Interactions of Prototype Foamy Virus Capsids with Host Cell Polo-Like Kinases Are Important for Efficient Viral DNA Integration. by Irena Zurnic, Sylvia Hütter, Ute Rzeha, Nicole Stanke, Juliane Reh, Erik Müllers, Martin V Hamann, Tobias Kern, Gesche K Gerresheim, Fabian Lindel, Erik Serrao, Paul Lesbats, Alan N Engelman, Peter Cherepanov, Dirk Lindemann

“…Strikingly similar defects were observed when cells infected with single-round wt Gag PFV vectors were treated with a pan PLK inhibitor. Analysis of entry kinetics of the mutant viruses indicated a post-fusion defect resulting in delayed and reduced integration, which was accompanied with an enhanced preference to integrate into heterochromatin. …”
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Virtual reality for older people: effectiveness of a training program for accident prevention by Alina Napetschnig, Wolfgang Deiters, Klara Brixius

“…Virtual reality (VR) applications offer novel opportunities for senior citizens to enhance their functional abilities. Routine activities, like crossing a street, can be simulated and practiced within a virtual environment.ObjectiveThis intervention study investigated the impact of a VR training application (‘Wegfest’) on physical function, fall-related confidence, and cognitive status in senior citizens. …”
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Daily activities and suspected dementia among community-dwelling older adults: a cross-sectional study by Shuhan Yan, Zihan Geng, Jie Zhang, Huahua Liu, Zhifang Chen, Yaqin Shi, Feng Zhang

“…Logistic regression was adopted to assess the influence of daily activities on the risk of suspected dementia after controlling for the covariates. Results The analysis included 2458 individuals. Daily activities included toileting (OR = 1.830, 95%CI 1.581 ~ 2.119), grooming (OR = 1.938, 95%CI 1.659 ~ 2.265), dressing (OR = 1.771, 95%CI 1.542 ~ 2.033), bathing (OR = 1.793, 95%CI 1.591 ~ 2.022), feeding (OR = 1.821, 95%CI 1.565 ~ 2.118), transportation (OR = 1.996, 95%CI 1.743 ~ 2.285), walking (OR = 2.069, 95%CI 1.685 ~ 2.542), telephone (OR = 3.640, 95%CI 2.738 ~ 4.838), housekeeping (OR = 1.415, 95%CI 1.213 ~ 1.649), and taking medications (OR = 1.633, 95%CI 1.451 ~ 1.839) were still related to the incidence of suspected dementia after controlling for age, education, post-retirement work, social activity, drinking, smoking, living with spouses, and diabetes. …”
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The relationship between decision regret, quality of life, and mindfulness in early-stage breast cancer survivors by Yu-Ling Kao, Ming-Shen Dai, Wan-Chen Tsai, Fei-Hsiu Hsiao

“…Multiple regression analysis showed that, after controlling for covariates, lower decision regret levels were associated with higher EORTC QLQ-C30 and QLQ-BR45 function scores. …”
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A review of periostin in orthopedics by Mark D. Wishman, William M. Sgrignoli, Brendan M. Patterson, James V. Nepola, Brian R. Wolf, Maria Bozoghlian, Carter M. Lane, Mitchell C. Coleman, Joseph W. Galvin

“…It investigates POSTN's potential as a biomarker and therapeutic target in orthopedic diseases, with a focus on post-traumatic osteoarthritis (PTOA), addressing the need for a comprehensive analysis of its current and future clinical significance in orthopedic and musculoskeletal health. …”
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Isolated abnormal diffusing capacity for carbon monoxide (iso↓DLco) is associated with increased respiratory symptom burden in people with HIV infection. by Katerina L Byanova, Jessica Fitzpatrick, Amanda K Jan, Maggie McGing, Marlena Hartman-Filson, Carly K Farr, Michelle Zhang, Kendall Gardner, Jake Branchini, Robert Kerruish, Sharvari Bhide, Aryana Bates, Jenny Hsieh, Rebecca Abelman, Peter W Hunt, Richard J Wang, Kristina A Crothers, Laurence Huang

“…<h4>Study design</h4>Cross-sectional analysis.<h4>Methods</h4>We used ATS/ERS compliant PFTs from PWH with normal spirometry (post-bronchodilator FEV1/FVC ≥0.7; FEV1, FVC ≥80% predicted) from the I AM OLD cohort in San Francisco, CA and Seattle, WA, grouped by DLco categorized as normal (DLco ≥lower limit of normal, LLN), mild iso↓DLco (LLN >DLco >60% predicted), and moderate-severe iso↓DLco (DLco ≤60% predicted). …”
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Aryl hydrocarbon receptor signaling in male fertility: Protective role of resveratrol and disruptive effects of CH223191 in adult male rats by Ghadeer Sabah Bustani, Hasan Falah Kashef Alghetaa

“…Background and Aim: The aryl hydrocarbon receptor (AhR) plays a pivotal role in spermatogenesis through its regulatory functions in redox balance and gene expression. This study aimed to investigate the effects of resveratrol (RES), a polyphenolic AhR modulator, and CH223191, a selective AhR antagonist, on male reproductive function in rats by assessing sperm quality, oxidative stress, testicular histopathology, and AhR gene expression. …”
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Approach to mechanical ventilation: a simplified approach for a pulmonologist by Pratap Upadhya, Sanjana H S, Harshith R, Vemuri Mahesh Babu, Karthik Balasoupramaniane, Zeenathaalam Nadaf

“…Successful weaning depends on maintaining stable respiratory function, with close monitoring to prevent post-extubation failure. …”
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Study protocol: a randomised controlled proof-of-concept real-world study – does maximising time in range using hybrid closed loop insulin delivery and a low carbohydrate diet rest... by Shareen Forbes, Faye Baxter, Nicola Baillie

“…Hybrid closed loop (HCL) technologies improve glycaemic time in range (TIR). However, post-prandial glycaemic excursions are still evident. …”
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Lyophilized Small Extracellular Vesicles (sEVs) Derived from Human Adipose Stem Cells Maintain Efficacy to Promote Healing in Neuronal Injuries by Brianna Jones, Rekha Patel, Bangmei Wang, Theresa Evans-Nguyen, Niketa A. Patel

“…To address this, here we demonstrate that hASC sEVs can be stored at room temperature (RT) for two months post lyophilization. <b>Methods:</b> A transmission electron microscope (TEM) and nanoparticle tracking analysis (NTA) were used to validate the morphology of lyophilized RT sEVs. …”
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513 A CTS team approach to investigate skeletal muscle diseases and countermeasures in a donor-derived bioengineered muscle platform by Karly Caples, Vinicius Mariani, Elisabeth Barton, Siobhan Malany

“…Finally, culture media pre- and post-terminal e-stim on Day 21 will be collected for extracellular vesicle (EV) isolation and EVs will be assessed by standard proteomics analysis. …”
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Osteoperiosteal versus osteochondral for autologous transplantation in the treatment of large cystic osteochondral lesions of the talus by Lequan Liu, Jiangtao Jin, Jinping Pan, Huikang Guo, Sen Li, Jisheng Li, Zheng Zhang

“…Results The within-group comparison showed significant improvements in pain severity and function in both groups post-treatment compared with pre-treatment. …”
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Interventional Radiology Management of Renal Artery Stenosis After Kidney Transplant: Single-Center Experience and Management Strategies by Ahmad Mirza, Munazza Khan, Usman Baig, Shameem Beigh, Imran Gani

“…The creatinine levels at one week, three months and one year post-intervention were 2.12 (SD ± 1.00), 1.83 (SD ± 0.63) and 2.15 (SD ± 1.68) mg/dL, respectively. …”
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Young Hip: an exploration into young patients’ (aged > 50 years) expectations following primary total hip arthroplasty: a qualitative study by Louise E Mew, Vanessa Heaslip, Tikki Immins, Thomas W Wainwright

“…Methods: Using interpretive phenomenological analysis (IPA) methodology, ten patients were recruited from one UK hospital. …”
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Explanation of visual components in the form of objects based on Deleuze's theory of form (Case study: Museum of Contemporary Arts and Azadi Tower Collection) by Roya Keyhani, Soroush Mohammadpour, Avideh Talaei

“…He analyzes form through six systemic layers: functional, aesthetic, socio-cultural, environmental, economic-political, and temporal, each contributing uniquely to perception and meaning. …”
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Phenotypic responses of differentiated asthmatic human airway epithelial cultures to rhinovirus. by Jianwu Bai, Steven L Smock, George R Jackson, Kenzie D MacIsaac, Yongsheng Huang, Courtney Mankus, Jonathan Oldach, Brian Roberts, Yu-Lu Ma, Joel A Klappenbach, Michael A Crackower, Stephen E Alves, Patrick J Hayden

“…Genome-wide gene expression changes in ALI cultures following HRV infection at 24 hours post exposure were further analyzed using RNA-seq technology. …”
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Application of PVA hydrogel loaded with luteolin nanoparticles in anti EMT treatment after GBM by Long Zhou, Qingyu Zhao, Lijuan Gu, Renfu Tian, Yong Li, Xiaoxing Xiong

“…Methods: Our objective is to develop an anti- EMT functional hydrogel for post-GBM surgery tamponade. …”
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Evidence that multiple defects in lipid regulation occur before hyperglycemia during the prodrome of type-2 diabetes. by Simon G Anderson, Warwick B Dunn, Moulinath Banerjee, Marie Brown, David I Broadhurst, Royston Goodacre, Garth J S Cooper, Douglas B Kell, J Kennedy Cruickshank

“…<h4>Interpretation</h4>Defects in adipocyte function from excess energy storage as relatively hypoxic visceral and hepatic fat, and impaired mitochondrial fatty acid oxidation may initiate the observed perturbations in lipid metabolism. …”
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Textbooks on the international relations theory: What they talk about, what they keep silent about, and what to do about it by N. V. Yudin

“…The latter imply reliance on extremely shaky philosophical assumptions, which, consciously or not, reproduce post-modernist views on the problems of ontology and epistemology of international relations and international studies. …”
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Anti-inflammatory actions of ripasudil ameliorate experimental autoimmune uveoretinitis in the acute phase by Tomohito Sato, Masaru Takeuchi, Kozo Harimoto, Hideaki Someya, Masataka Ito, Yoshiaki Nishio

“…Ripasudil or its vehicle, PBS, was intraperitoneally administered daily starting from 8 days post-immunisation. Clinical and histopathological examinations and analysis of T cell activation state were conducted. …”
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