The impact of elective spine surgery in Canada for degenerative conditions on patient reported health-related quality of life outcomes by Ragavan Manoharan, Nisaharan Srikandarajah, Jean-Christophe Murray, Christopher Nielsen, Supriya Singh, Sean Christie, Michael M.H. Yang, Michael Weber, Bernard Larue, Adrienne Kelly, Jerome Paquet, Raphaele Charest-Morin, Guy Hogan, Andrew Glennie, Henry Anh, Eugene Wai, Nicolas Dea, Neil Mason, Kenneth Thomas, Charles Fisher, Hamilton Hall, Christopher Bailey, Mayilee Canizares, Yoga Raja Rampersaud

“…This improved to a mean PCS of 40.5 (p < 0.001) and MCS of 49.3 (p < 0.0001) at 1-year post-operatively. The mean pre-operative PCS was over 2 standard deviations (SD) lower than the normative mean of the CGP; this improved to being close to 1-SD from the normative CGP mean at 1-year post-operatively. …”
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High NK cell counts at day 90 predict improved survival in event-free patients after T-cell depleted allogeneic stem cell transplantation by Andrej Pešić, Nevena Bešević, Nicolaus Kröger, Dejana Stanisavljević, Dejana Stanisavljević, Nada Kraguljac Kurtović, Zoran Bukumirić, Zoran Bukumirić, Natalija Kecman, Nikola Lemajić, Mihailo Smiljanić, Nada Suvajdžić Vuković, Nada Suvajdžić Vuković, Andrija Bogdanović, Andrija Bogdanović, Ana Vidović, Ana Vidović, Jelena Bila, Jelena Bila, Mirjana Mitrović, Mirjana Mitrović, Danijela Leković, Danijela Leković, Marijana Virijević, Marijana Virijević, Irena Đunić, Irena Đunić, Darko Antić, Darko Antić, Milena Todorović Balint, Milena Todorović Balint

“…Furthermore, the importance of immune reconstitution parameters in patients previously not experiencing major post-transplant complications is lacking.MethodsWe evaluated the clinical impact of day 90 NK cell, CD4+ T-cell, CD8+ T-cell, B-cell, and NKT cell counts on transplant outcomes by performing a landmark analysis in event-free patients. …”
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Evaluation and Management of Urological Complications Following Pediatric Kidney Transplantation: Experience from a Single Tertiary Center by Maria Sangermano, Enrico Montagnani, Serena Vigezzi, Marco Moi, Alessandro Morlacco, Nicola Bertazza Partigiani, Elisa Benetti

“…<i>Conclusions:</i> Regular post-transplant follow-up is crucial, especially for patients with known risk factors, to allow for timely detection and treatment of urological complications, avoiding detrimental effects on graft function and improving transplantation outcomes.…”
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The effect of probiotic (Clostridium butyricum) on adult patients with atopic dermatitis: a retrospective cohort study from TriNetX by Kuo-Hsiung Shu, Yun-Chien Tsai, Cheng-Hsu Chen, Shang-Feng Tsai

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Spatiotemporal Patterns and Regional Transport Contributions of Air Pollutants in Wuxi City by Mao Mao, Xiaowei Wu, Yahui Zhang

“…Based on the real-time monitoring data of criteria pollutants and GDAS (Global Data Assimilation System) reanalysis data, the spatiotemporal variation patterns, meteorological influences, and potential sources of major air pollutants in Wuxi across different seasons during 2019 (pre-COVID-19) and 2023 (post-COVID-19 restrictions) are investigated using the Pearson correlation coefficient, potential source contribution function (PSCF), and concentration-weighted trajectory (CWT) models. …”
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Efficacy of Yijinjing-inspired exercises on sleep disorders in Parkinson’s disease: a controlled fNIRS study by Zekai Hu, Jing Shi, Jinyan Wang, Ting Liu, Yujia Li, Han Xue, Xueming Jin, Yiting Xue, Jie Wang, Xinhao Liu, Jun Hu

“…Moderate effect sizes were observed in cognition (MoCA: d = 0.43) and motor function (UPDRS: d = 0.40), though these did not retain statistical significance after correction. …”
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Real-World effectiveness of eculizumab in atypical hemolytic uremic syndrome: a retrospective study from Western China by Yun Hu, Yanyan Zhang, Wei Wang, Guisen Li, Shasha Chen

“…To evaluate timing effects, patients were categorized as Early Initiators (treatment within 7 days of symptom onset, n=9) versus Delayed Initiators (treatment beyond 7 days, n=8) The main outcome measures included hematological parameters, renal function, and adverse events.ResultsThe cohort (n=17, 76.5% female, mean age 43.2 ± 20.0 years) demonstrated significant improvements post-eculizumab: creatinine decreased from 647.0 (439.0, 915.0) to 198.5 (86.5, 749.5) μmol/L, eGFR increased from 8.0 (5.0, 11.0) to 22.1 (6.4, 55.1) mL/min/1.73m², platelets rose from 75 ± 11 to 143 ± 33×109/L, and LDH declined from 787.5±908.0 to 232.8 ± 70.0 U/L (all P&lt;0.001). …”
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Transient pharmacological inhibition of SUMOylation during pregnancy induces craniofacial malformations in offspring mice by Jorge Mata-Garrido, Isabella Zafferri, Alice Nordlinger, Yann Loe-Mie, Anne Dejean, Jack-Christophe Cossec

“…Cell identity plays a pivotal role in embryo development, guiding the process of cellular differentiation essential for tissue and organ formation. Post-translational modification by the ubiquitin-related SUMO protein acts as a chromatin barrier to cell fate conversions. …”
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Impaired hippocampal neurogenesis associated with regulatory ceRNA network in a mouse model of postoperative cognitive dysfunction by Jingrun Lin, Xiaoqiu Zhu, Xuan Li, Yu Hong, Yaohui Liang, Siqi Chen, Chenzhuo Feng, Lin Cao

“…The surgery group underwent laparotomy under 1.5% isoflurane anesthesia, while controls received no intervention. Cognitive function was assessed 7–10 days post-surgery using open field, Y-maze, and novel object recognition tests. …”
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Testosterone Deficiency and Lipid Dysregulation in Individuals with Coexisting Hypothyroidism and Type 2 Diabetes: Clinical and Metabolic Implications by Mandayal Jamatia, Mohammad N Khan, Ashok Kumar

“…Various biochemical parameters, including fasting blood sugar (FBS), postprandial blood sugar (PPBS), HbA1c, lipid profile, thyroid hormones, and testosterone, were analyzed. Statistical analysis was performed using analysis of variance and Tukey's <i>post-hoc</i> test to compare group differences, while Pearson's correlation analysis assessed associations between biochemical markers. …”
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Synergistic combinations of Angelica sinensis for myocardial infarction treatment: network pharmacology and quadratic optimization approach by Wen-Di Wang, Xin-Yi Fan, Xiao-Qi Wei, Wang-Jing Chai, Fang-He Li, Kuo Gao, Bin Liu, Bin Liu, Shu-Zhen Guo

“…In vivo, Z-LIG/CGA significantly improved cardiac function and reduced the fibrotic area in mice post-MI, surpassing the results in groups treated with Z-LIG or CGA alone. …”
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IL-37 Gene Modification Enhances the Protective Effects of Mesenchymal Stromal Cells on Intestinal Ischemia Reperfusion Injury by Dejun Kong, Yonghao Hu, Xiang Li, Dingding Yu, Hongyue Li, Yiming Zhao, Yafei Qin, Wang Jin, Baoren Zhang, Bo Wang, Hongda Wang, Guangming Li, Hao Wang

“…Data were analyzed by one-way analysis of variance (ANOVA) after the normality test and followed by post hoc analysis with the least significant difference (LSD) test. …”
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Mesenchymal stromal cells from people with osteoporosis are fewer, and defective in both osteogenic and adipogenic capacity by Féaron C. Cassidy, Ciara Shortiss, Kerry Thompson, Ana Soriano Arroquia, Colin G. Murphy, Stephen R. Kearns, William Curtin, Katarzyna Goljanek-Whysall, Timothy O’Brien, Cynthia M. Coleman

“…It is highly prevalent, especially in post-menopausal women, resulting in high risk of fracture and morbidity. …”
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Clinical diagnostic and prognostic value of homocysteine combined with hemoglobin [f (Hcy-Hb)] in cardio-renal syndrome caused by primary acute myocardial infarction by Min-Juan Zeng, Yan-Quan Liu, Ping Pang, Xiao-Jun Chen, He Huang, Rui-Na Huang, Shi-Sen Li, He-Hui Zhang, Yue Yin, Chang-Sen Wang, Jin-Da Lin, Lin Lin, Shao-Peng Chen, Li Xu, Liang-Qing Zhang

“…Results Correlation analysis revealed a significant negative correlation between f (Hcy-Hb) and eGFR in patients with post-MI treatment (r = -0.45, P < 0.05). …”
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Mannan-Modified PLGA Nanoparticles for Targeted Gene Delivery by Fansheng Kong, Linfu Ge, Ximin Liu, Ning Huang, Fang Zhou

“…The results illustrate that MAN-DNA-NPs have the ability to target liver KCs and could function as promising active targeting drug delivery vectors.…”
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Effects of search intent on eye-movement patterns in a change detection task by Sangil Lee, Minho Lee, Hyeonggyu Park, Mun-Seon Chang, Ho-Wan Kwak

“…Finally, discriminant function analysis showed a reasonable classification rate for identifying a specific intent. …”
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Design of a Wearable Vibrotactile Stimulation Device for Individuals With Upper-Limb Hemiparesis and Spasticity by Caitlyn E. Seim, Brandon Ritter, Thad E. Starner, Kara Flavin, Maarten G. Lansberg, Allison M. Okamura

“…Vibratory stimulation may improve post-stroke symptoms such as spasticity; however, current studies are limited by the large, clinic-based apparatus used to apply this stimulation. …”
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Study protocol for an observational research study with an embedded N-of-1 design: Increasing the availability of goal-oriented cognitive rehabilitation for people living with deme... by Caoimhe Hannigan, Antoine Lemercier, Garret McDermott, Helena Lydon, Sean P Kennelly, Michelle Kelly

“…Sub-study 1 will employ a quantitative pre-post design with an embedded randomized N-of-1 experimental design. …”
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Release of apoptosis inhibitor of macrophage (AIM) from pentameric IgM in serum predicts prognosis after hemodialysis initiation by Keisuke Yasuda, Akemi Nishijima, Tomoko Inoue, Toshio Takagi, Kazunari Tanabe, Jun Minakuchi, Satoko Arai, Toru Miyazaki

“…We determined the fAIM% cutoff of 46.27%, which predicts mortality two years post-dialysis initiation. Conclusions These findings suggest that the serum fAIM% could function as a prognostic marker at dialysis initiation and may have potential as a criterion for determining dialysis timing.…”
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Biphasic behavior of T cell subsets reflects failure of early anti-myeloma response and leads to progressive T cell dysfunction by Suchita Suryakant Jadhav, Vipin Sharma, Aharon Lion, Lasser-Katz Efrat, Iftach Shaked, Galia Luboshits, Michael A. Firer

“…Blood and bone marrow samples were collected on days 80, 150, and 220 post cell inoculation. Blood samples were used to monitor levels of paraprotein and whole blood cell counts. …”
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