Machine learning-derived asthma and allergy trajectories in children: a systematic review and meta-analysis by Daniil Lisik, Saliha Selin Özuygur Ermis, Gregorio Paolo Milani, Giulia Carla Immacolata Spolidoro, Selin Ercan, Michael Salisu, Faozyat Odetola, Daniele Giovanni Ghiglioni, Danylo Pylov, Emma Goksör, Rani Basna, Göran Wennergren, Hannu Kankaanranta, Bright I. Nwaru

“…Associated risk factor and outcome estimates were pooled using a random-effects meta-analysis. Results 89 studies were included. …”
Get full text

Investigation of the HLA locus in autopsy-confirmed progressive supranuclear palsy by Jinguo Wang, Shelley L. Forrest, Sathish Dasari, Hidetomo Tanaka, Ekaterina Rogaeva, M. Carmela Tartaglia, Susan Fox, Anthony E. Lang, Subha Kalyaanamoorthy, Gabor G. Kovacs

“…The human leukocyte antigen (HLA) locus on chromosome 6 is a polymorphic region with complex linkage patterns that has been implicated in several autoimmune and neurological disorders. …”
Get full text

Bridging micro and macroevolution: insights from chromosomal dynamics in plants by Carmen Benítez-Benítez, Ashwini V. Mohan, Rogelio Sánchez-Villegas, Inés Gómez-Ramos, Ana Valdés-Florido, Kay Lucek, Marek Slovák, Marek Slovák, Filip Kolář, Filip Kolář, Ilia J. Leitch, Modesto Luceño, Isabel Larridon, Angelino Carta, Angelino Carta, Joan Cuscó-Borràs, Enrique Maguilla, Alegría Montero-Ramírez, Patrick G. Meirmans, Alison Dawn Scott, Santiago Martín-Bravo, Marcial Escudero

“…Here, we address the following questions: Are macroevolutionary patterns of chromosome evolution the result of accumulated microevolutionary changes, or do chromosomal dynamics drive larger shifts along the speciation continuum? …”
Get full text

Comparative Efficacy and Safety of Potassium-Competitive Acid Blocker– and Proton Pump Inhibitor–Based Bismuth Quadruple Therapy for Helicobacter pylori Eradication: A Network Meta... by Iqbal Taufiqqurrachman, Ari Fahrial Syam, Hasan Maulahela, Murdani Abdullah, Muhammad Miftahussurur, Yoshio Yamaoka

“…Therefore, tailored therapies based on local resistance patterns remain critical considerations in clinical practice.…”
Get full text

The 96-week outcomes and pharmacokinetics of long-acting cabotegravir plus rilpivirine in South Africans by Rosie Mngqibisa, Yashna Singh, Catherine Orrell, Johan Lombaard, Sandy Griffith, Conn Harrington, Ronald D’Amico, William Spreen, Marty St Clair, Christine Latham, Louise Garside, Rodica Van Solingen-Ristea, Veerle Van Eygen, Fafa Addo Boateng, Herta Crauwels, Prosperity Eneh, Ingrid Eshun-Wilsonova

“…Background: Evaluating long-term efficacy, safety and pharmacokinetics of long-acting cabotegravir + rilpivirine (CAB+RPV LA) in sub-Saharan African populations is important because of the region’s unique demographics and antiretroviral therapy resistance patterns. Objectives: To describe the 96-week efficacy, safety and pharmacokinetics of CAB+RPV LA in South African participants from the pooled FLAIR and ATLAS-2M Phase 3/3b randomised studies. …”
Get full text

Influences on limited antimicrobial use in small-scale freshwater aquaculture farms in central Thailand by Nour Alhusein, Boonrat Chantong, Sarin Suwanpakdee, Anuwat Wiratsudakul, Virginia C. Gould, Kantima Wichuwaranan, Kornrawan Poonsawad, Varapon Montrivade, Nutcha Charoenboon, Luechai Sringernyuang, Matthew B. Avison, Helen Lambert, Walasinee Sakcamduang, Henry Buller, Kristen K. Reyher

“…They relied on farm management practices to maintain the health of their aquatic animals, using lime and salt to maintain and improve water quality and pH and to disinfect aquaculture pools. Farmers also reported obtaining juvenile fish and shrimp selectively from farms known to produce healthy stock. …”
Get full text

Machine Learning-Based Intrusion Detection Systems for the Internet of Drones: A Systematic Literature Review by Mostafa Ogab, Sofiane Zaidi, Abdelhabib Bourouis, Carlos T. Calafate

“…Existing Intrusion Detection Systems (IDS) for IoD face several limitations, including high false positive rates, resource constraints of drones, limited adaptability to evolving attack patterns, and a lack of standardized datasets for benchmarking, despite ongoing research efforts. …”
Get full text

Sexual dimorphism in the association of umbilical cord blood lipidome with abdominal fat in early childhood by Kothandaraman Narasimhan, Mya Thway Tint, Li Chen, Sartaj Ahmad Mir, Suresh Anand Sadananthan, Navin Michael, Adaikalavan Ramasamy, Karen Mei-Ling Tan, Priti Mishra, Anne K. Bendt, Kok Hian Tan, David Cameron-Smith, Yap Seng Chong, Peter D. Gluckman, Peter J. Meikle, Melvin Khee Shing Leow, Fabian Yap, Yung Seng Lee, Chan Shiao Yng, Johan G. Eriksson, S Sendhil Velan, Neerja Karnani, Markus R. Wenk

“…Conclusions Our study reveals sexual dimorphism in the associations between cord blood lipidome and abdominal adiposity, suggesting depot-specific patterns in adipose tissue development and lipid metabolism in early life.…”
Get full text

Impact of alcohol consumption on outcomes and potential of immune biomarkers for postoperative complications in trauma patients by Mohammad Majd Hammour, Yelda Anuk, Regina Breinbauer, Romina H. Aspera-Werz, Yuxuan Xin, Guanqiao Chen, Tina Histing, Sabrina Ehnert, Andreas K. Nüssler, Stefan Döbele

“…Acute systemic alcohol levels at the time of injury were not measured or considered in this study, as the focus was on chronic consumption patterns. Routine blood screening data were analyzed.ResultsExcept for CRP, blood values were comparable between patients with risky alcohol consumption and controls. …”
Get full text

Women’s Empowerment and Gender-Related Factors Associated with Maternal Tetanus Protection in 39 Low- and Middle-Income Countries by Katherine Kirkby, Luisa Arroyave, Franciele Hellwig, M. Carolina Danovaro-Holliday, Nasir Yusuf, Shirin Heidari, Stephanie Shendale, Aluísio J. D. Barros, Ahmad Reza Hosseinpoor

“…To assess the association between measures of women’s empowerment and gender-related factors and maternal tetanus immunization coverage, we used multilevel logistic models with pooled data from the 39 countries to analyze overall patterns, and we used multivariable logistic regression for each country-specific dataset to analyze country-level associations. …”
Get full text

Anatomical Variants in Pancreatic Irrigation and Their Clinical Considerations for the Pancreatic Approach and Surrounding Structures: A Systematic Review with Meta-Analysis by Juan José Valenzuela-Fuenzalida, Camila Ignacia Núñez-Castro, Valeria Belén Morán-Durán, Pablo Nova-Baeza, Mathias Orellana-Donoso, Alejandra Suazo-Santibáñez, Alvaro Becerra-Farfan, Gustavo Oyanedel-Amaro, Alejandro Bruna-Mejias, Guinevere Granite, Daniel Casanova-Martinez, Juan Sanchis-Gimeno

“…Understanding different vascular patterns (such as those from the splenic and mesenteric arteries) is crucial for surgical interventions on the pancreas. …”
Get full text

The correlation between airborne pollen and asthma in children: a systematic review and meta-analysis by Xiaoya Wang, Bo Liu, Yujie Yang, Jimin Li, Ziyan Tian, Jinwei He, Yuanxia Li

“…Seasonal and geographic pollen variations, influenced by climate change, may affect asthma patterns. A comprehensive review is needed to clarify these associations and guide prevention strategies.MethodsRelevant literature on the association between airborne pollen and asthma in children was retrieved from CNKI, Wanfang Data, VIP, CBM, Web of Science, PubMed, Cochrane and Embase at home and abroad from the establishment of the database to March 1, 2025. …”
Get full text

Identification of long noncoding RNAs (lncRNAs) and co-transcriptional analysis of mRNAs and lncRNAs in transcriptomes of Anopheles gambiae by Jiannong Xu, Kai Hu, Michelle M. Riehle, Vedbar S. Khadka

“…Unsurprisingly, and similar to what has been reported for mRNAs, lncRNAs exhibited context-dependent expression patterns. Co-expression networks constructed using weighted gene co-expression network analysis (WGCNA) highlighted the interconnections among lncRNAs and mRNAs, which provide potential functional networks in which these lncRNAs are involved. …”
Get full text

Efficacy of sacituzumab govitecan versus treatment of physician’s choice in previously treated HR+ and HER2− mBC: a meta-analysis of TROPiCS-02 and EVER-132-002 trials by Oleg Gluz, Binghe Xu, Rita Nanda, Anandaroop Dasgupta, Ankita Kaushik, Wendy Verret, Akanksha Sharma, Barinder Singh, Hope S. Rugo

“…In the overall meta-analytic model, SG showed a significant improvement over TPC in PFS (hazard ratio (HR), 0.62 (95% confidence interval (CI): 0.50–0.77); p  < 0.001) and OS (HR, 0.66 (95% CI: 0.55–0.80); p  < 0.001). Similar patterns in efficacy were observed in both fast-progressors as well as patients previously treated with CDK4/6i. …”
Get full text

Wealth-based inequality in underweight among Scheduled Tribe women in India: a regional analysis by Anshika Singh, Aditya Singh, Mahashweta Chakrabarty, Shivani Singh, Pooja Tripathi

“…This study aims to explore trends and patterns of wealth-based inequalities in underweight prevalence among Scheduled Tribe (ST) women across various regions of India. …”
Get full text

Distribution of macrozoobenthic taxa - potential indicators of vulnerable marine ecosystems in the western part of Bering Sea. 1. Anadyr Bay area by Victor A. Nadtochy, Nickolay V. Kolpakov, Ilya A. Korneichuk

“…On the contrary, barnacles, sponges and sea squirts have similar distribution of the biomass, being complementary species. Distribution patterns of all species-indicators are stable for many decades. …”
Get full text

Macrophage Infiltration Correlated with IFI16, EGR1 and MX1 Expression in Renal Tubular Epithelial Cells Within Lupus Nephritis-Associated Tubulointerstitial Injury via Bioinformat... by Tian M, Tang M, Chen C, Lin Y, Chen H, Xu Y

“…Ming Tian,1,2,&ast; Min Tang,1,2,&ast; Caiming Chen,1– 3,&ast; Yufang Lin,1,2 Hong Chen,4 Yanfang Xu1– 3 1Department of Nephrology, Blood Purification Research Center, the First Affiliated Hospital, Fujian Medical University, Fuzhou, People’s Republic of China; 2Fujian Clinical Research Center for Metabolic Chronic Kidney Disease, the First Affiliated Hospital, Fujian Medical University, Fuzhou, People’s Republic of China; 3Department of Nephrology, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, 350212, People’s Republic of China; 4Department of Pathology, the First Affiliated Hospital, Fujian Medical University, Fuzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Hong Chen; Yanfang Xu, Email fychenhong@126.com; xuyanfang99@hotmail.comObjective: A comprehensive bioinformatics analysis was conducted to investigate potential new diagnostic biomarkers and immune infiltration characteristics associated with tubulointerstitial injury in lupus nephritis (LN), and to examine possible correlations between key genes and infiltrating immune cells.Methods: The GSE32591, GSE113342, and GSE200306 datasets were downloaded from the Gene Expression Omnibus database and differentially expressed genes (DEGs) were identified in the pooled dataset. Support vector machine-recursive feature elimination analysis and the least absolute shrinkage and selection operator regression model were used to screen for possible markers, and the compositional patterns of the 22 types of immune cell fractions in LN were determined using CIBERSORT. …”
Get full text

Depth-Resolved and Depth-Integrated Primary Productivity Estimates From In-Situ and Satellite Data in the Global Ocean by Harish Kumar Kashtan Sundararaman, Palanisamy Shanmugam

“…Estimates of marine phytoplankton primary productivity (PP) from satellite remote sensing observations are potentially used to assess global carbon budgets, biogeochemical response, pools and fluxes of carbon and its spatial and temporal variations due to ocean-atmospheric oscillations under climate change. …”
Get full text

Current clinical profiles for Chinese hemodialysis patients by Xinju Zhao, Chengqian Ma, Liangying Gan, Fan Fan Hou, Xinling Liang, Xiaonong Chen, Zhaohui Ni, Yuqing Chen, Xue Li, Wudong Guo, Li Zuo

“…Notably, 81.2% of patients had a single-pooled Kt/V ≥ 1.2, and 80.5% maintained albumin levels > 3.5 g/dl. …”
Get full text

Gender differences in use of cigarette and non-cigarette tobacco products among adolescents aged 13–15 years in 20 African countries by Israel T. Agaku, Rose Sulentic, Adriana Dragicevic, Gibril Njie, Candace K. Jones, Satomi Odani, Tina Tsafa, Joy Gwar, Constantine I. Vardavas, Olalekan Ayo-Yusuf

“…Differential gender patterns of cigarette and non-cigarette tobacco product use among youth may have implications for future disease burden. …”
Get full text