Dexmedetomidine Protects the Brain: Exploring the α2AR/FAK Pathway in Post-Stroke Intestinal Barrier Repair by Xinting Zhou, Yan Yang, Zixuan Su, Zhonghui Luo

“…Introduction: Globally, ischemic stroke is a major cause of mortality and disability, posing a significant challenge in clinical practice and public health. …”
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Exploring the Connections Between Grip Strength, Nutritional Status, Frailty, Depression, and Cognition as Initial Assessment Tools in Geriatric Rehabilitation—A Pilot Study by Amalia Teodora Vancea Nemirschi, Andreea Alexandra Lupu, Kamer-Ainur Aivaz, Mădălina Gabriela Iliescu, Michel Deriaz, Mircea Marzan, Luiza Spiru

“…<i>Background and Objective:</i> In the context of the rapidly aging global population, the older adult vulnerability poses a significant challenge for public health systems. …”
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Multi-omics profiling reveals Poria cocos polysaccharides mitigate PEDV-induced intestinal injury by modulating lipid metabolism in piglets by Qian Zhang, Shuaijie Wang, Mengjun Wu, Zihan Tan, Tao Wu, Dan Yi, Lei Wang, Di Zhao, Yongqing Hou

“…Abstract Background Porcine epidemic diarrhea virus (PEDV) infection poses a significant challenge to the swine industry, with limited effective control measures available. …”
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Le sanctuaire romain du Vigneau à Pussigny (Indre-et-Loire) : un lieu de mémoire, de vie et d’accueil by Arnaud Coutelas, Sébastien Lepetz

“…Their development is mutual. The function of the latter is undoubtedly linked to the existence of the former. …”
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Blue light induces corneal epithelial damage by activating the NLRP3 inflammasome pathway by Jiayun Ge, Qianjie Yang, Xin Yu, Yutong Xia, Xuhong Zhang, Liyue Zhang, Yanqing Li, Yinhao Wang, Chang Shen, Xiang Li, Dongjie Song, Zhitong Chen, Kuangqi Chen, Xiuyi Li, Ye Shen, Jianping Tong

“…Blue light (BL) emitted from light-emitting diodes in digital devices poses significant risks to corneal health, by inducing oxidative stress and inflammation. …”
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DNA methylation signatures of severe RSV infection in infants: evidence from non-invasive saliva samples by Sara Pischedda, Alberto Gómez-Carballa, Jacobo Pardo-Seco, Sandra Viz-Lasheras, Alba Camino-Mera, Xabier Bello, María José Curras-Tuala, Irene Rivero-Calle, Ana I. Dacosta-Urbieta, Federico Martinón-Torres, Antonio Salas, GENDRES Consortium

“…A weighted correlation network analysis emphasized the pivotal role of a module with RAB11FIP5 as the hub gene, known for its critical function in regulating viral infections. …”
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Healing of lytic lesions and restoration of bone health in multiple myeloma through sclerostin inhibition by Hayley M. Sabol, Aric Anloague, Japneet Kaur, Cecile Bustamante-Gomez, Sharmin Khan, Bethany C. Paxton, Mattie R. Nester, Jillian Hackney, Marta Diaz-delCastillo, Daniel Mann, Jeffrey B. Stambough, C. Lowry Barnes, Elena Ambrogini, Alison Frontier, Frank H. Ebetino, Syed Naqvi, Frits van Rhee, Christopher P. Wardell, Matthew T. Drake, Intawat Nookaew, Carolina Schinke, Maurizio Zangari, Jesus Delgado-Calle

“…Abstract Background Multiple myeloma (MM) is associated with a debilitating bone disease that poses significant therapeutic challenges. MM bone disease is characterized by increased bone resorption and suppression of osteoblasts, which hinders the repair of damaged bone. …”
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Huqi formula suppresses hepatocellular carcinoma growth by modulating the PI3K/AKT/mTOR pathway and promoting T cell infiltration by Donghao Yin, Xiang Li, Xuemeng Yang, Xiaofei Shang, Zhen Li, Jiahao Geng, Yanyu Xu, Zijing Xu, Zixuan Wang, Zimeng Shang, Zhiyun Yang, Linlan Hu, Quanwei Li, Jiabo Wang, Xinhua Song, Xiuhui Li, Xiaojun Wang

“…Abstract Background Hepatocellular carcinoma (HCC) poses ongoing difficulties for public health systems due to its high incidence and poor prognosis. …”
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Novel FKS1 and FKS2 modifications in a high-level echinocandin resistant clinical isolate of Candida glabrata by Xin Hou, Kelley R. Healey, Erika Shor, Milena Kordalewska, Cristina Jiménez Ortigosa, Padmaja Paderu, Meng Xiao, He Wang, Ying Zhao, Li-Yan Lin, Yan-Hai Zhang, Yong-Zhe Li, Ying-Chun Xu, David S. Perlin, Yanan Zhao

“…Echinocandin resistance in Candida glabrata poses a serious clinical challenge. The underlying resistance mechanism of a pan-echinocandin-resistant C. glabrata isolate (strain L74) was investigated in this study. …”
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Regulation of type 3 fimbria expression by RstA affects biofilm formation and virulence in Klebsiella pneumoniae ATCC43816 by Xiaoyun Zhang, Yaxuan Zhai, Jie Zhu, Zhichen Zhu, Yicheng Wen, Qizhao Gao, Liang Wang, Jiayao Lin, Yan Qian, Liang Chen, Hong Du

“…However, the role of RstBA in K. pneumoniae infection remains unknown. To determine its function, a wild-type K. pneumoniae strain (ATCC43816) and rstA mutant and complementation strains were constructed. …”
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Ginkgo Biloba Extract Reduces Cardiac and Brain Inflammation in Rats Fed a HFD and Exposed to Chronic Mental Stress through NF-κB Inhibition by Lijun Zhang, Guo Li, Shuhui Tao, Pengyan Xia, Naveed Chaudhry, Shawn Kaura, Sara Saymuah Stone, Meiyan Liu

“…Sucrose preference was established for the assessment of depressive behaviors. The heart function was evaluated by echocardiography. The rats were terminated at the end of the 10th or 13th week. …”
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Research on knowledge, attitude and practice (KAP) regarding dengue infection: a community-based study in rural Cox's Bazar by Saima Bibi

“…Face-to-face interviews were performed using a pretested and semi-structured questionnaire. Problem: DI poses a serious threat to public health, especially in tropical and subtropical areas where the dengue virus vector, the Aedes aegypti mosquito, is abundant.1,2 Bangladesh experienced its major dengue outbreak in 2019, with 100,000 cases and 120 deaths, followed by the second-largest outbreak in 2022, with 60,078 cases and 266 deaths.3,4 Assessment of problem and analysis of its causes: Bangladesh is severely affected by DI, largely due to factors including tropical climate, a dense population, unplanned urbanisation, inadequate vector control and low-literacy rates.5,6DI can cause mild fever to severe conditions, such as haemorrhagic fever, dengue shock syndrome, respiratory symptoms, gastrointestinal disturbance, low platelet count and deranged liver function tests. …”
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Biological control and mechanism characterization of endophytic Bacillus velezensis SJ22 against bulb rot of Fritillaria taipaiensis P. Y. Li by Shijie Wang, Keke Chen, Mian Wei, Le Zhou, Jiaqi Guo, Jiaxiang Zhang, Langjun Cui, Yi Qiang

“…Chemical fungicides are currently the primary means of controlling this disease; however, their use poses risks to human health and the environment. …”
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A nomogram for diagnosis of BI-RADS 4 breast nodules based on three-dimensional volume ultrasound by Xianping Jiang, Chen Chen, Jincao Yao, Liping Wang, Chen Yang, Wei Li, Di Ou, Zhiyan Jin, Yuanzhen Liu, Chanjuan Peng, Yifan Wang, Dong Xu

“…Logistic regression analysis was used to screen the clinical and ultrasound characteristics. …”
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A one-year follow-up study of systematic impact of long COVID symptoms among patients post SARS-CoV-2 omicron variants infection in Shanghai, China by Jianpeng Cai, Ke Lin, Haocheng Zhang, Quanlin Xue, Kun Zhu, Guanmin Yuan, Yuhan Sun, Feng Zhu, Jingwen Ai, Sen Wang, Wenhong Zhang

“…Long COVID hinders people from normal life and work, posing significant medical and economic challenges. …”
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Effects of postoperative antifungal therapy on the recurrence of Aspergillus infection after pulmonary aspergilloma resection: a prospective, randomized, controlled, single-center,... by Jian Yang, Chan Liu, Jianxiong Li, Xianqiu Chen, Beibei Wang, Jing Zhang, Haifeng Wang, Deping Zhao, Yiming Zhou, Haomin Cai, Jin-fu Xu, Shuo Liang

“…Ultimately, 36 patients in the VRZ group and 14 patients in the control group were included in the analysis, with balanced baseline characteristics between groups. …”
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Mathematical Modeling of Ebola Virus Disease in Bat Population by Zineb EL Rhoubari, Hajar Besbassi, Khalid Hattaf, Noura Yousfi

“…By analyzing the characteristic equations and constructing suitable Lyapunov functionals, the stability analysis of equilibria is investigated.…”
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A Fractional Order Model for Viral Infection with Cure of Infected Cells and Humoral Immunity by Adnane Boukhouima, Khalid Hattaf, Noura Yousfi

“…We first show that the model is mathematically and biologically well-posed. By constructing suitable Lyapunov functionals, the global stability of equilibria is established and characterized by two threshold parameters. …”
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Inhibition of neuronal necroptosis via disruption of RIPK1-RIPK3 Interactions: The role of neural stem cell-derived exosomes in spinal cord injury recovery by Shiming Li, Guoliang Chen, Kuileung Tong, Yunshu Che, Yifan Xie, Wenxiao Shi, Anquan Huang, Yefeng Wang, Jianfeng Li, Genlong Jiao, Dacheng He, Jun Shen, Fuxin Wei, Ningning Chen

“…Spinal cord injury (SCI) poses a significant economic and public health burden. …”
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circFTO binding with IGF2BP2 regulates trophoblast cells proliferation, migration, and invasion while mediating m6A modification of CCAR1 mRNA in spontaneous abortion by Yiwen Zhang, Meiyao Wu, Xiaoling Lin, Bingfeng Lu, Xi Chen, Qianhui Li, Yinan Jiang, Baixue Li, Dongmei Zhou, Xiujie Sheng

“…Reducing the level of IGF2BP2 partially restored the alterations in trophoblast function caused by circFTO knockdown. Colorimetric assay, RNA decay experiments, and meRIP-qRT-PCR analysis revealed that circFTO knockdown increased m6A methylation levels in CCAR1 mRNA, while circFTO overexpression decreased m6A methylation levels. …”
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