Comparison of the effectiveness of intra-infrapatellar fat pad and intra-articular glucocorticoid injection in knee osteoarthritis patients with Hoffa’s synovitis: protocol for a m... by Yiwei Chen, Changqing Zhang, Tao Gao, Hongyi Zhu, Qiuke Wang, Qianying Cai, Junqing Lin, Jiali Lin, Longxiang Shen

“…Primary outcomes are (1) Hoffa’s synovitis improvement rate, measured with the MRI Osteoarthritis Knee Score system (superiority outcome) at 24 weeks and (2) pain intensity, measured with the Western Ontario and McMasters University Osteoarthritis Index (WOMAC) at 2 weeks post-injection. Secondary outcomes include Hoffa’s synovitis score at 2 weeks post-injection, pain intensity with the numerical rating scale, WOMAC questionnaire score improvements (function, joint stiffness and total score), improvement rates in effusion synovitis at 2 and 24 weeks, articular cartilage thickness changes at 2 and 24 weeks, Intermittent and Constant Osteoarthritis Pain score, quality of life measured with the EuroQol-5D, OARSI-OMERACT response indicators, co-interventions and side effects at 2, 4, 8, 12 and 24 weeks.Ethics and dissemination Ethical approval has been granted by the Medical Ethics Committee of the Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine (2023–178). …”
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Pro-repair macrophages driven by CGRP rescue white matter integrity following intracerebral hemorrhage by Huaping Huang, Yirui Kuang, Yang Chen, Yi Zhang, Jiayin Zhou, Xian Yu, Yonghe Zheng, Lingxin Cai, Wanglu Hu, Liansheng Gao, Haijian WU, Hui Ling, Xiao Dong, Hang Zhou, Xiaobo Yu, Yucong Peng, Gao Chen, Xiaoyu Wang, Wei Yan

“…The role of calcitonin gene-related peptide (CGRP) was tested via intraperitoneal administration in ICH mice, with outcomes assessed through transcriptomics, ultrastructural imaging, and functional recovery. Results scRNA-seq revealed sustained accumulation of THBS1 + macrophages post-ICH, correlating with WM repair and neurological recovery. …”
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MicroRNA expression levels in lung recipients: correlations with clinical and laboratory data by O. P. Shevchenko, S. O. Sharapchenko, O. M. Tsirulnikova, I. V. Pashkov, O. E. Gichkun, D. A. Velikiy, E. F. Shigaev, D. O. Oleshkevich, M. T. Bekov

“…The average expression level of miR-424 in lung recipients in the long-term period after lung transplant was higher than in waitlisted patients (p = 0.03). Analysis of the relationship between miRNA expression levels and external respiration function in the long-term post-transplant period showed that miR-142 expression level (r = 0.61; p = 0.04) positively correlates with the Tiffeneau-Pinelli index. …”
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The Effect of Prism Presentation Order on Near Vertical Fusional Vergence Ranges of Normal Young Adults by Gantz L, Shneor E, Shaw N, Doron R

“…The mean of two consecutive measurements of break and recovery values for one eye in each of the 16 experimental conditions were compared using the Friedman test with post-hoc Bonferroni correction, and non-parametric Bland and Altman analysis.Results:  The mean break/recovery values of 27 participants (mean age: 22.5± 2.0, range: 20– 29, 20 female) when BU or BD were measured first were BU: 4.20± 1.15Δ/3.07± 1.04Δ and BD: 4.20± 1.21Δ/3.00± 0.96Δ for step, and BU: 4.31± 0.98Δ/2.97± 0.85Δ and BD: 4.15± 1.14Δ/2.70± 0.87Δ for smooth methods, respectively. …”
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Adverse Tissue Reaction to Metal and Polyethylene Particles as the Major Underlying Pathogenesis in Revision Total Ankle Arthroplasty by Jensen Henry MD, Yaxia Zhang MD, PhD, Emily Teehan MS, Thomas W. Bauer MD, PhD, Constantine Demetracopoulos MD

“…Case of a 67-year-old male who underwent primary TAA for post-traumatic arthritis from chronic instability. …”
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A double-blind, placebo-controlled, randomized, multi-centre, phase III study of MLC901 (NeuroAiDTMII) for the treatment of cognitive impairment after mild traumatic brain injury. by Pavel I Pilipenko, Anna A Ivanova, Yulia V Kotsiubinskaya, Vera N Grigoryeva, Alexey Y Khrulev, Anatoly V Skorokhodov, Maxim M Gavrik, Nona N Mkrtchan, Marek Majdan, Peter Valkovic, Daria Rabarova, Suzanne Barker-Collo, Kelly Jones, Valery L Feigin

“…<h4>Methods and analysis</h4>This randomized placebo-controlled multi-centre study was aimed to examine the efficacy of herbal supplement MLC901 on complex attention following mild TBI at 6 months post-randomisation, as a primary outcome measured by CNS Vital signs (CNS-VS). …”
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Development and Validation of a Machine Learning Model for Predicting Long-Term Depression Risk in ACS Patients After PCI: A Retrospective Cohort Study by Lv H, Sun F, Zhang Y, Zhou X

“…Decision curve analysis demonstrated the clinical benefit of both models across a range of thresholds.Conclusion: The models demonstrated potential for early risk stratification of post-PCI depression and may inform targeted clinical interventions.Plain Language Summary: Depression is a common but often overlooked problem in people recovering from heart procedures. …”
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Lung Health of Early COPD (LHEC): A Multi-Center Cohort Study&amp;mdash;Rational and Design by Li W, Lei J, Li B, Tang X, Peng Y, Huang K, Yang T

“…This study aimed to build a national cohort of patients with early COPD in China to address the current research gaps in this area.Methods and Analysis: We intend to enroll 1500 participants aged 35 to 75 years with post-bronchodilator spirometry showing a forced expiratory volume in one second (FEV1)/forced vital capacity ratio below 0.8 and an FEV1% predicted of at least 80%, classified as early COPD subjects. …”
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Breaking prolonged sitting with high-intensity interval training to improve cognitive and brain health in middle-aged and older adults: a protocol for the pilot feasibility HIIT2SI... by Charles Hillman, Talha Syed, Dominika M Pindus, Tomasz S Ligeza, Jin Kuang, Scott Paluska, Joseph So, Miroslaw Wyczesany, Jesus Sarol, Flor B Quiroz, Ramiya Shanmugam, Maciej Kos, Naiman Khan, Art Kramer

“…The study will address three aims: (1) to assess feasibility, acceptability, fidelity and safety of HIIT breaks to improve neurocognitive function in middle-aged and older adults; (2) to quantify the differences between conditions in the change in the amplitude and latency of the P3b component of event-related potentials (a marker for frontoparietal function) and (3) to explore the differences between conditions in attentional control, episodic memory and FC of the FPN and DMN in middle-aged and older adults.Methods and analysis 54 healthy adults, aged 40–75 years, will be recruited from the local community and randomly assigned to a condition sequence (HIIT, LIIT vs LIIT and HIIT). …”
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Molecular insights into the relationship between sustained CRP elevation and endothelial dysfunction in axial spondyloarthritis by Clementina López-Medina, Nuria Barbarroja, Alejandro Escudero-Contreras, Chary López-Pedrera, Carlos Perez-Sanchez, Pedro Segui, Eduardo Collantes, Jerusalem Calvo, Lourdes Ladehesa-Pineda, Desiree Ruíz-Vilchez, Laura Cuesta-López, Iván Arias-de la Rosa, Jesús Eduardo Martín-Salazar, Antonio Manuel Barranco, Miriam Ruiz-Ponce, María Ángeles Puche Larrubia, Rafaela Ortega, María Carmen Ábalos-Aguilera, Elena Moreno-Caño, Pedro Ortiz-Buitrago

“…Carotid intima-media thickness (CIMT) and microvascular endothelial function (post-ischaemic reactive hyperaemia) were measured. …”
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The effects of dance intervention on clinical symptoms and cognitive deficits in hospitalized patients with chronic schizophrenia: a randomized controlled trial by Gujing Li, Hui He, Kexin Gao, Yuanyuan Yu, Yayun Liu, Tianhuan Li, Ping Xi, Frank Pollick, Jing Lu, Lixue Yin, Dezhong Yao, Mingjun Duan, Li Mi, Cheng Luo

“…Results The PANSS total scores (P < 0.01**), PANSS negative scores (p < 0.001**), NOISE score (p < 0.001**), MCCB cognitive scores, and physiological indicators were significantly changed after the intervention in both groups compared with baseline. Post-hoc analysis revealed notable improvements in the specific cognitive subscales, including the Continuous Operation Test-identical pairs (CPT-IP, p = 0.026*), Hopkins Verbal Learning Test-Revised (HVLT-R, p = 0.019*) and the physiological indicators Cystatin C (CYS-C, p = 0.037*) in the dance intervention group. …”
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Neuroleptics used in critical COVID associated with moderate-severe dyspnea after hospital discharge by Carlos Toufen, Gustavo Corrêa de Almeida, José Eduardo Pompeu, Celso Ricardo Fernandes de Carvalho, Carlos Roberto Ribeiro de Carvalho

“…Descriptive statistics, including frequencies and percentages, were used, and logistic regression analysis was performed to identify factors associated with moderate to severe dyspnea at 1 and 12 months post-discharge. …”
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Glenoid Component Migration in Total Shoulder Arthroplasty: A Case Report by Thomas Saliba, Sanjiva Pather

“…Surgery restored functionality. This case highlights the diagnostic challenges of radiotransparent components with possible migration in unexplained post-arthroplasty shoulder pain. …”
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The effects of early exercise on cardiovascular biomarkers in patients with congestive heart failure by Yanxiang Sun, Xuansheng Huang, Bing Hu, Zidi Wu, Yanchun Zhang, Yong Yuan, Li Feng

“…Hs‐TnT, sST2 and Gal‐3 showed no significant changes (all P > 0.05). Survival analysis demonstrated higher baseline hs‐TnT [hazard ratio (HR) 2.1, 95% confidence interval (CI) 1.3–3.4] and greater NT‐proBNP elevation post‐exercise (ΔNT‐proBNP HR 1.8, 95% CI 1.1–2.9) were independent predictors of mortality. …”
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EXPERIENCE OF ENDOSCOPIC CORRECTION OF CONGENITAL DIAPHRAGMATOCELE IN NEWBORNS by A. Y. Tarasov, V. A. Savvina, A. R. Varfolomeev, V. N. Nikolaev

“…Study aim: analysis of surgical treatment of congenital diaphragmatocele on the basis of еру multi-profile republican hospital #1 of the National center of medicine. …”
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Temporal changes of neurobehavior in rats following varied blast magnitudes and screening of serum biomarkers in early stage of brain injury by Ning Ma, Hong Wang, Qing Lu, Jinren Liu, Xiaolin Fan, Liang Li, Qi Wang, Xiao Li, Boya Yu, Yuhao Zhang, Junhong Gao

“…Serum dopamine (DA), 5-hydroxytryptamine (5-HT), brain-derived neurotrophic factor (BDNF) and gamma-aminobutyric acid (GABA) were measured at the same time points. The proteomic analysis was conducted to identify potentially vulnerable cellular and molecule targets of serum in the immediate post-exposure period. …”
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Mayská náboženská bratrstva v antropologické imaginaci by Jan Kapusta

“…In this paper the institution in Mayan culture is described and the anthropological theories focused on the problem of extensive expenditure during the feasts are discussed. Through an analysis of the dynamic history and contemporary progress of the institution, the paper takes issue with both the approaches of cultural essentialism or functionalism and colonial historicism or Marxism. …”
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Is Co-Parenting Possible After Divorce?: A Scoping Review of the Effects on Children by Miyase Taşkıran, Demet Akarçay Ulutaş

“…Post-divorce adjustment efforts lead to significant changes in the roles and functions of parents and children. …”
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Effects of one-week intake of different edible oils on the urinary proteome of rats by Yan Su, Youhe Gao

“…Differentially expressed proteins and differential post-translational modifications in the urinary proteome were screened for functional analysis.ResultsAll edible oil groups exhibited significant alterations in metabolic pathways, with distinct proteomic profiles observed across oil types, but there were few common differentially expressed proteins among different groups. …”
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Ubiquitylomics: An Emerging Approach for Profiling Protein Ubiquitylation in Skeletal Muscle by Samuel O. Lord, Harvey E. Johnston, Rahul S. Samant, Yu‐Chiang Lai

“…The complexity of protein ubiquitylation has presented significant challenges in not only identifying ubiquitylated proteins but also characterising their functional significance. Mass spectrometry enables in‐depth analysis of proteins and their post‐translational modification status, offering a powerful tool for studying protein ubiquitylation and its biological diversity: an approach termed ubiquitylomics. …”
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