Luteolin mitigates hippocampal damage in a rat model of streptozotocin-induced diabetes by Omur Gulsum Deniz, Hayriye Soytürk, Aydın Him, Dilek Sağir, Ebru Annaç

“…Diabetes mellitus (DM) is a chronic metabolic disorder that poses a serious threat to human health by causing long-term damage to various vital organs. …”
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SNORA13 antisense oligonucleotides enhances the therapeutical effects of 5-fluorouracil in colon adenocarcinoma by Yanzhi Wang, Huihui An, Yaou Zhang, Yaou Zhang, Qing Rex Lyu, Zhe Zhang

“…IndroductionColorectal cancer (CRC) is a prevalent malignancy and is the second leading cause of cancer-related mortality worldwide. 5-Fluorouracil (5-FU) is widely used in clinical intervention, however, drug resistance to 5-FU poses a significant challenge to treatment efficacy. …”
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A high-performance extracellular field potential analyzer for iPSC-derived cardiomyocytes by Nidhi Patel, Alex Shen, Yuko Wada, Marcia Blair, Devyn Mitchell, Loren Vanags, Suah Woo, Matthew Ku, Kundivy Dauda, William Morris, Minjoo Yang, Björn C. Knollmann, Joe-Elie Salem, Andrew M. Glazer, Brett M. Kroncke

“…However, electrophysiological analysis can be complex and requires specialized expertise, posing a barrier to broader adoption in non-specialized labs. …”
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The Detrimental Effects of Sedentary Lifestyle on Human Health by Alicja Grzelak

“…Summary: A sedentary lifestyle poses a significant threat to human health, contributing to a range of physical, mental, and cognitive ailments. …”
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Visualizing the internalization and biological impact of nanoplastics in live intestinal organoids by Fluorescence Lifetime Imaging Microscopy (FLIM) by Irina A. Okkelman, Hang Zhou, Sergey M. Borisov, Angela C. Debruyne, Austin E. Y. T. Lefebvre, Marcelo Leomil Zoccoler, Linglong Chen, Bert Devriendt, Ruslan I. Dmitriev

“…Abstract Increased micro- and nanoplastic (MNP) pollution poses significant health risks, yet the mechanisms of their accumulation and effects on absorptive tissues remain poorly understood. …”
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Linking preclinical models to clinical realities: VEGF/VEGFR inhibitors and thrombotic microangiopathy in cancer therapy by Aimin Jiang, Zhanzhi Li, Ying Liu, Junyi Shen, Quan Cheng, Anqi Lin, Peng Luo, Linhui Wang

“…Notably, Bevacizumab, Sunitinib, Ramucirumab, and Aflibercept significantly increase TMA risks, with Bevacizumab showing the highest risk (reporting odds ratio 4.96 [4.08–6.03] in Vigibase and 2.33 [1.84–2.94] in FAERS). Biochemical analysis from 1698 patients indicated impaired kidney function and hemolytic events, confirming that VEGFi and VEGFRi significantly increase the risk of TMA/TTP in clinical use (p < 0.001). …”
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Optimal Subsampling for Upper Expectation Parametric Regression by Zhaolei Liu

“…To address the challenges posed by big data or the restrictions of privacy, we propose a method utilizing Poisson subsampling to devise a new loss function. …”
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Evaluation of Data Acquisition Areas in Geotechnical Seismic Tests: Insights from Field Applications by Gunwoong Kim

“…While other tests clearly define data acquisition areas based on their array paths, the SASW test posed challenges due to the complexity of data reconstruction. …”
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Single-Cell RNA Transcriptomics and Multi-omics Analyses Reveal the Clinical Effects of Acupuncture on Methadone Reduction by Yiming Chen, Baochao Fan, Jingchun Zeng, Yutian Zou, Chenyang Tao, Chen Chen, Peiming Zhang, Jian Liang, Fangfang Qi, Hailin Tang, Liming Lu

“…Opioid use disorders (OUDs) pose a substantial global health burden, with methadone maintenance treatment (MMT) widely adopted as an intervention; however, MMT is associated with immunosuppression, metabolic disturbances, and dysbiosis of the gut microbiota. …”
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Arterial and venous thromboembolic events in patients with cancer treated with targeted therapies: a population-based cohort studyResearch in context by Florian Moik, Erzsébet Horváth-Puhó, Cihan Ay, Ingrid Pabinger, Frits Mulder, Nick van Es, Henrik Toft Sørensen

“…We computed cumulative incidence functions and 95% confidence intervals (CIs) of ATE/VTE after therapy initiation, considering death as competing event. …”
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Efektivitas Kombinasi Kitosan dan Ampas Teh Sebagai Adsorben Alami dalam Menurunkan Konsentrasi Timbal Pada Limbah Cair PT PXI by Dhonny Suwazan, Nisa Nurhidayanti

“…ABSTRACT Heavy metal is one of the hazardous chemicals that can pose a danger to the environment and living things because it has high toxicity and cannot be biodegraded so that it becomes bioaccumulation in the food chain. …”
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Combination of skin sympathetic nerve activity and urine biomarkers in improving diagnostic accuracy for urge urinary incontinence by Yu-Chen Chen, Hao-Wei Chen, Tzu-Yu Liu, Yung-Shun Juan, Yu-Peng Liu, Shiou-Lan Chen, Chien-Hung Lee, Wei-Chung Tsai, Wen-Jeng Wu

“…This study proposes an innovative diagnostic algorithm, advancing UUI diagnostics by integrating autonomic function parameters and urine biomarker analysis.…”
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Ecological assessment of forest management approaches to develop resilient forests in the face of global change in Central Europe by Franka Huth, Alexander Tischer, Petia Nikolova, Heike Feldhaar, Alexandra Wehnert, Lisa Hülsmann, Jürgen Bauhus, Katrin Heer, Juliane Vogt, Christian Ammer, Uta Berger, Markus Bernhardt-Römermann, Manuela Böhme, Harald Bugmann, Jörn Buse, Laura Demant, Inken Dörfler, Jörg Ewald, Eike Feldmann, Andreas Fichtner, Martin M. Gossner, Thorsten E.E. Grams, Karl-Heinz Häberle, Jonas Hagge, Henrik Hartmann, Sven Herzog, Ansgar Kahmen, Ulrich Kohnle, Doris Krabel, Klara Krämer-Klement, Jürgen Kreyling, Michael Manthey, Karl Mellert, Peter Meyer, Andreas Mölder, Lena Muffler-Weigel, Bettina Ohse, Lars Opgenoorth, Boris Rewald, Andreas Rothe, Nadine Ruehr, Tobias Scharnweber, Michael Scherer-Lorenzen, Jonas Schmeddes, Joachim Schmerbeck, Markus Schmidt, Dominik Seidel, Frank M. Thomas, Malin Tiebel, Goddert von Oheimb, Sven Wagner, Robert Weigel, Martin Wilmking, Christian Zang, Bernhard Schuldt

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Development and validation of a risk prediction model for acute kidney injury in coronary artery disease by Ming Ye, Chang Liu, Duo Yang, Hai Gao

“…Abstract Background Acute Kidney Injury (AKI) is a sudden and often reversible condition characterized by rapid kidney function reduction, posing significant risks to coronary artery disease (CAD) patients. …”
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Insights from the European Nontuberculous mycobacterial pulmonary disease PAtient Disease Experience (ENPADE) survey– exploring disease burden and impact by Michal Shteinberg, Marko Obradovic, Roald van der Laan, Christian Hoenig, Roger J. Legtenberg, Andreas L. G. Reimann, Natalie Lorent

“…NTM-PD can severely impair lung function and quality of life, potentially leading to both increased healthcare costs and mortality. …”
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Exploring the Mediating Role of Multiple Organ Dysfunction in Sepsis-Induced Disseminated Intravascular Coagulation and Its Impact on Worsening Prognosis by Guangjie Wang MD, Chenxiao Hao MD, Sun Yao MD, Yiqin Wang PHD, Zongtao Xu MD, Huiying Zhao MD, Youzhong An MD

“…Disseminated intravascular coagulation (DIC) poses a high mortality risk, yet its exact impact remains contentious. …”
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Haplotype-resolved genomes of Trichophyton mentagrophytes and Trichophyton tonsurans by Sijie Feng, Zhenhui Wang, Kainan Lin, Kun Wang, Shuting Zheng, Qianqian Wang, Lianyu Lin, Yunkun Lu

“…Abstract Dermatophytes have posed a significant health concern due to their ability to parasitize human and animal skin, hair, and nails, causing a spectrum of dermatological conditions. …”
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Liver laceration as a post-cardiopulmonary resuscitation complication in a person with breast implants: a case report by Min-Jeong Cho

“…However, CPR procedure poses a risk of complications, even when CPR providers perform cardiac compressions as recommended. …”
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Effect of Random Vibration of Rotor Supports with Nano Additives Lubricants by Marwan Abdulrazzaq Salman, Mahmud R. Ismail

“… Rotors in various industries often encounter diverse vibrations from their supports, posing potential dangers to system integrity. The present study focuses on the effects of arbitrary stimulation brought on by random vibrations caused by supports, which necessitate statistical methods for evaluation due to their non-deterministic nature. …”
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Motivating factors for individuals aged 40–70 years with type-2 diabetes to engage in physical activity by Sólfríð A. Skoradal, Sarita Vesturdal Vesturtún, May Britt Skoradal, Annika Helgadóttir Davidsen

“…IntroductionType-2 diabetes (T2D) is a chronic disease resulting from inadequate insulin production or impaired insulin function. Globally, T2D poses a significant health burden with various complications. …”
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