Segregation and integration of resting-state brain networks in a longitudinal long COVID cohort by Yuchen Zhang, Gengchen Ye, Wentao Zeng, Ruiting Zhu, Chiyin Li, Yanan Zhu, Dongbo Li, Jixin Liu, Wenyang Wang, Peng Li, Liming Fan, Rong Wang, Xuan Niu

“…Here, we utilized a nested-spectral partition (NSP) approach to study the segregation and integration of resting-state brain functional networks in 34 patients with long COVID from acute to chronic phase post infection. …”
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Abstract 272: Effect of Level of Education on Outcomes of Mechanical Thrombectomy by Wilson Rodriguez, Gunjanpreet Kaur, Karthik Narayanan, Yongzhen Chen, Xiaoyi Gao, Jordan Scott, Aimalohi Esechie, Kara Christopher, Brian Miremadi

“…Conclusion In our cohort, patients with less than a high school education are more likely to have poorer functional outcomes 90 days post‐MT compared with patients with a college education or higher. …”
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Clinical manifestations, histopathological changes and quality of life in patients with advanced knee osteoarthritis caused by age, trauma, obesity and their combination by Kristina V. Korochina, Tatyana V. Chernysheva, Irina E. Korochina

“…Conclusion — Comprehensive comparative clinical and morphological analysis of late-stage knee OA of various origin was completed, and age-related, post-traumatic, metabolic and combined OA phenotypes were studied. …”
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SMS text message-delivered pain self-management intervention for patients undergoing total knee replacement surgery: protocol for a randomised controlled type 1 hybrid effectivenes... by Rachelle Buchbinder, Paul Glare, Claire Ashton-James, Ali Gholamrezaei, David Liew, Amy Gray McNeilage, Andrew Hardidge, Elizabeth Walkley, Charlotte Heldreich

“…Effectiveness outcomes will be pain intensity (primary), opioid dose, knee function and pain-related distress and will be recorded at baseline, 3 days, 3 weeks, 6 weeks, 3 months and 6 months after surgery using self-reported surveys. …”
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Dual-modal overcoming of physical barriers for improved photodynamic cancer therapy via soft organosilica nanocapsules by Wei Lu, Yang Li, Xiaojun Zhang, Ning Wang, Dong Chen, Yatong Zhao, Guang Li, Xuzhi Shi, Xiaobo Ma, Xiaodan Su, Feng Wang, Chuqiang Shu, Kun Chen

“…In addition, RNA-seq analysis of SMONs-HAase-Ce6 shows it alters gene expression, degrading the extracellular matrix and impairing mitochondrial function. …”
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Pharmacologically inducing regenerative cardiac cells by small molecule drugs by Wei Zhou, Kezhang He, Chiyin Wang, Pengqi Wang, Dan Wang, Bowen Wang, Han Geng, Hong Lian, Tianhua Ma, Yu Nie, Sheng Ding

“…In this study, we demonstrate that a two-compound combination, CHIR99021 and A-485 (2C), effectively induces RCCs from human embryonic stem cell-derived TNNT2+ CMs in vitro, as evidenced by lineage tracing experiments. Functional analysis shows that these RCCs express a broad spectrum of cardiogenesis genes and have the potential to differentiate into functional CMs, endothelial cells, and smooth muscle cells. …”
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Overexpression of endothelial S1pr2 promotes blood–brain barrier disruption via JNK/c-Jun/MMP-9 pathway after traumatic brain injury in both in vivo and in vitro models by Hongbo Cheng, Yijiao Men, Yaqing An, Jiegang Yu, Gengshen Zhang, Jiaming Li, Xiaoliang Wang, Guozhu Sun, Yang Wu

“…Through in vitro and in vivo Chip-qPCR experiments, we verified that AP-1a and AP-1b of MMP-9 promoter function as binding sites for phosphorylated c-Jun.ConclusionOur findings identify a previously undisclosed role of S1pr2 in the pathophysiology of TBI. …”
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Correlative 99m Tc-labeled tropane derivative single photon emission computer tomography and clinical assessment in the staging of parkinson disease by Ajit Shinto, Joppy Antony, Koramadai Kamaleshwaran, Krishnan Vijayan, Arul Selvan, Aruna Korde, Mythili Kameshwaran, Grace Samuel

“…Specific uptake in the striatum and its sub-regions, including the putamen and caudate nucleus was calculated and the ratios of specific striatal binding to nonspecific occipital binding were calculated. ANOVA with Dunnett C post-hoc analysis was conducted using SPSS 20. A stepwise reduction in specific striatal uptake of 99m Tc-TRODAT-1 with increasing disease severity between healthy control versus Stage I versus Stage II versus Stage III was found in PD patients (i.e., 3.77 vs. 2.56 vs. 1.57 vs. 0.63, P < 0.05). …”
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Thyroid, neurodevelopmental, and kidney toxicities of common organic UV filters in embryo-larval zebrafish (Danio rerio), and their potential links by Ba Reum Kwon, Ah-Reum Jo, Inae Lee, Gowoon Lee, Young Joo Park, Jung Pyo Lee, Na-Youn Park, Younglim Kho, Sungkyoon Kim, Kyunghee Ji, Kyungho Choi

“…Moreover, the OUVFs exposure caused increased proteinuria in the fish, along with transcriptional changes of wt1, nephrin, podocin, and cdh17 genes, which could explain the observed reduction in kidney functions. Principal component analysis (PCA) implied the potential interplay of THs with neurogenesis, or podocyte differentiation of the larval fish. …”
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Ziziphus spina-christi alleviates paracetamol-induced hepatorenal toxicity in rats through in vivo and computational approaches by Ehsan Kh. M. Khedre, Amany M. M. Hegab, Amira A. El-Mahis, Amina A. S. Abdel Rahman, Sherien H. B. Elwakeel, Ali S. Abdelhameed, Vittorio Calabrese, Ursula M. Jacob, Eman S. G. Hassan

“…The study included biochemical analysis of liver and kidney function markers, oxidative stress indicators, histological and immunohistochemical examinations, and molecular docking studies. …”
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Progressive subchondral bone cyst formation following autologous chondrocyte implantation with all-suture anchors: a Case Report with histological evaluation by Takuma Kaibara, Eiji Kondo, Masatake Matsuoka, Koji Iwasaki, Tomohiro Onodera, Daisuke Momma, Zen-Ichi Tanei, Shinya Tanaka, Norimasa Iwasaki

“…This case underscores the importance of secure suturing techniques in high-stress areas and suggests the potential benefit of extended post-operative monitoring of SBC progression beyond one year. …”
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The close association of Muribaculum and PA (10:0/a-17:0) with the occurrence of pancreatic ductal adenocarcinoma and immunotherapy by Enzhao Wang, Kuiwu Ren, Xiangyu Wang, Sen Du, Xiang Gao, Wang Niu, Chenyue Guan, Xue Liu, Panpan Wu, Chunlong Liu, Jiangtao Yu, Jiangtao Yu, Kun Song

“…Additionally, a retrospective analysis was conducted on PDAC patients post-surgery regarding immunotherapy and its correlation with metabolic components.ResultsPDAC patients exhibited a significantly higher abundance of bile microbiota compared to controls, with notable differences in microbiota structure between the two groups (P &lt; 0.05). …”
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Poststroke eHealth Technologies–Based Rehabilitation for Upper Limb Recovery: Systematic Review by Margherita Rampioni, Sara Leonzi, Luca Antognoli, Anna Mura, Vera Stara

“…ConclusionseHealth technologies hold promise for enhancing upper limb rehabilitation post stroke by addressing barriers such as cost and accessibility while providing engaging interventions. …”
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Biomechanical Changes to the Ankle After Zadek Osteotomy by Nicholas Bellas MD, Raghunandan Nayak BS, Mehreen Pasha BS, Megan R. Wolf MD, Elifho Obopilwe MS, Thomas McDonald MD, Lauren E. Geaney MD

“…These results may explain the improvements in pain and function seen in clinical studies. However, nonpathological foot and ankle specimens were used in this study, which should affect interpretation. …”
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Three decades of progress: evolution of outcomes and prognostic indicators in biliary atresia management by Senol Emre, Yalim Benibol, Ali Ekber Hakalmaz, Buse Karakurt, Ayse Kalyoncu Ucar, Nuray Kepil, Ömer Faruk Beşer, Sebuh Kuruğoğlu, Osman Faruk Senyuz

“…Clearance of jaundice was assessed at three months post-KPE, following established literature benchmarks. …”
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Effect of GLP-1 Receptor Agonists (Liraglutide) on Glycemic Parameters and Circulating miRNA Expression in Type 2 Diabetes Mellitus by Aqeel Meer AL-ZAMILY

“…In type 2 diabetes mellitus (T2DM), alteration in miRNA profiles can have a significant effect on insulin signaling, β-cell function, and inflammation. It has been suggested that antidiabetic therapies can normalize circulating miRNA levels and improve metabolic parameters, rendering miRNA as potential biomarkers for T2DM monitoring and treatment response. …”
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Single-centre, single-blind, randomized, active-controlled phase-3 non-inferiority study to investigate the safety and efficacy of the cardioplegic solution Cardioplexol™ by Hendrik T. Tevaearai Stahel, Gabriel Weiss, Gabriel Weiss, Peter Landowski, Peter Landowski, Sandra Folkmann, Sandra Folkmann, Marieluise Harrer, Marieluise Harrer, Bernard Voet, Martin Grabenwöger, Martin Grabenwöger, Martin Grabenwöger

“…Peak troponin-T (TnT) during the first 24 h post-reperfusion was defined as primary endpoint. …”
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Breaking down the recovery of O2 pathway: Peripheral extraction recovery pattern defines exercise capacity and clinical outcomes by Ahmed El Shaer, Mariana Garcia‐Arango, Anas Abed, Shannon Heffernan, Yuning Wang, Tashfeen Javed, Amirhossein Esmaeeli, Abdul Wahab Arif, Ran Tao, Naga Dharmavaram, James Runo, Jill N. Barnes, Farhan Raza

“…Abstract Poor recovery pattern of oxygen consumption (V̇O2) post‐exercise is associated with adverse clinical outcomes. …”
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A Novel Percutaneous Volume Reduction Technique for Giant Emphysematous Bullae: Combined Percutaneous Erythromycin Sclerotherapy With Bronchoscopic Occlusion by Wang Z, Liu Z, Zhang W, Liu W, Tan J, Li X, Wu H, Li Y, Deng H, Chen J, Chen L

“…George’s Respiratory Questionnaire (SGRQ), 6-minute walk test (6MWT), modified Medical Research Council (mMRC) score, pulmonary function, and blood gas analysis were assessed before the procedure, at discharge, and 6 months post-procedure. …”
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Evaluating the immunogenicity of a mouse partial hindlimb for composite allotransplantation by Jia Hui (Angela) Sun, Jia Hui (Angela) Sun, Samantha Ligi, Felor Biniazan, Siba Haykal, Siba Haykal

“…Samples were collected at post-operative days 7 (POD7) and 14 (POD14) for histological analysis (H&amp;E staining, immunohistochemistry for CD8, caspase-3, CD31, and TUNEL) to assess cell infiltration, inflammatory T cell presence, apoptosis, and vascularization. …”
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