The Role of Centella asiatica and Its Main Bioactive Compound, Asiatic Acid in Cardiac Remodeling: A Systematic Review of Animal Studies by Muhamad Rizqy Fadhillah, Wawaimuli Arozal, Heri Wibowo, Arleni Bustami, Suci Widya Primadhani, Nurul Gusti Khatimah, Rizky Clarinta Putri, Clara Riski Amanda, Nur Azizah

“…Cardiac remodeling is a phenotype of heart failure characterized by a molecular, cellular, and interstitial change in the heart, which manifests in the change of size and function of the heart after specific insults with multiple mechanisms. …”
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The TOR Signaling Pathway Governs Fungal Development, Virulence and Ustiloxin Biosynthesis in <i>Ustilaginoidea virens</i> by Yuejiao Li, Shuqin Sun, Guangsheng Li, Zezhong Yang, Yuqi Xing, Ruixiang Wang, Yuanhu Xuan, Xiurong Yang

“…<i>Ustilaginoidea virens</i> is an economically important plant pathogen that causes rice false smut, which causes yield reduction and produces mycotoxins in infected grains that pose a serious threat to human and animal health. …”
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Parent–Child Adaptive Responses for Digital Resilience by John P. Ziker, Jerry Alan Fails, Kendall House, Jessi Boyer, Michael Wendell, Hollie Abele, Letizia Maukar, Kayla Ramirez

“…Life history theory informs our approach to the development of parental control software that favors skill building and encourages parent–child discussions supporting child executive function and resilience to risks.…”
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Upcycling waste glass bottles as a binder within engineered cementitious composites (ECCs): Experimental investigation and environmental impact assessment by Avik Kumar Das, Jiacheng Xiao

“…Single-use waste glass bottles (WGB) pose significant environmental challenges in urban areas, and this study explores their upcycling into powdered glass (GP) as a supplementary cementitious material (SCM) in engineered cementitious composites (ECCs). …”
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Fire and Smoke Detection Based on Improved YOLOV11 by Zhipeng Xue, Lingyun Kong, Haiyang Wu, Jiale Chen

“…However, complex backgrounds, large environmental changes, and data requirements pose great challenges to high-precision outdoor smoke detection. …”
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Simultaneous surgical management of a giant tuberculum sellae meningioma and pregnancy-related complications: a case report and literature review by Muratbek A. Tleubergenov, Nurzhan A. Ryskeldiyev, Dauren S. Baymukhanov, Daniyar K. Zhamoldin, Serik Akshulakov, Aidos Doskaliyev

“…Meningiomas, tumors arising from the brain and spinal cord membranes, pose a unique challenge when diagnosed during pregnancy. …”
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Drug repurposing reveals posaconazole as a CYP11A1 inhibitor enhancing anti-tumor immunity by Jhuma Pramanik, Sanu Korumadathil Shaji, Megan Zaman, Bethany Brown, Baojie Zhang, Yumi Yamashita-Kanemaru, Natalie Z.M. Homer, Hosni A.M. Hussein, Qiuchen Zhao, Klaus Okkenhaug, Rahul Roychoudhuri, Abhik Mukhopadhyay, Bidesh Mahata

“…Undertaking in silico structure-based drug repurposing approach, we found posaconazole as an inhibitor of CYP11A1. The docking pose analysis showed that posaconazole can form multiple hydrogen bonds and hydrophobic interactions with the key residues at the binding site and the cofactor, stabilizing the protein-ligand complex. …”
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Oxidative Stress Responses and Recovery of Marine Medaka (<i>Oryzias melastigma</i>) in Early-Life Stages After Acute Exposure to Crude Oil by Xishan Li, Yuekun Dai, Xin Li, Haiqiang Guo, Jiarui Dai, Haonan Wang, Deqi Xiong, Guoxiang Liao

“…Differently, during the recovery period, all groups showed impaired antioxidant capacity (decreased SOD, CAT, GSH) and immune function (reduced AKP activity). Principal component analysis revealed strong correlations between survival, oxidative stress markers, and developmental toxicity. …”
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TSH and its Correlation in the Development of Fibrosis in Patients with Hypothyroidism in a Tertiary Care Hospital by Aranzazu G. Pérez Castañeda, Jose A. Velarde Ruiz Velasco, José R. Barrientos Ávalos, Juan M. Aldana Ledesma, Edgar S. García Jiménez

“…Introduction and Objectives: Fatty liver disease and hypothyroidism are two prevalent conditions in Mexico that pose significant public health challenges. The increase in their incidence over the past decades is due to changes in lifestyle, diet, and access to healthcare. …”
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Dysregulation of Retinal Melatonin Biosynthetic Pathway and Differential Expression of Retina-Specific Genes Following Blast-Induced Ocular Injury in Ferrets by Chetan Pundkar, Rex Jeya Rajkumar Samdavid Thanapaul, Manoj Govindarajulu, Gaurav Phuyal, Joseph B. Long, Peethambaran Arun

“…Background/Objectives: Blast-induced traumatic ocular injuries (bTOI) pose a significant risk to military and civilian populations, often leading to visual impairment or blindness. …”
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An Energy-Efficient Dynamic Feedback Image Signal Processor for Three-Dimensional Time-of-Flight Sensors by Yongsoo Kim, Jaehyeon So, Chanwook Hwang, Wencan Cheng, Jong Hwan Ko

“…These requirements can pose challenges, especially in developing AR and VR technologies for low-power portable devices. …”
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Dynamic synthetic-scanning photoacoustic tracking monitors hepatic and renal clearance pathway of exogeneous probes in vivo by Jing Lv, Hengrong Lan, Aoji Qin, Tong Sun, Dan Shao, Fei Gao, Junjie Yao, Kamran Avanaki, Liming Nie

“…Inspired by this, we investigated the clearance pathway of a clinical drug, mitoxantrone, revealing reduced liver clearance when hepatic function is impaired. Furthermore, immunoglobulin G clearance analysis revealed significant differences among mice with varying renal injury degrees. …”
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High and low similarity backbone extraction using similarity-based link prediction by Ali Yassin, Hocine Cherifi, Hamida Seba, Olivier Togni

“…However, their increasing size and complexity pose challenges for analysis and scalability. Backbone extraction simplifies networks by preserving key structures while reducing complexity. …”
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Nutritional Status and Lung Cavity in Pulmonary Tuberculosis Patient by Christi Giovani Anggasta Hanafi, Fariz Nurwidya, Wiji Lestari, Heidy Agustin, Shaogi Syam

“…These findings might indicate how malnutrition impaired the immune function in PTB patients.…”
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RAU-Net for precise lung cancer GTV segmentation in radiation therapy planning by Huai-wen Zhang, Bo Hu, Jun Yang, Liang-li Xiong, Huan-huan Shi, Qi-liang Xiong, Chen Yi, Shao-feng Jiang

“…However, the low contrast between the tumor and surrounding tissues, small size of the tumor area, and high heterogeneity of its internal structure pose significant technical challenges for accurate segmentation. …”
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Machine learning-driven integration of time-series InSAR and multiple surface factors for landslide identification and susceptibility assessment by Qianyu Wang, Wen Zhang, Jinglin Li, Ziyang Li, Zhi Luo, Qiang Zhao, Jianbo Jian, Fang Shangguan, Yuanxing Yang, Yangyang Ma, Zhen Zhang, Shuangming Zhao, Linyi Li, Lingkui Meng

“…Landslides pose a significant threat to the safety of reservoirs, particularly those situated in canyon terrains. …”
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Application of the U-Net Deep Learning Model for Segmenting Single-Photon Emission Computed Tomography Myocardial Perfusion Images by Ahmad Alenezi, Ali Mayya, Mahdi Alajmi, Wegdan Almutairi, Dana Alaradah, Hamad Alhamad

“…Proper segmentation is critical for accurate diagnosis, but segmentation issues can pose significant challenges, leading to diagnostic difficulties. …”
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YOLOv8n-SSDW: A Lightweight and Accurate Model for Barnyard Grass Detection in Fields by Yan Sun, Hanrui Guo, Xiaoan Chen, Mengqi Li, Bing Fang, Yingli Cao

“…Moreover, the morphological similarity, overlapping, and occlusion between barnyard grass and rice pose challenges for reliable detection in complex environments. …”
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Urinary Albumin-to-Creatinine Ratio (uACR) Point-of-Care (POC) Device with Seamless Data Transmission for Monitoring the Progression of Chronic Kidney Disease by Artitaya Thiengsusuk, Napaporn Youngvises, Runtikan Pochairach, Rehab Osman Taha, Kridsada Sirisabhabhorn, Nadda Muhamad, Wanchai Meesiri, Wanna Chaijaroenkul, Kesara Na-Bangchang

“…Chronic kidney disease (CKD) continues to pose a critical global health challenge, making ongoing monitoring vital for effective management and preventing its progression to end-stage renal disease. …”
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A cross-language perspective on the MAIDAN-concept by Olesia Yehorova, Antonina Prokopenko

“…The proce-dures described in this paper give way to subsequent stages of conceptual analysis and discourse representations. The paper also provides preliminaries to the state of inconsistency between the systemic and utterance meanings of the language expressions of MAIDAN-concept that pose a limitation for comprehending the concept when transmitted to a different linguoculture. …”
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