Understanding Altered Dynamics in Cocaine Use Disorder Through State Transitions Mediated by Artificial Perturbations by Yi Zheng, Yaqian Yang, Yi Zhen, Xin Wang, Longzhao Liu, Hongwei Zheng, Shaoting Tang

“…<b>Background/Objectives</b>: Cocaine use disorder (CUD) poses a worldwide health challenge, with severe consequences for brain function. …”
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A framework for researching African food systems by Julian May, Frans Swanepoel, Claire Helen Quinn, Melody Mentz-Coetzee, Elizabeth Mkandawire, Andrew John Dougill

“…The structure and functioning of current African food systems, together with unfavourable terms of trade and climate change impacts, pose significant challenges to achieving sustainability and more equitable outcomes. …”
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Mental health in children with and without disabilities in a register-based Swedish sample supports the two-continua model: a latent class analysis by Lina Homman, Lilly Augustine, Mats Granlund

“…These features differed significantly between children with and without disabilities, especially relating to participation, social bonds, family functioning, digital media use, and perceived safety. …”
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Metagenomic analysis revealed the bioremediation mechanism of lead and cadmium contamination by modified biochar synergized with Bacillus cereus PSB-2 in phosphate mining wasteland by Yuxin Zhang, Jun Peng, Ziwei Wang, Fang Zhou, Junxia Yu, Ruan Chi, Ruan Chi, Chunqiao Xiao, Chunqiao Xiao

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Comprehensive Transcriptomic Analysis of <i>Spodoptera frugiperda</i> Reveals Stage-Specific Gene Expression and P450-Mediated Adaptation Mechanisms by Ziqi Cheng, Zhe Huang, Bin Yan, Xing Huang, Yang Mei

“…The fall armyworm (<i>Spodoptera frugiperda</i>) is a significant agricultural pest with a broad host range and adaptability, posing challenges to pest management worldwide. To elucidate the molecular mechanisms underpinning their development and resilience, we performed a comprehensive transcriptomic analysis across nine developmental stages, spanning from the first instar larvae to adult forms. …”
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CT Analysis of Variations in the Medial Maxillary Wall Relative to the Medial Orbital Wall: Implications for Surgical Risk Stratification from an Endoscopic Perspective by Humaid Alhumaid, Abdulrahman Alsowinea, Ali Alamer

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Bioinformatics analysis identifies dysregulation of MiR-548F-3p and its hub gene in triple-negative breast cancer by Samira Behroozi, Mahdieh Salimi, Najaf Allahyari Fard

“…Functional enrichment and protein-protein interaction (PPI) network analyses were conducted. …”
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Beyond N-Grams: Enhancing String Kernels With Transformer-Guided Semantic Insights by Nazar Zaki, Reem Alderei, Mahra Alketbi, Alia Alkaabi, Fatima Alneyadi, Nadeen Zaki

“…We propose and evaluate four innovative kernel-based methods namely Attention-Augmented Kernel, Error Pattern Analysis, Transformer-Guided N-gram Selection, and a Custom Kernel Function each designed to uniquely capture semantic and structural distinctions of text. …”
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Efficacy and tolerability of pharmacological interventions for schizophrenia non-responsive to prior treatment: a systematic review and network meta-analysisResearch in context by Myrto Samara, Andreas S. Lappas, Elisavet Pinioti, Eleni Glarou, Iwo Fober, Christos Christogiannis, Spyridon Siafis, Nikos Christodoulou, Bartosz Helfer, Dimitris Mavridis, Stefan Leucht

“…Summary: Background: Treatment-resistant schizophrenia (TRS) poses significant challenges for both clinicians and patients. …”
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Shared and specific competing endogenous RNAs network mining in four digestive system tumors by Yulai Tang, Aamir Fahira, Siying Lin, Yiming Shao, Zunnan Huang

“…The ceRNA networks were constructed using the miRcode and ENCORI databases. Functional enrichment analysis and prognostic RNA screening were performed with ConsensusPathDB and univariate Cox regression analysis. …”
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Experimental validation of cuproptosis-associated molecular signatures and their immunological implications in pulmonary tuberculosis by Xiaofang Liu, Xiaofang Liu, Qianqian Ma, Zhiming Li, Yong Xue, Jie Mi, Yuxi Li, Chunfeng Bai, Donglin Guo, Yinping Liu, Yan Liang, Jianqin Liang, Xueqiong Wu

“…BackgroundThe pathogenic mechanism underlying Mycobacterium tuberculosis (MTB) remains elusive, posing challenges to its diagnosis and treatment. …”
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Expanding our understanding of (mal)adapted stress physiology in psychiatric disorders: achieving single-cell characterisation of steroids and neuropeptides by Katrina Z. Edmond, Natalie Matosin

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Prevalence and Variability of <i>Helicobacter pylori</i> Clarithromycin Resistance Mutations in Pediatric Patients in Poland: A Genotypic Analysis Using the Bosphore Genotyping Kit by Tomasz Bogiel, Anna Szaflarska-Popławska, Agnieszka Krawczyk

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Eco-friendly approach to corrosion inhibition of aluminum by Congo red dye in alkaline media: Experimental assessment, QSAR modeling, diffusion studies, and DFT/MC/MD simulations by Ayoub Chahid, Said Meftah, Mohamed Essahli, Mohammed Chafi, Rachid Kellal, Driss Benmessaoud Left, Mustapha Zertoubi

“…DFT and DFTB+ calculations identified key adsorption centers through Mulliken charges, MEP maps, and Fukui functions. COSMO-RS and sigma profile analysis revealed favorable solvation and hydrogen-bonding behavior. …”
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The safety and efficacy of spray cryotherapy after endoscopic sinus surgery in chronic rhinosinusitis: A systematic review of randomized controlled trials [version 2; peer review:... by Adham A. Aljariri, Ibrahim T. Abuawwad, Mohammad T. Abuawwad, Ayham R. Sara, Mohammad J. J. Taha, Obaida Falah, Abdulqadir J. Nashwan, Majed Akili, Ahmad J. Taha, Abdullah A. Elhakim

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Integrating Metabolomics, Histopathology, and Cardiac Marker Analysis to Assess Valsartan&rsquo;s Efficacy in Mitigating Dasatinib-Induced Cardiac Toxicity in Sprague-Dawley Rats by Alhazzani K, Mohammed H, Algahtani MM, Aljerian K, Alhoshani A, As Sobeai HM, Ahamad SR, Alotaibi MR, Alhamed AS, Alasmari F, Alqinyah M, Alhamami HN, Alanazi AZ

“…Immunohistochemical analysis revealed altered expression of apoptosis-related proteins, including caspase-3 and BCL-2, with improved levels in the combination group compared to DASA alone. …”
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Comprehensive genome analysis of two Cytospora (Cytosporaceae, Diaporthales) species associated with canker disease of spruce: C. piceae and C. piceicola sp. nov. by Evgeny Ilyukhin, Yanpeng Chen, Svetlana Markovskaja, Ashwag Shami, Sajeewa S. N. Maharachchikumbura

“…Furthermore, the comparative genomics component of the study will facilitate the functional analysis of the genes of unknown function in all fungal pathogens.…”
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Discovery of Genomic Targets and Therapeutic Candidates for Liver Cancer Using Single-Cell RNA Sequencing and Molecular Docking by Biplab Biswas, Masahiro Sugimoto, Md. Aminul Hoque

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Effect of intermolecular interactions and pharmacokinetic profile of antidiabetic agent (E)-N,N‑diethyl-2-(5(3‑hydroxy-4-methoxybenzylidene)-2,4-dioxothiazolidin-3-yl) acetamide... by Arubiya J, S.J. Jenepha Mary, V. Shally, Mohd Usman Mohd Siddique, J. Deva Anban

“…Geometry optimization of DMDA was carried out using density functional theory with 6–311+G(d, p) basis set to develop a theoretical model close to the previously synthesized and reported DMDA. …”
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Combining single-cell analysis and molecular docking techniques to construct a prognostic model for colon adenocarcinoma and uncovering inhibin subunit βb as a novel therapeutic ta... by Qinqing Wu, Qinqing Wu, Lu Ye, Yuwei Wu, Mengyu Zhao, Mengyu Zhao, Jiaxin Lu, Yanping Yu, Yanping Yu, Yixiao Niu, Yixiao Niu, Luxiao Zhang, Peijun Zuo, Peijun Zuo

“…Using Cox proportional hazards models and Lasso regression analysis, we developed a prognostic signature derived from these ARGs. …”
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