Role of Antimicrobial Stewardship in Modulating Antibiotic Use and Mitigating Bacterial Resistance in a Tertiary Care Setting During COVID-19 by Zhang X, Zhou L, Peng P, Zhang W, Liang C

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Asperosaponin VI suppresses ferroptosis in chondrocytes and ameliorates osteoarthritis by modulating the Nrf2/GPX4/HO-1 signaling pathway by Zhimeng Zhang, Daotong Yuan, Ximin Jin, Wenjie Chang, Yongkui Zhang, Wenpeng Xie

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Modulation of HER2 internalization enhances single-dose antibody-drug potency in HER2+ gastric cancer by Abbey Zidel, Alex Benton, Emma Brown, Shayla Shmuel, Alex Vanover, Sandeep Surendra Panikar, Ron Bose, Haeseong Park, Andrew A. Davis, Patrícia M. R. Pereira

“…Therapy, pre-treatment and post-treatment positron emission tomography/computed tomography (PET/CT) were performed in both male and female mice. …”
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Mitigating organophosphate nerve agent, soman (GD), induced long-term neurotoxicity: Saracatinib, a Src Tyrosine Kinase inhibitor, as a potential countermeasure by Nyzil Massey, Suraj S. Vasanthi, Claire Holtkamp, Christina Meyer, Nikhil S. Rao, Luis G. Gimenez-Lirola, Chong Wang, Hyunmook Im, Avinash S. Bevoor, Sridhar Kannurpatti, Thimmasettappa Thippeswamy

“…Abstract Background Acute exposure to soman (GD), an organophosphate nerve agent (OPNA), irreversibly inhibits acetylcholinesterase (AChE), induces seizures, and could be fatal if not treated immediately. …”
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IL-4Rα signalling influences behavioural and immune responses in Trypanosoma brucei-infected mice: Evidence for iloprost as a neuroprotective agent by OS Olaolu, H. Davids, GB Dealtry, A.S. Abubakar, ET Obishakin, B. Iliyasu, IA Azeez, DC Ajonijebu

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Therapeutic Implications of Traditional Chinese Medicine in Clinically Relevant Diseases: Perspectives From microRNA-Modulated Apoptotic Signaling by Xu Q, Wu D, Tan J, Khan FA, Pandupuspitasari NS, Huang C

“…MicroRNAs (miRNAs) are endogenous, non-coding RNA (ncRNA) molecules that regulate genetic expression via post-transcriptional mechanisms. By modulating miRNA expression, TCMs have been proven to confer protective benefits, notably by facilitating apoptosis induction. …”
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The stromal vascular fraction mitigates bleomycin-induced skin fibrosis in mice by modulating vascular lesions and secreting antifibrotic factors at different stages of disease by Ziyu Wang, Mengqi Shi, Zonghao Liu, Yahui Chen, Xiangguang Shi, Jiucun Wang

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Effects of Thermal Manipulation and Serotonin Modulation on Brain HSP70 and HSP90 Gene Expression in Late Embryogenesis of Broilers by Hamed KHasti, Ladan Emadi, Shahrzad Azizi, Elham Mohammadi, Hadi Tavakkoli

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Therapeutic potential of sulforaphane: modulation of NRF2-mediated PI3/AKT/mTOR pathway in oral fibrosis by Pooja Narain Adtani, Rajasekaran Subbarayan, Rupendra Shrestha, Walid Elsayed

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Progesterone Administration Modulates Cortical TLR4/NF-κB Signaling Pathway after Subarachnoid Hemorrhage in Male Rats by Zhong Wang, Gang Zuo, Xiao-Yong Shi, Jian Zhang, Qi Fang, Gang Chen

“…Administration of progesterone following SAH could down-regulate the cortical levels of these agents related to TLR4/NF-κB signaling pathway. Post-SAH progesterone treatment significantly ameliorated the EBI, such as the clinical behavior scale, brain edema, and blood-brain barrier (BBB) impairment. …”
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Transcriptomic analysis of non-leukemic cell subsets in azacytidine-responsive AML highlights pathways associated with adhesion, platelet aggregation, and angiogenesis in mice and... by Nancy D. Ebelt, Suvithanandhini Loganathan, Lara C. Avsharian, Edwin R. Manuel

“…Abstract Background Hypomethylating agents (HMAs), such as 5-azacytidine (AZA), are valuable treatment options for patients with acute myeloid leukemia (AML). …”
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Denosumab as an immune modulator in HER2-negative early breast cancer: results of the window-of-opportunity D-BIOMARK clinical trial by Andrea Vethencourt, Eva M. Trinidad, Eduard Dorca, Anna Petit, M. Teresa Soler-Monsó, Marina Ciscar, Alexandra Barranco, Gema Pérez-Chacón, María Jimenez, Mario Rodríguez, Clara Gomez-Aleza, Elvira Purqueras, Enrique Hernández-Jiménez, Ander Urruticoechea, Idoia Morilla, Isaac Subirana, Amparo García-Tejedor, Miguel Gil-Gil, Sonia Pernas, Catalina Falo, Eva Gonzalez-Suarez

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Effect of Xylitol and Maltitol Chewing Gums on Plaque Reduction and Salivary pH Modulation: A Retrospective Study in Pediatric Patients by Francesco Saverio Ludovichetti, Edoardo Stellini, Camilla Rodella, Marco Sambugaro, Pier Francesco Gaja, Alessia Rizzato, Sergio Mazzoleni

“…The Plaque Control Record Index (PCR) had been assessed in all participants using a plaque-disclosing agent, and salivary pH had been measured with a litmus test. …”
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Therapeutic potential of agmatine in the experimental autoimmune encephalomyelitis by Stevanović Ivana, Ninković Milica, Stanojević Jelena, Mančić Bojana, Stojanović Ivana

“…Thus, AGM may be considered as an agent with a beneficial effect on neuroinflammation in EAE.…”
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Targeting degradation of IKZF1 and IKZF3 through modulation of the E3 ligase substrates in the context of cellular therapies for multiple myeloma by David Kegyes, Anamaria Bancos, Adrian Bogdan Tigu, Ioana Rus, Delia Dima, Diana Cenariu, Madalina Nistor, Raluca Munteanu, Diana Gulei, Alina Tanase, Anca Colita, Anca Buzoianu, Cristina Iuga, Mihnea Zdrenghea, Evangelos Terpos, Stefan O. Ciurea, Aaron Ciechanover, Hermann Einsele, Ciprian Tomuleasa

“…Building on the success of immunomodulatory agents, CRBN E3 ligase modulators (CELMoDs), iberdomide (CC-220) and mezigdomide (CC-92480), have been designed as promising and more selective agents. …”
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Integrated In Silico, In Vitro, and In Vivo Studies Reveal Mangiferin as a Promising Antiviral Agent Against H1N1/pdm2009 Influenza Virus by Yinde Gan, Fucheng Guo, Ayan Roy, Xiao Wang, Yongyi Shen

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Preparation and Evaluation of Alpha-2-Macroglobulin Hydrogel for Drug Release Kinetics and Biocompatibility on Human Gingival Fibroblasts: An In-vitro Study by Poulami Chakraborty, ND Jayakumar, S Raghunandhakumar

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Alternative splicing fine-tunes prey shift of Coccinellini lady beetles to non-target insect by Xuefei Tang, Xinhui Xia, Yuqi Liu, Xiyao Hong, Yuhao Huang, Guannan Li, Yuansen Liang, Xueqing Wang, Hong Pang, Yuchen Yang

“…Conclusion These findings unraveled the functional significance of AS reprogramming in modulating acclimation of Coccinellini lady beetles to prey shift from aphids to non-target insects and provided new genetic clues for evaluating their ecological safety as biological control agents.…”
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Programmed Death Ligand 1 Modulation by Bacillus Calmette-Guérin and Toll-Like Receptor Agonists in Distinct Breast Cancer Cell Subtypes by Barbosa G, De Godoy MCX, Bighetto CC, Skakum EM, Pascoal LB, Gambero A, Reis LO

“…Understanding how different immunomodulatory agents influence PD-L1 expression in breast cancer cells could inform novel therapeutic strategies. …”
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Comparative analysis of melatonin’s protective role against flattening filter and flattening filter-free X-ray induced nephropathy: focus on apoptosis and SIRT1 modulation by Kubra Sevgin, Tansel Sapmaz, Esra Erdem, Sude Topkaraoglu, Kubra Basol Baki, Serhat Aras

“…Rats were sacrificed 48 h post-radiotherapy for histopathological and immunohistochemical analyses of the kidney. …”
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