First genome-wide association study in an Australian aboriginal population provides insights into genetic risk factors for body mass index and type 2 diabetes. by Denise Anderson, Heather J Cordell, Michaela Fakiola, Richard W Francis, Genevieve Syn, Elizabeth S H Scaman, Elizabeth Davis, Simon J Miles, Toby McLeay, Sarra E Jamieson, Jenefer M Blackwell

“…Imputation using the thousand genomes (1000G) reference panel extended the analysis to 6,724,284 post quality-control autosomal SNPs. …”
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Integrated transcriptomic and immune enzymatic analyses uncover coordinated immunometabolic responses in large yellow croaker (Larimichthys crocea) to Metanophrys sp. infection by Ruiling Zhou, Kangshuai Sun, Xiao Xie, Fei Yin, Jorge Galindo-Villegas

“…To elucidate the host response, we conducted an experimental infection followed by an integrated analysis combining immune enzymatic profiling and transcriptome sequencing. …”
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Development of a High-Cell-Density Production Process for a Biotherapeutic Yeast, <i>Saccharomyces cerevisiae</i> var. <i>boulardii</i>, for Use as a Human Probiotic by Ghaneshree Moonsamy, Sarisha Singh, Yrielle Roets-Dlamini, Koketso Kenneth Baikgaki, Santosh Omrajah Ramchuran

“…The final freeze-dried product retained an 81% viability post-exposure to simulated gastrointestinal conditions, meeting WHO probiotic viability standards. …”
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Receptor-Mediated SPION Labeling of CD4⁺ T Cells for Longitudinal MRI Tracking of Distribution Following Systemic Injection in Mouse by Yu Ping, Songyue Han, Brock Howerton, Francesc Marti, Jake Weeks, Roberto Gedaly, Reuben Adatorwovor, Fanny Chapelin

“…In vitro, analyses showed that CD4⁺ T cells were able to uptake CD4-SPION without affecting cellular activity and key functions, as evidenced by Prussian blue staining and flow cytometric analysis of IL-2 receptor and the IL-7 receptor α-chains, CD69 upregulation, and IFN-γ secretion. …”
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Circulating hepatocyte growth factor (HGF) in patients with comorbidity of chronic heart failure, type 2 diabetes mellitus and impaired lipid metabolism by Tatiana Nikolaevna Kochegura, P I Makarevich, A G Ovchinnikov, L V Zhigunova, Elena Leonidovna Lahova, Marina Vladimirovna Shestakova, F T Ageev, Elena Viktorovna Parfenova

“…AIM: To evaluate the plasma level of circulating heptocyte growth factor (HGF) in patients with comorbidity of post-infarction chronic heart failure (CHF), type 2 diabetes mellitus (T2DM) and obesity. …”
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Genome-Wide Identification and Expression of Neuropeptides and Their Expression Patterns After RNAi of CHH Genes in Pacific White Shrimp <i>Litopenaeus vannamei</i> by Long Zhang, Lichao Sun, Guanghao Song, Beibei Wang, Yanting Cui, Fei Liu, Yuquan Li, Zhongkai Wang

“…In contrast, the majority of these genes exhibit a steady uptick in expression from the nauplius stage onwards, culminating in the post-larval stage. Furthermore, comparative transcriptomic analysis of the eyestalk revealed that the expression of the majority of neuropeptide genes was downregulated following the suppression of CHH and VIH gene expression. …”
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Association Between Thyroid Hormone Levels and Disease Prognosis in Guillain–Barré Syndrome: A Retrospective Study by Yangrongzhuo Huang, Yuhan Li, Hailing Zhou, Juan Tang

“…., neutrophils, leukocytes). Functional status was assessed using the Hughes Functional Grading Scale (HFGS) within 3 months post‐discharge. …”
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Comparison of the efficacy of the modified S-P approach and the Ganz method for surgical hip dislocation in Pipkin I fractures: an early follow-up study by Hanwen Zhang, Wei Deng, Shengtao Wang, Yong Yin

“…However, longer-term follow-up is required to fully assess complications and functional outcomes.…”
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Multifunctional dietary approach reduces intestinal inflammation in relation with changes in gut microbiota composition in subjects at cardiometabolic risk: the SINFONI project by Hugo Hornero-Ramirez, Arianne Morissette, Bruno Marcotte, Armelle Penhoat, Béryle Lecomte, Baptiste Panthu, Jacob Lessard Lord, Florence Thirion, Laurie Van-Den-Berghe, Emilie Blond, Chantal Simon, Cyrielle Caussy, Nathalie Feugier, Joël Doré, Philippe Sanoner, Alexandra Meynier, Yves Desjardins, Geneviève Pilon, André Marette, Patrice D. Cani, Martine Laville, Sophie Vinoy, Marie-Caroline Michalski, Julie-Anne Nazare

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Construction and validation of frailty risk prediction model in elderly patients with colorectal cancer by Yuxiao Xia, Mengzhang He, Yiqun Guo, Fenghua Zhang, Xiongting Wu, Rong Chen, Linli Duan, Fang Chen, Xuewei Yang, Xiuli Feng

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Left ventricle myocardial remodeling following septal myectomy in patients with hypertrophic obstructive cardiomyopathy by Guanyu Lu, Liqi Cao, Jiehao Ou, Xinyi Luo, Wei Zhu, Zhicheng Du, Jian Liu, Yuelong Yang, Xinyue Zhang, Peijian Wei, Hongxiang Wu, Huiming Guo, Hui Liu

“…Results: A total of 43 patients (52±14years, 23 female) were included in the analysis. At 6months post-myectomy, there were significant within-person decreases in LV mass index (101.0 [82.5–121.0] to 85.8 [66.7–100.0]g/m2; p<0.001), indexed cell volume (68.6 [53.2–82.6]mL/m2 to 54.0 [42.6–62.0]mL/m2; p<0.001) and iECV (26.5 [22.4–30.1]mL/m2 to 21.2 [18.7–26.4]mL/m2; p<0.001). …”
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Platelet-Rich Plasma Provides Superior Clinical Outcomes Without Radiologic Differences in Lateral Epicondylitis: Randomized Controlled Trial by Taha Kizilkurt, Ahmet Serhat Aydin, Taha Furkan Yagci, Ali Ersen, Celal Caner Ercan, Artür Salmaslioglu

“…Radiological evaluations included vascularity and superb microvascular imaging (SMI) indices via ultrasonography before injection and three months post-injection. <i>Results:</i> Fourteen patients were lost to follow-up, leaving 36 patients (36 elbows, 16 males and 20 females; mean age 42.4 ± 6.15 years) for analysis. …”
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Patient centered outcomes in stroke: utility-weighted modified Rankin Scale results in a community-based study by Carlos Delfino, Gabriel Cavada, Lorena Hoffmeister, Pablo Lavados, Pablo Lavados, Paula Muñoz Venturelli, Paula Muñoz Venturelli, Paula Muñoz Venturelli

“…Key determinants of health-related quality of life in post-stroke patients included age, prior disability, and stroke severity. …”
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Effects of fermented Arctium lappa L. root by Lactobacillus casei on hyperlipidemic mice by MingJu Chen, Yuxiao Wu, Hongxuan Yang, Tianfeng Liu, Tongkun Han, Wangqiang Dai, Junyue Cen, Fan Ouyang, Jingjing Chen, Jianxin Liu, Lin Zhou, Xuguang Hu

“…It also improved liver injury as well as better regulation of lipid levels, pro-inflammatory cytokine levels, and cholesterol-related mRNA. 16S rRNA analysis revealed that LC-AR decreased the Firmicutes/Bacteroidetes ratio, which correlated negatively with triglycerides, total cholesterol, and low-density lipoprotein cholesterol levels.DiscussionThese findings suggest that LC-AR may serve as a promising functional food and drug raw material for improving hyperlipidemia, particularly through its beneficial effects on gut microbiota and lipid regulation.…”
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Improved Outcomes of Liver Transplant Recipients Discharged to a Dedicated Inpatient Rehabilitation Facility by Rachel Santiago, Nicole Barylski, Adam Schulman, Leona Kim-Schluger, Sander Florman, Chung-Yin Tsai, Thomas Schiano, Zoe Gottlieb, Allison Bean, Miguel Escalon

“…The purpose of this study was to determine if discharge to an inpatient rehabilitation facility (IRF) post-LT was associated with lower readmission and mortality rates compared to discharge home. …”
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Synbiotic combination of Bifidobacterium longum BB536 and lactulose improves the presenteeism of healthy adults associated with aromatic lactic acids - A single-arm, open-label stu... by Riko Mishima, Ryuta Ejima, Satoshi Arai, Ayako Horigome, Eri Mitsuyama, Hiroki Kaneko, Kana Yamaguchi, Keita Kamezaki, Yuka Togashi, Kiyoshi Nakamura, Noriyuki Iwabuchi, Miyuki Tanaka, Toshitaka Odamaki, Shinji Fukuda, Yuji Naito

“…Gut microbiota and their metabolites are crucial for metabolic regulation, immunomodulation, and brain and mental functions via the brain-gut axis. Synbiotics offer an effective strategy for improving gut health by modulating gut microbiota, leading to improved physical and mental health. …”
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In Vitro Characterization of 3D-Printed PLA/CPO Oxygen Releasing Scaffolds: Mechanical and Biological Properties for Bone Tissue Engineering by Abdullah Mohammed, Alice Tirnoveanu, William Richard Webb, Ammar A. Melaibari, Adnan Memić, Mohammad Aslam, Amr Elshaer, Hany Hassanin, Khamis Essa

“…In vitro characterization, including mechanical, morphological, and biological assessments, demonstrated that, post-cell culturing, mechanical strength improved, which indicates improved scaffold resilience. …”
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3‐HKA Promotes Vascular Remodeling After Stroke by Modulating the Activation of A1/A2 Reactive Astrocytes by Jun‐Min Chen, Guang Shi, Lu‐Lu Yu, Wei Shan, Jing‐Yu Sun, An‐Chen Guo, Jian‐Ping Wu, Tie‐Shan Tang, Xiang‐Jian Zhang, Qun Wang

“…In conclusion, 3‐HKA may promote post‐stroke vascular remodeling by regulating A1/A2 astrocyte activation, thereby improving long‐term neurological recovery, suggesting that supplementation with 3‐HKA may be an efficient therapy for stroke.…”
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Multidimensional pain profiling in people living with obesity and attending weight management services: a protocol for a longitudinal cohort study by Catherine Blake, Carel W le Roux, Keith M Smart, Catherine M Doody, Francis M Finucane, Brona M Fullen, Jean O’Connell, Natasha S Hinwood, Colin Dunlevy, Clare Gilsenan, Grainne O'Donoghue

“…Obesity is associated with increased self-reported pain intensity and pain-related disability, reductions in physical functioning and poorer psychological well-being. People living with obesity tend to respond less well to pain treatments or management compared with people living without obesity. …”
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Acute effect of proprioceptive exercises on balance, joint position sense and muscle strength among elder and adult by Mansour Sahebozamani, Abdolhamid Daneshjoo, Saeid Bahiraei, Shima Sheikhbahaie, Sanaz Namazi Zadegan, Faeze Firouzi, Elahe Nasrolahzade, Maliheh Soltanabi

“…Assessments were conducted before, immediately after, and one hour post exercises. Data analysis was performed using a mixed model for repeated measures design. …”
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