosperm Is Encoded by a Single Gene. by Vasilios M E Andriotis, Gerhard Saalbach, Robbie Waugh, Robert A Field, Alison M Smith

“…Multiple forms of the enzyme most likely arise from proteolysis and other post-translational modifications.…”
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Transiently elevated expression of different forms of brain-derived neurotrophic factor in the neonatal medial prefrontal cortex affected anxiety and depressive-like behaviors in a... by Dmitriy Lanshakov, Elizaveta Shaburova, Ekaterina Sukhareva, Veta Bulygina, Uliana Drozd, Irina Larionova, Tatiana Gerashchenko, Tatiana Shnaider, Evgeny V. Denisov, Tatyana Kalinina

“…BDNF undergoes complex post-translational processing with cellular proteases. …”
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Effects of Plasmodium berghei infection on the expression of salivary gland immune-related genes in the Anopheles stephensi mosquito by Sakineh Pirahmadi, Zahra Sadat Mousavi Shafi, Zeinab Mohammadi Firouz, Akram Abouie Mehrizi, Jafar J. Sani, Hemn Yousefi, Sepideh Siasi, Abbasali Raz, Flora Forouzesh, Leila Darzi

“…Since the innate immune responses of Anopheles salivary glands determine its vectorial capacity, a detailed assessment of vector-parasite interactions could help identify novel targets that play key roles in the immune response against Plasmodium. …”
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Xanthosine alleviates myocardial ischemia–reperfusion injury through attenuation of cardiomyocyte ferroptosis by Yang Xu, Wenfeng Zhou, Zhongguo Fan, Yiwei Cheng, Yujia Xiao, Yu Liu, Xinxin Li, Zhenjun Ji, Yi Fan, Genshan Ma

“…Integrated drug affinity responsive target stability (DARTS)-based drug target screening and RNA-seq transcriptomic profiling elucidate XTS-mediated mechanisms against I/R injury. …”
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Time-dependent RNA transcriptional profiling of abomasal mucosa in cattle infected with Ostertagia ostertagi by Clarissa Boschiero, Ethiopia Beshah, Mariam Bakshi, Peter Thompson, Xiaoping Zhu, George E. Liu, Wenbin Tuo

“…The results will help understand the gastric responses of the host, especially the immune responses, at different phases of early nematode infection. …”
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Dual role of Eisenia fetida and its excreta in boosting tomato biomass and defense against Botrytis cinerea by Maryan Chelkha, Rubén Blanco-Pérez, Jorge Dueñas-Hernani, Ignacio Vicente-Díez, Victoria Pastor, Raquel Campos-Herrera

“…The present study offers, for the first time, clear evidence that EW-derived CEx can induce resistance by stimulating plant defense responses. Further biochemical, transcriptomic, and metabolomic analyses are needed to confirm indirect results, along with field validation. …”
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Cell-free fat extract prevents diminished ovarian reserve by inhibiting granulosa cell senescence by Mengyu Liu, Hanfei Zhu, Xiaowei Zhou, Jingru Duan, Yuhong Shen, Aijun Zhang

“…CEFFE demonstrated favorable safety in the Prophylactic group and their offspring, with no significant adverse effects on organ morphology or coefficients, except for increased liver weight in treated mice. Transcriptomic analysis suggested CEFFE influences cell proliferation, hormone response, and oxidative stress pathways in ovarian granulosa cells, which was verified in primary mouse granulosa cells. …”
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A Maternal Gene Regulator CPEB2 Is Involved in Mating-Induced Egg Maturation in the <i>Cnaphalocrocis medinalis</i> by Yi Duan, Yueran Xiao, Guo Cai, Kepeng Wang, Chenfan Zhao, Pengcheng Liu

“…Tissue culture-based hormonal assays demonstrated the juvenile hormone-dependent regulation of <i>CmCPEB2</i>, as JH treatment induced its transcription, while knockdown of the JH-responsive transcription factor <i>CmKr</i>-h1 in the moths suppressed <i>CmCPEB2</i> expression post-mating. …”
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Exercise-mobilized donor lymphocyte infusions enhanced with cytokine stimulation for the prevention and treatment of leukemic relapse after allogeneic hematopoietic cell transplant... by London M. McDougal, Forrest L. Baker, Forrest L. Baker, Forrest L. Baker, Michael P. Gustafson, Emmanuel Katsanis, Emmanuel Katsanis, Emmanuel Katsanis, Emmanuel Katsanis, Emmanuel Katsanis, Richard J. Simpson, Richard J. Simpson, Richard J. Simpson, Richard J. Simpson

“…Preclinical evidence suggests that these exercise-mobilized lymphocytes infiltrate tumors, exhibit enhanced leukemic control in xenogeneic mice, and display transcriptomic and proteomic profiles indicative of heightened anti-tumor immunity, migration potential and cytokine responsiveness. …”
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Protein sequence editing defines distinct and overlapping functions of SKN-1A/Nrf1 and SKN-1C/Nrf2. by Briar Jochim, Irini Topalidou, Nicolas Lehrbach

“…Nrf1/NFE2L1 is primarily responsible for stress-responsive upregulation of proteasome subunit genes and is essential for adaptation to proteotoxic stress. …”
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Fibrocartilage repair involves chronic cellular senescence in a rat model of bone marrow stimulation by Luke Childress, Landon B. Gatrell, Hong Wu, Elisabeth Ferreira, Intawat Nookaew, Ryan M. Porter

“…Objective: Cellular senescence has been implicated in the progression of post-traumatic osteoarthritis, but any role in pre-osteoarthritic cartilage repair is unknown. …”
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Characterization of lysine acetyltransferase and deacetylase genes and their roles in anthocyanin biosynthesis in grape by Wen Tang, Feiyue Li, Danni Yang, Mengyu Xu, Jinggui Fang, Suwen Lu

“…Promoter region analysis revealed numerous cis-regulatory elements linked to light, hormone, and stress responsiveness. Transcriptomic data indicated that VvKATs and VvKDACs display distinct expression profiles across various tissues and developmental stages. …”
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Metabolic stress and early cell death in photoreceptor precursor cells following retinal transplantation by Raghavi Sudharsan, Natalia Dolgova, Jennifer Kwok, Alexa Gray, Yu Sato, Agustin Luz Madrigal, Praveen Joseph Susaimanickam, Emil Kriukov, Petr Baranov, John H. Wolfe, Gustavo D. Aguirre, David M. Gamm, William A. Beltran

“…Furthermore, host retinal responses shape the transplant microenvironment, influencing donor cell survival and integration. …”
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DNA glycosylases Ogg1 and Mutyh influence gene expression of PRC2 targets associated with cognition by Andreas Abentung, Teri Sakshaug, Rabina Dumaru, Nina-Beate Liabakk, Mingyi Yang, Junbai Wang, Magnar Bjørås, Katja Scheffler

“…PRC2 occupancy and associated histone post-translational modifications depend on Ogg1 and Mutyh in neurons and glia. …”
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