The 96-week outcomes and pharmacokinetics of long-acting cabotegravir plus rilpivirine in South Africans by Rosie Mngqibisa, Yashna Singh, Catherine Orrell, Johan Lombaard, Sandy Griffith, Conn Harrington, Ronald D’Amico, William Spreen, Marty St Clair, Christine Latham, Louise Garside, Rodica Van Solingen-Ristea, Veerle Van Eygen, Fafa Addo Boateng, Herta Crauwels, Prosperity Eneh, Ingrid Eshun-Wilsonova

“…Background: Evaluating long-term efficacy, safety and pharmacokinetics of long-acting cabotegravir + rilpivirine (CAB+RPV LA) in sub-Saharan African populations is important because of the region’s unique demographics and antiretroviral therapy resistance patterns. Objectives: To describe the 96-week efficacy, safety and pharmacokinetics of CAB+RPV LA in South African participants from the pooled FLAIR and ATLAS-2M Phase 3/3b randomised studies. …”
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Elder abuse without borders: a systematic review and meta-analysis by Tegene Atamenta Kitaw, Amsalu Baylie, Bruktawite Afework Tekle, Befkad Derese Tilahun, Addisu Getie, Biruk Beletew Abate, Sefineh Fenta Feleke, Alemu Birara Zemariam, Molla Azmeraw, Gizachew Yilak, Seada Seid, Ribka Nigatu Haile

“…Regional variations suggest cultural and socioeconomic factors significantly influence abuse patterns. These findings emphasize the urgent need for global screening tools, institutional staff training, community awareness programs, and policy reforms prioritizing elder protection.…”
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Genus-Wide Pan-Genome Analysis of <i>Oryza</i> Calcium-Dependent Protein Kinase Genes and Their Related Kinases Highlights the Complexity of Protein Domain Architectures and Expres... by Fu Shi, Li Li, Mingjie Chen, Junli Chang, Min Tu, Guangyuan He, Yin Li, Guangxiao Yang

“…The <i>Oryza</i> genus serves not only as a gene pool for rice improvement but also as a model system for plant evolutionary research. …”
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Gender differences in use of cigarette and non-cigarette tobacco products among adolescents aged 13–15 years in 20 African countries by Israel T. Agaku, Rose Sulentic, Adriana Dragicevic, Gibril Njie, Candace K. Jones, Satomi Odani, Tina Tsafa, Joy Gwar, Constantine I. Vardavas, Olalekan Ayo-Yusuf

“…Differential gender patterns of cigarette and non-cigarette tobacco product use among youth may have implications for future disease burden. …”
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Development of Primer Panels for Whole-Genome Amplification and Sequencing of Human Seasonal Coronaviruses: hCoV-OC43, hCoV-HKU1, hCoV-229E, and hCoV-NL63 by Tamila Musaeva, Artem Fadeev, Maria Pisareva, Veronika Eder, Andrey Ksenafontov, Margarita Korzhanova, Valery Tsvetkov, Alexander Perederiy, Irina Kiseleva, Daria Danilenko, Dmitry Lioznov, Andrey Komissarov

“…Human seasonal coronaviruses (hCoVs) are a group of viruses that affect the upper respiratory tract. While seasonal patterns and the annual variability of predominant hCoV species are well-documented, their genetic and species diversity in St. …”
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Prevalence of infection and associated factors after intramedullary nailing in African countries with the Surgical Implant Generation Network program: A systematic review and meta-... by Destaw Endeshaw, Natnael Kebede, Abiyu Abadi Tareke, Ousman Adal, Eyob Getachew, Asnake Gashaw Belayneh, Getnet Alemu Andargie, Kedir Seid, Gebeyehu Lakew, Amlaku Nigusie Yirsaw, Mitiku Tefera, Eyob Ketema Bogale, Tadele Fentabel Anagaw, Eneyew Talie Fenta

“…The review also identified significant predictors of infection, including open fracture type, complex fracture patterns, surgery performed within 15 days of injury, the presence of a prophylactic drain, female gender, and procedures conducted by junior surgeons. …”
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Comparison of efficacy and safety between surgical and conservative treatments for hemorrhoids: a meta-analysis by Longfang Quan, Xuelian Bai, Fang Cheng, Jin Chen, Hangkun Ma, Pengfei Wang, Ling Yao, Shaosheng Bei, Xiaoqiang Jia

“…Subgroup analysis showed clear superiority within four days (SMD = -1.26, 95% CI -1.84 to -0.68) but parity beyond ten days (SMD = 0.00, 95% CI -0.44 to 0.44; p = 0.99). Comparable patterns were observed in pregnant women with thrombosed external hemorrhoids. …”
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The effect of Vagus nerve stimulation (VNS) on seizure control, cognitive function, and quality of life in individuals with drug‐resistant epilepsy: A systematic review article by Daniel Molla Melese, Abebaye Aragaw, Wondyefraw Mekonen

“…In addition, the paper looks at a wide range of disease kinds and patterns. We have established a uniform and comprehensive approach throughout the selected studies by mandating the inclusion of all three crucial parameters: vagus nerve stimulation, cognitive function, and quality of life. …”
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Anatomical Variants in Pancreatic Irrigation and Their Clinical Considerations for the Pancreatic Approach and Surrounding Structures: A Systematic Review with Meta-Analysis by Juan José Valenzuela-Fuenzalida, Camila Ignacia Núñez-Castro, Valeria Belén Morán-Durán, Pablo Nova-Baeza, Mathias Orellana-Donoso, Alejandra Suazo-Santibáñez, Alvaro Becerra-Farfan, Gustavo Oyanedel-Amaro, Alejandro Bruna-Mejias, Guinevere Granite, Daniel Casanova-Martinez, Juan Sanchis-Gimeno

“…Understanding different vascular patterns (such as those from the splenic and mesenteric arteries) is crucial for surgical interventions on the pancreas. …”
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The Figure of the Migrant and Multilingual Practices in Selected Lithuanian Novels and Their English Translations: Antanas Škėma’s Balta drobulė and Gabija Grušaitė’s Stasys Šaltok... by Rūta Eidukevičienė, Kristina Aurylaitė

“…Drawing on theoretical propositions about multilingualism by Werner Helmich (2016), Till Dembeck (2017) and others, as well as about multilingualism in translation by Rainier Grutman (1998; 2006) and Reine Meylaerts (2006; 2013), this paper discusses the various manifestations of multilingualism in the selected literary texts and the ways they are conveyed in the English translations, focusing on the functions multilingual patterns perform in the original novels and how these patterns are adjusted in their translations. …”
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Effects of nitrogen levels on soil respiration of sympodial bamboo plantation and factor analysis by LI Weicheng, WANG Shuguang, SHENG Haiyan, ZHENG Youmiao, WANG Shudong, ZHONG Zheke

“…And it may have distinctly dynamic patterns at different temporal scales since it is affected by diverse abiotic and biotic factors. …”
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Comparative cardiovascular outcomes and safety of hypoglycemic drug classes in patients with type 2 diabetes and hypertension: a multicenter cohort analysis by Zhiyuan Wei, Wanqian Xu, Yu Wang, Yu Tian, Zhongmin Wang, Shenqi Jing, Weina Liu, Sipeng Shen, Chenlong Qin, Xin Zhang, Jingsong Li, Yun Liu

“…DPP4is, GLP-1 RAs, and glinides showed a lower risk of 3-point MACE compared with acarbose (HR: 0.62 [0.51–0.76], 0.47 [0.29–0.75], and 0.59 [0.43–0.81], respectively). Similar patterns were observed for 4-point MACE. For safety outcomes, DPP4is were associated with a reduced risk of chronic kidney disease, while insulin use was associated with reduced risks of inflammatory polyarthritis and insomnia. …”
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Dietary inflammatory index and the risk of esophageal cancer: a systematic review and meta-analysis by Hossein bahraami Yarahmadi, Kianoush Shahryari, Mahdi Bozorgi, Ahmadreza Shirdel, Zhina Mohamadi, Negar Rooshenas, Helia Karim Nezhad, Hesam Mobaraki, Majid Aryannejad, Anahita Emdadi, Yekta Khosravian, Seyed Amirabbas Shahidi Marnani, Seyyed Kiarash SadatRafiei, Mahsa Asadi Anar, Amir Marashi, Farbod Khosravi, Maryam Khodaei

“…This study suggests that modifying inflammatory properties of dietary patterns can reduce the risk of incidence of esophageal cancer.…”
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Comparative transcriptomics of atrazine-tolerant and sensitive alfalfa varieties under atrazine stress by Yingao Li, Chunyang Dong, Zeshan Zulfiqar, Haojie Wang, Jiading Lu, Xiaoxia Zhang, Jun Li, Yinghua Shi, Chengzhang Wang, Xiaoyan Zhu, Hao Sun

“…These findings highlight the distinct genetic responses of the two alfalfa varieties to atrazine stress, with JN5010 exhibiting more consistent gene expression patterns compared to the sensitive variety WL363. Conclusions The tolerant variety JN5010 shows improved tolerance to atrazine stress by maintaining stable gene expression and precise regulation in various pathways, such as antioxidant processes, signaling, photosynthesis, and toxin removal. …”
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Bridging micro and macroevolution: insights from chromosomal dynamics in plants by Carmen Benítez-Benítez, Ashwini V. Mohan, Rogelio Sánchez-Villegas, Inés Gómez-Ramos, Ana Valdés-Florido, Kay Lucek, Marek Slovák, Marek Slovák, Filip Kolář, Filip Kolář, Ilia J. Leitch, Modesto Luceño, Isabel Larridon, Angelino Carta, Angelino Carta, Joan Cuscó-Borràs, Enrique Maguilla, Alegría Montero-Ramírez, Patrick G. Meirmans, Alison Dawn Scott, Santiago Martín-Bravo, Marcial Escudero

“…Here, we address the following questions: Are macroevolutionary patterns of chromosome evolution the result of accumulated microevolutionary changes, or do chromosomal dynamics drive larger shifts along the speciation continuum? …”
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Identification of single nucleotide polymorphisms (SNPs) associated with heat stress and milk production traits in Chinese holstein cows by Jingyi Xu, Lirong Hu, Jingyang Ning, Fan Zhang, Qing Xu, Yachun Wang

“…Results In this study, we further validated the gene expression patterns and genetic effects of the three candidate genes on HS response and milk production in Chinese Holstein cows. …”
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The Elephant Ethogram: a library of African elephant behaviour by Joyce Poole, Petter Granli

“…The Elephant Ethogram replaces ElephantVoices' online Elephant Gestures and Elephant Calls Databases originally developed in 2003 and revamped in 2011 (Poole 2011; Poole and Granli 2011), that were based on our elephant studies in Amboseli National Park, Kenya between 1975 and 2009 (Poole 1987; Poole et al. 1988; Poole 1989a; Poole 1989b; Poole et al. 2005) and the work of other scientists (Douglas-Hamilton 1972; Berg 1983; Moss 1983; Kahl and Armstrong 2000; Kahl and Armstrong 2002). …”
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Comprehensive assessment of adverse event profiles associated with bispecific antibodies in multiple myeloma by Mobina Golmohammadi, Shahzad Raza, Maram Albayyadhi, Hossein Sholehrasa, Jack Khouri, Louis Williams, Doris K. Hansen, Azam Moradi, Xuan Xu, Moath Albliwi, Ali Hajj Ali, Danai Dima, Faiz Anwer, Barry Paul, Majid Jaberi-Douraki

“…PCA revealed agents with all grades and grade 3/4 showed similar clustering patterns except for three agents. Overall, our findings demonstrated the excellent efficacy on the use of BsAbs in MM; however, these agents have been linked to a unique AE profile. …”
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A Systematic Review and Meta-analysis of the Association Between ACTN3 R577X Genotypes and Performance in Endurance Versus Power Athletes and Non-athletes by El Mokhtar El Ouali, Benjamin Barthelemy, Juan Del Coso, Anthony C. Hackney, Ismail Laher, Karuppasamy Govindasamy, Abdelhalem Mesfioui, Urs Granacher, Hassane Zouhal

“…Finally, the genotypic and allelic frequency of ACTN3 genes were similar in male and female power athletes. Conclusions The pattern of the frequencies of the ACTN3 R577X genotypes in power athletes was RX > RR > XX. …”
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Age-related cognitive decline and associations with sex, education and apolipoprotein E genotype across ethnocultural groups and geographic regions: a collaborative cohort study. by Darren M Lipnicki, John D Crawford, Rajib Dutta, Anbupalam Thalamuthu, Nicole A Kochan, Gavin Andrews, M Fernanda Lima-Costa, Erico Castro-Costa, Carol Brayne, Fiona E Matthews, Blossom C M Stephan, Richard B Lipton, Mindy J Katz, Karen Ritchie, Jacqueline Scali, Marie-Laure Ancelin, Nikolaos Scarmeas, Mary Yannakoulia, Efthimios Dardiotis, Linda C W Lam, Candy H Y Wong, Ada W T Fung, Antonio Guaita, Roberta Vaccaro, Annalisa Davin, Ki Woong Kim, Ji Won Han, Tae Hui Kim, Kaarin J Anstey, Nicolas Cherbuin, Peter Butterworth, Marcia Scazufca, Shuzo Kumagai, Sanmei Chen, Kenji Narazaki, Tze Pin Ng, Qi Gao, Simone Reppermund, Henry Brodaty, Antonio Lobo, Raúl Lopez-Anton, Javier Santabárbara, Perminder S Sachdev, Cohort Studies of Memory in an International Consortium (COSMIC)

“…APOE*4 carriers declined slightly more rapidly than non-carriers on most cognitive measures, with processing speed showing the greatest difference (-0.08 SD/decade, 95% CI [-0.15, -0.01], p = 0.019). The same overall pattern of results was found when analyses were repeated with baseline dementia cases excluded. …”
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