ResPoNet: A Residual Neural Network for Efficient Valuation of Large Variable Annuity Portfolios by Heng Xiong, Jie Xu, Rogemar Mamon, Yixing Zhao

“…Accurately valuing large portfolios of Variable Annuities (VAs) poses a significant challenge due to the high computational burden of Monte Carlo simulations and the limitations of spatial interpolation methods that rely on manually defined distance metrics. …”
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Mycotoxins as antinutritional factors: occurrence, impacts and management by Alexandra C. Weaver

“…Attention has been given to antinutritional factors by poultry producers and nutritionists, and mycotoxins certainly deserve the same level of concern. However, through analysis of feedstuffs and feeds, understanding of mycotoxin risk, and proper management techniques, producers have the ability to mitigate the challenges posed by mycotoxins.…”
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Joint quantification of transmission dynamics and diagnostic accuracy applied to influenza by Hiroshi Nishiura

“…The influenza A (H1N1) pandemic 2009 posed an epidemiological challenge in ascertaining all cases. …”
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Investigating the Technical Efficiency and Balanced Development of Climate-Smart Agriculture in Northeast China by Viet Ha Trinh Thi, Wenqi Zhou

“…The study employs the stochastic frontier analysis approach to estimate the efficiency of the production function and highlight the significant factors that affect efficiency. …”
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CYP1B1 Knockout in a Bovine Hepatocyte-like Cell Line (BFH12) Unveils Its Role in Liver Homeostasis and Aflatoxin B1-Induced Hepatotoxicity by Silvia Iori, Ludovica Montanucci, Caterina D’Onofrio, Maija Lahtela-Kakkonen, Lorena Lucatello, Anisa Bardhi, Andrea Barbarossa, Francesca Capolongo, Anna Zaghini, Marianna Pauletto, Mauro Dacasto, Mery Giantin

“…In this study, we generated a <i>CYP1B1</i> knockout (<i>CYP1B1</i>^KO) bovine hepatocyte-like cell line to indirectly investigate its role in liver function. Transcriptomic analysis revealed alterations in immune regulation, epithelial barrier integrity, and detoxification pathways, with concurrent compensatory <i>CYP1A1</i> upregulation. …”
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Optimizing SVC placement for enhanced voltage stability using a novel index and hybrid ABC-PSO algorithm by Hafizur Rahman, Roman Mia, Mustafizur Rahman, Md. Faiyaj Ahmed Limon, Md. Shahid Iqbal, Md. Fahad Jubayer, Md. Rabiul Karim, Md. Janibul Alam Soeb

“…Voltage instability poses a great threat to power systems, typically leading to catastrophic failures such as voltage collapse. …”
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Integrating multi-dimensional data to reveal the mechanisms and molecular targets of baikening granules for treatment of pediatric influenza by Zhaoyuan Gong, Qianzi Che, Mingzhi Hu, Tian Song, Lin Chen, Haili Zhang, Ning Liang, Huizhen Li, Guozhen Zhao, Lijiao Yan, Xuefei Zhang, Bin Liu, Jing Guo, Nannan Shi

“…BackgroundChildren are the main group affected by the influenza virus, posing challenges to their health. The high risk of viral variability, drug resistance, and drug development leads to a scarcity of therapeutic drugs. …”
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RNA-Seq Revealed the Effects of Cold Stress on Different Brain Regions of <i>Leiocassis longirostris</i> by Senyue Liu, Qiang Li, Yongqiang Deng, Zhongwei Wang, Yang Feng, Zhongmeng Zhao, Han Zhao, Lu Zhang, Yuanliang Duan, Zhipeng Huang, Jian Zhou, Chengyan Mou

“…GO and KEGG enrichment analyses indicated that cold stress disrupted processes including gene expression regulation, circadian rhythms, and immune function within brain tissues. Through Weighted Gene Co-Expression Network Analysis (WGCNA), the MB was identified as the core responsive region, and the brain’s reaction to cold stress was strongly correlated with circadian rhythm, spliceosome, and ubiquitination. …”
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Ultrasound assessment of the association between left atrial remodeling and fibrosis in patients with valvular atrial fibrillation: a clinical investigation by Tao Xu, Haotian Hu, Runyu Zhu, Wenshu Hu, Xinyi Li, Dian Shen, Aoyi Zhang, Chang Zhou

“…During surgery, left atrial myocardial specimens were obtained to determine the CVF through histopathological evaluation, reflecting the extent of left atrial myocardial fibrosis. Comparative analysis was conducted between the AF group and the control group regarding left atrial volume, functional parameters, LASI, as well as their correlation with CVF. …”
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Superconducting critical temperature and dimensionality tuning of RbV3Sb5 via biaxial strain by Tsz Fung Poon, King Yau Yip, Ying Kit Tsui, Lingfei Wang, Kai Ham Yu, Wei Zhang, Zheyu Wang, Taketo Nakatani, Chishiro Michioka, Hiroaki Ueda, Siu Tung Lam, Kwing To Lai, Swee K. Goh

“…Among the three compounds, RbV3Sb5 has a notably lower superconducting critical temperature (Tc) at ambient pressure, posing challenges in exploring the superconducting state. …”
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A Review of Multidisciplinary Evidence on the Role of Urban Green Space in Improving the Sleep Quality of the Elderly by Ning KANG, Han XIE, Tao JIANG

“…ObjectiveSleep disorders pose a significant threat to the physical and mental health of the elderly and have emerged as one of the key public health challenges in aging societies. …”
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Wojna i pokój? Publicystyka rosyjskojęzyczna w przekładzie na język polski po lutym 2022 roku by Alicja Pstyga

“…The translation itself, often framed in terms of war, poses not only traditional translation problems related to equivalence, adequacy, and the function of translated texts but also introduces new challenges of a moral and ethical nature associated with experiencing and depicting human suffering. …”
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ClpB chaperone as a promising target for antimicrobial therapy: A narrative review by Sachini J. Udari, Sayoka Shamodhi, Rumesh M. Nelumdeniya, Udayana Ranatunga, Nimesha N. Senadeera, Chathuranga B. Ranaweera

“…This review explores the function of ClpB in the survival of ESKAPE pathogens and the protozoan Plasmodium falciparum. …”
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A design-based framework for optimal stratification using super-population models with application on real data set of breast cancer. by Faizan Danish

“…However, achieving optimal OSB and SS poses challenges in scenarios with a fixed total sample size, such as survey designs constrained by limited budgets. …”
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Forensic Construction Investigation of Reconstructed Premises by I. D. Platonova, N. G. TSaritova, E. G. Tekutov

“…The significance of the problem attributes to the volume of the stock of residential and public buildings which are older than 40 years (according to statistics, the housing stock of Russia in 1980 was 1,861 million m2 , in 2015 – 3,581 million m2 ), outdated layouts of premises, and the evolved consumers’ idea of comfort.A construction expert’s task is to determine if there is a possibility to change the layout, the function of premises to improve living conditions, or reconstruction poses a threat to the state of the object, its further proper operation, the integrity of the installed engineering systems, the appearance of the facades, nearby buildings and structures. …”
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A <i>Puccinia striiformis</i> f. sp. <i>tritici</i> Effector with DPBB Domain Suppresses Wheat Defense by Raheel Asghar, Yu Cheng, Nan Wu, Mahinur S. Akkaya

“…<i>tritici</i> (<i>Pst</i>) is a significant biotic stress agent and poses a major threat to world food security by causing stripe rust or yellow rust disease. …”
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Amphiphilic Bioactives of Freshwater Aquatic Plants <i>Nelumbo nucifera</i> (Indian Lotus) and <i>Lemna</i> sp. with Antioxidant, Anti-Inflammatory and Antithrombotic Activities: I... by Marina Seferli, Melina Lefkaki, Vasileios Manousakis, Anna Ofrydopoulou, Katie Shiels, Sushanta Kumar Saha, Grigorios Krey, Nikolaos Kamidis, Nikolaos Stamatis, Chryssa Anastasiadou, Alexandros Tsoupras

“…<b>Background-Objectives:</b> Chronic diseases linked to inflammation, such as cardiovascular disease (CVD) and cancer, continue to pose major public health challenges due to their high mortality rates. …”
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Isolation of a Novel <i>Streptomyces</i> sp. TH05 with Potent Cyanocidal Effects on <i>Microcystis aeruginosa</i> by Xuhan Wang, Siqi Zhu, Shenchen Tao, Shaoyong Zhang, Ruijun Wang, Liqin Zhang

“…Cyanobacterial blooms caused by <i>Microcystis aeruginosa</i> pose serious ecological and public health threats due to the release of microcystins (MCs). …”
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Abstract 218: Evaluating Thrombectomy Candidacy in Large Core Strokes: Lessons from the SELECT2 Trial at Our Institution by Mohammad Khasawneh, Eve Moll, Brendan Eby, Laura Heitsch

“…Historically, patients with large strokes have been excluded from major trials evaluating thrombectomy due to concern that thrombectomy would pose considerable risk with limited benefit. However, new evidence from the Select‐2 Trial found improved modified Rankin scale scores and higher rates of functional independence at 90 days following large stroke in patients who underwent thrombectomy versus medical therapy alone. …”
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Several colors of scientific consulting: Ukrainian cases by Artem Artyukhov

“…Type of the article: Reflexive Preface The proliferation of unethical scientific consulting practices, particularly in post-Soviet contexts, poses significant threats to academic integrity by transforming legitimate knowledge transfer services into commercialized systems that fabricate academic outputs to meet formal performance metrics rather than supporting genuine research efforts. …”
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