Successful treatment of advanced Birt-Hogg-Dubé syndrome-associated renal cell carcinoma with sarcomatoid dedifferentiation using anlotinib combined with PD-1 inhibitor after first... by Liqi Yi, Chuang Li, Danfeng Xu, Le Xu

“…Routine monitoring of blood counts, liver and kidney function, thyroid function, myocardial enzymes, and cortisol levels revealed no significant adverse effects, underscoring the safety and efficacy of the treatment regimen. …”
Get full text

Health Status After Total Hip Arthroplasty: A Literature Review by Mădălin Bulzan, Florica Voiță-Mekeres, Simona Cavalu, Gheorghe Szilagyi, Gabriel Mihai Mekeres, Lavinia Davidescu, Călin Tudor Hozan

“…This review examines the various factors impacting quality of life (QoL) before and after hip arthroplasty. An analysis of 67 studies reveals significant postoperative enhancements in physical function, pain alleviation, and overall patient satisfaction. …”
Get full text

Interface Alterations in Cellulose Synthases Redefine CESA Complex Assembly to Enhance Cellulosic Biomass Production by Linfang Wei, Huiying Cui, Jiahui Bi, Xili He, Yajun Guan, Yunheng Zhou, Bingcheng Xu, Chuang Ma, Sheng‐You Huang, Shaolin Chen

“…This study integrates evolutionary analysis, structural modeling, and functional data to elucidate the sequence‐structure–function relationships of CESAs. …”
Get full text

RETRACTED ARTICLE: MicroRNA-582–3p negatively regulates cell proliferation and cell cycle progression in acute myeloid leukemia by targeting cyclin B2 by Haixia Li, Xuefei Tian, Paoqiu Wang, Mao Huang, Ronghua Xu, Tian Nie

“…Abstract Background MicroRNAs (miRNAs) function as post-transcriptional gene expression regulators. …”
Get full text

Factors associated with adherence to tablet‐based cognitive training: J‐MINT study by Taiki Sugimoto, Kazuaki Uchida, Kenji Sato, Yoko Yokoyama, Ayaka Onoyama, Kosuke Fujita, Yujiro Kuroda, Satomu Wakayama, Hidenori Arai, Takashi Sakurai, J‐MINT study group

“…Abstract INTRODUCTION Cognitive training is a key component of multidomain interventions to prevent cognitive decline; however, low adherence remains a challenge. In this post hoc analysis of the Japan‐Multimodal Intervention Trial for Prevention of Dementia (J‐MINT), factors associated with cognitive training adherence in older adults with mild cognitive impairment were investigated. …”
Get full text

Clinical outcomes and safety of combined calcitriol and bisphosphonates in treating postmenopausal osteoporosis: a retrospective cohort study by Xu Zhou, Hui Long, Jui-Hua Wang, Zhen Huang, Liping Cao

“…Abstract Objective Despite the well-known benefits of calcitriol and bisphosphonates in managing osteoporosis, limited research has explored the combined therapeutic effects of these agents on bone metabolism, immune function, and clinical outcomes in postmenopausal osteoporosis patients. …”
Get full text

Altered O-Glycans in stimulated whole saliva from patients with primary Sjögren’s syndrome and non-pSS sicca by Sarah Kamounah, Kristina A. Thomsson, Christiane Elisabeth Sørensen, Eric Paul Bennett, Niclas G. Karlsson, Anne Marie Lynge Pedersen

“…Our findings indicate that the salivary mucin-type O-glycan profile is altered in pSS, reflecting a dysfunction of the post-translational modification of salivary mucins leading to rheological changes of saliva, oral dryness symptoms, and impaired oral mucosal barrier function. …”
Get full text

Effects of Three Sessions of Diaphragmatic Myofascial Release on Pain, Balance, and Quality of Life in Patients with Chronic Nonspecific Low Back Pain (A Regional Interdependence M... by soheil hejazi yekta, kazem malmir, Sara Fereydounnia, Khadijeh Otadi, Fatemeh Ehteshami

“…Improving diaphragm function may yield positive effects on chronic LBP. …”
Get full text

B cell maturation antigen (BCMA) is dispensable for the survival of long-lived plasma cells by Shannon R. Menzel, Edith Roth, Jens Wittner, Stefanie Brey, Leonie Weckwerth, Jana Thomas, Thomas H. Winkler, Wolfgang Schuh, Hans-Martin Jäck, Katharina Pracht, Sebastian R. Schulz

“…To unequivocally establish BCMA’s function in plasma cell survival, we generate two BCMA-deficient mouse lines and examine antigen-specific plasma cells post-immunization. …”
Get full text

Patient-Specific Bilateral Talus Replacement: A Case Report by Vladimir V. Skrebtsov, Victor G. Protsko, Alexander V. Skrebtsov, Sargon K. Tamoev, Vasilii V. Kuznetsov

“…Preoperative evaluation showed the following scores: Visual Analog Scale (VAS) — 9 points, American Orthopedic Foot and Ankle Society Ankle-Hindfoot Scale (AOFAS AH) — 25 points, and Foot Function Index (FFI) — 139 points. The diagnosis was confirmed: avascular necrosis of the talus in both feet with bilateral grade 3 post-traumatic ankle osteoarthritis. …”
Get full text

Heart Rate Variability in Young Adults with Bronchial Asthma with and without Previous COVID-19 Infection: A Cross-sectional Study by Gunaseelan Deivendran, Thamarai Selvi Kanagaraj, Bhavisha Sreenivasan Leelabai, Nalini Jayanthi, Saravanan Ayyavoo

“…Introduction: Heart Rate Variability (HRV) is a validated, non invasive measure of Autonomic Nervous System (ANS) function. Both bronchial asthma and post Coronavirus Disease-2019 (COVID-19) syndrome are independently associated with autonomic dysregulation. …”
Get full text

Outcomes following pharyngeal reconstruction in total laryngectomy – Institutional experience and review of literature by Deepak Balasubramanian, Narayana Subramaniam, Priyank Rathod, Samskruthi Murthy, Mohit Sharma, Jimmy Mathew, Krishnakumar Thankappan, Subramania Iyer

“…Partial pharyngeal defects were associated with a higher risk of PCF on univariate analysis (P = 0.006) but were not significant on multivariate analysis. …”
Get full text

Cloning and expression profile of an ubiquitin-conjugating enzyme-like gene OsCROC-1A in rice (Oryza sativa L.) by WANG Ya, LIU Jianping, XU Mengyun, JI Weijie, TU Jumin, ZHANG Xiaobo

“…Protein ubiquitination is a fundamental post-translational modification event that serves as a signaling function in diverse biological processes. …”
Get full text

Iron regulatory pathways differentially expressed during Madurella mycetomatis grain development in Galleria mellonella by Imad Abugessaisa, Mickey Konings, Ri-Ichiroh Manabe, Cathal M. Murphy, Tsugumi Kawashima, Akira Hasegawa, Chitose Takahashi, Michihira Tagami, Yasushi Okazaki, Kimberly Eadie, Wilson Lim, Sean Doyle, Annelies Verbon, Ahmed H. Fahal, Takeya Kasukawa, Wendy W. J. van de Sande

“…Larvae were infected with M. mycetomatis and, after 4, 24, 72 and 168 h post-inoculation, RNA was extracted from larval content and sequenced. …”
Get full text

Palmitoylation regulators drive the progression of clear cell renal cell carcinoma through Inhibition of cuproptosis: insights into the role of ZDHHC18 by Wei Xu, Xiao-chao Chen, Yang Wang, Jian-chun Chen, Zhi-jun Cao, Ru Huang, Chao Chen, Dao-rong Hou, Min-jun Jiang, Chen Xu

“…Abstract Background Protein palmitoylation is a reversible post-translational modification that increases protein hydrophobicity, which can affect protein localization, stability, and function. …”
Get full text

Probiotics mitigate stress and inflammation in malnourished adults via gut microbiota modulation: a randomized controlled trial by Maryam Ahmadi-Khorram, Maryam Ahmadi-Khorram, Alireza Hatami, Alireza Hatami, Parastoo Asghari, Parastoo Asghari, Ali Jafarzadeh Esfehani, Asma Afshari, Fateme Javdan, Fateme Javdan, Mohsen Nematy, Mohsen Nematy

“…ObjectiveMalnutrition negatively affects mental health by altering neurotransmitter function and increasing stress responses. The gut-brain axis is pivotal in this process, and probiotics may mitigate stress. …”
Get full text

Wear evaluation method of drilling shaft sinking hob based on rock slag morphology and rock abrasiveness by Hua CHENG, Bao XIE, Zhishu YAO, Chuanxin RONG, Jian LIN

“…Secondly, the rock slag of shaft drilling rig is pretreated on site, and the image recognition method is used for post-processing, and the geometric morphology of rock slag is statistically analyzed, and its cumulative distribution law is described by exponential distribution function. …”
Get full text

Rehabilitation after bone marrow transplant compared with usual care to improve patient outcomes (REBOOT): protocol for a randomised controlled trial by Linda Denehy, Shaza Abo, Christopher Swain, Camille E. Short, Nicole Kiss, Amit Khot, Eric Wong, Duncan Purtill, Clare O’Donnell, Marlena Klaic, Catherine L. Granger, Michelle Tew, Tim Spelman, Vinicius Cavalheri, Lara Edbrooke, on behalf on the REBOOT research team

“…The primary outcome is patient reported physical function measured using the EORTC QLQ-C30 version 3. …”
Get full text

Altered Lactylation Myocardial Tissue May Contribute to a More Severe Energy-Deprived State of the Tissue and Left Ventricular Outflow Tract Obstruction in HOCM by Ruoxuan Li, Jing Wang, Jia Zhao, Jiao Liu, Yuze Qin, Yue Wang, Yiming Yuan, Nan Kang, Lu Yao, Fan Yang, Ke Feng, Lanlan Zhang, Shengjun Ta, Bo Wang, Liwen Liu

“…We used the COIP experiment to verify the omics results and the ELISA assay to verify the function of the enzymes. We found that a decrease in lactylation modifications also led to a decrease in enzyme function. …”
Get full text

Effectiveness of a school-based high-intensity interval training intervention in adolescents: study protocol of the PRO-HIIT cluster randomised controlled trial by Yong Liu, Alan R. Barker, Anna-Lynne R. Adlam, Minghui Li, Stephanie L. Duncombe, Andrew O. Agbaje, Yaodong Gu, Huiyu Zhou, Craig A. Williams

“…Therefore, a PRO-HIIT intervention will be conducted to evaluate the effectiveness of a 12-week school-based HIIT intervention on cardiorespiratory fitness, physical activity, body composition, muscular strength, bone health, cognitive function, wellbeing and academic performance among 12–13-year-olds.Methods and analysisEight classes of year 7 students (12–13-year-olds) from a secondary school in Ningbo, China, will be recruited and randomly allocated into an intervention or control group. …”
Get full text