The epididymal microenvironment in Akodon cursor (Muridae, Sigmodontinae, Akodontini): The lifetime of spermatozoa from production to maturation by Tatiana Prata Menezes, Fernanda Carolina Ribeiro Dias, Nara Clara Lazaroni e Merchid, Camila Folly Batista, Camilo Jose Ramirez-Lopez, Arabela Guedes de Azevedo Viana, Renner Philipe Rodrigues Carvalho, Adrielli Ribeiro Araújo, José Lino-Neto, Gisele Lessa, Arlindo A. Moura, Mariana Machado-Neves

“…The epididymides were processed for histological, functional, and proteomic analyses, besides sperm quality evaluation. …”
Get full text

Platelet inhibition strategies in rescue stenting after failed thrombectomy: a large retrospective multicenter registry by Aikaterini Anastasiou, Alex Brehm, Johannes Kaesmacher, Adnan Mujanovic, Marta de Dios Lascuevas, Tomás Carmona Fuentes, Alfonso López-Frías, Blanca Hidalgo Valverde, Ansgar Berlis, Christoph J. Maurer, Thanh N. Nguyen, Mohamad Abdalkader, Piers Klein, Guillaume Thevoz, Patrik Michel, Bruno Bartolini, Marius Kaschner, Daniel Weiss, Andrea M. Alexandre, Alessandro Pedicelli, Paolo Machi, Gianmarco Bernava, Shuntaro Kuwahara, Kazutaka Uchida, Jason Wenderoth, Anirudh Joshi, Grzegorz Karwacki, Manuel Bolognese, Agostino Tessitore, Sergio Lucio Vinci, Amedeo Cervo, Claudia Rollo, Ferdinand Hui, Aaisha Siddiqua Mozumder, Daniele Giuseppe Romano, Giulia Frauenfelder, Nitin Goyal, Vivek Batra, Violiza Inoa, Christophe Cognard, Matúš Hoferica, Riitta Rautio, Daniel P. O. Kaiser, Johannes C. Gerber, Julian Clarke, Michael R. Levitt, Marcel N. Wolf, Ahmed E. Othman, Luca Scarcia, Erwah Kalsoum, Diana Melancia, Diana Aguiar de Sousa, Maria Porzia Ganimede, Vittorio Semeraro, Flavio Giordano, Massimo Muto, Aristeidis Katsanos, Umesh Bonala, Anil M. Tuladhar, Sjoerd F. M. Jenniskens, Victoria Hellstern, Ilka Kleffner, Paolo Remida, Susanna Diamanti, Leonardo Renieri, Elena Ballabio, Luca Valvassori, Nikki Rommers, Mira Katan, Victor Schulze-Zachau, Marios-Nikos Psychogios

“…Stent occlusion is associated with worse clinical outcomes, and the first 24 h post-RS are critical for stent patency. Compared to SAPT, DAPT was associated with better functional outcome, lower mortality, and lower stent occlusion rates.…”
Get full text

The Emergence of AI-Driven Virtual Hospitals: Redefining Patient Care Beyond Physical Boundaries by Ifrah Hameed, Hafiz Muhammad Haseeb Khaliq

“…This functionality not only increases the clinical intervention accuracy but also shortens the timeline necessary for the identification and treatment of health issues. …”
Get full text

Abnormal metabolic activation of CD8+ T cells correlates with poor prognosis in acute myeloid leukemia by Bixia Wang, Jianing Tang, Yang Zhou, Qianqian Huang, Xinya Jiang, Fangqing Zhang, Shuang Fan, Qi Zhang, Jingrui Zhou, Yu Wang, Xiao-Jun Huang, Huidong Guo

“…Understanding the TME’s impact on immune cells and their functional alterations is therefore of significant clinical importance. …”
Get full text

Temporal dynamics of medium and micronutrient requirements in Epimedium pubescens: key elements regulating growth and Icariin-Flavonoids biosynthesis by Xiaojing An, Yanting Wang, Shangnian Liu, Ying Wang, Xianen Li, Baolin Guo, Haiying Wang, Caixia Chen

“…Nutrient deficiency experiments confirmed Mg, Fe, and Zn functioned as core elements governing growth, with deficiency causing chlorophyll loss and biomass reduction. …”
Get full text

Intraoperative virtual reality for older patients undergoing total knee arthroplasty: study protocol for a randomized clinical trial by Juan P. Espinosa-Leon, Ryan Mathura, Guanqing Chen, Melisa Joseph, Trishna Sadhwani, Najla Beydoun, Edjay R. Hernandez, Tyler Riley, Lisa J. Kunze, Valerie Goodspeed, Brian P. O’Gara

“…Secondary outcomes include patient satisfaction, post-anesthesia care unit (PACU) length of stay, postoperative pain scores and analgesic requirements, functional outcomes, postoperative delirium, and postoperative neurocognition. …”
Get full text

Modified transforaminal epidural steroid injection combined with pulsed radiofrequency: an effective treatment measure for lumbar radiculopathy by Qi Yan, Xianggu Zhong, Jiarong Li, Leyu Zhao, Junjie Niu, Dawei Song, Jinning Wang, Yun Teng, Tianyi Wu, Xiao Sun, Rui Chen, Shuangfei Wang, Jun Zou

“…Consequently, clinicians require an expedited and efficacious approach to address radicular discomfort resulting from lumbar radiculopathy and promptly reinstate the patient's normal functionality.ObjectivesThis study seeks to assess the effectiveness of a modified transforaminal epidural steroid injection (TFESI) in conjunction with pulsed radiofrequency (PRF) for treating lumbar radiculopathy using a retrospective analysis.MethodsOur study examined patients with unilateral lower limb radicular pain persisting for three months or more due to LDH, in whom conservative therapies were ineffective, from January 1, 2023, to October 31, 2023. …”
Get full text

Effects of dietary mangosteen peel powder and extract on the growth performance, meat quality and indicators for immunity, gut health and antioxidant activity in broiler chicks by Da-Hye Kim, Hyeon Mo Yang, Ju-Yong Song, Jina Park, Byung-Yeon Kwon, Anh Viet Vu, Dae Sung Lee, Kyung-Woo Lee

“…Data were analyzed using analysis of variance, and post hoc comparisons of treatments were performed using Tukey's Honestly Significant Difference test. …”
Get full text

Back pain exercise therapy remodels human epigenetic profiles in buccal and human peripheral blood mononuclear cells: an exploratory study in young male participants by Claire Burny, Mia Potočnjak, Mia Potočnjak, Annika Hestermann, Sophie Gartemann, Michael Hollmann, Frank Schifferdecker-Hoch, Nina Markanovic, Simone Di Sanzo, Simone Di Sanzo, Michael Günsel, Victor Solis-Mezarino, Moritz Voelker-Albert, Moritz Voelker-Albert

“…We also performed an exploratory analysis to confirm the usability of molecular profiles in (1) mapping lifestyle choices and (2) evaluating the distance of a given participant to an optimal health state.ConclusionThis pre-post cohort study highlights the potential of integrated molecular profiles to score therapy efficiency. …”
Get full text

Individual Pharmacotherapy Management (IPM-II) for Patient and Drug Safety in Polypharmacy via Clinical Electronic Health Record Is Associated with Significant Fall Prevention by Ursula Wolf, Luise Drewas, Hassan Ghadir, Christian Bauer, Lars Becherer, Karl-Stefan Delank, Rüdiger Neef

“…Methods: On the basis of the most updated digital overall patient view via his inpatient electronic health record (EHR), IPM adapts each drug’s Summary of Product Characteristics to the patient’s condition. A retrospective pre-post intervention study in geriatric traumatology on ≥70 years old patients compared 200 patients before IPM implementation (CG) with 204 patients from the IPM intervention period (IG) for the entire medication list, organ, cardiovascular and vital functions and fall risk parameters. …”
Get full text

Community-based exercise for health promotion and secondary cancer prevention in Canada: protocol for a hybrid effectiveness-implementation study by Margaret L McNeely, Christopher Sellar, Tanya Williamson, Melissa Shea-Budgell, Anil Abraham Joy, Harold Y Lau, Jacob C Easaw, Albert D Murtha, Jeffrey Vallance, Kerry Courneya, John R Mackey, Matthew Parliament, Nicole Culos-Reed

“…Research evidence supports the benefit of exercise during and following cancer treatments for cancer-related symptoms, physical functioning and fitness, and health-related quality of life. …”
Get full text

CTF development, verification, and validation for VVER core thermal-hydraulics and multi-physics modeling and simulation by Yesim Kutlu, Ivan Spasov, Svetlomir Mitkov, Pascal Rouxelin, Agustin Abarca, Nikola Kolev, Maria Avramova, Kostadin Ivanov, Kostadin Ivanov

“…In recent years, there has been considerable progress in code development, including new functionalities, application-specific correlations, various multi-physics applications, built-in pre- and post-processors, improved solvers, parallelization, and extensive testing. …”
Get full text

Effects of integrating Feldenkrais method with dynamic neuromuscular stabilization exercises on clinical outcomes in older women with nonspecific chronic low back pain: A randomize... by Farzaneh Saki, Marziyeh Ziya

“…Assessments were conducted at baseline and post-intervention. Between-group differences were analyzed using analysis of covariance (ANCOVA) adjusted for baseline values, and paired t-tests were used to assess within-group changes (P≤0.05). …”
Get full text

Does initiating care in alternate care sites decrease time to disposition in the emergency department? by Alyssa Mangino, Lakshman Balaji, Bryan Stenson, Larry A. Nathanson, David Chiu, Shamai A. Grossman

“…Despite the end of the pandemic surge, many of these ACS remain functional given the burden of prolonged ED wait times, with providers now utilizing the waiting room or ACS to initiate care. …”
Get full text

<i>X</i><i>a</i><i>n</i><i>thoceras sorbifolium</i> Oil Attenuates Hyperlipidemia Through Dual Modulation of Gut Microbiota and Lipid Metabolites: Mechanistic Insights from Lipidom... by Yameng Tao, Miaomiao Yao, Qi He, Xiaoyang Kang, Fangkai Shi, Xuan Hu, Zhiyun Meng, Hui Gan, Ruolan Gu, Yunbo Sun, Guifang Dou, Shuchen Liu

“…While its prebiotic potential warrants further validation, these findings highlight XSO as a functional dietary adjunct for improving lipid homeostasis and mitigating cardiovascular risks. …”
Get full text

Exosomes derived from hypoxia-preconditioned M2 macrophages alleviate degeneration in knee osteoarthritis through the miR‑124‑3p/STAT3 axis by Hao Li, Yuze Yang, Yuanpeng Gao, Bo Li, Jiaju Yang, Pengyu Liu, Min Zhang, Guangzhi Ning

“…The underlying molecular mechanism is associated with increased delivery of miR-124-3p to chondrocytes, which subsequently inhibits the post-transcriptional expression of STAT3. This provides a promising therapeutic strategy for the clinical intervention of OA.…”
Get full text

Putting measurement-based care into action: a multi-method study of the benefits of integrating routine client feedback in coordinated specialty care programs for early psychosis by Piper Meyer-Kalos, Grace Owens, Melissa Fisher, Lionel Wininger, Anne Williams-Wengerd, Kimberleigh Breen, Josephine Pita Abate, Ariel Currie, Nathan Olinger, Sophia Vinogradov

“…Both groups showed significant improvement in symptoms and functioning. Results from the qualitative analysis indicated that the experience of receiving the reports was valuable and validating for both patients and clinicians. …”
Get full text

Feasibility of a Web-Based and Mobile-Supported Follow-Up Treatment Pathway for Adult Patients With Orthopedic Trauma in the Netherlands: Concurrent Mixed Methods Study by Gijs J A Willinge, Jelle F Spierings, Kim A G J Romijnders, Elke G E Mathijssen, Bas A Twigt, J Carel Goslings, Ruben N van Veen

“…Semistructured interviews were performed at 10‐12 weeks post injury. Anonymous data from a pre-existing database were used to compare health care resource use between the digital treatment pathways and traditional treatment. …”
Get full text

Machine learning-based prediction model for lung ischemia-reperfusion injury: insights from disulfidptosis-related genes by Yanpeng Zhang, Yanpeng Zhang, Yanpeng Zhang, Jingyang Sun, Jingyang Sun, Jingyang Sun, Yihan Lin, Yihan Lin, Yihan Lin, Rongxuan Jiang, Rongxuan Jiang, Rongxuan Jiang, Niuniu Dong, Niuniu Dong, Niuniu Dong, Huanhuan Dong, Huanhuan Dong, Huanhuan Dong, Peng Li, Peng Li, Peng Li, Jinteng Feng, Jinteng Feng, Jinteng Feng, Zijiang Zhu, Guangjian Zhang, Guangjian Zhang, Guangjian Zhang

“…Differential expressed analysis and functional enrichment analysis were conducted to identify key genes associated with lung transplant IRI. …”
Get full text

Engineered small extracellular vesicles for targeted delivery of perlecan to stabilise the blood–spinal cord barrier after spinal cord injury by Wei Peng, Wentao Zhang, Wei Cui, Wenjin Chen, Yin Zhuang, Rupeng Chu, Jinghua Tan, Jingbo Xue, Yiguo Yan, Guoyong Yin, Shujun Zhang, Yong Xie

“…Finally, we identified M2‐sEV‐derived perlecan as a key player in regulating BSCB integrity and functional recovery post‐SCI. Conclusion Our results indicate that RGD‐M2‐sEVs promote BSCB restoration by transporting perlecan to neovascular endothelial cells, representing a potential strategy for SCI treatment. …”
Get full text