tRF-5028c disrupts trophoblast function in recurrent spontaneous abortion by inhibiting CRKL-mediated Rap1 signaling pathway by Jialyu Huang, Jiawei Wang, Shuang Wang, Xiangpeng Xiong, Ruiyin Jiang, Chaoyi Xiong, Lu Wang, Lingling Huang, Yan Zhao, Zheng Fang, Xiaoyan Ai, Jiaying Lin

“…Abstract Background Recurrent spontaneous abortion (RSA) affects approximately 1–5% of childbearing women and poses a significant threat to global reproductive health. …”
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Persuasive Complex as a Unit of Analysis of Parliamentary Discourse by S. A. Gromyko

“…It is concluded that the persuasive complex is a unit of discourse analysis, which is aimed at identifying the semantic, formal and functional components of the addressee's impact on the recipient.…”
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Evolutionary Analysis and Antiviral Drug Prediction of Mpox Virus by Zhong-Hao Lian, Chen-Hui Yang, Ye Qiu, Xing-Yi Ge

“…An interaction network involving MIHPs and other viruses confirmed that these proteins can interact with various viruses that infect humans. Functional analysis of MIHPs suggested their enrichment in host immunity pathways. …”
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Privacy-preserving and verifiable spectral graph analysis in the cloud by Yuzhao Song

“…Abstract Resorting to cloud computing for spectral graph analysis on large-scale graph data is becoming increasingly popular. …”
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Association Between Treatment of Childhood Cancer and Its Late Effects on Gonadal or Growth Function in Childhood Cancer Survivors: A Retrospective Observational Study by Ryuta Urakawa, Amane Noi, Hiroto Kageyama, Mikiko Ueda, Yoshiko Hashii, Kenji Ikeda

“…Conclusion Female sex, allo‐HSCT, and use of platinum are possibly associated with an increased risk of late effects on gonadal function, while auto‐HSCT may pose a risk for late effects on both gonadal and growth functions. …”
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Analysis and validation of characteristic genes in RNA sequencing datasets from heart failure patients based on multiple algorithms by Yuxuan Li, Ying Bai, Wujiao Wang, Zhaotian Ma, Peng Li, Dong Li, Sinai Li, Jialin Jin, Jialin Jin, Qian Lin

“…BackgroundPatients with heart failure (HF) have a poor prognosis and continue to pose a global threat to human health. Consequently, it is crucial to employ bioinformatic approaches to analyze functional alterations within the transcriptome. …”
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HEP14-activated PKC-ERK1/2 pathway boosts HEP14-empowered hADSCs for ovarian regeneration and functional restoration by Jiajia Sun, Qin Zhong, Kan Liu, Qili Sun, Chunan Lu, Yingtong Di, Lin Bai, Helen Picton, Bin Tang, Xiaojiang Hao, Liming Gui

“…Abstract Premature ovarian insufficiency (POI) and age-related natural-aging ovarian insufficiency (ARNA-OI) pose pressing global health challenges, necessitating effective therapeutic strategies and a deep understanding of their underlying mechanisms. …”
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An EcDNA gene-based risk model and functional verification of a key ec-lncRNA AC016394.2 for prostate cancer by JiangPing Qiu, Jiang Wu, Nan Zhou, Cong Lai, Xin Huang, Cheng Liu, XiaoQing Yuan, Kewei Xu

“…The progression and heterogeneity of tumors pose significant challenges to clinical prognosis and treatment strategies. …”
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Heat Stress Effects on Animal Health and Performance in Monogastric Livestock: Physiological Responses, Molecular Mechanisms, and Management Interventions by José A. M. Prates

“…Rising global temperatures driven by climate change have markedly increased the incidence of heat stress (HS) in monogastric livestock, posing critical challenges to animal welfare, health and productivity. …”
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From Signal to Safety: A Data-Driven Dual Denoising Model for Reliable Assessment of Blasting Vibration Impacts by Miao Sun, Jing Wu, Junkai Yang, Li Wu, Yani Lu, Hang Zhou

“…However, the signals monitored are frequently tainted with noise, which undermines the precision of time–frequency analysis. To counteract the dangers posed by blast vibrations, effective signal denoising is crucial for accurate evaluation and safety management. …”
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NAF-MEEF: A Nonlinear Activation-Free Network Based on Multi-Scale Edge Enhancement and Fusion for Railway Freight Car Image Denoising by Jiawei Chen, Jianhai Yue, Hang Zhou, Zhunqing Hu

“…Furthermore, the structural complexity of freight cars, coupled with the small size, diversity, and complex structure of defect areas, poses serious challenges for image denoising. Specifically, it becomes extremely difficult to remove noise while simultaneously preserving fine-grained textures and edge details. …”
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Transformation of the capabilities of higher school teachers in conditions of uncertainty: Problem statement by E. F. Zeer, T. M. Rezer, N. V. Symaniuk

“…The problem is posed in the field of transformation of the capabilities and functions of higher school teachers in conditions of uncertainty from the perspective of different sciences. …”
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Research on Compliance Thresholds Based on Analysis of Driver Behavior Characteristics by Mingyue Ma, Weiqing Wang, Zelin Miao, Tao Wang, Guangming Zhao

“…Traffic regulations provide a solid foundation for the safety of all road users; however, the ambiguous provisions and unclear safety thresholds within these regulations pose significant challenges to compliance, particularly concerning the safe operation of autonomous vehicles. …”
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Prolonged Proofing Modulates the Acrylamide Content, Nutritional and Functional Characteristics of Pumpkin (<i>Cucurbita maxima</i> Plomo) and Soft Wheat Composite Bread by Durim Alija, Remigiusz Olędzki, Daniela Nikolovska Nedelkoska, Agata Wojciechowicz-Budzisz, Ewa Pejcz, Vezirka Jankuloska, Gafur Xhabiri, Joanna Harasym

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Evaluation of Taraxacum officinale phytoconstituents as potential JNK1 inhibitors: Perspectives from ADMET, molecular docking, molecular dynamics, and density functional theory by Sphelele C. Sosibo, Hendrik G. Kruger, Wonder P. Nxumalo, Zimbili Zondi

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Selective laser melting fabrication of functionally graded macro-porous Ti-6Al-4V scaffold for cavity bone defect reconstruction by Zhuangzhuang Li, Zhuangzhuang Li, Yi Luo, Yi Luo, Ruicheng Liu, Shanfang Zou, Yitian Wang, Yitian Wang, Taojun Gong, Taojun Gong, Xuanhong He, Xuanhong He, Yong Zhou, Yong Zhou, Minxun Lu, Minxun Lu, Li Min, Li Min, Chongqi Tu, Chongqi Tu

“…Reconstruction of cavitary bone defects poses significant challenges in orthopedic surgery due to the irregular shapes and compromised mechanical properties of surrounding bone. …”
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Research on Food Image Classification Algorithm based on Improved MobileNetV3-Large by HE Wei-chan, YANG Zhi-jing, QIN Jing-hui

“…Food image recognition plays a crucial role in food safety monitoring, nutritional analysis, and dietary recommendation systems. However, the diversity, complexity, and external factors such as lighting conditions pose numerous difficulties and challenges to the recognition task. …”
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An untargeted metabolomics analysis in feces and brain of Orthoflaviviruses-infected mice by Zhiwei Su, Ningze Sun, Chenghong Yin, Xiaoyan Zheng

“…These include diseases caused by the Dengue virus (DENV), Japanese encephalitis virus (JEV), and Zika virus (ZIKV), posing a formidable challenge to global public health. …”
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The Role of Potassium and KUP/KT/HAK Transporters in Regulating Strawberry (<i>Fragaria</i> × <i>ananassa</i> Duch.) Fruit Development by José A. Mercado-Hornos, Claudia Rodríguez-Hiraldo, Consuelo Guerrero, Sara Posé, Antonio J. Matas, Lourdes Rubio, José A. Mercado

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Advancing periodontitis microbiome research: integrating design, analysis, and technology by Yibing Han, Pei-Hui Ding

“…We reviewed the analytical paradigms of metatranscriptomics and found that current analysis is largely limited to assessing functional changes in known periodontal pathogens, highlighting the need for a functional-driven approach. …”
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