Double‐blind, randomized, 8‐week multicenter study of the efficacy and safety of STW 5‐II versus placebo in functional dyspepsia by Bettina Vinson, Careen Fink, Manfred Wargenau, Nicholas J Talley, Gerald Holtmann

“…We also conducted a post hoc analysis including patients meeting Rome IV criteria for FD and evaluated the effect of the G‐protein beta 3 (GNB3) subunit polymorphism (C825T) on therapeutic response. …”
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Different Trajectories of Functional Connectivity Captured with Gamma-Event Coupling and Broadband Measures of Electroencephalographic in the Rat Fluid Percussion Injury Model by Rachel Fox, Cesar Santana-Gomez, Mohamad Shamas, Aarja Pavade, Richard Staba, Neil G. Harris

“…Functional connectivity (FC) after traumatic brain injury (TBI) is affected by an altered excitatory-inhibitory balance due to neuronal dysfunction, and the mechanistic changes observed could be reflected differently by contrasting methods. …”
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AMF30a promotes survival and function of human corneal endothelial cells by regulating TGF-β/ROCK/HIPPO pathway by Yunkyoung Ryu, Hye-Jin Son, Jin Sun Hwang, Kyung Bo Noh, Sun-Hee Oh, Eun-Kyoung Choi, Young Joo Shin

“…RNA sequencing revealed differentially expressed genes, with functional enrichment via GO analysis. AMF30a enhanced cell viability, proliferation, and adhesion while reducing cytotoxicity and oxidative stress. …”
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APOL1 High-Risk Genotype is Not Associated With New or Worsening of Proteinuria or Kidney Function Decline Following COVID-19 Vaccination by Sarah E. Nystrom, Karen L. Soldano, Micki Rockett, Somenath Datta, Guojie Li, Daniel Silas, Melanie E. Garrett, Allison E. Ashley-Koch, Opeyemi A. Olabisi

“…There were no detectable differences between pre- and post-serum creatinine or pre- and post-urine albumin creatinine ratio irrespective of the participants’ APOL1 genotype. …”
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SARS-CoV-2-induced cytokine storm drives prolonged testicular injury and functional impairment in mice that are mitigated by dexamethasone. by Stefanos Giannakopoulos, Jin Pak, Jackson Bakse, Monika A Ward, Vivek R Nerurkar, Michelle D Tallquist, Saguna Verma

“…This study characterized the consequences of SARS-CoV-2 on testis function. The K18-hACE2 mice that survived SARS-CoV-2 infection were followed for one month after infection and the testicular injury and function markers were assessed at different stages of infection and recovery. …”
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Development of evaluation index system for functional ability of older patients with stroke based on healthy aging: a modified Delphi study by Wei Zhang, Wei Zhang, Wei Zhang, Xiu-bin Tao, Xiao-li Fan, Ai-ping Wang

“…BackgroundThe prevalence of stroke in the older population is high and it is critical to promote and maintain the functional status of older patients post stroke. Health measures centered on functional ability can scientifically reflect the health status of older individuals. …”
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Selective Modulation of Osteoclast Function by <i>Bothrops moojeni</i> Venom and Its Fractions: Implications for Therapeutic Targeting in Bone Diseases by Fernanda D’Amélio, Hugo Vigerelli, Isabel de Fátima Correia Batista, Rodrigo Pinheiro Araldi, Álvaro R. B. Prieto-da-Silva, Daniel Carvalho Pimenta, Irina Kerkis

“…In contrast, the LMW fraction influences matrix remodeling, energy metabolism, and gene regulation. Gene interaction analysis LMW fraction post-treatment identifies FNIP1 and FNIP2 as critical targets involved in osteoclastogenesis. …”
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Tezepelumab can Restore Normal Lung Function in Patients with Severe, Uncontrolled Asthma: Pooled Results from the PATHWAY and NAVIGATOR Studies by Ian D. Pavord, Christopher E. Brightling, Stephanie Korn, Nicole L. Martin, Sandhia S. Ponnarambil, Nestor A. Molfino, Jane R. Parnes, Christopher S. Ambrose

“…Abstract Introduction This post hoc analysis assessed the ability of tezepelumab treatment to restore normal lung function in patients with severe, uncontrolled asthma with abnormal lung function at baseline pooled from the PATHWAY and NAVIGATOR studies. …”
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Autophagy modulation by hADSCs and green light therapy alleviates inflammation and promotes functional recovery after spinal cord injury by Junjie Chen, Quanxin He, Huan Xie, Bin Gu, Liyi Zhou, Daoyuan Jiang, Hongxin Xie, Li Liang, Zhilai Zhou, Hui Zhang

“…This study investigated the therapeutic effects of human adipose-derived mesenchymal stem cells (hADSCs) transplantation combined with green light (GL) therapy to modulate inflammation, enhance autophagy, and facilitate functional restoration post-SCI. Methods In a murine SCI model, hADSCs (1 × 106 cells) were intraspinally delivered with concurrent GL irradiation (100 lux, 8 h/d). …”
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Impact of PM2.5 Exposure from Wood Combustion on Reproductive Health: Implications for Fertility, Ovarian Function, and Fetal Development by Paulo Salinas, Nikol Ponce, Mariano del Sol, Bélgica Vásquez

“…Reproductive parameters, ovarian follicle counts, and hormonal levels were assessed via vaginal cytology, histological analysis, and chemiluminescence immunoassays. PM2.5 exposure disrupted estrous cyclicity (<i>p</i> = 0.0001), reduced antral and growing follicles (<i>p</i> = 0.0020; <i>p</i> = 0.0317), and increased post-implantation losses (<i>p</i> = 0.0149). …”
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Body percussion and selective attention. Interdisciplinary quantitative study through neuromotricity activities BAPNE method based on the dual task in Primary Education by Francisco Javier Romero Naranjo, Francisco Javier Pujalte Cantó, Antonio Francisco Arnau-Mollá

“…The main results of the intra-subjects analysis were statistically significant in favour of the experimental group in the variables TRPOST (p=<.001), DifTR (p=<. 001), TAPOST (p=.025), DifTA (p=.021), CPOST (p=<.001), DifC (p=.021), VARPOST (p=<.001), DifVAR (p=.002), TR+POST (p=<.001), and DifTR+ (p=<.001). …”
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Functional Characterization of <i>MaSPL8</i> Reveals Its Different Roles in Biotic and Abiotic Stress Responses in Mulberry by Longyan Zheng, Wenhao Zhang, Liuqing Wei, Mengqi Li, Li Liu

“…<i>MaSPL8</i> encodes a 364-amino acid protein with a conserved SBP domain and lacks <i>miR156/157</i> binding sites. Phylogenetic analysis confirmed its orthology to <i>Arabidopsis</i> AtSPL8, albeit with functional divergence. …”
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Pan‐Immune‐Inflammation Value Predicts 3‐Month Functional Outcomes in Patients With Acute Ischemic Stroke Treated With Mechanical Thrombectomy by Meltem Karacan Gölen, Keziban Uçar Karabulut, Muhammed Kamiloğlu, Aynur Yonar

“…Severity of stroke was assessed using the National Institute of Health Stroke Scale (NIHSS) scores on admission. Poor 3‐month functional outcome was defined as Modified Rankin Scale (mRS) scores of >2. …”
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Lokomat-Assisted Robotic Rehabilitation in Spinal Cord Injury: A Biomechanical and Machine Learning Evaluation of Functional Symmetry and Predictive Factors by Alexandru Bogdan Ilies, Cornel Cheregi, Hassan Hassan Thowayeb, Jan Reinald Wendt, Maur Sebastian Horgos, Liviu Lazar

“…Results: No statistically significant asymmetries were found between left and right limb measurements, indicating functional symmetry post-treatment (<i>p</i> > 0.05). …”
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Application of functional near-infrared spectroscopy and machine learning to predict treatment response after six months in major depressive disorder by Cyrus Su Hui Ho, Jinyuan Wang, Gabrielle Wann Nii Tay, Roger Ho, Hai Lin, Zhifei Li, Nanguang Chen

“…Seventy patients with MDD were included in this 6-month longitudinal study, with the primary treatment outcome measured by changes in the Hamilton Depression Rating Scale (HAM-D) scores. fNIRS and clinical information were strictly evaluated using nested cross-validation to predict responders and non-responders based on machine-learning models, including support vector machine, random forest, XGBoost, discriminant analysis, Naïve Bayes, and transformers. The task change of total haemoglobin (HbT), defined as the difference between pre-task and post-task average HbT concentrations, in the dorsolateral prefrontal cortex (dlPFC) is significantly correlated with treatment response (p < 0.005). …”
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Hybrid genre in persuasive communication by Valeria E. Chernyavskaya, Natalia E. Gorschkova

“…This kind of genre mixing results inter alia in an advertisement that is shaped as a chat in internet, private talk or recipe but sustains its genre status as an advertisement. The analysis is based on advertisement texts functioning as hybrid genres in modern Russian socio-cultural prac­tice. …”
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Effect of exercise training on cardiac function and glucose metabolism in the ischemic border zone: insights from multi-modal imaging techniques by Jun Zhang, Jun Zhang, Jun Zhang, Chunrong Jin, Xiao Han, Xiao Han, Ping Wu, Ping Wu, Jianbo Cao, Jianbo Cao, Jianbo Cao, Sheng He, Sheng He, Li Li, Li Li, Ruonan Wang, Ruonan Wang, Min Zhang, Min Zhang, Yuxin Xiao, Yuxin Xiao, Hongju Guo, Tianshuo Zhang, Zhifang Wu, Zhifang Wu, Zhifang Wu, Sijin Li, Sijin Li, Sijin Li

“…Additionally, the expression levels of GLUT4 and PFKFB3 mRNA and proteins were significantly elevated following exercise training.ConclusionsEarly exercise post-AMI, as assessed by CMR and PET imaging, significantly improved cardiac function, reduced myocardial remodeling, and enhanced glucose metabolism. …”
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Using X-ray velocimetry to measure lung function and assess the efficacy of a pseudomonas aeruginosa bacteriophage therapy for cystic fibrosis by Stephanie A. Harker, Melissa Preissner, Rachel Yoon Chang, David Trevascus, Chengxi Liu, Yuncheng Wang, Michael Y. T. Chow, Patricia Cmielewski, Nicole Reyne, Ying Ying How, James A. Pollock, Mitzi Klein, Christopher A. Wright, Stephen Dubsky, Martin Donnelley, Hak-Kim Chan, Kaye S. Morgan

“…We aim to use XV techniques as non-invasive alternatives to demonstrate efficacy of bacteriophage therapy for treating Pseudomonas aeruginosa CF lung infections, measuring functional changes post-treatment. Time-resolved in vivo PCXI-CT scans of control, Pseudomonas-infected, and phage-treated mouse lungs were taken at the Australian Synchrotron Imaging and Medical Beamline. …”
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Association Between Premorbid Frailty Status and Functional Independence in Acute Ischemic Stroke Patients Following Endovascular Treatment in the Late Window by Huang L, Gong C, Qiu Z, Jiang S, Song M, Wang Z, Chen Y, Xu T, Hu P, Chen S, Chen Y, Nguyen TN, Liu C

“…After identifying the cut-off value of mFI-5 by the marginal effects approach, patients were divided into the frail group (mFI-5≥ 2) and the non-frail group (mFI-5&lt; 2). In multivariable analysis, frailty significantly reduced the likelihood of functional independence (aOR 0.37, 95% CI 0.21– 0.65, P&lt; 0.001). …”
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EXPERIMENTAL EVALUATION OF LONG-TERM ADVERSE SIDE EFFECTS OF CYTOSTATIC DRUGS ON FEMALE REPRODUCTIVE FUNCTION AND PHARMACOLOGICAL WAYS TO REDUCE THEM by T. G. Borovskaya, V. E. Goldberg, M. E. Poluektova, A. V. Vychuzhanina, Yu. A. Shchemerovа, V. A. Grigoreva, A. A. Ligacheva, E. A. Bokhan

“…The mating and fertility ability of female rats as well as pre- and post-implantation fetal mortality were determined. …”
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