Training in normobaric hypoxia induces hematological changes that affect iron metabolism and immunity by Svenja Nolte, Deeksha Malhan, Anna Klemmer, Tom Kastner, Nico Walter, Daniel Fleckenstein, Johannes Keck, Simon Klügel, Celina Maier, Kristina Gebhardt, Tobias Stauber, Angela Relógio, Karsten Krüger, Karsten Hollander

“…Pre- and post-performance was assessed via VO2max tests. Statistical analyses included paired t-tests, Wilcoxon rank-sum test, Spearman correlations, and Granger causality analysis to explore systemic temporal interactions. …”
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Changes in the quality of life of adults with sickle cell disease following allogeneic stem cell transplantation: A mixed‐methods, prospective cohort study by Elisabeth Dovern, Sterre J. A. M. Nijland, Annemarie M. J. Braamse, Maud M. vanMuilekom, Elisabeth M. J. Suijk, Gerianne M. Hoogendoorn, Charlotte F. J. vanTuijn, Michael R. DeBaun, Bart J. Biemond, Lotte Haverman, Erfan Nur

“…However, prospective studies comparing pre‐ and post‐transplant patient‐reported health outcomes are scarce. …”
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Advancements in Electrochemical Biosensors for Comprehensive Glycosylation Assessment of Biotherapeutics by Preety Ahuja, Manpreet Singh, Sanjeev Kumar Ujjain

“…Proteins represent a significant portion of the global therapeutics market, surpassing hundreds of billions of dollars annually. Among the various post-translational modifications, glycosylation plays a crucial role in influencing protein structure, stability, and function. …”
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Constraint-induced Movement Therapy in Patients with Upper Limb Peripheral Nerve Injury by Hamid Reza Rostami, Batol Mandani, Meimanat Akbari

“…Outcome measures including Semmes Weinstein Monofilaments (SWM), Nine-hole Peg Test (9-HPT), and Motor Activity Log (MAL) questionnaire were administered pre, and post, and 4 weeks after the treatment period.Results: Data analysis did not show any changes in touch perception at tip of the fingers in SWM at post-test session; however, affected hand motor performance in 9-HPT and affected hand’s amount of use in activities of daily living according to MAL were significantly improved at the post-test session (P< 0.01) and this improvement was maintained at the follow up (P> 0.05). …”
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The Cole Osteotomy: Maximizing Sagittal Plane Cavus Correction by Kelly McKeon, DPM, AACFAS, Brent Blanck-Singer, DPM, AACFAS, Craig Camasta, DPM, FACFAS

“…Analysis and discussion: The Cole midfoot osteotomy is an underutilized procedure, and when done correctly can vastly improve deformity and function. …”
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Phase-Dependent Modulation of Muscle Activity and Intermuscular Coupling During Walking in Patients After Stroke by Yifan Li, Yueling Lyu, Rong Song

“…Compared with age-matched healthy subjects, patients recruit more motor units throughout their gait while increasing muscle coupling to achieve gait function. The combined application of fApEn and TE provide a more comprehensive understanding of phase-dependent muscle modulation mechanisms in post-stroke patients.…”
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Surgery-induced neuroinflammatory transcriptional programs in medial prefrontal cortex of mice during early phase of perioperative neurocognitive disorders by Xiaodong Tang, Xuwu Xiang, Yang Yu, Shuyuan Huang, Caifei Pan, Shuyuan Gan, Yongxing Yao

“…To gain insight into the mechanisms of PND, we collected mouse mPFC tissues 6 h post-surgery and performed RNA sequencing analysis. …”
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Catheter‐Based Renal Denervation for Resistant Arterial Hypertension: 10‐Year Real‐World Follow‐Up Data by Sofie Brouwers, Giulia Botti, Matthias Verbesselt, Lucio Addeo, Marta Belmonte, Kostas Bermpeis, Dario Tino Bertolone, Chiara Valeriano, Michele Mattia Viscusi, Eric Wyffels

“…Medication changes, renal function, and device generation disparities were analyzed. …”
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Krajobraz miasta w narracji filmów dokumentalnych o Lublinie by Natasza Ziółkowska-Kurczuk

“… The article is an attempt at a critical original analysis of documentary films in relation to the documentary and narrative function of the landscape. …”
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Reflexões sobre diversidade de representações, de públicos e de estratégias interpretativas by Andreia Vale Lourenço

“…The paper aims to reflect on the issue of museum context and position in the contemporary world, and society, as influenced by post-modern trends. The author examines audiences and visitors, their relationship with the institution, focusing in the issues that relate to the representations of the heritage promoted by the museum and the interpretative process conducted by the visitors. …”
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Translational research from bioinformatics to animal studies: Exploring gene expression and muscle health in COPD through selenium nanoparticles and exercise by Mahdi Bakhshi, Abdolali Bnaeifar, Sajjad Arshadi, Behzad Bazgir

“…Recent studies highlight the role of molecular pathways, such as oxidative stress response and mitochondrial function, in COPD. This study explores the role of the PGC-1α gene, a key regulator of mitochondrial biogenesis and energy metabolism, using a rat model and bioinformatics analysis of human lung tissue samples. …”
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Psychopersonal characteristics of women with varying degrees of menopausal disorders by N. S. Lutsenko, O. D. Mazur, O. S. Shapoval, L. I. Zvarich, N. F. Efimenko

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Novel Adiposity Indices Are Associated With Poor Prognosis in Heart Failure With Preserved Ejection Fraction Without the Obesity Paradox by Shuai Zhang, Panpan Xu, Tianhao Wei, Changjiang Wei, Yanling Zhang, Huixia Lu, Cheng Zhang

“…Methods and Results This study is a post hoc analysis of data from the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist) trial. …”
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Berberine Enhances Neuroregeneration in a Rat Model of Peroneal Nerve Transection Injury: An Animal Study by Chung HJ, Kim DJ, Kim YS, Lee SH, Kim KI, Lee JH, Kim MS

“…Electromyography (EMG) was performed to evaluate quantitative neuromuscular function (latency and amplitude) and the regeneration ratio of the injured nerve was evaluated through histological analysis at 6 weeks post-transection. …”
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Influence of combined vitamin D3 supplementation and resistance exercise training on musculoskeletal health in older men and women (EXVITD): protocol for a randomised controlled tr... by Carolyn A Greig, Neil Gittoes, Janet Lord, Susan Lanham-New, Alison Doyle, Anneka Elizabeth Welford, Julie Robinson

“…However, very little data exist on the influence of combining the two interventions of vitamin D supplementation and resistance exercise training, although a recent systematic review provides tentative support for the current study’s hypothesis that the combined intervention may further improve musculoskeletal function above exercise training alone. The aim of the present study is to determine whether vitamin D3 supplementation is any more effective in improving musculoskeletal function when combined with RET compared with exercise training alone in older adults.Methods and analysis This double-blinded randomised placebo-controlled trial will recruit a target of 127 eligible men and women aged ≥65 years living independently or in sheltered housing within the Birmingham area to two groups: (1) 6 months RET and placebo or (2) 6 months RET and 800 IU/d vitamin D3. …”
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Effect of Marital Relationship Enhancement EducationBased on the Approach of Religious Teachings on Sexual, Spiritual and Mental Health by Hajar Pasha, Zohreh Khalajinia, Mohammad Hadi Yadollahpour, Hemmat Gholinia

“…The Independent and paired t-tests, Chi-square test, and ANCOVA were used for data analysis. Results: The mean scores of female sexual function, spiritual well-being, and mental health were 25.96±3.69, 95.82±14.31 and 21.17±12.56, respectively. …”
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Patient Reported Outcomes Following Triple Arthrodesis for Adult Acquired Flat Foot Deformity: Minimum Two Year Follow Up by Tyler Kelly, Ashish Shah MD, Mila Scheinberg MD, MS

“…Foot Function Index (FFI) scores and scores were utilized as a validation tool for our results. …”
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Vision-related Quality of Life (VRQOL) and its determinants among the Elderly in rural blocks of Haryana, India by Mona Duggal, Ankita Kankaria, Latika Rohilla, Harashish Jindal, Limalemla Jamir, Parul Chawla Gupta, Debarati Sarkar, Vaibhav Miglani, Akash Kumar, Drishti Sharma, Neha Dahiya, Siddhartha Sharma, Sandeep Grover

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[Comment] Assessing outcomes in laparoscopic vs open surgical manage ment of adhesive small bowel obstruction by Tong Weihua

“…There was no significant difference in return of bowel function, length of stay, post-operative mortality, or re-admission laparoscopic preferred or open preferred surgeons. …”
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From prediction to practice: mitigating bias and data shift in machine-learning models for chemotherapy-induced organ dysfunction across unseen cancers by Heather Shaw, Pinkie Chambers, Matthew Watson, Luke Steventon, James Harmsworth King, Angelo Ercia, Noura Al Moubayed

“…This study aims to develop models that could support individualised decisions on the timing of renal and hepatic monitoring while exploring the effect of data shift on model performance.Methods and analysis We used retrospective data from three UK hospitals to develop and validate ML models predicting unacceptable rises in creatinine/bilirubin post cycle 3 for patients undergoing treatment for the following cancers: breast, colorectal, lung, ovarian and diffuse large B-cell lymphoma.Results We extracted 3614 patients with no missing blood test data across cycles 1–6 of chemotherapy treatment. …”
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