Reliability of multi-site UK Biobank MRI brain phenotypes for the assessment of neuropsychiatric complications of SARS-CoV-2 infection: The COVID-CNS travelling heads study. by Eugene Duff, Fernando Zelaya, Fidel Alfaro Almagro, Karla L Miller, Naomi Martin, Thomas E Nichols, Bernd Taschler, Ludovica Griffanti, Christoph Arthofer, Gwenaëlle Douaud, Chaoyue Wang, Thomas W Okell, Richard A I Bethlehem, Klaus Eickel, Matthias Günther, David K Menon, Guy Williams, Bethany Facer, David J Lythgoe, Flavio Dell'Acqua, Greta K Wood, Steven C R Williams, Gavin Houston, Simon S Keller, Catherine Holden, Monika Hartmann, Lily George, Gerome Breen, Benedict D Michael, Peter Jezzard, Stephen M Smith, Edward T Bullmore, COVID-CNS Consortium

“…These acquisition and analysis protocols are now in use for MRI assessments of post-COVID patients (N = 700) as part of the ongoing COVID-CNS study.…”
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VOLODYMYR VYNNYCHENKO’S PHILOSOPHICAL AND AESTHETIC VIEWS: THE EXPERIENCE OF FRENCH EXISTENTIAL by Galyna M. Syvachenko, Antonina V. Anistratenko

“…The critical optics of the research make it possible to combine the historical and philosophical specificity of the interwar twenty years and the post-war period, on which are built the works of Vynnychenko, Sartre and Camus. …”
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Coeliac plexus radiosurgery for pain management in patients with advanced cancer : study protocol for a phase II clinical trial by Laura A Dawson, Camilla Zimmermann, Aisling Barry, Galia Jacobson, Ronen Fluss, Amira Dany-BenShushan, Talia Golan, Tikva Meron, Marcin Miszczyk, Michael Buckstein, Dayssy Diaz Pardo, Artur Aguiar, Liat Hammer, Adam P Dicker, Maoz Ben-Ailan, Ofir Morag, David Hausner, Zvi Symon, Yaacov R. Lawrence

“…The goals of this study are to validate these findings in an international multisetting, and investigate the impact on quality of life and functional status among patients with terminal cancer.Methods and analysis A single-arm prospective phase II clinical trial. …”
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Approaches used to prevent and reduce the use of restrictive practices on adults with learning disabilities: a realist review by Joy Duxbury, Alina Haines-Delmont, John Baker, Peter Baker, Gary Bourlet, Elaine Craig, James Ridley, Rachel Whyte, Beth Morrison, Michaela Thomson, Anthony Tsang, Tella Lantta

“…Organisations should ensure that there is training for post-incident reviews including debriefing and post-incident support. …”
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Topical TLR7 agonist and radiotherapy in patients with metastatic breast cancer by Ping Jin, Xiaochun Li, Francesco Marincola, Ena Wang, Sandra Demaria, Davide Bedognetti, Darawan Rinchai, Sylvia Adams, Yelena Novik, Ruth Oratz, David Stroncek, Judith Goldberg, Silvia Chiara Formenti, Maria Fenton-Kerimian, Pascale G Levine

“…No post-treatment activation of immune-effector functions was observed in stable and progressing lesions.Conclusions Our findings support the safety and clinical efficacy of combining topical IMQ with local RT for recurrent breast cancer, with evidence of local and occasional systemic antitumor activity.Trial registration number NCT01421017.…”
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Development mechanism and practical significance of deep coalbed methane (coal rock gas) infiltration and displacement by Lihong ZHOU, Xia YAN, Hongtao LIU, Xianyue XIONG, Feng WANG, Shuguang LI, Jiyuan ZHANG, Chuanqing LIU, Xiong HU, Pu YUAN, Qianli MA, Xueguang ZHU

“…Key findings include:Hydrophilic characteristics: Mineralogical analysis, high-temperature/high-pressure (HTHP) wettability experiments, and macromolecular modeling revealed that deep coal exhibits macroscale hydrophilicity and microscale strong hydrophilicity due to hydrophilic clay mineral filling and oxygen-containing functional groups. …”
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Development of a clinical decision support tool for Primary care Management of lower Urinary tract Symptoms in men: the PriMUS study by Adrian Edwards, Ridhi Agarwal, Janine Bates, Alison Bray, Sarah Milosevic, Emma Thomas-Jones, Michael Drinnan, Marcus Drake, Peter Michell, Bethan Pell, Haroon Ahmed, Natalie Joseph-Williams, Kerenza Hood, Yemisi Takwoingi, Chris Harding

“…Age, post-void residual volume and median voided volume were included in detrusor overactivity main model, while age and storage symptoms subscore predicted detrusor overactivity sensitivity analysis 2. …”
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Is there an association between superoxide dismutase gene polymorphisms, antioxidants in oxidative stress pathway, and oral health-related quality of life after root canal treatmen... by Ludmila da Silva Guimarães, Erlange Andrade Borges da Silva, Juliana Miranda Bonelli, Heitor Ganier Ribeiro, Alice Corrêa Silva-Sousa, Manoel Damião Sousa-Neto, Erika Calvano Küchler, Lívia Azeredo Alves Antunes, Fernanda Signorelli Calazans, Leonardo Santos Antunes

“…Results: The rs2855262 polymorphism in the SOD3 gene showed a significant difference in the functional limitation domain in both codominant (p = 0.037) and recessive (p = 0.040) models. …”
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Isobavachalcone ameliorates Alzheimer disease pathology by autophagy-mediated clearance of amyloid beta and inhibition of NLRP3 inflammasome in primary astrocytes and 5x-FAD mice by Dilpreet Kour, Dilpreet Kour, Parul Khajuria, Parul Khajuria, Kuhu Sharma, Kuhu Sharma, Alpa Sharma, Alpa Sharma, Ankita Sharma, Ankita Sharma, Syed Mudassir Ali, Priya Wazir, P. Ramajayan, P. Ramajayan, Sanghapal D. Sawant, Sanghapal D. Sawant, Sanghapal D. Sawant, Utpal Nandi, Utpal Nandi, Zabeer Ahmed, Zabeer Ahmed, Ajay Kumar, Ajay Kumar

“…Two months of treatment of 5x-FAD mice with IBC at 25 and 50 mg/kg significantly improved cognitive functions, as evidenced by enhanced memory and motor performance in behavioral tests. …”
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Expression Profile of Human Cytomegalovirus <i>UL111A</i> cmvIL-10 and LAcmvIL-10 Transcripts in Primary Cells and Cells from Renal Transplant Recipients by Giovana W. C. Almeida, Martha T. Oliveira, Isabella G. L. Martines, Giuliano C. Fiori, Michael M. Nevels, Ian J. Groves, John Sinclair, José Medina-Pestana, Rayra Sampaio da Silva, Monica Nakamura, Lucio Requião-Moura, Emma Poole, Maria C. Carlan da Silva

“…Other isoforms are produced (C to H) but have unknown functions. Here, we investigated the expression of the most abundant transcripts, cmvIL-10 and LAcmvIL-10, in productively and latently infected cells and in peripheral blood mononuclear cells from renal transplant recipients up to 60 days post-transplantation. …”
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Honeybees fed D-galactose exhibit aging signs with changes in gut microbiota and metabolism by Guanzhou Zhou, Jiabin Hu, Mengqi Xu, Yiyuan Li, Ruqi Chang, Jiaqi Zeng, Wanyue Dan, Lihua Peng, Zikai Wang, Gang Sun, Fei Pan, Yunsheng Yang

“…A comprehensive assessment was conducted on day 15 post-treatment, including survival analysis, starvation test, motor, learning and memory ability tests, malondialdehyde test, and Smurf test. …”
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Cardiac MRI of differing ischemia and reperfusion times in a myocardial infarction pig model by David Boll, Simon Reiss, Heidi R. Cristina Schmitz, Christian Weber, Julien Thielmann, Felix Spreter, Kian Tadjalli Mehr, Diana Chiang, Markus Jäckel, Lukas Heger, Jonathan Rilinger, Dirk Westermann, Constantin von zur Mühlen, Timo Heidt, Michael Bock, Alexander Maier

“…CMR was performed at a clinical 3 T system including functional imaging, T1 and T2 mapping and late gadolinium enhancement (LGE) 2–5 h or three days post-reperfusion. …”
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History and development direction of iterative upgrading of deep coalbed methane reservoir reconstruction technology：Taking the Daji Block in the eastern margin of the Ordos Basin... by Fengyin XU, Huaibin ZHEN, Shuguang LI, Feng WANG, Lei ZHANG, Yubin WANG, Weichu YU, Weiping ZHU, Borui XU, Yun YANG, Haifeng ZHAO, Kunsen BAI

“…Practical application of finely tailored fracturing designs based on geological characteristics has yielded remarkable results.However, the paper identifies five key challenges and areas for improvement in deep coal reservoir stimulation: High water consumption and difficulties in managing flowback fluids during ultra-large-scale fracturing; The need for breakthroughs in intelligent fracturing technologies; Immaturity of collaborative fracturing methods; The urgent requirement to establish fracturing technology systems for deep, medium-to-low-rank coal seams; Incomplete functionality of fracturing fluids.To address these challenges, six development directions are proposed:① Advancing water-reducing fracturing techniques; ② Conducting research on fishbone horizontal wells combined with matrix acidizing for large-scale water-reduction and production enhancement; ③ Expanding the application of artificial intelligence in intelligent fracturing and post-fracturing evaluation; ④ Developing and implementing collaborative fracturing techniques to optimize well-to-fracture network integration; ⑤ Strengthening research and development and application of stimulation technologies for deep, medium-to-low-rank coal reservoirs; ⑥ Innovating new fracturing materials to further reduce costs, improve efficiency, and enhance recovery rates for deep CBM.…”
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Infant Parent Support (IPS): a multidisciplinary intervention to improve the mental health of children with a social worker - a study protocol for a feasibility randomised controll... by Jaycee Pownall, Karen Crawford, Lindsay Dalgarno, Judith Fisher, Sharon Graham, Fiona Turner, Helen Minnis, Kathleen Boyd, Abril Seyahian, Alex McConnachie, Nicola Cosgrave, Matt Forde, Carol Atkinson, Janet McCullough, Kapil Sayal, Dennis Ougrin

“…We will utilise a pre-post and 3/6-month follow-up design with embedded mixed-method process evaluation and exploratory economic analysis. …”
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Discovery of natural CdnP inhibitors through structure-based virtual screening and molecular dynamics simulations by Xiaoxia Gu, Chaohu Xiong, Xinyu Wang, Hucheng Zhu, Weiguang Sun, Yan He, Jinwen Zhang

“…ABSTRACT Tuberculosis, caused by Mycobacterium tuberculosis, remains one of the most lethal infectious diseases both historically and in the post-coronavirus disease 2019 era. CdnP (Rv2837c) functions as a bifunctional oligoribonuclease and 3′(2′)-phosphoadenosine 5′-phosphate-phosphatase that impedes host immune responses by recognizing bacterial cyclic dinucleotides such as c-di-AMP, which serve as pathogen-associated molecular patterns. …”
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LEO or LEO baby within enterprise overlapping stents combined with coil embolization treatment for ruptured vertebrobasilar artery dissecting aneurysms by Zengbao Wu, Minghui Zhou, Ali Abdi Maalim, Yang Han, Xiao Guo, Cao Chen, Ting Lei, Kai Shu, Mingxin Zhu

“…Patient characteristics, clinical outcomes, and radiological results were thoroughly reviewed. Functional data were evaluated using the modified Rankin scale (mRS). …”
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Representation of Iran among Iraqi social media users (A case study of Facebook users after the defeat of ISIS until the martyrdom of Hajj Qassem Soleimani) by mohsen finizadeh bidgoli

“…The study employed thematic analysis to examine content posted by Iraqi Facebook users from the period following the defeat of ISIS up to the martyrdom of General Qassem Soleimani. …”
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Protocol of the pilot study to test and evaluate the iCARE tool: a machine learning-based e-platform tool to make health prognoses and support decision-making for the care of older... by John P Hirdes, Hao Luo, Davide L Vetrano, Graziano Onder, Jonathan Chen, Violetta Kijowska, Katarzyna Szczerbińska, Johanna Edgren, Amaia Calderón-Larrañaga, George Heckman, Ron MC Herings, Johanna de Almeida Mello, Anja Declercq, Mark Hoogendoorn, Caitlin McArthur, Mari Aaltonen, Yi Chai, Karlijn J Joling, Micaela Jantzi, Rosa Liperoti, Melissa Northwood, Ilona Barańska, Agata Stodolska, Hein P J van Hout, Margaret Saari, Luca Mariotti, Emiel O Hoogendijk, Luke Turcotte, Louk Smalbil, Elizabeth P Howard, John N Morris, Daniela Fialová, Eline CM Kooijmans, Riikka-Leena Leskelä, Jokke Häsä, Georg Ruppe, Carmen Angioletti, Olena Antonenko, Shireen Aziz, Gustavo Betini, Jovana Brkič, Roberto Da Cas, Daniel Da Cunha Leme, Lu Dai, Cecilia Damiano, Natalia Drapała, Bonaventure Egbujie, Collin JC Exmann, Harriet Finne-Soveri, Charlene France, Tiziana Grisetti, Ira Haavisto, Sophie Hogeveen, Paweł Jagielski, Laurian Jongejan, Jet E Klunder, Ingrid Kummer, Anna Lukačišinová, Matti Mäkelä, Krista Mathias, Amanda Mofina, Reem Mulla, Mikko Nuutinen, Sandra Ochwat, Paula Pennanen, Jitka Pokladníková, Bregtje Proost, Ahmer Raza, Emanuele Rocco Villani, Jindra Reissigová, Erez Schachter, Katarzyna Sekulak, Chi-Ling Joanna Sinn, Andrea Vokálová, Adrianna Ziuziakowska, Mari Lahelma, Anna-Maria Hiltunen, Anna Salminen, Mor Alon, Collin Exmann, Wiebe Boorsma, Johanna de Almeida Mello, Hein PJ van Hout

“…Descriptive statistics and bivariate and multivariate analysis will be conducted. All notes and text field data will be translated into English, and a thematic analysis will be performed. …”
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Comparing the Effectiveness of Self-Compassion and Mindfulness Therapies on Affection Control of Poor Parenting Adolescents by Zahra EffatDoost Sani, Mohammad Reza Zarbakhsh Bahri, Alireza Homayuni

“…Epsilon modification was applied, and Greenhouse Geisser statistics was utilized to test the examinees’ inner effects.Table 2 The Results repeated measure analysis of variance on Experimental and Control Groups in Pre, Post and follow up with Greenhouse - Geisser Scale  Source of ChangesSum of SquaresdfMean SquaresFpEta SquareStatistical PowerAffection ControlInner GroupsIntervention Levels4233.411.5327602.9964.540.0010.531Intervention Levels × Group1407.223.064599.3310.570.0010.170.99Within groupsGroup17394.0887.21427.679.280.0010.240.97The results indicated that the self-compassion and mindfulness treatments were effective with 0.24 effect (p= 0.001) on affection control of adolescences, which were significantly different from the control group. …”
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Thinning intensity influences the C:N:P stoichiometry in forest ecosystems: A global synthesis by Chongwei Fan, Guiyao Zhou, Hongyang Chen, Zhenggang Du, Ruiqiang Liu, Yanghui He, Changjiang Huang, Shuying Qiu, Yimin Zhu, Jie Li, Xuhui Zhou

“…Future forest management could implement an appropriate forest thinning intensity to ensure ecosystem functionality and maintain the balance and stability of ecosystem elements.…”
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