Comparison of tumor assessments using RECIST 1.1 and irRECIST, and association with overall survival by James L Gulley, Sandra P D'Angelo, Marcis Bajars, Andrea B Apolo, Juliane Manitz, S Peter Eggleton, Oliver Bohnsack

“…Immune-response criteria were developed to better capture novel response patterns seen with ICIs.Methods We pooled data from 1765 patients with 12 types of advanced solid tumors treated with avelumab (an anti-programmed death ligand 1 (PD-L1) monoclonal antibody) monotherapy in the JAVELIN Solid Tumor and JAVELIN Merkel 200 trials, conducted a comparative analysis of tumor assessments by investigators according to RECIST 1.1 and immune-related RECIST (irRECIST), and evaluated the correlation between progression-free survival (PFS) and overall survival (OS).Results In total, 147 patients (8.3%) had a best overall response (BOR) of PD by RECIST 1.1 but had immune-related disease control by irRECIST (defined as immune-related BOR (irBOR) of immune-related stable disease or better). …”
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Context specific effects of substrate composition on the taxonomic and functional diversity of macroinvertebrate communities in temperate lowland streams by Kate L. Mathers, Patrick D. Armitage, Matthew Hill, Melanie Bickerton, Morwenna Mckenzie, Isabel Pardo, David Tickner, Paul J. Wood

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In Vitro and In Situ Evaluation of Fermented High Moisture Corn and Ear Corn as Alternative Feedstuffs for Feedlot Calves by H. Rajaei-Sharifabadi, D. Villalba, J. Mora, G. de la Fuente, J. Balcells, A. R. Seradj

“…Ammonia nitrogen concentrations remained above microbial requirements across all treatments, with HMG and HME showing similar patterns. Volatile fatty acid profiles indicated enhanced fiber degradability in high-moisture products compared to CG. …”
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Intramedullary nailing with and without cerclage in subtrochanteric fractures: an updated systematic review and meta-analysis by Ahmed Oun, Omar Abdelaziz, Islam Saeed Elhois, Mohamed Al-Badaineh, Karim Zinhom, George Jabrieh, Hamza S. Al-Himyari, Abdullah A. Nada

“…However, achieving proper reduction remains challenging in unstable patterns, leading to poor outcomes. Cerclage wiring, used alongside IMN, has shown potential in improving fracture stability and alignment, yet concerns regarding soft tissue damage persist. …”
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Dissecting the properties of circulating IgG against streptococcal pathogens through a combined systems antigenomics-serology workflow by Alejandro Gomez Toledo, Sounak Chowdhury, Elisabeth Hjortswang, James T. Sorrentino, Nathan E. Lewis, Anna Bläckberg, Simon Ekström, Sven Kjellström, Arman Izadi, Berit Olofsson, Pontus Nordenfelt, Lars Malmström, Magnus Rasmussen, Johan Malmström

“…Moreover, antigen-specific IgG analysis reveals individual variation in titers, subclass distributions, and Fc-signaling capacity, despite similar epitope and Fc-glycosylation patterns. Finally, we show that GAS antibodies may cross-react with Streptococcus dysgalactiae (SD), a bacterial pathogen that occupies similar niches and causes comparable infections. …”
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Deep Learning-Based Cascaded Light Source Detection for Link Alignment in Underwater Wireless Optical Communication by Bowen Jia, Wenmin Ge, Jingxuan Cheng, Zihao Du, Renming Wang, Guangbin Song, Yufan Zhang, Chengye Cai, Sitong Qin, Jing Xu

“…In this paper, deep neural networks (DNNs) with strong feature extraction capabilities are introduced to automatically learn the patterns of the light source from diverse images. A detection architecture cascading an object detector and a keypoint detector is adopted, achieving better comprehensive performance in terms of accuracy and speed. …”
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Time-Domain Versus Frequency-Embedded EEG Sequences for Sensorimotor BCI Using 1D-CNN by Simanto Saha, Mathias Baumert, Alistair Mcewan

“…We used dataset IVa from BCI Competition III in 5−fold cross-validation settings to evaluate intra-subject, inter-subject (pairwise) and inter-subject (pooled) BCI classification accuracies. We compared the performance of the proposed methods with classification algorithms featuring common spatial patterns (CSP) for benchmarking. …”
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Atypical causes of respiratory virus infections in Sub-Saharan Africa from 2013– 2023: a systematic review and meta-analysis by George Agyei, Philip El-Duah, Jonathan Mawutor Gmanyami, Oscar Lambert, Brice Armel Nembot Fogang, Sherihane Aryeetey, Augustina Sylverken, Rexford Mawunyo Dumevi, Yaw Adu-Sarkodie, Richard Odame Phillips, Christian Drosten, Michael Owusu

“…Abstract Background Atypical respiratory viruses (ARVs) are a diverse group of pathogens that cause respiratory infections through less common mechanisms or in unique epidemiological patterns, unlike the typical viruses like respiratory syncytial virus, influenza and human rhinoviruses. …”
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The role of surrounding residential greenness in healthy behaviours: a systematic review and meta-analysis by I. Marcilla-Toribio, B. Bizzozero-Peroni, B. Notario-Pacheco, A. I. Ribeiro, M. P. Santos, M. Fernandez-Perez, S. Cekrezi, L. Lucas-de la Cruz, M. Martinez-Andres

“…The aim of this systematic review and meta-analysis was to systematically review the evidence of the relationships between surrounding residential greenness and a range of health-related behaviors, including physical activity, dietary habits, sleep patterns, and the consumption of alcohol and tobacco. …”
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Mining-affected water resources and ecological effects in ecologically fragile mining areas of western China by Qiangling YAO, Liqiang YU, Shengyan CHEN, Yinghu LI, Xuehua LI

“…The regional water cycle pattern and the ecological damage process under the influence of mining were analyzed, the calculation method of the total amount of mining-affected water resources required to maintain ecological balance was explored, the concepts of the optimal, reasonable and minimum ecological water demand in the region were defined, the indicators for evaluating the effect of surface ecological environment restoration were proposed, and the mine planning and design ideas and technical system based on the whole cycle of coal mining were constructed. …”
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Photon Fluence Rate and Temperature Effects on Temperate Atlantic Kelp Species by Tomás F. Pinheiro, Silvia Chemello, Isabel Sousa-Pinto, Tânia R. Pereira

“…<i>S. polyschides</i>, a high light-requiring species, dominates the shallow subtidal region, while <i>L. ochroleuca</i>, also high light-requiring and temperature-tolerant, is abundant in both intertidal pools and shallow subtidal habitats. These findings raise new hypotheses regarding future distribution patterns under climate change: while <i>L. ochroleuca</i> may continue expanding polewards and potentially replace other <i>Laminaria</i> spp. at shallow depths, low-light-adapted, cold-water species may retain a competitive advantage in deeper zones.…”
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Structural mechanisms for centrosomal recruitment and organization of the microtubule nucleator γ-TuRC by Qi Gao, Florian W. Hofer, Sebastian Filbeck, Bram J. A. Vermeulen, Martin Würtz, Annett Neuner, Charlotte Kaplan, Maja Zezlina, Cornelia Sala, Hyesu Shin, Oliver J. Gruss, Elmar Schiebel, Stefan Pfeffer

“…NEDD1 forms a tetrameric structure at the γ-TuRC base through interactions with four GCP3/MZT1 modules and GCP5/6-specific extensions, while multiple copies of CDK5RAP2 engage the γ-TuRC in two distinct binding patterns to promote γ-TuRC closure and activation. …”
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Toward skillful forecasting of super El Niño events using a diffusion-based westerly wind burst parameterization by Chaopeng Ji, Mu Mu, Bo Qin, Tao Lian, Shijin Yuan, Jie Feng, Xunshu Song, Yuntao Wei, Guokun Dai, Jinyu Wang, Xianghui Fang

“…Consequently, DDPM produces more realistic eastern Pacific sea surface temperature anomaly warming patterns. These findings underscore WWB's accuracy as key to super El Niño prediction and demonstrate machine learning’s potential for WWB's parameterization.…”
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Investigating difficult to detect pancreatic lesions: Characterization of benign pancreatic islet cell tumors using multiparametric pancreatic 3-T MRI. by Kwadwo Antwi, Patricia Wiesner, Elmar M Merkle, Christoph J Zech, Daniel T Boll, Damian Wild, Emanuel Christ, Tobias Heye

“…All patients received a 3-T MRI and a 68Ga-DOTA-exendin-4-PET/CT. Pooled accuracy, sensitivity, specificity and inter-reader agreement were calculated. …”
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Prevalence of phenotypic drug resistance profiles and multi-drug-resistant Pseudomonas and Acinetobacter species recovered from clinical specimens in Ethiopia: a systematic review... by Mihret Tilahun, Alemu Gedefie, Abdurahaman Seid, Habtu Debash, Agumas Shibabaw

“…The high prevalence and resistance patterns of these bacteria need immediate action to inform treatment guidelines, increase infection control measure, and develop effective public health policies. …”
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Aedes-borne arboviral human infections in Europe from 2000 to 2023: A systematic review and meta-analysis by Nadja Hedrich, Maria Bekker-Nielsen Dunbar, Martin P. Grobusch, Patricia Schlagenhauf

“…Conclusion: The systematic review provides a comprehensive overview of over 20 years of Aedes -borne infections in Europe, highlighting the dynamic nature of virus transmission influenced by global travel patterns, climate change, the expanding spread of Aedes populations, and evolving public health campaigns.…”
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Spatiotemporal dynamics of soil organic carbon in desert region and its response to climate change: A case study of Heihe river by Yuqing Chen, Haiyang Xi, Wenju Cheng

“…Spatially, SOC density in the HRL is primarily distributed along river corridors, aligning closely with vegetation patterns. Additionally, SOC density shows a positive correlation with temperature and a negative correlation with precipitation. …”
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Music medicine and music therapy in neonatal care: a scoping review of passive music listening research applications and findings on infant development and medical practice by Efthymios Papatzikis, Maria Agapaki, Rosari Naveena Selvan, Deanna Hanson-Abromeit, Christian Gold, Shulamit Epstein, U. Wun Vivian Lok, Evrykleia Barda, Varun Pandey

“…Objectives This scoping review aims to provide a comprehensive foundation by mapping the existing literature on passive music listening and identifying gaps, trends, and patterns that are crucial precursors to the development of best practices. …”
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In vivo estimation of motor unit intrinsic properties in individuals with spinal cord injury by Zhihao Duan, Asta Kizyte, Emelie Butler Forslund, Elena M. Gutierrez-Farewik, Pawel Herman, Ruoli Wang

“…The HD-EMG signals were subsequently decomposed into MN spike trains and the common synaptic input to the MN pool was estimated. A simplified leaky integrate-and-fire neuron model was then used to simulate MN spiking trains, with soma size and inert period as tunning parameters, which are crucial for MU recruitment and firing patterns, respectively. …”
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The Impact of Misinformation on Social Media in the Context of Natural Disasters: Narrative Review by Sonya Hilberts, Mark Govers, Elena Petelos, Silvia Evers

“…The selected studies revealed consistent patterns in how misinformation spreads during natural disasters, highlighting the role of users, some influencers, and bots in amplified false narratives. …”
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