From Breathlessness to Better Living: Transforming COPD Care with Home-Based Pulmonary Rehabilitation by Abins Thozhuthinkal Kasim, Ravi Gaur, Nitesh Manohar Gonnade, Nagma Sheenam, Chinchu Kolakkanni, Sarankumar Ganesan, Adharshna Thangamalai Kannan

“…However, comprehensive assessments of the impact of home-based PR on both lung function and disability in COPD patients remain limited. …”
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Load Model Construction and Parameter Identification Method of Inverter-Interfaced Distributed Generator by Jie LI, Jie WANG, Wenteng LIANG, Lushan SHI, Bolun WANG, Yufeng XIONG, Liangju ZHANG, Xia ZHOU

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Spatial database applications for network analysis: Case study of bicycle accessibility of forested areas in the Poznań Metropolitan Area, Poland by Kostecki Robert

“…The proposed application uses open-source software tools such as PostgreSQL with PostGIS extension. The solution includes a complete description of how to perform network analysis using a spatial database with SQL and pgRouting. …”
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Survivorship in robotic total knee arthroplasty compared with conventional total knee arthroplasty: A systematic review and meta-analysis by Jiawei Chen, Ryan Wai Keong Loke, Katelyn Kaye-Ling Lim, Barry Wei Loong Tan

“…Secondary outcomes included associated complications, post-operative pain scores, and functional outcomes. …”
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Fatigue after stroke: baseline predictors and influence on survival. Analysis of data from UK patients recruited in the International Stroke Trial. by Gillian E Mead, Catriona Graham, Paul Dorman, Slot Karsten Bruins, Steff C Lewis, Martin S Dennis, Peter A G Sandercock, UK Collaborators of IST

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Using the Space Syntax Analysis to Examine the Spatial Configuration of Houses Layouts and Its Transformation over Time in Biskra City by Rihane Barkat, Yassine Bada, Yasemin İnce Güney, Hafnaoui Hamzaoui

“…This paper explores the influence of inhabitant’s behaviors and the socio-cultural effects on the spatial configuration and space-functions of the houses layouts. In the context of discovering the differentiation and the similarities between the samples that consist of 16 houses: four houses from each period; an analysis has been carried out by applying the “Gammaanalysis” using the A-graph program in detecting the genotypical consistencies in their patterning.  …”
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Gene expression profiling in pure neural leprosy: insights into pathogenesis and diagnostic biomarkers by Mariana Martins de Athaide, Thyago Leal-Calvo, Tatiana Pereira Da Silva, Thabatta Leal Silveira Andrezo Rosa, Helen Ferreira, Bernardo Miguel de Oliveira Pascarelli, Ana Caroline Siquara de Sousa, Marcia Rodrigues Jardim, Marcia Rodrigues Jardim, Marcia Rodrigues Jardim, Marcia Rodrigues Jardim, Marcia Rodrigues Jardim, Roberta Olmo Pinheiro, Roberta Olmo Pinheiro, Roberta Olmo Pinheiro

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Weighted Gene Co-Expression Network Analysis Identifies Hub Genes Governing Resistance to <i>Fusarium oxysporum</i> f. sp. <i>niveum</i> in Watermelon (<i>Citrullus lanatus</i>) by Chen Zhang, Xufeng Fang, Jing Zhang, Xinying Wang, Zhao Liu, Shusen Liu, Zhengfeng Song, Peng Gao, Feishi Luan

“…Transcriptional profiling at these stages revealed six disease-resistance-associated gene modules through differential expression analysis, expression pattern clustering, weighted gene co-expression network analysis, and functional enrichment. …”
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Immune checkpoint inhibitors and cancer-related cognitive decline: a propensity score matched analysis in active chemotherapy patients by Guangmin Jian, Jiling Zeng, Jun Lu, Weidong Wang, Yongluo Jiang, Tong Huang, Yu Si Niu, Zhoufang Chai, Xin Qi, Nianqi Liu, Youlong Wang, Cantong Liu, Jiacai Lin, Guanqing Zhong, Yiming Li, Pengfei Zhu, Zong-qing Zheng, Zong-qing Zheng, Fadian Ding, Fadian Ding, Fadian Ding, Fadian Ding, Xinjia Wang, Xinjia Wang, Weizhi Liu, Weizhi Liu, Ao Zhang, Yifei Ma, Yifei Ma, Yifei Ma, Yifei Ma

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Key Neuropeptides Regulating Molting in Pacific White Shrimp (<i>Penaeus vannamei</i>): Insights from Transcriptomic Analysis by Xianliang Li, Yunjiao Li, Zecheng Li, Hu Chen

“…Functional enrichment analysis indicated that these genes play significant roles in cuticle formation and molting regulation. …”
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Market Regime Identification and Variable Annuity Pricing: Analysis of COVID-19-Induced Regime Shifts in the Indian Stock Market by Mohammad Sarfraz, Guglielmo D’Amico, Dharmaraja Selvamuthu

“…Advanced methodologies, including regime-switching hidden Markov models, artificial neural networks, and Monte Carlo simulations, were applied to analyze pre- and post-COVID-19 market behavior. The regime-switching hidden Markov models effectively capture latent market regimes and their transitions, which traditional models often overlook, while neural networks provide flexible functional approximations that enhance pricing accuracy in highly non-linear environments. …”
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Serum fibrinogen level and fibrinogen administration in patients with traumatic brain injury: A systematic review and meta-analysis protocol. by Joanne Igoli, Jeremiah Oluwatomi Itodo Daniel, Halleluyah Oludele, Adedoyin Esther Alao, Idemudia Stephen Ogedegbe, Adewale Olaniyan, Michael Adeshola Adebayo, Damilola Matthew, Temidayo Elizabeth Oyepitan, Daniel Brabi, Olatomiwa Olukoya, Temidayo Osunronbi

“…Primary outcomes include functional outcome and mortality assessments such as the Glasgow Outcome Score and modified Rankin Score. …”
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Unveiling metabolic pathways in the hyperglycemic bone: bioenergetic and proteomic analysis of the bone tissue exposed to acute and chronic high glucose by Rita Araújo, Raquel L. Bernardino, Mariana P. Monteiro, Pedro S. Gomes

“…Despite the importance of bioenergetics in tissue functionality, the impact of hyperglycemia on bone bioenergetics has not been previously investigated. …”
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Time to resolution of symptoms and recovery after mild traumatic brain injury: protocol for a systematic review and meta-analysis by Daniel P Whitehouse, Sophie Richter, Virginia Newcombe, Owen Hibberd, Adrian Ngai, Hamda Hassan

“…Results will be categorised by symptom groups, including but not limited to post-concussive symptoms, mental health, functional recovery and health-related quality of life. …”
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Two-Centre Retrospective Analysis on Selective Sensory Denervation of Shoulder Joint by Means of Cooled Radiofrequency in Chronic Shoulder Pain by Santi C, Haag T, Cooke C, Schatman ME, Tinnirello A

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Genome-wide identification, transcriptional profiling, and miRNA-binding site analysis of the LBD gene family in the camphor tree by Jiaqi Zhang, Luyang Shan, Haoran Qi, Haoran Qi, Caihui Chen, Yongda Zhong, Meng Xu

“…Despite multiple published C. camphora genome assemblies, functional characterization of LBD transcription factors in this species remains limited. …”
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SUMOylation-related genes define prognostic subtypes in stomach adenocarcinoma: integrating single-cell analysis and machine learning analyses by Kaiping Luo, Kaiping Luo, Donghui Xing, Donghui Xing, Xiang He, Yixin Zhai, Yanan Jiang, Hongjie Zhan, Zhigang Zhao

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Cooling devices used to avoid warm ischemia time injury during kidney transplantation. Systematic review and meta-analysis by Marco A. Arizmendi-Villarreal, Alejandro Diaz Gonzalez-Colmenero, Jorge A. Cantú-Hernández, Javier Sanchez-Maldonado, Gerardo E. Muñoz-Maldonado, Edelmiro Perez-Rodriguez, Homero A. Zapata-Chavira, Rene Rodriguez-Gutierrez, Rene Rodriguez-Gutierrez, Francisco J. Reyna-Sepulveda

“…Cooling devices effectively lower graft temperature and may improve early functional outcomes. However, evidence of histological benefit remains inconclusive. …”
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AI-enabled drug prediction and gene network analysis reveal therapeutic use of vorinostat for Rett Syndrome in preclinical models by Richard Novak, Tiffany Lin, Shruti Kaushal, Megan Sperry, Frederic Vigneault, Erica Gardner, Sahil Loomba, Kostyantyn Shcherbina, Vishal Keshari, Alexandre Dinis, Anish Vasan, Vasanth Chandrasekhar, Takako Takeda, Rahul Nihalani, Sevgi Umur, Jerrold R. Turner, Michael Levin, Donald E. Ingber

“…To our knowledge, this is the first Rett syndrome treatment to demonstrate pre-clinical efficacy across multiple organ systems when dosed after the onset of symptoms. Gene network analysis also reveals a putative therapeutic mechanism for the cross-organ normalizing effects of vorinostat based on its impact on acetylation metabolism and post-translational modifications of microtubules. …”
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Analysis of phosphomotifs coupled to phosphoproteome and interactome unveils potential human kinase substrate proteins in SARS-CoV-2 by Vineetha Shaji, Vineetha Shaji, Ahmad Rafi, Mukhtar Ahmed, Athira Perunelly Gopalakrishnan, Athira Perunelly Gopalakrishnan, Sowmya Soman, Amjesh Revikumar, Ganesh Prasad, Abhithaj Jayanandan, Rajesh Raju

“…IntroductionViruses exploit host kinases to phosphorylate their proteins, enabling viral replication and interference with host-cell functions. Understanding phosphorylation in SARS-CoV-2 proteins necessitates identifying viral phosphoproteins, their phosphosites, and the host kinase–viral protein interactions critical for evading host antiviral responses.MethodsEmploying the protein kinase substrate sequence-preference motifs derived by Poll B G. et. al., 2024, we performed kinase-substrate phosphomotif pattern analysis on the SARS-CoV-2 proteome. …”
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