Unraveling Genetic Causality Between Type 2 Diabetes Mellitus and Hemiplegia Based on Mendelian Randomization by Li Y, Zhang Z, Jin W, Yuan Y, Cen X, Tan J, Wu X

“…The causal effects were evaluated using inverse variance weighted (IVW), MR-Egger, weighted median, simple mode, and weighted mode. …”
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Therapeutic potential of IL6R blockade for the treatment of sepsis and sepsis-related death: A Mendelian randomisation study. by Fergus W Hamilton, Matt Thomas, David Arnold, Tom Palmer, Ed Moran, Alexander J Mentzer, Nick Maskell, Kenneth Baillie, Charlotte Summers, Aroon Hingorani, Alasdair MacGowan, Golam M Khandaker, Ruth Mitchell, George Davey Smith, Peter Ghazal, Nicholas J Timpson

“…We weighted SNPs by their effect on CRP and combined results across them in inverse variance weighted meta-analysis, proxying the effect of IL6RA. …”
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Genetically proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers: A mendelian randomization analysis. by James Yarmolinsky, Virginia Díez-Obrero, Tom G Richardson, Marie Pigeyre, Jennifer Sjaarda, Guillaume Paré, Venexia M Walker, Emma E Vincent, Vanessa Y Tan, Mireia Obón-Santacana, Demetrius Albanes, Jochen Hampe, Andrea Gsur, Heather Hampel, Rish K Pai, Mark Jenkins, Steven Gallinger, Graham Casey, Wei Zheng, Christopher I Amos, International Lung Cancer Consortium, PRACTICAL consortium, MEGASTROKE consortium, George Davey Smith, Richard M Martin, Victor Moreno

“…Cancer GWAS and FinnGen consortia data were restricted to individuals of European ancestry. Inverse-variance weighted random-effects models were used to examine associations between genetically proxied inhibition of these drug targets and risk of cancer. …”
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Causal association between plasma phosphatidylethanolamine and risk of colorectal adenocarcinoma: a two-sample Mendelian randomization study by XU Ling, HUANGFU Yuchan, SHEN Lisong, MA Yanhui

“…Four Mendelian randomization (MR) methods, inverse-variance weighted (IVW) method, MR-Egger regression, weighted median (WME) method, and weighted mode (WM) method, were employed to assess the causal effect. …”
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Exploring Bidirectional Causality between Obstructive Sleep Apnea and Chronic Kidney Disease via Mendelian Randomization by Liu X, Liu M, Zhong B, He X, Xu Y, Zhou Z, Qin P

“…The Cochrane’s Q test reveals significant heterogeneity between various single nucleotide polymorphisms. MR-Egger indicated no evidence of genetic pleiotropy. …”
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Mapping QTLs for Pyricularia leaf spot, nematode resistance, and yield related traits in pearl millet [Cenchrus americanus (L.) Morrone] by Sairam Vutla, Joseph E. Knoll, Anvesh Sankuratri, Risha G. Nayak, Limei Liu, Limei Liu, Peng W. Chee, Raghupathy Karthikeyan, Bashasab Fakrudin, Mahendar Thudi, Patricia Timper, Karen Harris-Shultz, Jason G. Wallace, Jason G. Wallace, Hari Singh, Bharat Singh, Somashekhar M. Punnuri

“…These QTLs explained 6.31 to 32.51% of phenotypic variance for each trait and were consistently detected over different environments. …”
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UMOD Genotype and Determinants of Urinary Uromodulin in African Populations by Michél Strauss-Kruger, Eric Olinger, Patrick Hofmann, Ian J. Wilson, Carina Mels, Ruan Kruger, Lebo F. Gafane-Matemane, John A. Sayer, Cristian Ricci, Aletta E. Schutte, Olivier Devuyst

“…Introduction: Single-nucleotide polymorphisms (SNPs) in the UMOD-PDILT genetic locus are associated with chronic kidney disease (CKD) in European populations, through their effect on urinary uromodulin (uUMOD) levels. …”
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Development of a cost‐effective high‐throughput mid‐density 5K genotyping assay for germplasm characterization and breeding in groundnut by Manish K. Pandey, Vinay Sharma, Aamir W. Khan, Pushpesh Joshi, Sunil S. Gangurde, Prasad Bajaj, Pasupuleti Janila, Annapurna Chitikineni, Ramesh Bhat, Babu N. Motagi, Chandramohan Sangh, Thankappan Radhakrishnan, Sandip K. Bera, Gregor Gorjanc, Krishna Reddy Gujjula, Nathan Hall, Claudio D. Carrasco, Kandalam Arjun, Srinivas Chandram, Rajeev K. Varshney

“…Here, a cost‐effective and high‐throughput genotyping assay has been developed with 5,081 single nucleotide polymorphisms (SNPs) referred to as “mid‐density assay.” …”
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QTL mapping of seedling biomass and root traits under different nitrogen conditions in bread wheat (Triticum aestivum L.) by Meng-jiao YANG, Cai-rong WANG, Muhammad Adeel HASSAN, Yu-ying WU, Xian-chun XIA, Shu-bing SHI, Yong-gui XIAO, Zhong-hu HE

“…Inclusive composite interval mapping based on a high-density map from the Wheat 660K single nucleotide polymorphisms (SNP) array identified 51 QTLs from the three N treatments. …”
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Transcriptome characterisation and population genetics of Cunninghamia konishii Hayata – An endangered gymnosperm and implication for its conservation in Vietnam by Bich Hong Ha, Mai Phuong Pham, Quoc Khanh Nguyen, Thi Tuyet Xuan Bui, Giap Vu, Syed Noor Muhammad Shah, Dinh Duy Vu

“…The analysis of molecular variance (AMOVA) showed that high genetic variation existed within individuals (90.68%) compared to amongst populations (2.97%). …”
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Non‐alcoholic fatty liver disease and heart failure: A comprehensive bioinformatics and Mendelian randomization analysis by Yayun Zhang, Lu Feng, Xin Guan, Zixiong Zhu, Yubin He, Xuewen Li

“…Single nucleotide polymorphism (SNP) data for HF and NAFLD were sourced from genome‐wide association studies (GWAS). …”
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Causal correlations between inflammatory proteins and heart failure: A two‐sample Mendelian randomization analysis by Xian‐Guan Zhu, Gui‐Qin Liu, Ya‐Ping Peng, Li‐Ling Zhang, Xian‐Jin Wang, Liang‐Chuan Chen, Yuan‐Xi Zheng, Xue‐Jun Xiang, Rui Qiao, Xian‐He Lin

“…For each inflammatory protein, instrumental variables (IVs) were chosen following the three foundational assumptions of the MR analysis, requiring a minimum of three qualifying single nucleotide polymorphisms (SNPs) each with a P < 5e‐8. Associations between inflammatory proteins and HF were assessed through inverse‐variance weighted (IVW), MR‐Egger regression, weighted median and weighted mode analysis. …”
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Two-sample Mendelian randomization study on the causal association between air pollution and Alzheimer′s disease by ZHANG Yingying, ZHANG Junyao, SONG Jiwei, WANG Shengjie, YAO Junyan

“…The main analysis was conducted by using the inverse variance weighted (IVW) method, and four methods including weighted median, MR-Egger regression, mode-based simple estimation and mode-based weighted estimation were used for quality control. …”
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A genome-wide association study identifies genetic determinants of hemoglobin glycation index with implications across sex and ethnicity by John S. House, Joseph H. Breeyear, Farida S. Akhtari, Violet Evans, John B. Buse, James Hempe, Alessandro Doria, Josyf C. Mychaleckyi, Vivian Fonseca, Mengyao Shi, Changwei Li, Shuqian Liu, Tanika N. Kelly, Tanika N. Kelly, Tanika N. Kelly, Daniel Rotroff, Daniel Rotroff, Daniel Rotroff, Alison A. Motsinger-Reif

“…We conducted replication analyses of top findings in the Atherosclerosis Risk in Communities (ARIC) study with inverse variance-weighted meta-analysis. We followed up with stratified GWAS analyses by sex and self-reported race.ResultsIn ACCORD, we identified single nucleotide polymorphisms (SNPs) associated with HGI, including a peak with the strongest association at the intergenic SNP rs73407935 (7q11.22) (P = 5.8e−10) with a local replication in ARIC. …”
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The Association between Myopia and Anxiety: A Bidirectional 2-Sample Mendelian Randomization Study by Waihang Wong, MD, Yimin Qin, MD, Chi Liu, PhD, Shiran Zhang, PhD, Yu Jiang, PhD, Yangfa Zeng, MD, Decai Wang, PhD, Lingyi Liang, PhD, Xiaotong Han, PhD

“…Subjects: For the forward MR, 11 single nucleotide polymorphisms (SNPs) associated with GAD were obtained from the FinnGen Research (5280 cases and 368 054 controls; European). …”
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Association between myopia and diabetic retinopathy: A two-sample mendelian randomization study by Jinyi Xu, Shengsong Xu, Xiao Wang, Chuqi Xiang, Zhenbang Ruan, Mingxin Lu, Liying He, Yin Hu, Xiao Yang

“…The inverse variance weighted (IVW) method was mainly used to assess the causality, and was complemented with sensitivity analyses and causality direction analyses. …”
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Causal association of antibody-mediated immune responses to infectious disease agents with lung cancer: a Mendelian randomization study by Guicai Liang, Lyubo Wang, Zhiqiang Wang, Tao Li, Lei Jiang, Yuncheng Bai, Lei Yang, Yi Feng, Yan Li, Meng Yang, Jiling Chang, Haiyue Yang, Xilong Zhou, Lincan Duan, Chunlei Ge

“…The instrumental variables were single nucleotide polymorphisms associated with lung cancer and its subtypes. …”
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Effect of communicating genetic risk of type 2 diabetes and wearable technologies on wearable device-measured behavioural outcomes in East Asians: protocol of a randomised controll... by Youngwon Kim, Shan Lou, Brian Chung, Simon Griffin, Ziyuan Chen, Job G Godino, Flora Lai Tung Cheung, Michael Multhaup, Derwin King Chung K C Chan, Harrison Hin Sheung Ho, Tsz Him Timothy Tse, Shiu Lun Ryan Au Yeung, Joni H Zhang, Mengyao Wang

“…Genetic risk of T2D will be estimated based on 113 single-nucleotide polymorphisms associated with T2D among East Asians. …”
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Causal Relationship Between Depression and Traumatic Brain Injury: A Two‐Sample Mendelian Randomization Analysis by Shiping Wang, Lei Pan, Binyang Wang, Qianwen Ruan, Ying Shi, Tong Sun, Xu Yang, Lei Zhang, Xiaohua Ke, Geng Li, Meihua Qiu, Chuanxiong Li

“…Genetic instruments were selected as single nucleotide polymorphisms (SNPs) significantly associated with exposures (depression/TBI) and outcomes (TBI/depression) at genome‐wide significance (P < 5 × 10⁻⁶). …”
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Association between genetically proxied PCSK9 inhibition and prostate cancer risk: A Mendelian randomisation study. by Si Fang, James Yarmolinsky, Dipender Gill, Caroline J Bull, Claire M Perks, PRACTICAL Consortium, George Davey Smith, Tom R Gaunt, Tom G Richardson

“…<h4>Methods and findings</h4>Single-nucleotide polymorphisms (SNPs) associated with LDL-c (P < 5 × 10-8) from the Global Lipids Genetics Consortium genome-wide association study (GWAS) (N = 1,320,016) and located in and around the HMGCR, NPC1L1, and PCSK9 genes were used to proxy the therapeutic inhibition of these targets. …”
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