Comparative analysis of Microtus fortis and murine hosts reveals a correlation between BRD4 and hepatic inflammation during Schistosoma japonicum infection by Ming Yuan, Mingrou Wu, Yunyi Hu, Siyu Zhao, Jehangir Khan, Zhanhong Yuan, Yun Huang, Tianqiong He, Zhijun Zhou, Jia Shen, Zhongdao Wu

“…BRD4-associated gene expression patterns were analyzed through correlation-based classification, followed by protein–protein interaction network construction and functional enrichment analyses. In addition, BRD4 was pharmacologically inhibited in vivo using JQ1, and hepatic inflammation and worm load were evaluated at 14 days post-infection. …”
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P-4 HYPOTHERMIC OXYGENATED PERFUSION USING AN ECMO DEVICE IN LIVER TRANSPLANTATION: AN ANALYSIS OF THE FIRST 100 CASES AT A CHILEAN PUBLIC HOSPITAL by FRANCISCA MAGDALENA MARTÍNEZ VENEZIAN, Elizabeth Rivas, Valeria Galaz, Valentina Castillo, Julio Benitez, Edmundo Martinez, Rodrigo Wolff, Blanca Norero, Erwin Buckel, Rolando Rebolledo

“…Post-transplantation, key outcomes such as liver functionality, early complications, and overall survival were monitored in all patients. …”
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Transcriptomic analysis of non-leukemic cell subsets in azacytidine-responsive AML highlights pathways associated with adhesion, platelet aggregation, and angiogenesis in mice and... by Nancy D. Ebelt, Suvithanandhini Loganathan, Lara C. Avsharian, Edwin R. Manuel

“…Results We observed hematologic recovery in the peripheral blood of AZA-treated groups, versus vehicle control, that was associated with significant extensions in survival. Transcriptional analysis of AZA-treated samples revealed decreased cell type scores for suppressive subsets and increased pathway scores for T and B cell functions. …”
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Multidimensional advances in neural interface technology for peripheral nerve repair: From material innovation to clinical translation by Jianchao Wu, Qixin Han, Dingkun Gui, Yun Qian

“…Preclinical and clinical researches validated the therapeutic efficacy of neural interfaces in promoting axon regeneration, managing chronic pain, and restoring sensorimotor function. However, persistent challenges (such as limited long-term interfacial stability, post-implantation inflammatory responses, signal quality attenuation, and interindividual therapeutic heterogeneity) hinder widespread clinical adoption. …”
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Comparative Effectiveness of Different Frequencies of Spinal Cord Stimulation for the Treatment of Patients with Failed Back Surgery Syndrome: Systematic Review and Network Meta-An... by Qin YY, Zhang CP, Tang SS, Wu JP, Zhu LX, Li YH, Xu F

“…Bayesian random-effects network meta-analysis assessed outcomes including pain reduction, functional capacity, and health-related quality of life.Results: This NMA (11 RCTs; n=2275) revealed efficacy variations among SCS modalities. …”
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Model for evaluating the effectiveness of the educational activities of the class teacher by V. V. Nikolina, A. A. Loshchilova, S. I. Aksenov

“…At the present stage, the institution of class leadership exists in the territory of the post-Soviet space, in China, France and a number of other countries. …”
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Comparison of perioperative efficacy and indications between laparoscopic capsule-preserving resection and partial nephrectomy for renal angiomyolipoma: a decade-long retrospective... by Haipeng Zhang, Guangcan Yang, Changxiu Tian, Wei Song, Houliang Zhang, Jinliang Ni, Ziming Jiang, Keyi Wang, Bo Peng

“…The average GFR 1-3 days after surgery and the renal function grade 3 months post-surgery were significantly better in the LCPR group compared to the LPN group (P = 0.001). …”
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Changes in Race Performance During the Underwater Phases of a 200 m Bi-Fins Race Simulation After Application of Respiratory Muscle Training—A Case Study in the Current World Recor... by Tomáš Michalica, Jakub Březina, Marek Polach, Dennis-Peter Born, Jiří Mališ, Zbyněk Svozil, Eva Kociánová

“…Performance variability was assessed based on pre-test, inter-test, and post-test data. Each measurement included pulmonary function and swim performance evaluations. …”
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Effect of vigorous-intensity exercise on the working memory and inhibitory control among children with attention deficit hyperactivity disorder: a systematic review and meta-analys... by Ruiyun Zhang, Haixia Li

“…Based on the systematic meta-analysis results, vigorous-intensity exercises have effective working memory, cognitive function, and motor ability-increasing effects on children with ADHD. …”
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Exploring postoperative nasal airflow dynamics and impact on crust formation and mucosal healing after endoscopic tumor resection using computational fluid dynamics analysis. by Yang Na, Minhae Park, Yong Gi Jung

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The evolution of three-dimensional knee kinematics after ACL reconstruction within one year by Lingchuang Kong, Huahao Lai, Xiaolong Zeng, Peng Gao, Peng Gao, Wenhao Liang, Qi Gao, Qi Gao, Zhiyuan Kong, Wu Wu, Xiaona Wu, Tao Zhang

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Data-independent LC-MS/MS analysis of ME/CFS plasma reveals a dysregulated coagulation system, endothelial dysfunction, downregulation of complement machinery by Massimo Nunes, Mare Vlok, Amy Proal, Douglas B. Kell, Etheresia Pretorius

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Randomized clinical trial to evaluate the effectiveness of different thicknesses of stabilization splints in treating temporomandibular disorder using joint vibration analysis as a... by Jyoti Sharma, Rajlakshmi Banerjee, Vijeta Gajbhiye, Anushree Bhoge, Priti Jaiswal, Kiran Nayak

“…Aim: The purpose of the study was to comparatively evaluate temporomandibular joint function and treatment response using joint vibration analysis (JVA) in patients exhibiting disc displacement with reduction (DDR), treated with three variable thickness of stabilization splints. …”
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Global disparities in access to hepatitis C medicines before and during the early phase of the COVID-19 pandemic: an ARIMA-based interrupted time series analysis by Nick Bansback, Mina Tadrous, Marie Paul Nisingizwe, Michael R Law, Bethany Hedt-Gauthier, Naveed Z Janjua, Katie J Suda

“…In contrast, first-generation and second-generation DAAs were the predominant types of DAAs sold in lower middle-income countries (LMICs). The pre-post analysis showed a 23% (p<0.001) average decrease in global sales of DAAs during the first phase of COVID-19. …”
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Exploring the Genetic Networks of HLB Tolerance in Citrus: Insights Across Species and Tissues by Rodrigo Machado, Sebastián Moschen, Gabriela Conti, Sergio A. González, Máximo Rivarola, Claudio Gómez, Horacio Esteban Hopp, Paula Fernández

“…Weighted gene co-expression network analysis (WGCNA) was applied to identify gene modules associated with citrus species, tissue types, and days post-infection (DPIs). …”
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Neurocognitive Outcomes After Extracranial Surgery and General Anesthesia in Patients with a History of Mild-to-Moderate Traumatic Brain Injury: Systemic Review and Meta-Analysis by Zeeshan A. Khan, Tahiris A. Duran, Dewan Md. Sumsuzzman, Ling-Sha Ju, Christoph N. Seubert, Anatoly E. Martynyuk

“…We systematically searched five databases for studies examining cognitive function in patients with mild-to-moderate TBI with (participant) or without (control) subsequent extracranial surgeries/GA. …”
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Multimorbidity frameworks impact the composition of patterns and their associations with patient-reported outcomes among people with HIV by Luxsena Sukumaran, Alan Winston, Jane Anderson, Marta Boffito, Frank A. Post, Memory Sachikonye, Patrick W. G. Mallon, Laura Waters, Jaime Vera, Fiona Burns, Caroline A. Sabin

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A systematic review and meta-analysis of urinary incontinence following successful obstetric fistula repair: findings from five countries in sub-Saharan Africa by Gedion Asnake Azeze, Kirubel Eshetu Haile, Natnael Atnafu Gebeyehu, Sintayehu Solomon Kena, Tewodros Getachew Tsegaye, Amanuel Yosef Gebrekidan, Yitateku Alelgn, Gizachew Ambaw Kassie, Yordanos Sisay Asgedom

“…Conclusion and implications Overall, our findings show post-fistula repair incontinence remains an important clinical problem. …”
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Systematic review and meta-analysis: do best-evidenced trauma-focused interventions for children and young people with PTSD lead to changes in social and interpersonal domains? by Alice R. Phillips, Sarah L. Halligan, Megan Bailey, Marianne Skogbrott Birkeland, Iris Lavi, Richard Meiser-Stedman, Hannah Oram, Susan Robinson, Tamsin H. Sharp, Rachel M. Hiller

“…Our meta-analysis included 13 studies which investigated social skills and functioning, revealing a small but non-significant effect favouring the evidence-based treatment versus comparison (g = .20, 95% CI [−0.03, 0.44], p = .09). …”
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Enhanced Lightweight Quantum Key Distribution Protocol for Improved Efficiency and Security by Ashutosh Bhatia, Sainath Bitragunta, Kamlesh Tiwari

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