Comparative Clinical-Imaging and Histogenetic Analysis Between Astrocytoma IDH-Mutant Grade 4 and Glioblastoma IDH-Wildtype—Is There Really a Worse One? by Cristian Ionut Orasanu, Mariana Aschie, Mariana Deacu, Madalina Bosoteanu, Sorin Vamesu, Manuela Enciu, Georgeta Camelia Cozaru, Anca Florentina Mitroi, Sinziana Andra Ghitoi, Ana Maria Cretu, Oana Andreea Ursica, Raluca Ioana Voda

“…<b>Background:</b> Brain tumors pose a significant health threat, leading to high morbidity and mortality rates. …”
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Genomic insights into the population structure, antimicrobial resistance, and virulence of Brachyspira hyodysenteriae from diverse geographical regions by Maria Hakimi, Fangshu Ye, Anugrah Saxena, Xiao Hu, Huigang Shen, Paarthiphan Elankumaran, Chloe C. Stinman, Nubia Macedo, Orhan Sahin, Eric R. Burrough, Ganwu Li

“…Importantly, the study detects AMR genes, including tva(A) and lnu(C), linked to tiamulin and lincomycin resistance, that may pose significant challenges to disease management. …”
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Ultra-low-input cell-free DNA sequencing for tumor detection and characterization in a real-world pediatric brain tumor cohort by Tom T. Fischer, Kendra K. Maaß, Pitithat Puranachot, Markus Mieskolainen, Martin Sill, Paulina S. Schad, Stefanie Volz, Fabian Rosing, Tatjana Wedig, Nathalie Schwarz, Agnes M. E. Finster, Florian Iser, Jochen Meyer, Felix Sahm, Olli Lohi, Ahmed El Damaty, Benedikt Brors, Hannu Haapasalo, Stefan M. Pfister, Joonas Haapasalo, Kristian W. Pajtler, Kristiina Nordfors

“…However, in pediatric neuro-oncology, low cfDNA yields pose a major barrier to translating these assays from bench to bedside. …”
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Design and Calibration of Electron Stack Spectrometer for Diagnosing Hot Electron Temperature in Intense Laser-plasma Interactions by BO Nan1, 2, TIAN Baoxian2, WANG Haoran3, 4, WANG Naiyan2

“…Accurate diagnosis of the hot electron temperature within these plasmas is essential for understanding energy coupling mechanisms and the spatiotemporal evolution of the plasma. However, the intense electromagnetic pulses (EMPs) and high-flux radiation produced during these interactions pose significant challenges to conventional electronic measurement techniques, often leading to signal saturation or interference. …”
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Detection of Four Intermediate-mass Stars with Cool Companions in Low Mass Ratio Eclipsing Binaries by Linfeng Chang, Shengbang Qian, Lei Zang, Fuxing Li

“…They are valuable targets for testing theories of binary formation and evolution.…”
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An Electrochemical/Thermodynamic Analytical Model for Hard‐Pack Lithium‐Ion Batteries in Engineering Education by Ligang Wang, Hangyang Li, Zhiliang Huang, Peng Wu, Jiayuan Huangfu

“…ABSTRACT Modeling lithium‐ion battery states plays a crucial role in supporting engineering education, yet applying existing models in the classroom poses challenges. This paper presents an electrochemical/thermodynamic analytical model with 19 parameters for hard‐pack lithium‐ion batteries, providing efficient and compact MATLAB code as an instructional tool for engineering education. …”
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De quelques visions mondiales des limites de l'environnement by Edwin Zaccai

“…Nous revenons sur plusieurs manières dont ce problème a été posé, sur leurs évolutions et sur certaines solutions proposées : Halte à la croissance ? …”
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Analysis of genomic heterogeneity and the mutational landscape in cutaneous squamous cell carcinoma through multi-patient-targeted single-cell DNA sequencing by Wen Chen, Jiawei Xu, Chengdong Yu, Meng Zhou, Yong Ai, Wenbing Rao, Qingchuan Wang, Siyi Xu, Lei Tang, Si Gong, Jun Rao

“…Abstract Background Cutaneous squamous cell carcinoma (CSCC) is a prevalent skin cancer with aggressive progression that poses significant challenges, especially in metastatic cases. …”
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Research Framework and Anticipated Outcomes of Flash Flood Disasters Due to the Combined Effects of Extreme Rainfall and Intense Human Activities by Xiekang WANG

“…Numerous major flash flood events have demonstrated that the processes and characteristics of flash floods induced by extreme rainfall vary significantly, posing substantial challenges for prediction, warning, and defense. …”
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Re-use of Building Products in the Netherlands by Loriane Icibaci

“…The industry of reuse, by analogy, relies on the evolution of the building stock to supply the consumption of reusable building products. …”
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Zoological exhibitions in natural history museums: classic design and modern approach by Igor Evstafiev

“…The Evolution Gallery exhibition is a vivid example of a new approach that skilfully combines the display of stuffed animals and modern technologies to convey information about the principles of evolution, biodiversity, and the role of animals in ecosystems. …”
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Phage-mediated virulence loss and antimicrobial susceptibility in carbapenem-resistant Klebsiella pneumoniae by Yanshuang Yu, Mengzhu Wang, Liuying Ju, Minchun Li, Mengshi Zhao, Hui Deng, Christopher Rensing, Qiu E. Yang, Shungui Zhou

“…ABSTRACT Bacteriophages, known for their ability to kill bacteria, are hampered in their effectiveness because bacteria are able to rapidly develop resistance, thereby posing a significant challenge for the efficacy of phage therapy. …”
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Innovation systems: a bibliometric review of the contemporary research employing natural language processing by Hendrik J. Jansen

“…Innovation systems research has seen rapid evolution, expanding in both depth and scope. The increasing frequency of contributions has added complexity, posing challenges for scholars and practitioners in management and policy. …”
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PERSPECTIVES REGARDING THE USAGE OF TECHNOLOGY IN THE HOTEL INDUSTRY by ALEXANDRU CRISTIAN DOBRE

“…However, it concurrently poses challenges in maintaining currency within the technological landscape and discerning the most recent and suitable solutions available. …”
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Russian Migration Policy: New Starting Points by M. A. Neimark

“…The author traces the evolution of the conceptual foundations of Russia’s migration policy and the features of its implementation at various stages of social, economic and political development of the country. …”
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Plant long noncoding RNAs: why do we not know more? by Paulina Kościelniak, Łukasz Walas, Agata Konecka, Włodzimierz Buraczyk, Ewelina A. Klupczyńska

“…Abstract Analysis of plant and animal genomes is essential for understanding their biological function, adaptation, and evolution. Human genomic databases are the most advanced due to extensive research on the genetic basis of disease and personalized medicine. …”
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Interplay between HIV-1 and Host Genetic Variation: A Snapshot into Its Impact on AIDS and Therapy Response by Raghavan Sampathkumar, Elnaz Shadabi, Ma Luo

“…The fact that there are CRFs, which are an amalgamation of sequences derived from six or more subtypes (CRF27_cpx (cpx refers to complex) is a mosaic with sequences from 6 different subtypes besides an unclassified fragment), serves as a testimony to the continual divergent evolution of the virus with its approximate 1% per year rate of evolution, and this phenomena per se poses tremendous challenge for vaccine development against HIV/AIDS, a devastating disease that has killed 1.8 million patients in 2010. …”
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A broadly neutralizing antibody against the SARS-CoV-2 Omicron sub-variants BA.1, BA.2, BA.2.12.1, BA.4, and BA.5 by Zhe Chen, Leilei Feng, Lei Wang, Li Zhang, Binyang Zheng, Hua Fu, Fengdi Li, Ligai Liu, Qi Lv, Ran Deng, YanLi Xu, Yongfeng Hu, Jianhua Zheng, Chuan Qin, Linlin Bao, Xiangxi Wang, Qi Jin

“…(SARS-CoV-2) and its variant strains, including Alpha, Beta, Gamma, Delta, and now Omicron, pose a significant challenge. With the constant evolution of the virus, Omicron and its subtypes BA.1, BA.2, BA.3, BA.4, and BA.5 have developed the capacity to evade neutralization induced by previous vaccination or infection. …”
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Evolving SARS-CoV-2 Vaccines: From Current Solutions to Broad-Spectrum Protection by Rui Qiao, Jiayan Li, Jiami Gong, Yuchen Shao, Jizhen Yu, Yumeng Chen, Yinying Lu, Luxuan Yang, Luanfeng Lin, Zixin Hu, Pengfei Wang, Xiaoyu Zhao, Wenhong Zhang

“…The continuous evolution of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the emergence of variants of concern (VOCs) underscore the critical role of vaccination in pandemic control. …”
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Neutralization and spike stability of JN.1-derived LB.1, KP.2.3, KP.3, and KP.3.1.1 subvariants by Pei Li, Julia N. Faraone, Cheng Chih Hsu, Michelle Chamblee, Yajie Liu, Yi-Min Zheng, Yan Xu, Claire Carlin, Jeffrey C. Horowitz, Rama K. Mallampalli, Linda J. Saif, Eugene M. Oltz, Daniel Jones, Jianrong Li, Richard J. Gumina, Joseph S. Bednash, Kai Xu, Shan-Lu Liu

“…These findings emphasize the critical role of NTD mutations in shaping viral evolution and immune evasion, underscoring the urgent need for updated coronavirus disease 2019 vaccines that account for these adaptive changes.…”
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