Investigating the use of cuprizone and lysolecithin to model demyelination ex vivo in sagittal rat brain organotypic slice cultures by Brooke Hawker, Bronwen Connor, Amy McCaughey-Chapman

“…We have previously reported the ability to generate sagittal organotypic brain slice cultures, allowing us to investigate the anterior-to-posterior integrity of the corpus callosum during demyelination and remyelination processes. To extend our sagittal organotypic brain slice culture model, this study compares the ability for two common demyelinating agents, cuprizone (CPZ) or lysolecithin (LPC), to induce demyelination of the corpus callosum.MethodsRat brain sagittal organotypic slice cultures were generated with clear visualization of the corpus callosum and treated either with CPZ (1 mM) or LPC (0.5 mg/mL).ResultsWe demonstrate that CPZ treatment induces acute demyelination followed by endogenous remyelination 1-week post-treatment. …”
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Keir Starmer’s Labor Government: Resetting the UK’s Relations with the European Union by Tatyana N. Cherkashina

“…After a 14-year gap, the UK’s Labor government needs to re-establish its post-Brexit ties with the European Union. …”
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Harnessing digital health technologies and real-world evidence to enhance clinical research and patient outcomes by Shreyash Mahadik, Prerona Sen, Ekta J. Shah

“…As healthcare systems progressively integrate these various data sources, they are reshaping regulatory approval processes and enhancing post-market surveillance of therapies. …”
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Evaluation of synergistic effect of entomopathogenic fungi Beauveria bassiana and Lecanicillium lecacii on the mosquito Culex quinquefaciatus. by Aditya Shankar Kataki, Francesco Baldini, Anjana Singha Naorem

“…However, their combined efficacy has not yet been evaluated against mosquito control in prior research and a gap of knowledge is still existing. So, this research was an attempt to bridge up the knowledge gap by (1) Assessing the combined efficacy of Beauveria bassiana and Lecanicillium lecanii on Culex quinquefasciatus (2) To investigate the sub-lethal concentration (LC50) of the combined fungal concentration and (3) To examine the post-mortem effects caused by the combined fungal concentration under Scanning Electron Microscope (SEM). …”
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Bidirectional cohort study protocol to construct and validate a prediction model for perioperative pulmonary complications in elderly hip fracture patients by Ling Wang, Yalin Tian, Jintao Shen, Xiaotao Fan, Xujun Dong, Jianhua Chen, BenTao Jiang, Li Qin, Shaojin Bu, Jiaxi Tang

“…To address this gap, this bidirectional cohort study aims to develop and validate a predictive model for POPCs across all surgical stages in elderly patients with hip fracture. …”
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Design and Experiment of Opposed Roller-Type Picking Device for Chrysanthemum Indicum by Yiduo Bai, Zhuanghong Ma, Suyuan Liu, Zhengdao Liu, Xiaoli Yan, Yuxiang Huang

“…The design focused on an opposed drum picking mechanism. Taking the critical post-collision acceleration as the evaluation metric, a theoretical analysis was conducted on the post-collision motion behaviors of wild chrysanthemum and the roller bow tooth. …”
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Long-term analysis of land cover changes resulting from mining activities: Strzelin case study (S–W Poland) by K. Romańczukiewicz, J. Górniak-Zimroz

“…The study also documents parallel urbanisation trends and infrastructure development, highlighting the complex interaction between industrial activity and socio-environmental processes. This work contributes to research on land use and land cover (LULC) by extending the time frame of the analysis beyond the limitations of satellite era data and filling a gap in the literature on land use changes caused by mining activities. …”
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Instagram's impact on dental consumers: analyzing toothpaste hashtags by Khalifa S. Al-Khalifa, Rasha AlSheikh, Basmah O. Alakloby, Hind M. Alharbi, Razan F. Alghamdi, Saqib Ali, Laila Al Dehailan

“…This raised the necessity to comprehensively understand the influence of social media, particularly Instagram, on consumer decision-making processes and behavior related to toothpaste selection.Aimto explore toothpaste-related content on Instagram by addressing this gap and highlighting the characteristics of the top-performing toothpaste posts. …”
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Digitalised validation systems as an enabler for quality 4.0 within a medical device manufacturer by Olivia McDermott, Neasa Conroy, M. Thenarasu, Susana Duarte

“…Findings: Digitalised validation systems have benefits, including more sustainable processes with the elimination of paper, a streamlined review and approval process, and the successful management of data integrity for large volumes of validation data while also decreasing opportunities for audit findings. …”
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Reduction of artifacts associated with missing data in coherent diffractive imaging by Erik Malm, Yuriy Chushkin

“…The first algorithm assumes that there is an accurate estimate of the phase and can be used for pre- and post-processing. The second algorithm attempts to simultaneously minimize the total variation and recover the phase. …”
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UV-induced reorganization of 3D genome mediates DNA damage response by Veysel Oğulcan Kaya, Ogün Adebali

“…Employing temporal maps of contact matrices and transcriptional profiles, we illustrate the immediate and holistic changes in genome architecture post-irradiation, emphasizing the significance of this reconfiguration for effective DNA repair processes. …”
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Explainable AI in Education: Techniques and Qualitative Assessment by Sachini Gunasekara, Mirka Saarela

“…The methodology involved evaluating the DT, an intrinsically explainable model, against the more complex ANN, which requires post hoc explainability techniques. The results show that, although the feature-based and structured decision-making process of the DT facilitates natural interpretability, it struggles to model complex data relationships, often leading to misclassification. …”
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Enhancement of NMP Degradation Under UV Light by Nitrogen-Doped TiO2 Thin Films Using a Design of Experiment by F. Arefi-Khonsari, F. Meshkini, R. Jafari, H. Mortaheb, J. Pulpytel, W. Smith, H. Fakhouri, A. Zolfaghari

“…However, the post annealing process did not effect the activity under UV irradiation. …”
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The Use of Data Mining in Public Budgeting: A Systematic Literature Mapping by Jose Claudio Guedes Das Neves, Veronica Oliveira De Carvalho

“…Generally, data mining consists of three major steps: pre-processing, pattern extraction, and post-processing. …”
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Three-Dimensionally Printed Splints in Dentistry: A Comprehensive Review by Luka Šimunović, Samir Čimić, Senka Meštrović

“…While current limitations include material aging, post-processing complexity, and variability in long-term outcomes, ongoing innovations—such as flexible resins, multi-material printing, and AI-driven design—hold promise for broader adoption. …”
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Human Retinal Organoid Model of Ocular Toxoplasmosis by Liam M. Ashander, Grace E. Lidgerwood, Amanda L. Lumsden, João M. Furtado, Alice Pébay, Justine R. Smith

“…Both developing (1 month post-isolation) and matured (6 months post-isolation) organoids were susceptible to infection. …”
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Design of a Solar Dryer for Tomatoes. by Bwire, Samlex Sibagaya

“…This project addresses this gap by proposing the design, development, and testing of a solar dryer specifically for drying tomatoes. …”
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Analysis and Verilog-A Modeling of Floating-Gate Transistors by Sayma Nowshin Chowdhury, Matthew Chen, Sahil Shah

“…Designing and fabricating these circuits typically involves extensive SPICE-based simulations, yet integrating and calibrating floating-gate transistors post-fabrication is a common practice. To bridge this gap, we present a Verilog-A model based on empirical measurements for a floating-gate transistor fabricated using a 65 nm CMOS process. …”
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How to deal with future uncertainty? An empirical study of undergraduates based on the theory of motivation information management by Zhuowen Feng, Chuyu Guo, Guancheng Wang, Chunyan Mo

“…Based on the Theory of Motivated Information Management (TMIM), this study examines how undergraduates manage information related to post-graduation pathways, with a particular focus on their interactions with teachers, family, and friends. …”
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EmoFusion: An integrated machine learning model leveraging embeddings and lexicons to improve textual emotion classification by Anjali Bhardwaj, Muhammad Abulaish

“…Human emotions are complicated and intertwined with cognitive processes, influencing mental health, learning, and decision-making. …”
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