Formation of the depreciation policy mechanism of enterprises in the context of strengthening the investment security of the state by V.V.

“…The need to restore the investment potential of the state not only at the expense of external investments, but also to restore the full functioning of the involvement of internal sources requires the formation of new progressive approaches to align the interests of the state and enterprises, especially in the conditions of martial law and post-war reconstruction. …”
Get full text

Effect of Squat Exercises on Fatigue and Quality of Life of Pregnant Women: A Randomized Controlled Trial Study by Maryam Malmir, Seyedeh Zahra Masoumi, Farideh Kazemi, Mansoureh Refaei

“…The effect size of different domains of quality of life varied from 1.51 (energy fatigue) to 3.50 (physical function). The effect size of fatigue was 2.81 (95%CI: 3.36- 2.25, P=0.001). …”
Get full text

Length–Weight Distribution of Non-Zero Elements in Randomized Bit Sequences by Christoph Lange, Andreas Ahrens, Yadu Krishnan Krishnakumar, Olaf Grote

“…The focus of the current work is on detecting deviations from the ideal gap-density function describing randomized bit sequences. For testing and verification purposes, the well-researched post-quantum cryptographic CRYSTALS suite, including its Kyber and Dilithium schemes, is utilized. …”
Get full text

Constructed transferrin receptor-targeted liposome for the delivery of fluvoxamine to improve prognosis in a traumatic brain injury mouse model by Liang Mi, Jiangyuan Yuan, Yuxing Jiang, Yuqian Hu, Chuanxiang Lv, Yongqiang Xu, Mingqi Liu, Tao Liu, Xuanhui Liu, Jinhao Huang, Rongcai Jiang, Wei Quan

Get full text

Toxicities Associated with Systemic Administration of Interleukin-6 in Wistar Albino Rats by Nabisubi P, Mugasa CM, Matovu E, Ssekatawa K, Uwituze V, Ssentamu G, Namayanja M, Kato CD

“…Blood was used to determine liver and renal function, and hematology parameters, while liver and kidney tissue sections were used for histopathological analysis.Results: The results revealed that systemic administration of interleukin-6 for 21 days significantly decreased levels of serum creatinine (p< 0.00) and serum urea (p< 0.01). …”
Get full text

Kidney transplant program in Irkutsk Region by A. V. Novozhilov, S. E. Grigoriev, O. Yu. Yakovleva, S. A. Yezhikeev

“…Length of hospital stay was 16 (range: 13–25) bed days. Primary renal function was achieved in 95 patients (77%), while 25 patients (20%) experienced delayed graft function. …”
Get full text

A 24‐week double‐blind placebo‐controlled study of the efficacy and safety of the AMPA modulator S47445 in patients with mild to moderate Alzheimer's disease and depressive symptom... by Katy Bernard, Sylvie Gouttefangeas, Sylvie Bretin, Stéphanie Galtier, Philippe Robert, Vjera Holthoff‐Detto, Jeffrey Cummings, Maria Pueyo

“…An improvement on neuropsychiatric symptoms assessed by NPI was evidenced at the lower dose 5 mg/d (Δ ‐2.55, P = .023, post hoc analysis) compared to placebo. CSDD and total NPI scores improved in all groups including placebo. …”
Get full text

Safety, pharmacokinetics, and potential benefits of TSH-receptor-specific monoclonal autoantibody K1-70TM in Japanese Graves’ disease patients: results of a phase 1 trial by Jaeduk Yoshimura Noh, Natsuko Watanabe, Koichi Ito, Mika Tsuiki, Yuki Ishihara, Tetsuya Tagami, Ichiro Yamauchi, Ai Kozaki, Toshu Inoue, Bernard Rees Smith

“…Twelve patients were enrolled, divided into four dosage cohorts (5 mg, 25 mg, 75 mg, and 150 mg), and monitored for 100 days post-administration. The primary objective was to assess safety and tolerability, and the secondary objectives were evaluation of PK and thyroid function. …”
Get full text

Kynu inhibition mitigates bile duct ischemic injury by rewiring tryptophan metabolism to restore tight junction integrity by Guoqing Bao, Siliang Zhang, Zhengchen Ye, Ding Luo, Pinduan Bi, Bin Yang

“…Abstract Background Disruption in bile duct barrier function contributes to hepatocyte toxicity in ischemia–reperfusion injury, often leading to surgical complications in liver resection, transplantation, and hemorrhagic shock. …”
Get full text

Perioperative and short-term outcomes of laparoscopic radical prostatectomy in elderly patients by Qi Zhang, Guobin Weng, Xuping Yao, Gang Wang, Jianjun Huang

“…Nonetheless, the recovery time of intestinal function [1 (1, 2) days vs. 1 (1, 1) days] demonstrated a conspicuous difference (P < 0.05). …”
Get full text

Comparisons of anticoagulatory and therapeutic effects of low-molecular-weight heparin sodium versus sodium citrate in patients with severe acute kidney injury on continuous renal... by Munire Abuliz, Zhang Jing-jing, Munire Erken, Li Su-hua, Wang Shun

“…Objective To explore the effects of sodium citrate anticoagulation on inflammatory state in patients with severe acute renal injury（AKI）on continuous renal replacement therapy（CRRT）.Methods From January 2018 to December 2019,50 AKI patients on CRRT in intensive care unit（ICU）were randomly assigned into two groups of sodium citrate（with bleeding tendency or surgical perioperative period）and low-molecular-weight heparin（without bleeding tendency）.The levels of tumor necrosis factor（TNF-a）,interleukin-6（IL-6）,procalcitonin（PCT）,C-reactive protein（CRP）,white blood cell count（WBC）,neutrophil to lymphocyte ratio（NLR）,activated partial thromboplastin time（APTT）,prothrombin time（PT）,thrombin time（TT）,serum total calcium, serum magnesium, blood phosphorus and clinical curative effect were compared between two groups before and after treatment.Results A total of 100 cases/207 times were recruited, including 50 cases/103 times in sodium citrate group and 50 cases/104 times in low-molecular-weight heparin group.After treatment, the declines of TNF-a, IL-6 and PCT was significantly greater in sodium citrate group than those in low-molecular-weight heparin group.And the differences were statistically significant（P<0.05）.The longer treatment duration, the greater reduction.When dialysis duration was >24 h, the decline in NLR was significantly higher in regional citrate group than that in low-molecular-weight heparin group.And the difference was statistically significant（P<0.05）;Further subgroup analysis was carried out for these patients with AKI patients complicated by severe infection.Compared with low-molecular-weight heparin group, the levels of TNF-a, IL-6 and PCT decreased markedly in sodium citrate group at 6/12/24 h post-dialysis.The longer treatment duration, the greater reduction.And the difference was statistically significant（P<0.05）.Significant inter-group differences existed in the declines of WBC at 6/12/24 hours.And the declines of serum levels of phosphorus, magnesium and total calcium were significantly higher in sodium citrate group than those in low-molecular-weight heparin group（P<0.05）.Serum levels of phosphorus and magnesium dropped markedly in sodium citrate group while serum total calcium decreased obviously in low-molecular-weight heparin group.When the duration of dialysis was 6-12 hours, the prolongation of APTT/TT was significantly lower in sodium citrate group than that in low-molecular-weight heparin group.After treatment, no significant inter-group difference existed in the proportion of deceased patients, the recovery of renal function, the proportion of non-recovery of renal function or the proportion of patients with continuous dialysis（P>0.05）.Conclusion Regional use of sodium citrate anticoagulation is not only safe, but also it lowers the inflammatory state in AKI patients in ICU on CRRT.…”
Get full text

Modulation of the Epithelial–mesenchymal transition process by Forkhead Box C2 in the repair of airway epithelium after injury by Yudong Wang, Jun Liu

“…Conclusions These data highlight the important function of FOXC2 as a regulator in repair of bronchial epithelium after injury. …”
Get full text

Yishen-Huoxue formula alleviates renal interstitial fibrosis by attenuating hypoxia-induced renal cell injury and promoting angiogenesis via miR-210/HIF-1α pathway by Mouying Du, Chun Yao, Qinke Lv, Aimei Gong, Yonghua Zhu, Jiayuan Li, Jian Zhong

“…The histopathological changes of rat kidney and its function were evaluated 14 days post-UUO. miRNA sequencing and differential gene analysis identified miR-210 as a potential target of YHF treatment. …”
Get full text

Tokenization of creativity: user motivation, consensual value and Chinese copyright law by R. A. Budnik

“…We constructed the non-fungible token owner's moral right consisting of two powers: the right to designate one's name as the owner of a token for a specific creative product and to demand such an indication from others; and also, as a duty of NFT platforms to support the function of informing about the name or pseudonym of the token's owner.Analysis of the appropriate accumulated knowledge, development, and verification of formulated hypotheses on tokenized works' consensual value and additional economic utility, allowed us to achieve the goals of this study. …”
Get full text

Intelligent Approaches to Computer Testing of Perception and Production Skills of Russian EFL Speakers by Marina Kolesnichenko, Vitalii Kapitan

“…Twenty-five Russian EFL students (B1–B2 CEFR, aged 19–22) completed three test iterations at one-week intervals. Post-test questionnaire assessed usability and perceived learning gains. …”
Get full text

Clinical and genetic characteristics of type 3 lissencephaly caused by a mutation in the TUBA1A gene (OMIM: 611603) by D. M. Guseva, T. V. Markova, L. A. Bessonova, S. S. Nikitin, E. L. Dadali, O. A. Shchagina

“…Possible effects of new missense mutations in the gene on the function of the protein product of the gene are discussed.Conclusions. …”
Get full text

Temporal and Severity-Dependent Alterations in Plasma Extracellular Vesicle Profiles Following Spinal Cord Injury by Jamie Cooper, Scott Tait Airey, Eric Patino, Theo Andriot, Mousumi Ghosh, Damien D. Pearse

“…Using a graded thoracic contusion model in mice, plasma was collected at defined timepoints post-injury. sEVs were isolated via size-exclusion chromatography and characterized using nanoparticle tracking analysis (NTA), transmission electron microscopy (TEM), and MACSPlex surface marker profiling. …”
Get full text

Single-cell sequencing and transcriptomic data reveal that P65 activation significantly promotes microglia-mediated neuroinflammation after ischemic stroke by Ruiyu Wang, Yilun Qian, Xinchen Zhou, Hang Xu, Yu Wang, Yao Geng, Tianshu Wang, Binxiu Sha

“…We identified microglial subtypes associated with inflammatory responses following cerebral ischemia-reperfusion injury, with their proportions increasing post-injury. P65 was confirmed as a critical regulator of the inflammatory response, contributing to neuronal protection and the restoration of neurological function.…”
Get full text

Characterizing the impact of CPSF30 gene disruption on TuMV infection in Arabidopsis thaliana by Yanping Wei, Quan Yuan, Dalal Sulaiman Alshaya, Abdul Waheed, Kotb A. Attia, Sajid Fiaz, Muhammad Shahid Iqbal

“…CPSF30, a key polyadenylation factor, also serves as an m6A reader, playing a crucial role in determining RNA fate post-transcription. While its homologs mammals are known to be vital for viral replication and immune evasion, the full scope of CPSF30 in plant, particular in viral regulation, remains less explored. …”
Get full text

PRIVATIZED VIOLENCE: THE ESSENCE AND TYPES OF ITS IMPLEMENTATION IN MODERN WORLD by Микола Адамович Козловець, Вадим Миколайович Слюсар

“…On the basis of the historical experience analysis and modern practice, the content and specifics of the privatized violence manifestation, mechanisms and factors of its implementation in the modern world are investigated. …”
Get full text