Proinflammatory Cytokines Trigger the Onset of Retinal Abnormalities and Metabolic Dysregulation in a Hyperglycemic Mouse Model by Gaganashree Shivashankar, Julie C. Lim, Monica L. Acosta

“…To further understand and validate the metabolic biomarkers of DR, we investigated the effect of intravitreal proinflammatory cytokines on the retinal structure, function, and metabolism in an in vivo hyperglycemic mouse model. …”
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Association between insulin resistance and left ventricular remodeling after STEMI in patients without a history of diabetes mellitus by YANG Chendie, HU Changqing, YUAN He, TAY Guan Poh, AMUTI Abulikemu, ZHANG Ruiyan, WANG Xiaoqun

“…Multivariate regression analysis demonstrated that higher HOMA-IR was independently associated with greater LV dilation after STEMI, even after adjusting for age, gender, traditional risk factors (history of hypertension, body mass index, smoking status, renal function and lipid profiles), pharmacological treatment, baseline LV ejection fraction and peak troponin levels. …”
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Human umbilical cord mesenchymal stem cells-derived extracellular vesicles as a therapeutic approach to ameliorate bladder injury in animal models of radiation cystitis by Parmida Sadat Pezeshki, Amir Mahboubi, Negar Mohammadi Ganjaroudi, Reza Ghalehtaki, Masoumeh Majidi Zolbin, Samaneh Salarvand, Somayeh Jolany Vangah, Asma Mehrjoo, Abdol-mohammad Kajbafzadeh

“…Pro-inflammatory cytokines TNF-α, IL-1ß, and IL-6 were markedly lowered and their levels were similar to the non-radiated NC group in LT-treated rats (p = 1.00, p = 0.22, p = 0.16), 24 weeks post-irradiation. Conclusions Local huMSC-EVs therapy effectively reduces RC-related bladder injury and preserves function, likely by modulating inflammatory response and epithelial regeneration. …”
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Dayuan Yin alleviates symptoms of HCoV-229E-induced pneumonia and modulates the Ras/Raf1/MEK/ERK pathway by Rui Li, Wen Zhang, Bei Huang, Guotong Sun, Yifei Xie, Junke Song, Shumei Wang, Guanhua Du

“…This study employed an HCoV-229E virus-infected mouse model to investigate the therapeutic potential and underlying molecular mechanisms of DYY on virus-induced pneumonia. The respiratory function and organ indices post-treatment were assessed. …”
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Efficacy of Cooling Blankets and Cold Fluid Infusions in Classic Heatstroke Treatment: A Controlled Study in Rats by Chen L, Liu C, Zhang Z, Zhang Y, Feng X

“…Blood samples were taken at 0.5 and 2 hours post-cooling for analysis. Half the rats underwent pathological evaluation and apoptosis analysis of heart and kidney tissues at 2 hours. …”
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Are physical factors associated with poor prognosis following a whiplash trauma?: a protocol for a systematic review and data synthesis by Deborah Falla, Alessio Gallina, Ahmed Alalawi

“…Observational cohort studies will be considered if they involve participants with acute WAD followed for at least 3 months post-injury. Studies will be required to assess the prognostic ability of one or more physical factors that directly involve a body function and/or structure and can be measured objectively. …”
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The implications of surgery on sexual dysfunction in patients with lumbar disc herniation with cauda equina syndrome: a systematic review by Zahra Moradi, Shadab Shahali, Fazlollah Ahmadi, Ali Montazeri

“…Conclusion Studies indicated a considerable enhancement in sexual function post-surgery for lumbar disc herniation patients (68% to 99%). …”
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A competitive protein interaction network buffers Oct4‐mediated differentiation to promote pluripotency in embryonic stem cells by Silvia Muñoz Descalzo, Pau Rué, Fernando Faunes, Penelope Hayward, Lars Martin Jakt, Tina Balayo, Jordi Garcia‐Ojalvo, Alfonso Martinez Arias

“…We uncover a key role for post‐translational regulation in the maintenance of pluripotency, which complements the well‐established transcriptional regulatory layer. …”
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From aspectual to degree quantifiers: Context expansion of por completo and completamente in Spanish and Portuguese by Katharina Gerhalter, Stefan Koch

“… This paper examines four adverbial cognates in Spanish and Portuguese, Sp. por completo, Pt. por completo, Sp. completamente, and Pt. completamente, from a historical and functional point of view. Our analysis is based on three major corpora of Spanish and Portuguese (CDH, CdP, and CORPES XXI). …”
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Numerical Mixing Index: Definition and Application on Concrete Mixer by Cristian Ferrari, Nicolò Beccati, Luca Magri

“…The cell mixing index, defined by a statistical method in terms of mean, variance, and density probability function, is applied to the analysis of the simulation results. …”
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Inhibition of Cyclic GMP-AMP Synthase Ameliorates Cardiac Dysfunction in Rats After Cardiac Arrest by Ruiyu Wang, Ning Zhou, Yue Luo, Xiaohong Zhang, Chuanzhu Lv

“…Targeting cGAS might provide a promising therapeutic strategy for improving cardiac function in patients with CA.…”
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Development of a cell line from the gill of turbot (Scophthalmus maximus) and its application in the study of Edwardsiella piscida infection by Yuping Liu, Yanmin Wang, Yiping Liu, Xuefeng Ge, Chao Li, Ting Xue

“…In this study, we established and characterized a continuous cell line derived from the gill tissue of turbot (Scophthalmus maximus) and assessed its applicability in studying the gill's function as a mucosal immune barrier. This cell line, designated SMG, has been successfully subcultured for up to 70 passages. …”
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TET3 is a positive regulator of mitochondrial respiration in Neuro2A cells. by Valeria Leon Kropf, Caraugh J Albany, Anna Zoccarato, Hannah L H Green, Youwen Yang, Alison C Brewer

“…This is particularly important in post-mitotic neurons where changes in DNA methylation are known to associate with changes in neural function. …”
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Zebrafish as a Model to Study the Role of Peroxisome Proliferating-Activated Receptors in Adipogenesis and Obesity by Marjo J. Den Broeder, Victoria A. Kopylova, Leonie M. Kamminga, Juliette Legler

“…This review synthesizes knowledge on the role of PPARs in zebrafish and focuses on the putative function of PPARs in zebrafish adipogenesis. Using in silico analysis, we confirm the presence of five PPARs (pparaa, pparab, pparda, ppardb, and pparg) in the zebrafish genome with 67–74% identity to human and mouse PPARs. …”
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Successful eculizumab treatment as an adjunctive therapy to desensitization in ABO-incompatible living donor kidney transplantation and its molecular phenotypes by Ga Young Heo, Minsun Jung, Honglin Piao, Hyun Jeong Kim, Hyung Woo Kim, Juhan Lee, Kyu Ha Huh, Beom Seok Kim, Jaeseok Yang

“…Both patients received eculizumab from KT day to two or four weeks post-KT and maintained stable renal function up to one-year post-transplantation without overt infection, despite early episodes of probable AMR or borderline T cell-mediated rejection. …”
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Wavefront-guided pupilloplasty in patients following penetrating keratoplasty: Optimizing results by Vijay K Sharma, GN Divyashree, Preeti, Vikas Ambiya, Ashok Kumar, Srishti Khullar, Vipin Rana

“…Purpose: To describe the role of wavefront-guided pupilloplasty in improving visual quality and wavefront parameters in post-keratoplasty patients with pathologically irregular, mydriatic pupils. …”
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COMMERCIAL BANKS OF UKRAINE DURING THE WAR: NEW TRENDS AND OLD PROBLEMS by Yurii A. Zadoia

“…The article is devoted to the analysis of the peculiarities of the activities of commercial banks in Ukraine during the period of full-scale war. …”
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Effect of Web Causation Epidemiological Model on Preventive Behaviors of Diabetic Females with Genitourinary Tract Infection by Shaimaa A. E. Hemida, Seham G. Ragheb, Hemat A. El Sayied, Hala M. Mohamed

“…Results: 69% of diabetic females had a family history of diabetes mellitus. 39% of them had satisfactory knowledge about causes that increased blood glucose in diabetic females shift to 81% at post-intervention. 35% of diabetic females had satisfactory knowledge about the function of the reproductive system at preprogram shift to 93% at post-program implementation. 34% of diabetic females had satisfactory knowledge about entry urinary tract infection methods at preprogram shift to 81% at post-program implementation. …”
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The importance of the preoperative clinical parameters and the intraoperative electrophysiological monitoring in brachial plexus surgery by Leandro Pretto Flores

“…OBJECTIVE: The study aims to demonstrate the impact of some preoperative clinical parameters on the functional outcome of patients sustaining brachial plexus injuries, and to trace some commentaries about the use of intraoperative monitoring techniques. …”
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Patient Resilience, Is it Nature or Nurture? by Nathaniel Zona BA, Kenneth Hunt MD

“…Differences in preoperative BRS scores by gender and tobacco use were assessed non-parametrically using an unpaired t-test and Kruskal-Wallis one-way analysis of variance with Tukey’s test for post-hoc analysis. …”
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