Functionally characterizing obesity-susceptibility genes using CRISPR/Cas9, in vivo imaging and deep learning by Eugenia Mazzaferro, Endrina Mujica, Hanqing Zhang, Anastasia Emmanouilidou, Anne Jenseit, Bade Evcimen, Christoph Metzendorf, Olga Dethlefsen, Ruth JF Loos, Sara Gry Vienberg, Anders Larsson, Amin Allalou, Marcel den Hoed

“…Aiming to systematically characterize candidate genes for a role in accumulation of lipids in adipocytes and other cardiometabolic traits, we developed a pipeline using CRISPR/Cas9, non-invasive, semi-automated fluorescence imaging and deep learning-based image analysis in live zebrafish larvae. Results from a dietary intervention show that 5 days of overfeeding is sufficient to increase the odds of lipid accumulation in adipocytes by 10 days post-fertilization (dpf, n = 275). …”
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Safety, tolerability and clinical effects of rovunaptabin, also known as BC007 on fatigue and quality of life in patients with Post-COVID syndrome (reCOVer): a prospective, explora... by Bettina Hohberger, Marion Ganslmayer, Thomas Harrer, Friedrich Kruse, Stefanie Maas, Tobias Borst, Ralph Heimke-Brinck, Andreas Stog, Thomas Knauer, Eva Rühl, Victoria Zeisberg, Adam Skornia, Alexander Bartsch, Armin Ströbel, Monika Wytopil, Caroline Merkel, Sophia Hofmann, Katja G. Schmidt, Petra Lakatos, Julia Schottenhamml, Martin Herrmann, Christian Mardin, Jürgen Rech

“…Summary: Background: Rovunaptabin neutralises functional autoantibodies targeting G-Protein coupled receptors (GPCR-fAAbs), observed in patients with Post-COVID syndrome. …”
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Sociological study of religiosity in post-atheist Kazakhstan by Aigul Zabirova, Natalya Seitakhmetova, Sholpan Zhandossova, Marhabbat Nurov

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Characterizing Neurocardiovascular Responses to an Active Stand Test in Older Women: A Pilot Study Using Functional Data Analysis by Feng Xue, Roman Romero-Ortuno

“…This observational pilot study investigated neurocardiovascular responses to an active stand test using continuous physiological monitoring and functional data analysis (FDA) in older women. A sample of 25 community-dwelling female adults aged 59–78 years (mean age: 70.3 years) participated. …”
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Efficacy of argatroban plus alteplase according to time from onset to thrombolysis in acute ischemic stroke: a prespecified post-hoc analysis of the ARAIS trial by Yu Cui, Er-Qiang Wang, Yi-Han Wang, Hui-Sheng Chen

“…BackgroundThe Argatroban Plus Recombinant Tissue-Type Plasminogen Activator for AIS (ARAIS) trial failed to demonstrate the benefit of argatroban in patients diagnosed with acute ischemic stroke who were treated with intravenous alteplase. A post-hoc analysis was conducted to investigate whether the time from onset to thrombolysis (OTT) affected the outcomes.MethodsThe included patients were classified into two subgroups according to OTT. …”
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Safety and performance of oropharyngeal muscle strength training in the treatment of post-stroke dysphagia during oral feeding: protocol for a systematic review and meta-analysis by Xin Wang, Ying Wang, Fenghua Zhou, Minxing Gao, Lingyuan Xu, Heying Wang, Jinan Song, Xiaoqiu Yang

“…Introduction Dysphagia is a common functional disorder after stroke. Most patients post-stroke are incapable of oral feeding, which often leads to complications such as malnutrition, aspiration pneumonia and dehydration that seriously affect the quality of life of patients. …”
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Relationship Between Location of Cell Transplantation and Recovery for Intracerebral Stem Cell Transplantation for Chronic Traumatic Brain Injury: Post-hoc Analysis of STEMTRA Tria... by Masahito Kawabori, Yasuaki Karasawa, Jun Suenaga, Hajime Nakamura, Hideaki Imai, Takao Yasuhara, Naoki Tani, Tatsuya Sasaki, Takashi Kawasaki, Kenta Totsuka, Dai Chida, Yoichi M. Ito, Tetsuya Yamamoto, Isao Date, Shota Tanaka, Haruhiko Kishima, Miki Fujimura

“…Twelve patients were included in this post-hoc analysis. No patients in the 2.5 × 106 cells group showed improvement and were therefore excluded from further analysis. …”
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Effect of fixed dental prosthesis on the brain functions of partially edentulous patients – pilot study with power spectrum density analysis by Uddipta Prafulla Saikia, N. Gopi Chander, Muthukumar Balasubramanian

“…Power spectral density (PSD) analysis of EEG alpha waves was made pre- treatment, post treatment and 3 months after FDP treatment to analyse the brain function. …”
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A Clinical Case of Two-Stage Visual-Functional Rehabilitation of a Patient with Postinfectious Central Corneal Opacity in Combination with Mixed Astigmatism Using Laser Keratorefra... by N. V. Maychuk, I. A. Mushkova, M. R. Obraztsova

“…Introduction: to evaluate the clinical and functional results of two-stage treatment in a patient with post-infectious Central corneal opacity combined with mixed astigmatism.Patient and methods. …”
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CLU, FOS, and CXCL8 as diagnostic biomarkers for heart failure progression post-acute myocardial infarction: an integrated RNA-Seq and multi-machine learning study by Jingjing Wei, Peng Yu, Peng Yu, Yucai Hu, Lijie Qiao, Lijie Qiao, Bin Li, Bin Li, Haitao Li, Shiyang Xie, Zhengwei Dong, Aolong Wang, Yilin Zhang, Xinlu Wang, Yongxia Wang, Mingjun Zhu

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Early Rehabilitation in Patients with Proximal Humeral Fracture: A Comparative Analysis of Functional Outcomes Between Surgical and Conservative Treatments. by Maria Venra Menzo

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Metagenomic Analysis of Microbial Community Structure and Functional Profiling during Different Fermentation Stages of Xinjiang Sea Buckthorn Jiaosu by Rui FAN, Wenwen WANG, Linna WEI, Tengbin WANG, Sijia WEI, Jinrong LIU, Fang LI

“…Objective: The aim of this study was to investigate the dynamics of microbial community structure and function during the natural fermentation process of sea buckthorn ferment at different stages using metagenomic analysis techniques. …”
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Morphological analysis and functional connectivity of the insular in patients with dysphagia after cerebral infarction based on resting-state fMRI by Ming Guo, Bingjie Li, Jun Zhao, Chen Bai, Weiyong Yu, Hongxia Zhang, Haoyuan Li, Yongxue Yuan, Qingsu Zhang, Tong Zhang

“…Abstract Objective The insula, as a critical hub for multimodal information integration, plays a pivotal role in post-stroke dysphagia(PSD). However, the mechanisms underlying its structural and functional network reorganization remain elusive. …”
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Typical Changes in Gait Biomechanics in Patients with Subacute Ischemic Stroke by Dmitry V. Skvortsov, Sergey N. Kaurkin, Natalya V. Grebenkina, Galina E. Ivanova

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Early weight-bearing after ankle fracture surgery: a systematic review and meta-analysis of functional outcomes and safety by Chengjing Wang, Changqing Li

“…Primary outcomes included functional scores, pain, range of motion, and complications. …”
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The neuroanatomy of active hand movement in patients with severe traumatic brain injury: Analysis of functional magnetic resonance imaging data by T. S. Mukhina, E. V. Sharova, G. N. Boldyreva, L. A. Zhavoronkova, A. S. Smirnov, M. A. Kulikov, E. V. Aleksandrova, M. V. Chelyapina, E. L. Masherov, I. N. Pronin

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GhLPF1 Associated Network Is Involved with Cotton Lint Percentage Regulation Revealed by the Integrative Analysis of Spatial Transcriptome by Hongyu Wu, Luyao Wang, Shengjun Zhao, Mengtao Gao, Junfeng Cao, Yupeng Hao, Li Yu, Ting Zhao, Siyuan Wang, Jin Han, Yumeng Zhu, Yongyan Zhao, Jie Li, Ke Nie, Kening Lu, Linyun Ding, Zhiyuan Zhang, Tianzhen Zhang, Xueying Guan

“…Here, we identify an R2R3 MYB transcription factor coding gene GhLPF1 within the QTL‐LP‐ChrA06 locus for lint percentage (LP, percentage of lint to seed cotton) through constructing the 1‐Day Post Anthesis Cotton Ovule Spatial Transcriptome Atlas. …”
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Effects of music training on executive functions in preschool children aged 3–6 years: systematic review and meta-analysis by Yanan Lu, Lin Shi, Lin Shi, Ahmad Faudzi Musib

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Upper extremity function and disability recovery with vibration therapy after stroke: a systematic review and meta-analysis of RCTs by Yueh-Hsun Lu, Hung-Ju Chen, Chun-De Liao, Po-Jung Chen, Xin-Miao Wang, Chieh-Hsiang Yu, Po-Yin Chen, Chueh-Ho Lin

“…Randomized controlled trials (RCTs) that evaluated the effects of vibration therapy on upper extremity motor impairment, function, and disability recovery post-stroke were analyzed. …”
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Methylglyoxal-Induced Modifications in Human Triosephosphate Isomerase: Structural and Functional Repercussions of Specific Mutations by Ignacio de la Mora-de la Mora, Itzhel García-Torres, Luis Antonio Flores-López, Gabriel López-Velázquez, Gloria Hernández-Alcántara, Saúl Gómez-Manzo, Sergio Enríquez-Flores

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