Beyond auditory sensitivity: cognitive and linguistic influences on clinical performance in post-lingual adult cochlear implant users by Nadine Buczak, Nadine Buczak, Eugen Kludt, Eugen Kludt, Thomas Lenarz, Thomas Lenarz, Andreas Büchner, Andreas Büchner

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Impact on Metabolism Generated by Surgical and Pharmacological Interventions for Weight Loss in Women with Infertility by Paulo César Gete Palacios, Alberto Moscona-Nissan, Renata Saucedo, Aldo Ferreira-Hermosillo

“…However, its invasive nature increases the potential of nutritional deficiencies and the need for a delayed conception post-surgery. On the other hand, pharmacological treatments such as glucagon-like-peptide 1 receptor agonists offer non-invasive alternatives with promising results in body weight, improving insulin sensitivity and restoring ovarian function. …”
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Designing novel “Smell-Aids” to improve olfactory function in post COVID-19 era by Veronica L. Formanek, Barak M. Spector, Gabriela Zappitelli, Zhenxing Wu, Kai Zhao

“…Next, we tested the prototypes on 54 patients with confirmed olfactory losses (age 21–80 years, median 54.5), the majority of whom (37/54 = 69%) were post-COVID long haulers (infected 12/15/2019 to 10/4/23; persisted 30 to 1260 days, median 22 months). …”
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Loss function of tumor suppressor FRMD8 confers resistance to tamoxifen therapy via a dual mechanism by Weijie Wu, Miao Yu, Qianchen Li, Yiqian Zhao, Lei Zhang, Yi Sun, Zhenbin Wang, Yuqing Gong, Wenjing Wang, Chenying Liu, Jing Zhang, Yan Tang, Xiaojie Xu, Xiaojing Guo, Jun Zhan, Hongquan Zhang

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Anterior insular cortex glutamate-glutamine (Glx) levels predict general psychopathology via heightened error sensitivity by Haeorum Park, Minchul Kim, Minchul Kim, Jaejoong Kim, Jaejoong Kim, Sunghwan Kim, Sunghwan Kim, Bumseok Jeong

“…We therefore combined functional MRS (fMRS) with reinforcement-learning modeling to test whether (i) baseline AIC Glx predicts the G-score derived from bifactor analysis of PHQ-9, GAD-7, and STAI-X1, and (ii) task-evoked Glx changes track individual differences in error sensitivity during gain- and loss-based learning.MethodsFifty-six healthy adults (22 ± 2 yr, 16 women) completed the questionnaires and performed a two-armed bandit task (40 loss then 40 gain trials) while single-voxel semi-LASER spectra were acquired from AIC and medial prefrontal cortex (mPFC) at rest and during each block. …”
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MicroRNA: sex steroids, hormonal carcinogenesis, hormonal sensitivity of tumor tissue by A. V. Malek, L. M. Bershtein

“…The most established and clinically significant example of such phenomenon is the loss of sensitivity of cells to the regulatory action of these hormones. …”
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The RAE1-STOP1 module regulates ABA sensitivity in early seedlings of Arabidopsis by Yuqing Zhang, Min Huang, Yinyin Liu, Mengmeng Yang, Yuqi Hou, Chao-Feng Huang, Ning Ning Wang, Lei Li

“…This study revealed that exogenous ABA supplementation reduced STOP1 levels by promoting the expression of RAE1. Notably, both RAE1 loss-of-function mutants and STOP1 overexpressing lines showed enhanced sensitivity to exogenous ABA treatment, which correlated with early stage post-transcriptional upregulation of ABSCISIC ACID INSENSITIVE5 (ABI5). …”
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A Cost-Sensitive Small Vessel Detection Method for Maritime Remote Sensing Imagery by Zhuhua Hu, Wei Wu, Ziqi Yang, Yaochi Zhao, Lewei Xu, Lingkai Kong, Yunpei Chen, Lihang Chen, Gaosheng Liu

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Comprehensive study of SNAREs involved in the post-Golgi transport in Drosophila photoreceptors by Yuka Ochi, Hitomi Yamashita, Shogo Sasaki, Takumi Ogawa, Yumi Yamada, Tatsuya Tago, Takunori Satoh, Akiko K. Satoh

“…We conducted a comprehensive soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) screening of the fly genome using RNAi knockdown and CRISPR/Cas9 somatic knockout combined with the CoinFLP system to identify SNAREs involved in post-Golgi trafficking. …”
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Development of Smart pH-Sensitive Collagen-Hydroxyethylcellulose Films with Naproxen for Burn Wound Healing by Elena-Emilia Tudoroiu, Mădălina Georgiana Albu Kaya, Cristina Elena Dinu-Pîrvu, Lăcrămioara Popa, Valentina Anuța, Mădălina Ignat, Emilia Visileanu, Durmuș Alpaslan Kaya, Răzvan Mihai Prisada, Mihaela Violeta Ghica

“…In vitro degradation proved structural stability maintenance for at least one day, with more than 40% weight loss. Films presented a biphasic naproxen release profile with more than 75% of the drug released after 24 h, properly managing inflammation and pain on the first-day post-burn. …”
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Loss of NUMB drives aggressive bladder cancer via a RHOA/ROCK/YAP signaling axis by F. A. Tucci, R. Pennisi, D. C. Rigiracciolo, M. G. Filippone, R. Bonfanti, F. Romeo, S. Freddi, E. Guerrera, C. Soriani, S. Rodighiero, R. H. Gunby, G. Jodice, F. Sanguedolce, G. Renne, N. Fusco, P. P. Di Fiore, G. Pruneri, G. Bertalot, G. Musi, G. Vago, D. Tosoni, S. Pece

“…Retrospective cohort studies show that NUMB-loss correlates with poor prognosis in post-cystectomy muscle-invasive BCa patients and increased risk of muscle invasion progression in non-muscle invasive BCa patients. …”
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Prolonging calcineurin inhibitor therapy post kidney allograft failure: a prospective study by Rita Leal, Pedro Fragoso, João Venda, José Gomes, Maria Inácio, Maria Guedes Marques, Luís Rodrigues, Lídia Santos, Catarina Romãozinho, Francisco Caramelo, Helena Oliveira Sá, António Martinho, Arnaldo Figueiredo, Rui Alves

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Noise-induced ribbon synapse loss in the mouse basal cochlear region does not reduce inner hair cell exocytosis by David Oestreicher, David Oestreicher, Alfonso Mauro Malpede, Alfonso Mauro Malpede, Annalena Reitmeier, Annalena Reitmeier, Carolin Paula Bräuer, Carolin Paula Bräuer, Laura Schoch, Laura Schoch, Nicola Strenzke, Nicola Strenzke, Tina Pangrsic, Tina Pangrsic, Tina Pangrsic

“…Extensive previous work has shown that the highly sensitive synapses of the inner hair cells (IHCs) may be the first target for irreparable damage and permanent loss in the noise-exposed cochlea, more precisely in the cochlear base. …”
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Soil-transmitted helminth infection, loss of education and cognitive impairment in school-aged children: A systematic review and meta-analysis. by Noel Pabalan, Eloisa Singian, Lani Tabangay, Hamdi Jarjanazi, Michael J Boivin, Amara E Ezeamama

“…<h4>Background</h4>Evidence of an adverse influence of soil transmitted helminth (STH) infections on cognitive function and educational loss is equivocal. Prior meta-analyses have focused on randomized controlled trials only and have not sufficiently explored the potential for disparate influence of STH infection by cognitive domain. …”
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Acuity and colour vision changes post intravitreal dexamethasone implant injection in patients with diabetic macular oedema. by Ahmed Abdel-Hay, Sobha Sivaprasad, Ahalya Subramanian, John L Barbur

“…All tests were performed monocularly at baseline and 24 weeks post injection.<h4>Results</h4>All patients (n = 14 eyes), had significant loss of RG and YB chromatic sensitivity at baseline (p<0.05). …”
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A conserved role for Syntaxin-1 in pre- and post-commissural midline axonal guidance in fly, chick, and mouse. by Oriol Ros, Pablo José Barrecheguren, Tiziana Cotrufo, Martina Schaettin, Cristina Roselló-Busquets, Alba Vílchez-Acosta, Marc Hernaiz-Llorens, Ramón Martínez-Marmol, Fausto Ulloa, Esther T Stoeckli, Sofia J Araújo, Eduardo Soriano

“…We also confirmed that STX1 loss-of-function results in reduced sensitivity of commissural axons to Slit-2 and Netrin-1. …”
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Glymphatic dysfunction in classical trigeminal neuralgia: DTI-ALPS index stratification from healthy controls to post-MVD by Xiaolin Hou, Bo Wu, Ruxiang Xu, Cheng Yin

“…ROC analysis indicated preliminary diagnostic potential for distinguishing CTN from HCs (AUC = 0.609, sensitivity/specificity = 83%). Conclusions CTN is characterized by persistent glymphatic impairment and structural atrophy—hippocampal and amygdala volume loss with ventricular enlargement—that do not normalize at 6 months post-MVD. …”
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Binary program taint analysis optimization method based on function summary by Pan YANG, Fei KANG, Hui SHU, Yuyao HUANG, Xiaoshao LYU

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Predicting kidney graft function and failure among kidney transplant recipients by Yi Yao, Brad C. Astor, Wei Yang, Tom Greene, Liang Li

“…Abstract Background Graft loss is a major health concern for kidney transplant (KTx) recipients. …”
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LKB1 dictates sensitivity to immunotherapy through Skp2-mediated ubiquitination of PD-L1 protein in non-small cell lung cancer by Wei Liu, Dong Wang, Qing Miao, Peilin Chen, Hongbing Liu, Jiawen Lv, Jie Yin, Jian Feng, Yong Song, Tangfeng Lv, Mingxiang Ye, Wenjie Yan, Liting Lv, Sutong Zhan

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