DNMT3A regulates murine megakaryocyte-biased hematopoietic stem cell fate decisions by Sarah M. Waldvogel, Virginia Camacho, Dandan Fan, Anna G. Guzman, Alejandra Garcia-Martell, Elmira Khabusheva, Jacey Rodriguez Pridgen, Josephine De La Fuente, Rachel Rau, Ashlyn G. Laidman, Maria N. Barrachina, Estelle Carminita, Justin A. Courson, Michael R. Williamson, Joanne I. Hsu, Chun-Wei Chen, Jaime Reyes, Subhashree Pradhan, Rolando E. Rumbaut, Alan R. Burns, Benjamin Deneen, Jianzhong Su, Kellie R. Machlus, Margaret A. Goodell

“…Although transcriptional differences between WT and Dnmt3a+/– megakaryocyte-biased HSCs are subtle, the pattern of DNA methylation loss in this HSC subset is almost completely different from that in non–megakaryocyte-biased HSCs. …”
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Early childhood education and care quality and associations with child outcomes: A meta-analysis. by Antje von Suchodoletz, D Susie Lee, Junita Henry, Supriya Tamang, Bharathy Premachandra, Hirokazu Yoshikawa

“…Together, the results might have been biased towards patterns prevalent in the U.S. that might not apply to other, non-U.S. …”
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Mechanism Analysis of an Abrupt Torrential Rain Event under Weak Synoptic Forcing by Mingjuan LI, Damei GUO, Dian FENG, Kuifeng ZHAO, Jiahuimin LIU, Liwei QU

“…On July 18， 2021， abrupt rainstorms， torrential rain and local torrential rain occurred in areas of northeastern Xi'an and southern Weinan.The global numerical model and multiple Meso-scale numerical models failed to predict this torrential rain process.Based on data of aerological sounding， surface observation， ERA5 reanalysis， TBB data of FY-2G satellite， lidar wind vector data of Lintong station， radar data of Jinghe station， and microwave radiometer data， circulation patterns， environmental conditions and Meso-scale convective system evolution are investigated in this paper to enhance the understanding of mechanisms of this type of torrential rain and improve its predicting accuracy.Results show that the abrupt torrential rain process occurred under the forcing of a weak synoptic system， on the edge of the continental high at 500 hPa.There were no shear lines， warm advections and high-speed wind transporting water vapor at 700 hPa and 850 hPa， and neither cold front nor warm front on surface.Before the torrential rain process， on environmental fields， vertical wind shear was weak from 0 to 6 km on T-lnP chart， and 0 ℃-level was high， which was conducive to formation of deep warm clouds.A light rain appeared on surface， increasing atmospheric humidity near ground and lowering atmospheric lifting condensation level and lower cloud base， which was favorable for developing Meso-scale convective systems and improving precipitating efficiency.On radar wind profile map and wind lidar map， the low-level easterly wind was increased to 6~10 m·s-1， transferring abundant water vapor and energy to the rainstorm area， giving the atmosphere a certain amount of convective available potential energy（CAPE）.Satellite image， ERA5 reanalysis data and microwave radiometer data show a weak ascent was found in the middle and low levels which produced a deep wet layer and a large value of total atmospheric precipitable water.TBB data indicates that quasi-stationary isolated Meso-β-scale convective systems caused the abrupt torrential rain.On radar composite reflectivity factor map， the heavy rainfall was induced by a Meso-γ-scale and Meso-β-scale convective cell or a Meso-β-scale convective system.The Meso-γ-scale convective cell developed near Lishan Mountain with loose structure and organization.The maximum center of reflectivity factor demonstrates a consistently vertical structure from top to bottom with a low centroid， showing characteristics of highly efficient warm cloud precipitation.The abrupt torrential rain was caused by convections triggered by interaction of the ground convergence line induced by weak cold air on surface， topographic uplift of the Lishan Mountain and funneling effect of Bahe Valley collectively.The initial heavy rainfall formed a cold pool， then， the outflow of the cold pool generated new convergence lines around， triggering new convective systems.The Meso-β-scale convective system on the northeast side of the Jinghe River propagated backwards and moved slowly southwestwards.In the Meso-β-scale convective system， multiple new Meso-γ-scale convective cells developed and created a “train effect” over Jinghe River， resulting in this torrential rain process.For prediction under the forcing of weak synoptic systems， it is necessary to strengthen the understanding of its formation mechanism and the use of new observation data， pay close attention to the influence of early weak precipitation on near-surface humidification and lifting condensation level， water vapor and unstable energy transport to rainstorm areas by increased low-level wind， and the triggering effect of weak cold air on the ground and terrain， combined with maximum values predicted by a number of Meso-scale numerical models， comprehensively consider the possibility of abrupt torrential rain.…”
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Investigation of the HLA locus in autopsy-confirmed progressive supranuclear palsy by Jinguo Wang, Shelley L. Forrest, Sathish Dasari, Hidetomo Tanaka, Ekaterina Rogaeva, M. Carmela Tartaglia, Susan Fox, Anthony E. Lang, Subha Kalyaanamoorthy, Gabor G. Kovacs

“…The human leukocyte antigen (HLA) locus on chromosome 6 is a polymorphic region with complex linkage patterns that has been implicated in several autoimmune and neurological disorders. …”
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Distinct virologic trajectories in chronic hepatitis B identify heterogeneity in response to nucleos(t)ide analogue therapy by Tingyan Wang, Cori Campbell, Alexander J. Stockdale, Stacy Todd, Karl McIntyre, Andrew Frankland, Jakub Jaworski, Ben Glampson, Dimitri Papadimitriou, Luca Mercuri, Erik Mayer, Christopher R. Jones, Hizni Salih, Gail Roadknight, Stephanie Little, Theresa Noble, Kinga A. Várnai, Cai Davis, Ashley I. Heinson, Michael George, Florina Borca, Louise English, Luis Romão, David Ramlakhan, Kerrie Woods, Jim Davies, Eleni Nastouli, Salim I. Khakoo, William Gelson, Graham S. Cooke, Eleanor Barnes, Philippa C. Matthews, Eleanor Barnes, Philippa C. Matthews, William Gelson, Graham S. Cooke, Salim I. Khakoo, Eleni Nastouli, Jim Davies, Kerrie Woods, Alexander J. Stockdale, Stephen Ryder, Ahmed Elsharkawy, Nicholas Easom, William Bernal, Shazaad Ahmad, Douglas Macdonald, Tingyan Wang, Cori Campbell, Simon Stanworth, Suzanne Maynard, Gail Roadknight, Stephanie Little, Kinga A. Várnai, Ben Glampson, Dimitri Papadimitriou, Luca Mercuri, Christopher R. Jones, Jakub Jaworski, Cai Davis, Florina Borca, Ashley Heinson, Michael George, Heidi MacNaughton, Yun Kim, Josune Olza Meneses, Louise English, Timothy Roberts, Luis Romão, David Ramlakhan, Stacy Todd, Heather Rogers, Karl McIntyre, Andrew Frankland, Hizni Salih, Theresa Noble, Lara Roberts, Finola Higgins, Javier Vilar, Ruth Norris, George Tilston, Ilina Serafimova, Sarah Montague, Juliette Verheyden, Irene Juurlink, Kathryn Jack, Alex Waldren-Glenn, Lizzie Poole, Victoria Day, Berit Reglar

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Global glucose metabolism rate as diagnostic marker for disorder of consciousness of patients: quantitative FDG-PET study by Dongsheng Liu, Dongsheng Liu, Dongsheng Liu, Nan Wang, Nan Wang, Nan Wang, Ming Song, Ming Song, Ming Song, Xiaoke Chai, Xiaoke Chai, Qiheng He, Tianqing Cao, Dawei Kong, Zhuhuan Song, Guangming Zhang, Lei Liu, Xiaosong Wang, Guoqiang Chen, Shaoya Yin, Shaoya Yin, Shaoya Yin, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Yi Yang, Jizong Zhao, Jizong Zhao

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Local nutrient addition drives plant diversity losses but not biotic homogenization in global grasslands by Qingqing Chen, Shane A. Blowes, W. Stanley Harpole, Emma Ladouceur, Elizabeth T. Borer, Andrew MacDougall, Jason P. Martina, Jonathan D. Bakker, Pedro M. Tognetti, Eric W. Seabloom, Pedro Daleo, Sally Power, Christiane Roscher, Peter B. Adler, Ian Donohue, George Wheeler, Carly Stevens, G. F. Ciska Veen, Anita C. Risch, Glenda M. Wardle, Yann Hautier, Catalina Estrada, Erika Hersch-Green, Yujie Niu, Pablo L. Peri, Anu Eskelinen, Daniel S. Gruner, Harry Olde Venterink, Carla D’Antonio, Marc W. Cadotte, Sylvia Haider, Nico Eisenhauer, Jane Catford, Risto Virtanen, John W. Morgan, Michelle Tedder, Sumanta Bagchi, Maria C. Caldeira, Miguel N. Bugalho, Johannes M. H. Knops, Chris R. Dickman, Nicole Hagenah, Anke Jentsch, Petr Macek, Brooke B. Osborne, Lauri Laanisto, Jonathan M. Chase

“…Overall, we find proportionally similar species loss at local and larger scales, suggesting similar declines of spatially restricted and widespread species, and no biotic homogenization after 4 years and up to 14 years of treatment. These patterns of diversity changes are generally consistent across species groups. …”
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The structural and functional brain alternations in tobacco use disorder: a systematic review and meta-analysis by Longyao Ma, Longyao Ma, Qiuying Tao, Qiuying Tao, Jinghan Dang, Jinghan Dang, Jieping Sun, Jieping Sun, Xiaoyu Niu, Xiaoyu Niu, Mengzhe Zhang, Mengzhe Zhang, Yimeng Kang, Yimeng Kang, Weijian Wang, Weijian Wang, Jingliang Cheng, Jingliang Cheng, Yong Zhang, Yong Zhang

“…Furthermore, two meta-analyses were pooled for multimodal analysis to discover multimodal anomalies. …”
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Distribution of alkylamines in surface waters around the Antarctic Peninsula and Weddell Sea by A. Rocchi, A. Rocchi, M. F. Fitzsimons, P. Akenga, A. Sotomayor, E. L. Sà, Q. Güell-Bujons, M. Vila, Y. M. Castillo, M. Dall'Osto, D. Vaqué, C. Wohl, C. Wohl, C. Wohl, R. Simó, E. Berdalet

“…However, knowledge of the sea surface distribution patterns and factors modulating alkylamines remain limited due to their high reactivity and low concentrations, which hamper accurate measurements. …”
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Precipitation–fire functional interactions control biomass stocks and carbon exchanges across the world's largest savanna by M. Williams, M. Williams, D. T. Milodowski, D. T. Milodowski, T. L. Smallman, T. L. Smallman, K. G. Dexter, G. C. Hegerl, I. M. McNicol, M. O'Sullivan, C. M. Roesch, C. M. Ryan, C. M. Ryan, S. Sitch, A. Valade

“…The emergent spatial variation in biogenic fluxes and C pools is strongly correlated with mean annual precipitation and burned area. …”
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The role of collagen type VI alpha 6 chain as a potential tumor suppressor in breast cancer: an immune regulation perspective by Jian-Di Li, Li-Li Deng, Jia-Yuan Luo, Chao-Hua Mo, Bang-Teng Chi, Wan-Ying Huang, Rong-Quan He, Di-Yuan Qin, Chang Song, Wen Zou, Gang Chen

“…This study aimed to elucidate COL6A6 expression patterns, assess its impact on the tumor immune microenvironment, and uncover underlying molecular mechanisms in breast cancer progression. …”
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Sexual dimorphism in the association of umbilical cord blood lipidome with abdominal fat in early childhood by Kothandaraman Narasimhan, Mya Thway Tint, Li Chen, Sartaj Ahmad Mir, Suresh Anand Sadananthan, Navin Michael, Adaikalavan Ramasamy, Karen Mei-Ling Tan, Priti Mishra, Anne K. Bendt, Kok Hian Tan, David Cameron-Smith, Yap Seng Chong, Peter D. Gluckman, Peter J. Meikle, Melvin Khee Shing Leow, Fabian Yap, Yung Seng Lee, Chan Shiao Yng, Johan G. Eriksson, S Sendhil Velan, Neerja Karnani, Markus R. Wenk

“…Conclusions Our study reveals sexual dimorphism in the associations between cord blood lipidome and abdominal adiposity, suggesting depot-specific patterns in adipose tissue development and lipid metabolism in early life.…”
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Association Between Cardiometabolic Multimorbidity and 15-year Mortality in the Asia Cohort Consortium by Sangjun Lee, Choonghyun Ahn, Sarah Krull Abe, Md Shafiur Rahman, Md Rashedul Islam, Eiko Saito, Seokyung An, Norie Sawada, Xiao-Ou Shu, Woon-Puay Koh, Hui Cai, Atsushi Hozawa, Seiki Kanemura, Chisato Nagata, San-Lin You, Daehee Kang, Rieko Kanehara, Yu-Tang Gao, Jian-Min Yuan, Wanqing Wen, Yumi Sugawara, Keiko Wada, Chien-Jen Chen, Keun-Young Yoo, Habibul Ahsan, Kee Seng Chia, Aesun Shin, Jeongseon Kim, Jung Eun Lee, Keitaro Matsuo, Nathaniel Rothman, You-Lin Qiao, Wei Zheng, Paolo Boffetta, Manami Inoue, Sue K. Park

“…Moreover, the age- and sex-adjusted HRs for CVD mortality were highest in participants with stroke, ischemic heart disease, and diabetes (HR 10.6; 95% CI, 6.16–18.25). These patterns remained consistent after additional adjustments for smoking status and body mass index. …”
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Aquatic and soil CO₂ emissions from forested wetlands of Congo's Cuvette Centrale by A. de Clippele, A. C. H. Jaeger, S. Baumgartner, S. Baumgartner, M. Bauters, P. Boeckx, C. Botefa, G. Bush, J. Carilli, T. W. Drake, C. Ekamba, G. Lompoko, N. B. Mukwiele, K. Van Oost, R. A. Werner, J. Zambo, J. Six, M. Barthel

“…The time series data revealed no marked seasonal pattern in CO<span class="inline-formula">₂</span> fluxes. …”
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Characteristics of patients prescribed SGLT-2i and/or GLP-1RA among cardiology clinics in the US: insights from the COORDINATE-diabetes trial by Adam J Nelson, Lisa A. Kaltenbach, Hussein R. Al-Khalidi, Monica Leyva, Laura Webb, Darren K. McGuire, Rodica Pop-Busui, Matthew A Cavender, Vanita R. Aroda, Melissa L. Magwire, Caroline R. Richardson, Ildiko Lingvay, Julienne K. Kirk, Ambarish Pandey, Tanya Gaynor, Jonathan Pak, Alana Washington, Cagri Senyucel, Renato D. Lopes, Jennifer B. Green, Christopher B. Granger, Neha J Pagidipati

“…Understanding the prescribing patterns of these agents by cardiologists may aid in implementation efforts. …”
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Community structure and diversity of soil nematodes in different slope directions of wild cherry plum forests in Xinjiang, China by CAO Jing, CUI Dong, JIANG Zhicheng, YAN Jiangchao, WU Yunhao, LIU Junqi, GUO Jinfeng, HAN Yaxin, HAN Shutong

“…[Objective] This study elucidates the spatial differentiation pattern of nematode communities in soils in slopes facing different directions and provides reference for the conservation and scientific management of wild cherry plum forest population. …”
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A regional physical–biogeochemical ocean model for marine resource applications in the Northeast Pacific (MOM6-COBALT-NEP10k v1.0) by E. J. Drenkard, C. A. Stock, A. C. Ross, Y.-C. Teng, T. Cordero, W. Cheng, W. Cheng, A. Adcroft, A. Adcroft, E. Curchitser, R. Dussin, R. Dussin, R. Hallberg, C. Hauri, K. Hedstrom, A. Hermann, A. Hermann, M. G. Jacox, M. G. Jacox, K. A. Kearney, R. Pagès, D. J. Pilcher, D. J. Pilcher, M. Pozo Buil, V. Seelanki, V. Seelanki, N. Zadeh

“…In the Gulf of Alaska, the simulation captured patterns of sea surface height variability and variations in thermal, oxygen, and acidification risk associated with local modes of interannual to decadal climate variability. …”
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Knowledge management in higher education: a meta-synthesis of success factors, challenges, and implementation strategies by Mohammad Hossein Zerafati, Reza Hosseinpour

“…The selected studies were analyzed using qualitative content analysis to identify recurring themes, patterns, and relationships. The Critical Appraisal Skills Programme (CASP) was employed to ensure methodological rigor, and peer review was used to enhance the reliability of the findings.Findings: The meta-synthesis revealed five critical success factors for knowledge management implementation in higher education:1. …”
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Bias in the estimated association between all-cause mortality and long-term exposure to a specific chemical component of fine particulate matter: The example of black carbon by Jianyu Deng, Ning Kang, Xueqiu Ni, Hong Lu, Meng Wang, Mingkun Tong, Pengfei Li, Mingjin Tang, Tao Xue, Mei Zheng, Tong Zhu

“…Finally, based on the estimated effects of BC and NBC, we investigated global patterns in PM2.5 toxicity (i.e., the per-unit effect of PM2.5) and the degree of OVB associated with ignoring the differential effects of BC and NBC. …”
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Biogeochemical versus biogeophysical temperature effects of historical land-use change in CMIP6 by A. A. Amali, C. Schwingshackl, A. Ito, A. Barbu, C. Delire, D. Peano, D. M. Lawrence, D. Wårlind, E. Robertson, E. L. Davin, E. L. Davin, E. L. Davin, E. Shevliakova, I. N. Harman, N. Vuichard, P. A. Miller, P. J. Lawrence, T. Ziehn, T. Hajima, V. Brovkin, V. Brovkin, Y. Zhang, V. K. Arora, J. Pongratz, J. Pongratz

“…Still, there is a discernible cooling pattern between 30° N and 60° N, extending across large landmasses from the Great Plains of North America to the Northeast Plain of Asia. …”
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