The spatial landscape of glial pathology and T cell response in Parkinson’s disease substantia nigra by Maxwell Ma, Fahad Paryani, Kelly Jakubiak, Shengnan Xia, Susumu Antoku, Adithya Kannan, Jaeseung Lee, Nacoya Madden, Shailesh Senthil Kumar, Juncheng Li, David Chen, Gunnar Hargus, Aayushi Mahajan, Xena Flowers, Ashley S. Harms, David Sulzer, James E. Goldman, Peter A. Sims, Osama Al-Dalahmah

“…Here, we employed single-nucleus RNAseq, spatial transcriptomics, and T cell receptor (TCR) sequencing to analyze T cell and glial cell states in post-mortem PD brain tissue. …”
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Molecular profiles of tumor contrast enhancement: A radiogenomic analysis in anaplastic gliomas by Xing Liu, Yiming Li, Zhiyan Sun, Shaowu Li, Kai Wang, Xing Fan, Yuqing Liu, Lei Wang, Yinyan Wang, Tao Jiang

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Impacts of Early Weaning on Lamb Gut Health and Immune Function: Short-Term and Long-Term Effects by Chong Li, Yunfei Xu, Jiale Jia, Xiuxiu Weng, Yang Zhang, Jialin Peng, Xueming An, Guoxiu Wang

“…Plasma stress/immune markers were dynamically monitored, and intestinal morphology, antioxidant capacity, apoptosis, and transcriptomic profiles were analyzed at 5 and 28 days post-weaning. …”
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Over Time Changes in the Transcriptomic Profiles of Tomato Plants with or Without <i>Mi-1</i> Gene During Their Incompatible or Compatible Interactions with the Whitefly <i>Bemisia... by Susana Pascual, Clara I. Rodríguez-Álvarez, Irene López-Vidriero, José M. Franco-Zorrilla, Gloria Nombela

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Elevated NK and T cell-associated cytokines in plasma are associated with serological response to influenza vaccination by Harry Pickering, Michael A. Carlock, Monica Cappelletti, David W. Gjertson, Ted M. Ross, Ted M. Ross, Ted M. Ross, Elaine F. Reed

“…IntroductionNumerous pre-vaccination factors are known to be associated with differential responses to influenza vaccination, including age, prior infection, vaccination history, immune cell frequencies, and transcriptomic profiles. …”
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Transcriptomic defense mechanism of Japanese Eel (Anguilla japonica) against Edwardsiella anguillarum infection after bath immunization with Bacillus subtilis spores displaying Omp... by Minxia Chen, Zihao Chen, Guanghua Sun, Qiuhua Yang, Songlin Guo

“…Histopathology and gene expression were assessed 48 hours (h) post-infection. The WA and EA groups showed significantly lower mortality rates (64.3 % and 57.1 % relative survival, respectively) compared to the Con group. …”
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Morpho-Physiological and Molecular Responses to Seedling-Stage Drought Stress in Different Cowpea Cultivars by Inocent Paulin Ritte, Marceline Egnin, Gregory Christopher Bernard, Desmond Mortley, Osagie Idehen, Michelle Pamelas Okoma, Conrad Bonsi

“…Future research using transcriptomic profiling could unravel the complex molecular mechanisms of drought responses in cowpeas, providing valuable insights for breeding genotypes with improved resiliency to drought.…”
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Obese individuals exhibit distinct temporal gene expression dynamics in response to influenza vaccination by Megan Hockman, Julia Matthews, Michael A. Carlock, Ted M. Ross, David Gresham, Elodie Ghedin

“…Previously, we identified a transcriptomic signature prior to seasonal influenza vaccination that is predictive of an individual’s response to the influenza vaccine. …”
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Identifying molecular signatures of post-traumatic stress disorder vulnerability and progression in a longitudinal study: a study protocol by Federico Suprani, Federico Suprani, Pasquale Paribello, Pasquale Paribello, Giulia Federica Mancini, Giulia Federica Mancini, Maria Morena, Maria Morena, Marco Pinna, Marco Pinna, Federica Pinna, Federica Pinna, Martina Contu, Martina Contu, Caterina Visioli, Fabio Medas, Gian Luigi Canu, Federico Cappellacci, Pietro Giorgio Calò, Gabriele Finco, Salvatore Sardo, Monica Maria Francesca Puligheddu, Monica Maria Francesca Puligheddu, Ernesto D’Aloja, Claudia Pisanu, Alessio Squassina, Donatella Congiu, Gian Marco Leggio, Mirko Manchia, Mirko Manchia, Mirko Manchia, Patrizia Campolongo, Patrizia Campolongo

“…Post-Traumatic Stress Disorder (PTSD) is a highly debilitating psychiatric disorder, which develops in a subset of trauma-exposed individuals. …”
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Age-dependent glial heterogeneity and traumatic injury responses in a vertebrate brain structure by Huiwen Qin, Shuguang Yu, Ruyi Han, Jie He

“…However, the influence of age on the glial dynamics and their TBI responses remains mostly unexplored. Here, we obtain a comprehensive single-cell transcriptome atlas of three major glial types under the physiological and TBI conditions across four post-embryonic life stages in the zebrafish midbrain optic tectum. …”
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Transcriptomic Analysis Reveals the Molecular Defense Mechanisms of <i>Poa pratensis</i> Against Powdery Mildew Fungus <i>Blumeria graminis</i> f. sp. <i>Poae</i> by Zhiyu Xu, Zhanchao Guo, Fan Wu, Yining Zhang, Yumin Zhao, Lingjuan Han, Peng Gao, Huisen Zhu, Qingfang Xu, Xiang Zhao, Yinping Liang

“…We explored the molecular mechanisms underlying the response of different <i>P. pratensis</i> varieties at 48 h post-inoculation via transcriptomic techniques. …”
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Extracellular vesicle digital scoring assay for assessment of treatment responses in hepatocellular carcinoma patients by Chen Zhao, Yi-Te Lee, Andrew Melehy, Minhyung Kim, Jacqueline Ziqian Yang, Ceng Zhang, Jina Kim, Ryan Y. Zhang, Junseok Lee, Hyoyong Kim, Yong Ju, Yuan-Jen Tsai, Xianghong Jasmine Zhou, Steven-Huy B. Han, Saeed Sadeghi, Richard S. Finn, Sammy Saab, David S. Lu, Jason Chiang, Jae-Ho Park, Todd V. Brennan, Steven A. Wisel, Manaf Alsudaney, Alexander Kuo, Walid S. Ayoub, Hyunseok Kim, Hirsh D. Trivedi, Yun Wang, Aarshi Vipani, Irene K. Kim, Tsuyoshi Todo, Justin A. Steggerda, Georgios Voidonikolas, Kambiz Kosari, Nicholas N. Nissen, Rola Saouaf, Amit G. Singal, Myung Shin Sim, David A. Elashoff, Sungyong You, Vatche G. Agopian, Ju Dong Yang, Hsian-Rong Tseng, Yazhen Zhu

“…Results HCC EV TR Scores, calculated from pre- and post-treatment plasma samples in the phase-2 case–control study, accurately differentiated post-treatment viable from nonviable HCC in the training (area under the ROC curve [AUROC] of 0.90, n = 49) and validation set (AUROC of 0.88, n = 51). …”
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In Vitro Pollen Viability, Fluorescence Microscopy, and Transcriptomic Comparison of Self-Pollinated and Cross-Pollinated Inflorescence of <i>Artemisia annua</i> L. to Analyze Cand... by Yimei Zang, Shengrong Cui, Shugen Wei, Limei Pan, Lingyun Wan, Xiaojun Ma, Zuliang Luo, Jine Fu, Chongnan Wang

“…To address this, our study employed fluorescence microscopy and transcriptomic analysis on stigmas post self- and cross-pollination to explore the molecular mechanisms of SI in <i>Artemisia annua</i> L. …”
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Breed-Associated Differences in Differential Gene Expression Following Immunotherapy-Based Treatment of Canine High-Grade Glioma by Susan A. Arnold, Walter C. Low, Grace Elizabeth Pluhar

“…Given this breed-specific observation, we hypothesized that within the French bulldog breed, there are key transcriptomic differences when compared to other breeds, and that their tumors change differently in response to immunotherapy. …”
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Prediction and characterisation of the human B cell response to a heterologous two-dose Ebola vaccine by Daniel O’Connor, Elizabeth A. Clutterbuck, Malick M. Gibani, Sagida Bibi, Katherine A. Sanders, Rebecca Makinson, Dominic F. Kelly, Andrew J. Pollard

“…Our findings reveal robust plasma cell and lasting B cell memory responses post-vaccination. Machine-learning models trained on blood gene expression predicted antibody response magnitude. …”
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MAPK and phenylpropanoid metabolism pathways involved in regulating the resistance of upland cotton plants to Verticillium dahliae by Mingli Zhang, Mingli Zhang, Yanjun Ma, Yuan Wang, Haifeng Gao, Sifeng Zhao, Yu Yu, Xuekun Zhang, Hui Xi

“…However, the mechanism of resistance to V. dahliae in cotton is still unclear, which limits the breeding of resistant cultivars.MethodsTo analyze the defense mechanisms of cotton in response to V. dahliae infection, we compared the defense responses of two upland cotton cultivars from Xinjiang (JK1775, resistant; Z8,susceptible) using transcriptome sequencing at different infection stages.ResultsThe results revealed a significant differential expression of genes in the two cotton cultivars post V. dahliae infection, with the number of DEGs in JK1775 being higher than that in Z8 at different infection stages of V. dahliae. …”
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Herpes simplex virus-induced upregulation of inflammatory cytokines in human gingival fibroblasts by Yu Zhang, Kalam Lo, Chunmei Wang, Guoliang Zhou, Xiping Feng, Jing Ni, Xi Chen

“…The present study used RNA sequencing to investigate the transcriptomes of human gingival fibroblasts (HGFs) following HSV-1 infection from the early to late stages (12–72 h). …”
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Weighted Gene Co-Expression Network Analysis Identifies Hub Genes Governing Resistance to <i>Fusarium oxysporum</i> f. sp. <i>niveum</i> in Watermelon (<i>Citrullus lanatus</i>) by Chen Zhang, Xufeng Fang, Jing Zhang, Xinying Wang, Zhao Liu, Shusen Liu, Zhengfeng Song, Peng Gao, Feishi Luan

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Impact of β-defensin 103 (DEFB103) copy number variation on bull sperm parameters and post-insemination uterine gene expression. by Ozge Sidekli, Edward J Hollox, Sean Fair, Kieran G Meade

“…Transcriptomic analysis on uterine tissue harvested 12 h post-insemination showed differential expression of 58 genes (FDR < 0.1) involved in sperm migration, immune signalling and chemotaxis. …”
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Gene expression response under thermal stress in two Hawaiian corals is dominated by ploidy and genotype by Erin E. Chille, Timothy G. Stephens, Deeksha Misri, Emma L. Strand, Hollie M. Putnam, Debashish Bhattacharya

“…Our results strongly support the GDE model, even under severe stress. We suggest that post‐transcriptional processes (e.g., control of translation, protein turnover) modify the signal from the transcriptome, and may underlie the observed differences in coral bleaching sensitivity via the downstream proteome and metabolome.…”
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