Serious issues with cryo-EM structures of human prothrombinase by James A. Huntington, Alexandre Faille, Fatma Isik Ustok

“…In this article, we provide a post hoc analysis of the quality of the reported coordinates and maps, and look closely at the claimed intermolecular contacts on which the supposed breakthrough depends. …”
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Surgical timing and approach for brainstem cavernous malformation warranting thorough preoperative evaluation by Xiao Qian, Weihai Ning, Deshan Liu, Yanming Qu, Hongwei Zhang

“…Patients were divided into groups with favorable and unfavorable outcomes based on their best post-treatment modified Rankin Scale (mRS) scores. …”
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The Effect of Different Bonding Agents on the Bond Strength of Denture Teeth to Acrylic Resin by Neha Verma, Dhanya P. Nampoothiri, Deepika R. Pai, Upasana Reddy, Deepthi Venugopalan, Justin Ninan

“…Group C was found to be superior to Groups A and B by post-hoc analysis. Conclusion: Bonding agents significantly improve the adhesion of denture teeth to AR. …”
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Glycosylation of serine/threonine-rich intrinsically disordered regions of membrane-associated proteins in streptococci by Mohammad M. Rahman, Svetlana Zamakhaeva, Jeffrey S. Rush, Catherine T. Chaton, Cameron W. Kenner, Yin Mon Hla, Ho-Ching Tiffany Tsui, Vladimir N. Uversky, Malcolm E. Winkler, Konstantin V. Korotkov, Natalia Korotkova

“…We link this phenotype to the C-terminal IDR of the post-translocation chaperone PrsA. Our data reveal that O-linked glycosylation protects the IDR-containing proteins from proteolytic degradation and is critical for the biological function of PrsA in biofilm formation.…”
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Quantitative crack evaluation in slender reinforced concrete walls with rectangular section by Priyana Rajbhandari, Chanipa Netrattana, Taku Obara, Kono Susumu

“…Past earthquakes have shown that cracking affects post-earthquake functionality and accounted for huge repair costs for reinforced concrete (RC) wall buildings, even though the code-compliant seismic design prevents collapse. …”
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Generation and clearance of myelin debris after spinal cord injury by Chaoyuan Li, Wenqi Luo, Irshad Hussain, Renrui Niu, Xiaodong He, Chunyu Xiang, Fengshuo Guo, Wanguo Liu, Rui Gu

“…The abnormal buildup of myelin debris at sites of injury greatly impedes nerve regeneration, making the clearance of debris within these microenvironments crucial for effective post-spinal cord injury repair. In this review, we comprehensively outline the mechanisms that promote the clearance of myelin debris and myelin metabolism and summarize their roles in spinal cord injury. …”
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Coactivator-associated arginine methyltransferase 1 promotes cell growth and is targeted by microRNA-195-5p in human colorectal cancer by Meifeng Zhang, Wei Wu, Ming Gao, Jie Zhang, Xinde Ding, Ronghua Zhu, Haiqun Chen, Zhewei Fei

“…Using bioinformatics-based prediction and luciferase reporter system, we found that coactivator-associated arginine methyltransferase 1 is post-transcriptionally targeted by microRNA-195-5p in colorectal cancer. …”
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Genetic polymorphism of interferon regulatory factor 5 (IRF5) correlates with allograft acute rejection of liver transplantation. by Xiaobo Yu, Bajin Wei, Yifan Dai, Min Zhang, Jian Wu, Xiao Xu, Guoping Jiang, Shusen Zheng, Lin Zhou

“…IRF-5, a member of Interferon Regulatory Factors, functions as a key regulator in TLR4 cascade, and is capable of inducing inflammatory cytokines. …”
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PcG-mediated higher-order chromatin structures modulate replication programs at the Drosophila BX-C. by Federica Lo Sardo, Chiara Lanzuolo, Federico Comoglio, Marco De Bardi, Renato Paro, Valerio Orlando

“…Polycomb group proteins (PcG) exert conserved epigenetic functions that convey maintenance of repressed transcriptional states, via post-translational histone modifications and high order structure formation. …”
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Chronic Trichuris muris Infection in C57BL/6 Mice Causes Significant Changes in Host Microbiota and Metabolome: Effects Reversed by Pathogen Clearance. by Ashley Houlden, Kelly S Hayes, Allison J Bancroft, John J Worthington, Ping Wang, Richard K Grencis, Ian S Roberts

“…Changes in microbial composition occurred between 14 and 28 days post infection, resulting in significant changes in α and β- diversity. …”
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Transforming Heritage into Innovation Spaces: Exploration of Heritage Helix Ecosystems by Gozde Yildiz, Asli Hetemoglu-Venedik

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M64HCl, a focal adhesion kinase activator, promotes intestinal mucosal healing in rats by Guiming Liu, Ahmed Adham R. Elsayed, Louis Boafo Kwantwi, Ricardo Gallardo-Macias, Vadim J. Gurvich, Marc D. Basson

“…Immediately after injury, rats received either a continuous infusion of M64HCl (25 mg/kg/day) or its vehicle (saline). Four days post-injury, blood was drawn to measure M64HCl levels and assess liver and kidney function. …”
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Effects of Surgery on Hemodynamics and Postoperative Delirium in Stanford Type A Aortic Dissection by Fan Y, Liu X, Li Z, Xiang D

“…Group sizes differ due to retrospective categorization based on observed outcomes rather than controlled sampling.Results: ① Hemodynamic parameters: Postoperative MAAD and LVEDd were significantly reduced, while LVEF increased compared to preoperative levels (P < 0.05). ② Surgical and postoperative conditions: Group A had longer surgery, cardiopulmonary bypass, and deep hypothermic circulatory arrest times than Group B (P < 0.05). ③ Univariate analysis of baseline data: Group A had higher rates of patients aged ≥ 60, hypertension, history of stroke, and elevated preoperative D-dimer levels (P < 0.05). ④ Multivariate logistic analysis: Independent risk factors for postoperative delirium included age ≥ 60, hypertension, history of stroke, surgery time > 6 hours, cardiopulmonary bypass time > 3 hours, and deep hypothermic circulatory arrest time > 40 minutes (OR > 1, P < 0.05).Conclusion: Surgical treatment of Stanford Type A aortic dissection has a good effect, significantly improving long-term cardiac function. …”
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Network Pharmacology and Serum Nontargeted Metabolomics Reveal the Protective Effects of Propionate Against Liver Damage Induced by a High-Fat and AGE-Rich Diet in Diabetic Mice by Liang Wu, Jiajun Tan, Wen Sun, Xueyun Dong, Jiayuan He, Asmaa Ali, Min Chen, Leilei Zhang, Pingping Wang

“…Network pharmacology analysis showed that NaP has anti-inflammatory and antioxidant effects, mainly involving multiple targets such as mitochondrial function, insulin resistance, and glucose metabolism. …”
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LZTR1 expression as a novel predictive biomarker for early recurrence of hepatocellular carcinoma by Xi Yu, Shuqi Mao, Yuying Shan, Kedan Cen, Caide Lu, Yi Huang

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Application of Imaging Algorithms for Gas–Water Two-Phase Array Fiber Holdup Meters in Horizontal Wells by Ao Li, Haimin Guo, Yue Niu, Xin Lu, Yiran Zhang, Haoxun Liang, Yongtuo Sun, Yuqing Guo, Dudu Wang

“…In the experiment, GAT was utilized for real-time water holdup measurement, and the acquired sensor data were analyzed using three interpolation algorithms: simple linear interpolation, inverse distance weighted interpolation, and Gaussian radial basis function interpolation. The results were subsequently post-processed and visualized with 2020 version MATLAB software, generating two-dimensional representations of water holdup in the wellbore. …”
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Quantitative micro-CT-derived biomarkers elucidate age-related lung fibrosis in elder mice by Davide Buseghin, Andrea Grandi, Erica Ferrini, Gino Villetti, Roberta Ciccimarra, Nicola Sverzellati, Andrea Aliverti, Francesca Pennati, Franco Fabio Stellari

“…After fibrosis induction, animals received Nintedanib once-daily for two weeks and longitudinally monitored by micro-CT, which provided structural and functional biomarkers, followed by post-mortem histological analysis as terminal endpoint. …”
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Everolimus in clinical practice after liver transplantation: a single-center experience by O. A. Gerasimova, D. A. Granov, F. K. Zherebtsov

“…Aim. Single-center analysis of everolimus treatment after liver transplantation. …”
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Rearrangement of the liver ubiquitome and NEDDylome in metabolic dysfunction-associated steatotic liver disease by Teresa C. Delgado, Benoît Lectez, Marina Serrano-Maciá, Fernando Lopitz-Otsoa, Leire Uraga-Gracianteparaluceta, Ibon Martínez-Arranz, Jesús M. Arizmendi, Kerman Aloria, Mikel Azkargorta, Félix Elortza, James D. Sutherland, Rosa Barrio, Ugo Mayor, María Luz Martínez-Chantar

“…Ubiquitinated proteins were enriched in processes related to endoplasmic reticulum and peroxisomal lipid metabolism, while NEDDylated targets primarily localized to mitochondrial pathways. Proteomic analysis revealed impaired proteasome function, endoplasmic reticulum stress, and mitochondrial dysfunction, suggesting that dysregulation of ubiquitin-like PTMs plays a critical role in MASLD. …”
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Effect of sodium-glucose co-transporter 2 inhibitor on contrast-induced acute kidney injury and prognosis in type 2 diabetes patients undergoing percutaneous coronary intervention by Shicheng Yang, Huifang Hao, Xiufeng Zhai, Peng Zhang, Naikuan Fu

“…Patients were grouped based on dapagliflozin use (dapagliflozin vs. no dapagliflozin). Renal function was assessed before PCI, 48 h, and 1 week post-PCI, measuring serum creatinine, estimated glomerular filtration rate, cystatin C, and neutrophil gelatinase-associated lipocalin. …”
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