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Histone ZmH2B regulates resistance to the Southern corn leaf blight pathogen Bipolaris maydis in maize
Published 2025-08-01“…Abstract Background H2B histones play crucial roles in plant responses to biotic stress. However, to date, most research on H2B histones has focused on their roles in post-translational modification, and studies specifically investigating the intrinsic properties of these histones remain relatively limited. …”
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242
Gene Expression Comparison Between the Injured Tubercule Skin of Turbot (<i>Scophthalmus maximus</i>) and the Scale Skin of Brill (<i>Scophthalmus rhombus</i>)
Published 2024-11-01“…A skin injury involving epidermal and dermal levels was evaluated 72 h post-injury to compare the skin regeneration processes between both species. …”
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243
Uncovering the key miRNA-target network of tea plants in resistance to sooty mold disease
Published 2025-04-01“…Post-transcriptional regulation by miRNAs was identified through sRNAome-degradome mapping, with six miRNA-target defense pairs validated by 5′ RLM-RACE and qRT-PCR. …”
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244
RNA-sequencing studies suggest that microRNAs and alternative splicing of pre-mRNAs modulate immune and inflammatory responses in Holstein cattle infected with Mycobacterium avium...
Published 2025-06-01“…As bioinformatic tools continue to develop, microRNAs (miRNAs) and alternative splicing (AS) have emerged as important contributors to host responses during infections. Although RNA-Seq enables AS analysis, most transcriptomic studies still emphasize gene-level expression due to the complexity of AS workflows, the need for deeper sequencing, and incomplete transcript annotations, even in humans. …”
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245
Preliminary Analysis of the Salt-Tolerance Mechanisms of Different Varieties of Dandelion (<i>Taraxacum mongolicum</i> Hand.-Mazz.) Under Salt Stress
Published 2025-06-01“…Here, we compared the transcriptome and metabolome responses of 0.7% NaCl-stressed dandelion ‘BINPU2’ (variety A) and ‘TANGHAI’ (variety B). …”
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246
Response‐adapted zanubrutinib and tislelizumab as a potential strategy to enhance CD19 CAR T‐cell therapy in relapsed/refractory large B‐cell lymphoma: A retrospective observationa...
Published 2025-04-01“…Patients were treated with zanubrutinib daily from leukapheresis to day 28 post‐infusion; those achieving complete response continued zanubrutinib monotherapy for 3 months, while partial responders received combined zanubrutinib for 3 months and tislelizumab for up to 2 years. …”
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In silico identification and functional annotation of universal stress protein (USP) gene family in Chenopodium quinoa
Published 2025-05-01“…Domain architecture helped us understand the multifunctional nature of CqUSPs. Analysis of transcriptome data has demonstrated that the CqUSP gene family plays a role in the defence response to drought and heat stress conditions in quinoa. …”
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249
Cell-specific transcriptional signatures of vascular cells in Alzheimer’s disease: perspectives, pathways, and therapeutic directions
Published 2025-01-01“…Recent advances in high throughput single-cell transcriptomics technology have enabled the study of the human brain vasculature at an unprecedented depth. …”
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250
Exosomes originating from neural stem cells undergoing necroptosis participate in cellular communication by inducing TSC2 upregulation of recipient cells following spinal cord inju...
Published 2025-11-01“…In addition, Slc16a3 participated in cellular communication in ependymal cells at 7 days post-injury via the vascular endothelial growth factor and macrophage migration inhibitory factor signaling pathways. …”
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251
Time-resolved oxidative signal convergence across the algae–embryophyte divide
Published 2025-02-01Get full text
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252
Dynamic Dysregulation of Ribosomal Protein Genes in Mouse Brain Stress Models
Published 2024-12-01“…However, this evolutionarily conserved stress response is not well explored in mouse models of neurobiological stress. …”
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253
Non-reciprocal Interspecies Hybridization Barriers in the Capsella Genus Are Established in the Endosperm.
Published 2015-06-01“…While hybridizations of C. rubella maternal plants with C. grandiflora pollen donors resulted in complete seed abortion caused by endosperm cellularization failure, the reciprocal hybridization resulted in the formation of small seeds with precociously cellularized endosperm. Strikingly, the transcriptomic response of both hybridizations mimicked respectively the response of paternal and maternal excess hybridizations in Arabidopsis thaliana, suggesting unbalanced genome strength causes hybridization failure in both species. …”
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254
Regulation of Protein Synthesis at the Translational Level: Novel Findings in Cardiovascular Biology
Published 2025-05-01“…During cardiac remodeling, transcriptomic changes are often modest, suggesting that post-transcriptional mechanisms, particularly translation, play a dominant role in cellular adaptation. …”
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255
Functional studies of plant transcription factors and their relevance in the plant root-knot nematode interaction
Published 2024-05-01“…Yet, the plant-nematode interaction is normally accompanied to dramatic transcriptomic changes within the galls and giant cells. …”
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256
Transcriptional Profiling Underscores the Role of Preprocurement Allograft Metabolism and Innate Immune Status on Outcomes in Human Liver Transplantation
Published 2024-06-01“…Therefore, we sought to characterize transcriptomic profiles of IRI during multiple phases in human OLT. …”
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257
Succinylation-related molecular activities in cancer: metabolic adaptations, immune landscape, and prognostic significance in colorectal cancer
Published 2025-05-01“…BackgroundSuccinylation, a key post-translational modification, plays a crucial role in metabolic regulation and tumor progression. …”
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258
DksA-dependent regulation of RpoS contributes to Borrelia burgdorferi tick-borne transmission and mammalian infectivity.
Published 2021-02-01“…Together, these data suggest DksA plays a central role in coordinating transcriptional responses in B. burgdorferi required for infectivity through DksA's interactions with RNA polymerase and post-transcriptional control of RpoS.…”
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259
ER-PM membrane contact site regulation by yeast ORPs and membrane stress pathways.
Published 2022-03-01“…Although the elimination of OSH genes and the deletion of ER-PM tether genes have divergent effects on cortical ER-PM association, both elicit the Environmental Stress Response (ESR). Through comparisons of transcriptomic profiles of cells lacking OSH genes or ER-PM tethers, changes in ESR expression are partially manifested through the induction of the HOG (high-osmolarity glycerol) PM stress pathway or the ER-specific UPR (unfolded protein response) pathway, respectively. …”
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260
Lurasidone induces developmental toxicity and behavioral impairments in zebrafish embryos
Published 2025-07-01“…Behavioral assessments revealed significant locomotor impairment and diminished touch response, especially at higher concentrations. Transcriptomic analysis identified 1,907 differentially expressed genes, with upregulation in circadian regulation pathways and downregulation in cell cycle and oxidative phosphorylation pathways. …”
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