Health perceptions of older individuals on the cognitive benefits of a multicomponent green physical activity program: A qualitative exploration in the Southwest Region of Bahia, B... by Carolina Rego Chaves Dias, Saulo Vasconcelos Rocha, Milena Fernandez Dias, Bruno Morbeck de Queiroz, Natália Nascimento Silva, Ariani França Conceição, Bruna Maria Palotino-Ferreira, Sonia Brito-Costa, Sofia de Lurdes Rosas da Silva, Clarice Alves dos Santos, Lélia Renata Carneiro Vasconcelos, Guilherme Eustáquio Furtado

“…Results: The analysis revealed six main themes: (1) ''Role of Socialization in Older Individuals' Health Context,'' (2) ''Positive Effects of Guided Programs on Functional Capacity,'' (3) ''Relationship Between Healthy Habits and Successful Aging,'' (4) ''Physical Exercise as an Effective Non-Pharmacological Treatment for Mental Health,'' (5) ''Adherence to a More Active Lifestyle,'' and (6) ''Negative Effects of a Sedentary Lifestyle on Mental Health. …”
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Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial. by John A Todd, Marina Evangelou, Antony J Cutler, Marcin L Pekalski, Neil M Walker, Helen E Stevens, Linsey Porter, Deborah J Smyth, Daniel B Rainbow, Ricardo C Ferreira, Laura Esposito, Kara M D Hunter, Kevin Loudon, Kathryn Irons, Jennie H Yang, Charles J M Bell, Helen Schuilenburg, James Heywood, Ben Challis, Sankalpa Neupane, Pamela Clarke, Gillian Coleman, Sarah Dawson, Donna Goymer, Katerina Anselmiova, Jane Kennet, Judy Brown, Sarah L Caddy, Jia Lu, Jane Greatorex, Ian Goodfellow, Chris Wallace, Tim I Tree, Mark Evans, Adrian P Mander, Simon Bond, Linda S Wicker, Frank Waldron-Lynch

“…Furthermore, there was a dose-dependent down modulation of one of the two signalling subunits of the IL-2 receptor, the β chain (CD122) (mean decrease = 58.0%, SE = 2.8%, range 9.8%-85.5%, n = 33), on Tregs and a reduction in their sensitivity to aldesleukin at 90 min and day 1 and 2 post-treatment. Due to blood volume requirements as well as ethical and practical considerations, the study was limited to adults and to analysis of peripheral blood only.…”
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Spaces of Struggle: Socialism and Neoliberalism With a Human Face Among Digital Parties and Online Movements in Europe by Emiliana De Blasio, Michele Sorice

“…This article presents the first findings of a research project on the use of digital platforms by: a) parties of socialist inspiration in Italy, France, Spain, Portugal and the USA; and b) bottom-up social movements. The analysis follows an empirical approach based on: a) the analysis of organisations; b) content analysis (Evaluation Assertion Analysis) of political and policy documents on the use of digital as a tool for political struggle; c) in-depth interviews to digital activists of social movements. …”
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Treatment of Chronic Neck Pain with Transcranial Direct Current Stimulation: A Single-Blinded Randomized Clinical Trial by Manuel Rodríguez-Huguet, Miguel Ángel Rosety-Rodríguez, Daniel Rodríguez-Almagro, Rocío Martín-Valero, Maria Jesus Vinolo-Gil, Jorge Bastos-Garcia, Jorge Góngora-Rodríguez

“…<b>Results</b>: The within-group analysis revealed statistically significant improvements for both groups at post-treatment, one-month follow-up, and three-month follow-up. …”
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DNA methylation dynamics play crucial roles in shaping the distinct transcriptomic profiles for different root-type initiation in rice by Wei Jiang, Zhou Zhou, Xiaoying Li, Yu Zhao, Shaoli Zhou

“…Moreover, our work reveals that the activation of DNA glycosylase 702 (DNG702) and repression of Domains Rearranged Methyltransferase 2 (DRM2) play important roles in the erasure of CHH methylation and activation of functional genes during the processes, such as a novel identified key regulatory bZip65, thus directly impacting the initiation of post-embryonic roots in rice. …”
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A unique protein phosphatase with kelch-like domains (PPKL) in Plasmodium modulates ookinete differentiation, motility and invasion. by David S Guttery, Benoit Poulin, David J P Ferguson, Balázs Szöőr, Bill Wickstead, Paula L Carroll, Chandra Ramakrishnan, Declan Brady, Eva-Maria Patzewitz, Ursula Straschil, Lev Solyakov, Judith L Green, Robert E Sinden, Andrew B Tobin, Anthony A Holder, Rita Tewari

“…However, functions for any of the plasmodial protein phosphatases are unknown. …”
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Immune reconstitution of human cytomegalovirus-specific T lymphocytes after allogeneic hematopoietic stem cell transplantation and their predictive role in reactivation by Yuanqi Zhao, Yuanqi Zhao, Yuanqi Zhao, Sisi Zhen, Sisi Zhen, Jiali Wang, Jiali Wang, Jieru Wang, Jieru Wang, Runzhi Ma, Runzhi Ma, Li Liu, Li Liu, Aiming Pang, Aiming Pang, Rongli Zhang, Rongli Zhang, Xin Chen, Xin Chen, Weihua Zhai, Weihua Zhai, Donglin Yang, Donglin Yang, Yi He, Yi He, Mingzhe Han, Mingzhe Han, Erlie Jiang, Erlie Jiang, Sizhou Feng, Sizhou Feng

“…This study investigates the post-transplantation reconstitution of HCMV-specific T cells and their role in the regulation of HCMV infections. …”
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Association between malnutrition risk and the prognosis of geriatric heart failure patients undergoing left ventricular assist device implantation by Rui Shi, Zhenhan Li, Xinyue Duan, Jun Luo, Yuxiang Luo, Qingchen Wu, Dan Chen, Xin Tian, Hongtao Tie

“…Mortality decreased with increasing pre-implant GNRI up to approximately 100 and 6-month post-implant GNRI up to 104. Patients with malnutrition risk also had an increased risk of infection, poor quality of life (QoL), and reduced functional exercise capacity after the LVAD implantation. …”
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Development of Social institution of Mass media in Information Society and Legal Field of the Personal and Corporative Information Security by Alexander Anatolyevich Markov, Nadezhda Nikolaevna Pokrovskaya, Pavel Dmitrievich Smirnov

“…Sociological analysis of mechanisms and tools of the information and knowledge’ creation and transmission, as well as channels of open access to data and competences, raises questions on the new opportunities, but also on the social constraints for the functioning of mass communication systems. …”
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Improving older people’s experiences and safety at transitions of care: the PACT mixed-methods study including RCT by Jenni Murray, Ruth Baxter, Jane O’Hara, Laura Sheard, Catherine Hewitt, Natasha Hardicre, Charles Vincent, Eirini Oikonomou, Gerry Richardson, Rosie Shannon, Kalpita Baird, Stephen Brealey, Robbie Foy, Laura Mandefield, Sarah Hampton, Ed Breckin, Lubena Mirza, Alfredo Palacios, Sally Moore, Jayne Marran, Jacqui Elliot, Jane Schofield, Alison Cracknell, Beth Woods, Sarah Cockayne, Thomas Mills, Yvonne Birks, Olivia Joseph, Rebecca Lawton

“…Work package 4: Development and refinement of a care transitions intervention Intervention development Functional resonance analysis method was used to model the transition process. …”
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Flexible host–microbe interaction aid adaptation of black-necked crane to seasonal shifts by Ruifeng Ma, Shujuan Ma, Yujia Zhang, Lei Hu, Keyi Tang, Hongyi Liu, Ke He, Yudong Li, Suolangduoerji, Ying Zhu

“…We found that the black-necked crane harbored more gut bacterial communities and more diverse plant-derived foods during the post-breeding period than during the pre-breeding period. …”
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The Relationship Between Psychosocial Factors and Response to Epidural Steroid Injection for Chronic Lumbosacral Radicular Pain: A Prospective Pilot Study by Stensland M, Sanford E, Houle TT, McGeary C, Cobos BA, Lugosi S, Lehman L, Nabity PS, Covell C, Fitzgerald E, Mojallal M, Reed DE, Pangarkar S, Eapen BC, Nanda U, McCormick ZL, McGeary D

“…Higher pre-injection pain was predictive of higher post-injection pain at all time points (p< 0.001). …”
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Explainable data mining model for hyperinsulinemia diagnostics by Nevena Rankovic, Dragica Rankovic, Mirjana Ivanovic, Igor Lukic

“…To address these challenges in the medical data analysis, we propose a model employing Functional Principal Component Analysis (FPCA), which also accounts for outliers that could otherwise lead to the inclusion of irrelevant features. …”
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Sample preparation using multiple microbial pattern recognition proteins and magnetic bead ratcheting by Jessica Martinez, Dong Jin M. Park, Samantha Abate, James Hill, George Downey, Craig Galligan, Tyler Hammond, Michael T. McCurdy, Surekha Gurung, Shanjana Shawon, Ralf Lenigk, Kuangwen Hsieh, Michael Super, Erik Kvam, Tza-Huei Wang, Coleman Murray, Chris Puleo

“…The flow-through system was operated up to 1 mL per minute and enabled pathogen isolation from 10 mL samples in <30 min. Demonstration of post-ratcheting PCR-based microbe analysis was also performed, showing that the technology may have applicability across different infectious agents, sample types/volumes, and analytical assays. …”
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Development, opportunities, and challenges of siRNA nucleic acid drugs by Bowen Xiao, Shaopeng Wang, Yu Pan, Wenjun Zhi, Chensheng Gu, Tao Guo, Jiaqi Zhai, Chenxu Li, Yong Q. Chen, Rong Wang

“…The high blood flow, natural filtration function, and drug delivery methods of the liver overall ensure high efficacy and stability of the drugs themselves. …”
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Serum glial fibrillary acidic protein and protein gene product 9.5 for predicting neurological outcomes in cardiac arrest patients with cortical response to somatosensory evoked po... by Chenchen Hang, Rui Shao, Xingsheng Wang, Luying Zhang, Weijie Cheng, Zihao Jiang, Ziqi Zhong, Le An, Ziren Tang

“…Serum glial fibrillary acidic protein, protein gene product 9.5 and neuron-specific enolase levels were measured at 72 h post-resuscitation. Patients were evaluated for neurological outcomes at 3 months using the Glasgow-Pittsburgh Classification of Cerebral Function scale. …”
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Sex‐related pathophysiological mechanisms may be present before symptoms of HFpEF develop by B. Wong, J.D. Dodd, J. Gallagher, B. Dyer, C. Ryan, K. McDonald, M. Ledwidge

“…Methods and results This post hoc analysis of the PARABLE trial enrolled 250 patients with pre‐HFpEF. …”
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Implementing an online-delivered exercise program for childhood cancer survivors: A hybrid effectiveness-implementation protocol for the MERRIER studyKey points by David Mizrahi, Alexandra Martiniuk, Laurence Hibbert, Dinisha Govender, Tora Sibbald, Richard Mitchell, Natalia Millard, Lauren Ha, Damian Ragusa, Kylie Brown, Ben Smith

“…The RE-AIM framework will assess reach (e.g. recruitment rate), effectiveness (e.g. physical activity levels), adoption (e.g. qualitative interviews), implementation (e.g. exercise adherence), and maintenance (e.g. self-efficacy at follow-up). Physical function and patient-reported outcomes will be assessed at baseline (T0), post-intervention (T1; week 12) and follow-up (T2, week 24). …”
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Salvianolic Acid B Alleviates LPS-Induced Spleen Injury by Remodeling Redox Status and Suppressing NLRP3 Inflammasome by Hao Wang, Xiao Dou, Ruixue Wang, Yuxin Jiang, Jinsong Zhang, Xianjuan Qiao, Yingjun Liu, Hao Zhang, Chenhuan Lai, Yanan Chen, Qiang Yong

“…Blood and spleen tissues were harvested 6 h post-injection for biochemical analysis. <b>Results</b>: LPS induced systemic immune disorders in piglets, as evidenced by increased immune organ indices and decreased white blood cell, lymphocyte, and basophil counts in blood (<i>p</i> < 0.05). …”
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Association of social contact with dementia and cognition: 28-year follow-up of the Whitehall II cohort study. by Andrew Sommerlad, Séverine Sabia, Archana Singh-Manoux, Glyn Lewis, Gill Livingston

“…Results were consistent in a series of post hoc analyses, designed to assess potential biases. …”
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