A multi-centre, participant-blinded, randomized, 3-year study to compare the efficacy of Virtual Surgical Planning (VSP) to Freehand Surgery (FHS) on bony union and quality of life... by Khanh Linh Tran, Sena Turkdogan, Anat Bahat Dinur, Thomas D. Milner, Edward Wang, Anthony Nichols, Danielle MacNeil, Adrian Mendez, Jake Jervis-Bardy, John De Almeida, Christopher Yao, David Goldstein, Ralph Gilbert, Antoine Eskander, Kevin Higgins, Danny Enepekides, Michael Gupta, Han Zhang, Michael Au, Sally Nguyen, Sidney Fels, Antony Hodgson, Penelope Brasher, Craig Mitton, Farahna Sabiq, Charles Fisher, David Yang, Angela Wong, Cathie Garnis, Catherine Poh, J. Scott Durham, Eitan Prisman

“…The primary endpoint is bony-union rates at 1 year post-operatively. Secondary outcomes include complication rates, QOL, functional outcomes, and economic burden. …”
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Host-specific adaptation in Fusarium oxysporum correlates with distinct accessory chromosome content in human and plant pathogenic strains by Dilay Hazal Ayhan, Serena Abbondante, Domingo Martínez-Soto, Siyuan Wu, Ricardo Rodriguez-Vargas, Shira Milo, Katherine Rickelton, Vista Sohrab, Shunsuke Kotera, Tsutomu Arie, Michaela Ellen Marshall, Marina Campos Rocha, Sajeet Haridas, Igor V. Grigoriev, Neta Shlezinger, Eric Pearlman, Li-Jun Ma

“…Interestingly, ACs from both genomes also encode proteins with shared functions, such as chromatin remodeling and post-translational protein modifications. …”
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Circular RNA profiling identifies circ_0001522, circ_0001278, and circ_0001801 as predictors of unfavorable prognosis and drivers of triple-negative breast cancer hallmarks by Dania Awata, Vishnubalaji Radhakrishnan, Hibah Shaath, Ramesh Elango, Sameera Rashid, Mohammed Akhtar, Thasni Karedath Abdul Azis, Ikhlak Ahmed, Khalid Ouararhni, Ammira S. Al-Shabeeb Akil, Nehad M. Alajez

“…Additionally, circRNA-RBP bioinformatic analysis identified common binding partners, including AGO2, CPSF7, TARDBP, UPF1, and LIN28B, suggesting roles in post-transcriptional regulation. …”
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Cdc48 plays a crucial role in redox homeostasis through dynamic reshaping of its interactome during early stationary phase by Meytal Radzinski, Tal Oppenheim, Ohad Yogev, Adi Levy, Melamed-Book Naomi, Assaf Kacen, Yifat Merbl, Tommer Ravid, Dana Reichmann

“…Here, we show that entry to the stationary phase in yeast is accompanied by increased cytosolic and mitochondrial oxidation, imposing stress on the proteostasis network. We establish a functional link between redox and protein homeostasis, mediated by a key protein quality control member, Cdc48/p97/VCP.Comparative proteomic analysis of post-mitotic yeast cells reveals that while the global proteome remains largely stable during the first stages of stationary phase, the Cdc48 interactome undergoes significant remodeling, including altered interactions with antioxidants and its cofactors Shp1/Ubx1 and Ubx2.To challenge yeast Cdc48's capacity as a redox-switch protein during the early stages of the stationary phase, we utilized redox proteomics to map changes in reversible oxidation modification on Cdc48's cysteines upon entry to the stationary phase. …”
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QUALITY OF LIFE OUTCOMES FOLLOWING ULTRASONIC DISSECTOR-ASSISTED VS. ELECTROCAUTERY DISSECTION IN MODIFIED RADICAL MASTECTOMY: PROSPECTIVE OBSERVATIONAL COHORT by Nazgul Dzhantemirova, Marat Mauletbaev, Asiya Kukanova, Aizhan Bekisheva, Abay Makishev

“…QoL was assessed using the EORTC QLQ-C30 and QLQ-BR45 questionnaires at baseline, 3-, 6-, and 9-months post-treatment. Statistical analysis included chi-square tests for categorical variables and independent t-tests for continuous variables, with p<0.05 significancy. …”
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Controlling endotoxin contamination in PDMS-based microfluidic systems for organ-on-chip technologies by V. Guarino, E. Perrone, A. Zizzari, M. Bianco, G. Giancane, R. Rella, M.G. Manera, V. Arima

“…A critical aspect of their functionality is sterilization, which is necessary to eliminate bacterial contamination. …”
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A Quantitative Risk Assessment Model for <i>Listeria monocytogenes</i> in Non-Ready-to-Eat Frozen Vegetables by Ursula Gonzales-Barron, Régis Pouillot, Juliana De Oliveira Mota, Akio Hasegawa, Ana Allende, Qingli Dong, Matthew J. Stasiewicz, Jovana Kovacevic, Vasco Cadavez, Laurent Guillier, Moez Sanaa

“…Based on available published data, the model was coded in nine sequential R functions designed to assess the effectiveness of blanching, the improvement in processing environment hygiene, the implementation of sampling schemes at the end of processing, and improved consumer instructions on the product’s package. …”
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Prevalence and clinical significance of loneliness in older patients admitted to acute hospital wards by Gloria Brombo, Paola Guindani, Dario Pedrini, Giovanni Lorenzo Squintani, Barbara Carrieri, Massimiliano Fedecostante, Giuseppina Dell’Aquila, Flaminia Lucchini, Andrea Ungar, Enrico Mossello, Antonio Cherubini, Giovanni Zuliani

“…We aimed to evaluate the prevalence of loneliness among hospitalized older patients, and its association with baseline characteristics and clinical post-discharge outcomes. Design: Multicenter observational study, including a cross-sectional and a longitudinal phase. …”
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Predictors for quantitative flow ratio loss in patients with de novo coronary artery disease treated with drug-coated balloons by Yunhui Zhu, Tianli Hu, Qianqian Bian, Yufei Chen, Tianping Zhou, Jing Li, Guosheng Fu, Wenbin Zhang, Xulin Hong

“…The QFR loss was defined as difference between the immediate post-procedure QFR and follow-up QFR. The subjects were divided into high QFR loss and low QFR loss groups according to the binary method. …”
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The Australian and New Zealand Fontan Registry Quality of Life Study: Protocol for a population-based assessment of quality of life among people with a Fontan circulation, their pa... by Daniel S J Costa, Kim Dalziel, Yves d’Udekem, David S Winlaw, David S Celermajer, Nadine A Kasparian, Diana Zannino, Rachel Bishop, Kate H Marshall, Susan R Woolfenden, Gary F Sholler

“…Study eligibility criteria includes (1) individuals with a Fontan circulation aged ≥6 years, at least 12 months post-Fontan procedure and enrolled in the ANZFR; (2) parents of individuals enrolled in the ANZFR; and (3) siblings aged ≥6 years of an individual enrolled in the ANZFR. …”
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BioBone – A prospective, blinded, multicenter validation study of the CD8 + terminal differentiated effector memory cells (CD8 + TEMRA cells) as prognostic biomarker for disturbed... by Simon Reinke, Anja Maria Bauer, Michael Dahne, Georg Duda, Denis Gümbel, Christian Kleber, Georg Matziolis, Sven Märdian, Georg Osterhoff, Carsten Perka, Michael J. Raschke, Sebastian Rohe, Klaus-Dieter Schaser, Philipp Schwabe, Frederik Maximilian Schäfer, Richard Stange, Maik Stiehler, Ulrich Stöckle, Hans-Dieter Volk, Stefan Weber, Sven Geißler, the BioBone Author Consortium

“…Key outcome measures include radiographic analysis (RUST/RUSH scores), functional and patient-reported outcomes (e.g. weight bearing ability, range of motion, and the SF-36 questionnaire), as well as socioeconomic parameters (e.g. work capacity, rehabilitation needs, mobility). …”
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Health-related quality of life with bemarituzumab plus mFOLFOX6 in patients with FGFR2b-overexpressing, advanced gastric or gastroesophageal junction cancer by Z.A. Wainberg, P.C. Enzinger, S. Qin, K. Yamaguchi, J. Wang, X. Zhou, A. Gnanasakthy, K. Taylor, A. Yusuf, I. Majer, A. Jamotte, Y.-K. Kang

“…Analyses were exploratory post hoc. Results: PRO scale scores at baseline and compliance rates across PRO assessments over time were similar between the bemarituzumab and placebo arms. …”
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Profiling disease experience in patients living with brain aneurysms by analyzing multimodal clinical data and quality of life measures by Sebastian R. Reder, Jochen Hardt, Marc A. Brockmann, Carolin Brockmann, Suam Kim, Melina Kawulycz, Marie Schulz, Sven Rainer Kantelhardt, Katja Petrowski, Sabine Fischbeck

“…Two sub-profiles highlighted trauma-induced impairments, functional disabilities from LV, and persistent anxiety. …”
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Analytical model of Iran-Saudi Arabia relations from 1979 to 2024 by Sajad Mohseni

“…Over the years, both Iran and Saudi Arabia have adapted to a political existence that functions independently of the other, shaped by longstanding distrust and tension. …”
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Lowering the osteotomized level of fibular osteotomy reduces neuromuscular complications while maintaining clinical efficacy in treating medial compartment knee osteoarthritis: a r... by Ting-Yu Chang, Chih-Wei Chang, Yen-Nien Chen, Chyun-Yu Yang, Jou-Hua Wang

“…Although a priori power analysis was performed—a limitation of this retrospective design—post hoc calculations confirmed adequate effect size detection. …”
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Knowledge and Awareness about Anesthesia and Perception about Anesthesiologists and their Role during the COVID-19 Pandemic among Patients at a Zonal Hospital: A Cross-sectional Su... by Mayank Rajput, Dewendra J. Gajbhiye, Nagesh Venkata Ivaturi, Shambhavi Rajiva, Vivek Yadav

“…However, even today, in the 21st century, anesthesia functions in relative obscurity, succinctly labelled as a ‘behind the screen’ specialty by the medical fraternity itself. …”
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Exploring the Use of an Augmented Reality Device Learning Tool for Multidisciplinary Staff Training on Domestic Abuse and Sexual Violence: Postintervention Qualitative Evaluation by Dilroshini Karunaratne, Jessica Whittock, Amber Moore, Krishna Dasigan, Jasmine Chevolleau, Brent Bartholomew, Nikki Kelly, Charlotte E Cohen

“…Participants were given the opportunity to wear the headset and familiarize themselves with the technology during the sessions. A post-intervention evaluation research model was used to explore the feasibility and functionality of the HP as an educational tool. …”
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Clinical and radiographic outcomes using standard length of cannulated screws for traditional Latarjet procedure by Juan M. Lopez-Ovenza, MD, Amaury Tapia, MD, Juan I. Duca, MD

“…Level of significance was 0.05. The post hoc power analysis was 0.89. Results: A total of 69 patients met the criteria for inclusion. …”
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Overcoming challenges of developing a live-attenuated dengue vaccine and the path forward by Dr Walid Kandeil, Dr Mayuri Sharma

“…Additional immunogenicity analysis across phase I/II/III trials revealed engagement of long-lasting tetravalent, functional antibody, and cell-mediated immune responses directed against the structural and nonstructural components of the vaccine, irrespective of baseline serostatus. …”
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Abstract 278: Patterns of Mechanical Thrombectomy for Stroke Before and After the 2015 Pivotal Trials:5 Years Follow‐up by Yaswanth S Chintaluru, Kunakorn Atchaneeyasakul, Nicholas Liaw, Keiko Fukuda, Aldo Mendez, Okkes Kuybu, Shasvat Desai, Agostinho Pinheiro, Ashutosh Jadhav, Kathryn C Fitzgerald, Bradley Gross, Sandra Narayanan, Raul Nogueira, Michael Lang

“…Introduction The 2015 American Heart Association Guidelines recommended mechanical thrombectomy with stent‐retriever devices. A prior published analysis of national trends after one year in mechanical thrombectomy use and outcomes for stroke before and after publication of the 2015 US guideline update showed improved functional outcomes and lower peri‐procedural mortality. …”
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