RBIS regulates ribosome biogenesis to affect progression in lung adenocarcinoma by Hongyu Pan, Li Liao, Siwei Xu, Yujian Xu, Wenjun Chai, Xiaoli Liu, Jing Li, Yue Cao, Lei Sun, Qian Liu, Mingxia Yan

“…In this study, we investigated the function and underlying molecular mechanism of ribosome biogenesis factor (RBIS) in the progression of non-small cell lung cancer (NSCLC). …”
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Stratification of the Extent of Visual Impairment Identifies Sex-Specific Degenerative Changes in Retinal Structure and Function during Aging by Genea Edwards, Sean M. Riordan, Caitlin Buchholz, Marc Mardelli, Carlyn P. Euritt, Rodrigo Perez-Magnelli, Ariej Rafiq, Avery Engelmeyer, Peter Koulen

“…Eyes were categorized by vision impairment: normal vision, or low, moderate, or severe vision loss at the end of the study. Male and female mice differed in mean contrast sensitivity, indicating less sensitivity to fine detail and moving stimuli in female mice (11–12 months old, p < 0.001). …”
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Six‐Minute Walk Test Is Superior to Grip Strength as a Marker of Functional Recovery During Cancer Cachexia Rehabilitation by Addison Barber, Amber Willbanks, Kathryn Abplanalp, Christopher W. Lewis, Ben Binder‐Markey, Prakash Jayabalan, Richard L. Lieber, Ishan Roy

“…This may be, in part, due to a lack of outcomes that are appropriate and sensitive enough to detect functional recovery. Grip strength is a frequently used outcome measure in cachexia clinical studies; however, the use of gait‐based measures is now emerging. …”
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Different Trajectories of Functional Connectivity Captured with Gamma-Event Coupling and Broadband Measures of Electroencephalographic in the Rat Fluid Percussion Injury Model by Rachel Fox, Cesar Santana-Gomez, Mohamad Shamas, Aarja Pavade, Richard Staba, Neil G. Harris

“…Edge and global connectivity measures revealed injury-related differences across time in GEC-FC as compared with BBA-FC, demonstrating greater sensitivity to FC changes post-injury. There was no significant association between sleep fragmentation, HFOs, or seizures with FC changes. …”
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Dose-dependent changes in global brain activity and functional connectivity following exposure to psilocybin: a BOLD MRI study in awake rats by Evan Fuini, Arnold Chang, Richard J. Ortiz, Richard J. Ortiz, Taufiq Nasseef, Josh Edwards, Marc Latta, Elias Gonzalez, Taylor J. Woodward, Bryce Axe, Ashwath Maheswari, Noah Cavallaro, Heather B. Bradshaw, Praveen P. Kulkarni, Craig F. Ferris, Craig F. Ferris

“…Data for resting state functional connectivity were collected approximately 35 min post injection. …”
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The Role of Autophagy in Excitotoxicity, Synaptic Mitochondrial Stress and Neurodegeneration by Charleen T. Chu

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Impact on Mental, Physical and Cognitive functioning of a Critical care sTay during the COVID-19 pandemic (IMPACCT COVID-19): protocol for a prospective, multicentre, mixed-methods... by Felipe González-Seguel, Agustín Camus-Molina, Jaime Leppe, Ana Cristina Castro-Avila, Catalina Merino-Osorio, Ana Castro-Ávila, Camilo Cáceres Parra, Eduardo González Tapia, Felipe Muñoz-Muñoz, Fernanda Baus Auil, Javiera Aguilera Scarpati, Joaquín Olave, Macarena Leiva-Corvalán, Pilar Castro, Yerko Villagra Jofré

“…Trajectories of mental, physical, and cognitive impairments will be estimated using multilevel longitudinal modelling. A sensitivity analysis using multiple imputations will be performed to account for missing data and loss-to-follow-up. …”
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Ubiquitin-specific protease: an emerging key player in cardiomyopathy by Danlei Li, Qilin Ma

“…Abstract Protein quality control (PQC) plays a vital role in maintaining normal heart function, as cardiomyocytes are relatively sensitive to misfolded or damaged proteins, which tend to accumulate under pathological conditions. …”
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Perform-therapy as a method for restoring identity under conditions of postmodernist fragmentation by Anatoliy A. Grebenyuk

“…Perform-therapy is found to be particularly effective in working with clients exhibiting features of postmodern identity (hyper-reflection, fragmentation of self, emotional alienation), and it is also applicable in self-therapy and culturally sensitive interventions. The proposed concept opens up prospects for the development of new forms of symbolic therapy suited to the post-postmodern era. …”
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Unravelling the Role of Serum Kallistatin on Cardiorenal Outcomes in Kidney Transplant Survivors by Krzysztof Batko, Anna Sączek, Małgorzata Banaszkiewicz, Jolanta Małyszko, Ewa Koc-Żórawska, Marcin Żórawski, Karolina Niezabitowska, Katarzyna Siek, Andrzej Kraśniak, Marcin Krzanowski, Katarzyna Krzanowska

“…The median (interquartile range) time post-transplant was 52 (36–97) months, and the follow-up time was 83 (41–85) months. …”
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Cardiac MRI study of adverse events in patients treated with immune checkpoint inhibitors: a prospective cohort study of cardiac adverse events by Antonio Di Muzio, Alessandro Marchese, Lorenzo Monti, Cristina Panico, Marinos Kallikourdis, Gianluigi Condorelli, Armando Santoro, Matteo Simonelli, Angelo Dipasquale, Pasquale Persico, Laura Giordano, Giovanna Finocchiaro, Agnese Losurdo, Matteo Perrino, Marco Francone, Chiara Catalano, Simone Serio, Federica Catapano, Stefano Figliozzi, Carla D’Andrea, Marco Cremonesi, Maria Chiara Tronconi, Enrico Lugli

“…ICI treatment was associated with a significant left ventricular ejection function (LVEF) reduction pre-ICI versus post-ICI treatment (60.1±8% to 58.1±8%, p=0.002, paired t-test) and more than 3% LVEF loss in a substantial proportion of patients (18; 32%). …”
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Mucosal colonization of Mannheimia haemolytica capsular and adhesin mutants in cattle by Anna K. Goldkamp, Harish Menghwar, Carly Kanipe, Robert E. Briggs, Bradley O. Chriswell, Eduardo Casas, Michael L. Clawson, Fred M. Tatum, Rohana P. Dassanayake

“…Polysaccharide capsule and surface adhesins are suggested to function in adherence and colonization of M. haemolytica to the mucosa of the upper respiratory tract. …”
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Design of a Nested Hollow-Core Anti-Resonant Fiber Sensor for Simultaneous Measurement of Temperature and Strain by Yueyu Xiao, Jiayao Cheng

“…A highly sensitive sensor, which can detect the temperature and strain simultaneously, is proposed using a hollow-core anti-resonant fiber with composite nested tubes. …”
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Digitising the on-call medical team's patient list system: a QIP by Fahad-Bin Zahid

“…This posed challenges, including frequent loss of sensitive patient information, inefficient handovers and no audit trail. …”
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Structural knowledge-driven meta-learning for task offloading in vehicular networks with integrated communications, sensing and computing by Ruijin Sun, Yao Wen, Nan Cheng, Wei Wang, Rong Chai, Yilong Hui

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Sesame oil improves biomarkers of glycemic control in women with metabolic dysfunction-associated steatotic liver disease: a randomized, double-blind, controlled clinical trial by Masoumeh Atefi, Hamid Vahedi, Mina Darand, Mohammad Hassan Entezari

“…Serum fasting blood glucose (FBG), fasting serum insulin (FSI), homeostatic model assessment for insulin resistance (HOMA-IR), homeostasis model assessment of β-cell function (HOMA-β), quantitative insulin sensitivity check index (QUICKI), serum high-sensitivity C-reactive protein (hs-CRP), and serum malondialdehyde (MDA) were measured at the pre- and post-intervention phases. …”
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Minimum proportion of future liver remnant in safe major hepatopancreatoduodenectomy by Kentaro Umemura, Akira Shimizu, Tsuyoshi Notake, Koji Kubota, Kiyotaka Hosoda, Koya Yasukawa, Atsushi Kamachi, Takamune Goto, Hidenori Tomida, Yuji Soejima

“…While all remnant liver function scores predicted PHLF, the remnant ALICE demonstrated the best predictability (AUC 0.85, p < 0.01), with the sensitivity and specificity at 89% and 83%, respectively, using −0.86 as the cutoff. …”
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Regulating effect of empagliflozin plus liraglutide on glucose/lipid metabolism and serum levels of SFRP5， Irisin and tAPN in obese type 2 diabetics by Gao Rui-chao, Li Min, Jin Peng-ran, Liu Xuan, Feng Xue, Tan Zeng-huan

“…At pre-treatment and 3 months post-treatment， two groups were compared regarding the parameters of weight loss ［weight， waist circumference （WC）， body mass index （BMI）］， glucose metabolism ［glycated hemoglobin （HbA1c）， fasting blood glucose （FPG）， 2 h postprandial blood glucose （2 hPG）］， lipid metabolism ［low-density lipoprotein cholesterol （LDL-C）， high-density lipoprotein cholesterol （HDL-C）， triglycerides （TG）， total cholesterol （TC）］， insulin sensitivity ［homeostasis model islet β cell function index （HOMA-β）， homeostasis model insulin resistance index （HOMA-IR）］， serum levels of SFRP5， Irisin and tAPN and occurrences of adverse reactions.ResultsAfter 3-month treatment， body weight ［（74.93±2.68） <italic>vs</italic> （78.21±3.47） kg］， WC ［（90.40±2.17） <italic>vs</italic> （93.28±2.53） cm］ ，BMI ［（26.57±0.94） <italic>vs</italic> （27.94±1.06） kg/m²］ ，HbA1c ［（6.03±0.59）% <italic>vs</italic> （6.76±0.68）%］， FPG ［（6.24±0.73） <italic>vs</italic> （6.97±0.95） mmol/L］， 2 hPG ［（8.06±1.25） <italic>vs</italic> （8.83±1.50） mmol/L］， LDL-C ［（2.27±0.21） <italic>vs</italic> （2.58±0.27） mmol/L］， TG ［（1.83±0.34） <italic>vs</italic> （2.20±0.48） mmol/L］， TC ［（5.36±0.42） <italic>vs</italic> （5.92±0.53） mmol/L］ and HOMA-IR （2.35±0.24 <italic>vs</italic> 2.69±0.31） were lower in observation group than those in control group（<italic>P</italic>&lt;0.05）. …”
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DTC-m6Am: A Framework for Recognizing N6,2′-O-dimethyladenosine Sites in Unbalanced Classification Patterns Based on DenseNet and Attention Mechanisms by Hui Huang, Fenglin Zhou, Jianhua Jia, Huachun Zhang

“…Background: m6Am is a specific RNA modification that plays an important role in regulating mRNA stability, translational efficiency, and cellular stress response. m6Am’s precise identification is essential to gain insight into its functional mechanisms at transcriptional and post-transcriptional levels. …”
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Multi-authority attribute hidden for electronic medical record sharing scheme based on blockchain by Lin JIN, Youliang TIAN

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