Predictors and lesion patterns of dysphagia and swallowing outcomes after acute intracerebral hemorrhage by Xiao Hu, Min Wang, Zijie Wang, Yanfang Xie, Mengqiu Zhang, Shanyu Zhang, Tiannan Yang, Chuanqin Fang, Libo Zhao, Yanghua Tian, Qi Li

“…Objectives: This study aimed to explore associated lesion patterns and contributing factors of post-ICH dysphagia, and predict dysphagia outcomes following ICH. …”
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Constructing a research model for liver regeneration by using hepatocyte-like organoid derived from human pluripotent stem cells by WANG Chenxi, YANG Shuchun, JIA Yuyan, HUANG Yue

“…HLO as a model for liver regeneration studies was further evaluated by morphological observation, RT-qPCR, Western blot and pathological analysis. Results Morphology evidence as well as expres-sion of marker genes showed that hPSCs-derived HLO was able to initiate a post-injury regeneration response after APAP treatment. …”
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Effect of Myofascial Release with Kinesiotaping on Flexibility, Strength, and Sprint Performance in Recreational Football Players with Hamstring Tightness: A Randomized Trial by Irivichetty Sai chandana, Vinod Kumar Kanakapura Chananke Gowda, Feba Roy

“…Results: Statistical analysis revealed significant improvements in AKE test scores, hamstring strength, and sprint times for both groups (p < 0.001). …”
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Effects of basic life support training on the knowledge of healthcare students: A quasiexperimental and multicenter study by Lucas Casagrande Passoni Lopes, Camila Bertoni Palis Samor, Guilherme Santos da Silva, Helena Vasconcelos Guimarães, Rodrigo Kendi Murakami, Tereza Cristina Ribeiro Vilas Boas, Winicius Loureiro de Albuquerque, Marcos Marton Antonio Filho, Rodrigo Magri Bernardes

“…BACKGROUND: Cardiac arrest (CA) is defined as the sudden cessation of effective cardiac function. This condition is highly prevalent worldwide and is associated with significant morbidity and mortality. …”
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The value of echocardiography in the staging of preexcitation syndrome and the assessment of left ventricular wall dyskinesia in children by Yahui Yuan, Shu Li, Jun Chen, Yu Mao, Ming Yang, Shiwei Yang, Wentao Kong, Hao Liu

“…All the postoperative ultrasound parameters were better than the preoperative ones, and the results of the 3-month postoperative review showed that there was a difference between the ventricular synchronisation indexes and those of the healthy group, suggesting that the LV synchronisation had not yet completely returned to normal. ROC curve analysis showed GLS, TDSD, TDRV−LV, PSD and MPTD could predict the prognosis of recovering post RFA.ConclusionsConventional echocardiography and two-dimensional speckle tracking imaging have the capacity to provide reference data for the reduction of cardiac function and ventricular wall motion disorder caused by WPWs. …”
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Milk sialyl-oligosaccharides mediate the early colonization of gut commensal microbes in piglets by Ryoga Hashimoto, Keita Nishiyama, Fu Namai, Kasumi Suzuki, Taiga Sakuma, Itsuko Fukuda, Yuta Sugiyama, Kenji Okano, Takafumi Shanoh, Eita Toyoshi, Ryusuke Ohgi, Sudeb Saha, Sae Tsuchida, Eri Nishiyama, Takao Mukai, Mutsumi Furukawa, Tomonori Nochi, Julio Villena, Wakako Ikeda-Ohtsubo, Gou Yoshioka, Eri Nakazaki, Yoshihito Suda, Haruki Kitazawa

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Surgical management of skull base and spinal chordomas: A case series with comprehensive review of the literature by Sarah Lee, Nahom Teferi, Juan Vivanco-Suarez, Ajmain Chowdhury, Stephen Glennon, Kyle Kato, Tyson Matern, Kathryn L. Eschbacher, Michael Petronek, Patrick Hitchon

“…Post op- 90 [60–100], p = .0911) and all patients either maintained or improved their neurological function. …”
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Effect of Acute Resistance Exercise and Resistance Exercise Training on Central Pulsatile Hemodynamics and Large Artery Stiffness: Part II by Denis J. Wakeham, Gary L. Pierce, Kevin S. Heffernan

“…Summary: Our reanalysis of key studies assessing arterial stiffness in the hour post-RE suggests changes in both load-dependent and load-independent indices of arterial (aortic) stiffness. …”
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Intraoperative change in distal motor latency as a predictor for clinical outcome after mini-OCTR: a retrospective cohort study by Mingjie Zhou, Mingjie Zhou, Mingjie Zhou, Mingjie Zhou, Mingjie Zhou, Mingjie Zhou, Chuxiang Chen, Chuxiang Chen, Chuxiang Chen, Chuxiang Chen, Chuxiang Chen, Chuxiang Chen, Chenpei Xu, Chenpei Xu, Chenpei Xu, Chenpei Xu, Chenpei Xu, Chenpei Xu, Biao Yan, Philippe Liverneaux, Philippe Liverneaux, Su Jiang, Su Jiang, Su Jiang, Su Jiang, Su Jiang, Su Jiang, Su Jiang

“…Multivariate and simple logistic regression analyses were used to quantify the predictive value of LRP on postoperative outcomes.ResultsThe results of patient-reported outcome measures (PROMs) demonstrated that Mini-OCTR was an effective procedure in treating CTS generally with some of the patients experiencing significant improvement in sensory function at 1 day Post-op. Multivariate logistic regression analysis which involves demographic information, CTS-related medical history, electrodiagnostic test results, PROMs and LRP revealed that the prognostic model has high AUC and accuracy, and LRP is a significant predictor among all the involved variables. …”
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Application of Isokinetic Dynamometry Data in Predicting Gait Deviation Index Using Machine Learning in Stroke Patients: A Cross-Sectional Study by Xiaolei Lu, Chenye Qiao, Hujun Wang, Yingqi Li, Jingxuan Wang, Congxiao Wang, Yingpeng Wang, Shuyan Qie

“…Background: Three-dimensional gait analysis, supported by advanced sensor systems, is a crucial component in the rehabilitation assessment of post-stroke hemiplegic patients. …”
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Genomic insights into mRNA COVID-19 vaccines efficacy: Linking genetic polymorphisms to waning immunity by Min-Jia Hsieh, Ping-Hsing Tsai, Pin-Hsuan Chiang, Zih-Kai Kao, Zi-Qing Zhuang, Ai-Ru Hsieh, Hsiang-Ling Ho, Shih-Hwa Chiou, Kung-Hao Liang, Yu-Chun Chen

“…We hypothesize that specific gene variants may modulate the development of vaccine-initiated immunity, leading to impaired immune function. This study investigates genetic determinants influencing the sustainability of immunity post-mRNA vaccination through a genome-wide association study (GWAS). …”
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MicroRNA: sex steroids, hormonal carcinogenesis, hormonal sensitivity of tumor tissue by A. V. Malek, L. M. Bershtein

“…As a result, the effect of many microRNA is converging on the single mRNA, results in suppression of corresponding protein function and, in the end, leads to inhibition of regulatory cascade downstream of sex steroids.Finally, the analysis of the fundamental aspects of sex hormones – microRNA interplay is supplemented by brief overview of clinically significant problems. …”
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Dynamic development of gut microbiota and metabolism during and after weaning of kittens by Hong Zhang, Yang Ren, Siyu Wei, Hongli Jin, Yizhen Wang, Mingliang Jin

“…In this study, we conducted a comprehensive investigation of the dynamic changes in the gut microbiota, serum metabolism, antioxidant capacity, and immune function of kittens at various time points: days 0, 4, and 30 post-weaning. …”
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Cardiac Sympathetic Denervation Mitigated Ischemic Cardiomyopathy Progression in a Rat Model of Sleep Apnea by Maximin Détrait, Jonathan Gaucher, Emma Billoir, Sophie Bouyon, Emeline Lemarié, Stéphanie Paradis, Guillaume Vial, Florent Chuffart, Côme Pasqualin, Fabien Hubert, Francesca Rochais, Stéphane Doutreleau, Jean‐Louis Pépin, Diane Godin‐Ribuot, Elise Belaidi, Claire Arnaud

“…At 14 weeks, sympathovagal balance, cardiac function, and remodeling were evaluated. Results Post myocardial infarction, CSD prevented IH‐induced blunting of cardiomyocyte response to isoproterenol challenge and reduced cardiac sympathetic activity. …”
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PO10 | Clinical and laboratory features of long-Covid syndrome: a cross-sectional study of 1,337 Covid-19 survivors

“… Background: The term ‘long-Covid’ is used to describe in Covid-19 survivors the persistence of symptoms beyond 4 weeks and includes ‘ongoing symptomatic’ (4-12 weeks) and ‘post-Covid-19’ syndrome (>12 weeks) phases, based on symptoms’ duration. …”
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Perceptions, expectations and experiences of recovery before and after anterior cruciate ligament reconstruction: the patient voice – a protocol for a qualitative systematic review... by Alison B Rushton, Nicola R Heneghan, Andrew Middlebrook, Charlotte Halpin

“…Individuals commonly believe that post-ACLR, they will eventually return to preinjury levels of function. …”
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SBRT for bridging and downstaging HCC before transplant by Zhihao Li, Michael Yan, Marco P.A.W. Claasen, Luckshi Rajendran, Christian T.J. Magyar, Saheli Saha, Cameron Lee, Nazia Selzner, Elmar Jaeckel, Anand Ghanekar, Mark Cattral, Blayne A. Sayed, Markus Selzner, Ian McGilvray, Chaya Shwaartz, Trevor Reichman, Grainne M. O’Kane, Arndt Vogel, Robert C. Grant, Tae Kyoung Kim, Catherine Soo-Yee Naidoo, Ali Hosni, Rebecca Wong, Aruz Mesci, Jelena Lukovic, Aisling Barry, John Kim, Laura A. Dawson, Gonzalo Sapisochin

“…Endpoints, included treatment-related toxicities, liver function decline, and LT probability post SBRT, were analyzed using competing risk analysis. …”
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Exploring the patient's recovery journey and information needs following a shoulder fracture: A qualitative interview study. by Pauline May, Firoza Davies, Gillian Yeowell, Chris Littlewood

“…The themes identified were dependence, vulnerability, information needs, and recovery. Loss of function and identity were associated with dependence. …”
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Mis-localization of endogenous TDP-43 leads to ALS-like early-stage metabolic dysfunction and progressive motor deficits by Yiying Hu, Alexander Hruscha, Chenchen Pan, Martina Schifferer, Michael K. Schmidt, Brigitte Nuscher, Martin Giera, Sarantos Kostidis, Özge Burhan, Frauke van Bebber, Dieter Edbauer, Thomas Arzberger, Christian Haass, Bettina Schmid

“…Behavior was investigated by video tracking and quantitative analysis of swimming parameters. RNA sequencing was used to identify mis-regulated pathways with validation by molecular analysis. …”
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Effect of initial dialysis dose on survival in peritoneal dialysis patients by Wang Xiao-pei, Ma Ying, Lyu Jing, Lu Wang-hong, Liang Chang-na, Qian Bao, Jin Yin-Hong

“…Objective To compare the effect of initial daily dialysis dose of 8 L versus 6 L on the survival rate in peritoneal dialysis（PD）patients with different baseline residual renal function.Methods From January 2012 to December 2019,504 PD patients treated over 3 months were enrolled retrospectively.According to the baseline value of estimated glomerular filtration rate（eGFR）,they were divided into three groups.That was eGFR<4 mL·（min·1.73 m²）^-1in group A（n=52）,4-6 mL·（min·1.73 m²）^-1in group B（n=156）and≥6 mL·（min·1.73 m²）^-1in group C（n=296）.Primary etiologies, laboratory parameters at Month 1 post-PD,peritoneal transport functions and clinical outcomes were recorded.The survival rate of different initial daily dialysis doses（6 L versus 8 L）was compared among 3 groups.Results The 5-year survival rates of three groups were 64.0%,79.0% and 71.6% respectively.And there was no statistical difference（P=0.306）.Kaplan-Meier analysis indicated that, except for group C,median survival time of PD patients with 6 L initial dialysis dose was lower than that with 8 L in group A/B（48.78±7.18 versus 95.46±7.18 months, χ²=5.439 P=0.020,79.78±5.87 versus 99.66±4.09 months, χ²=4.509,P=0.034）.No significant difference existed in survival time of patients with 8 L/d with different timing of dialysis（χ²=0.280,P=0.870）.Multivariate Cox regression analysis revealed that diabetes mellitus, baseline hypoalbuminemia and advanced age were independent risk factors for patient mortality.The initial daily dialysis dose of 8 L was a protective factor（OR=0.577,95%CI 0.336-0.990,P=0.037）.Peritoneal transport function and baseline eGFR had no effect upon the prognosis of PD patients.Conclusions For PD patients with poor residual renal function at the initiation of PD,low dialysis dose independently predicts patient mortality.And 8 L initial daily dialysis dose yields no greater survival benefits than 6 L/d in those with eGFR≥6 mL·（min·1.73 m²）^-1at the initiation of dialysis.…”
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