Mendelian randomization analysis of causal relationship between celiac disease and autoimmune thyroid disease by YAN Junhao, GUO Xiaolei, LUO Zhaofeng, TANG Jian, WANG Zheng

“…The inverse-variance weighted (IVW) method served as the primary analytical approach, supplemented by MR-Egger, weighted median (WME) and weighted mode (WMO) methods, to evaluate the causal associations between CeD and both HT and GD. …”
Get full text

Gene flow, subspecies composition, and dengue virus-2 susceptibility among Aedes aegypti collections in Senegal. by Massamba Sylla, Christopher Bosio, Ludmel Urdaneta-Marquez, Mady Ndiaye, William C Black

“…Allele and genotype frequencies were analyzed at 11 nuclear single nucleotide polymorphism (SNP) loci using allele specific PCR and melting curve analysis. …”
Get full text

Causal relationship between physical activity, sleep duration, sedentary behavior, and hypertension: A Mendelian randomisation study by Chunmei Wang, Jianting Zeng, Hongduan Liu, Li Zhang

“…In MR analysis, inverse-variance weighting (IVW), weighted median, and MR-Egger regression were employed for causal inference. …”
Get full text

Exploring causal relationships between brain imaging-derived phenotypes and ovarian cancer risk: a bidirectional Mendelian randomization by Ting Liu, Xiaoqian Tuo, Huifang Zhao, Yan Wang, Yu Jiang, Jiaojiao Lu

“…We selected single nucleotide polymorphisms (SNPs) as instrumental variables based on rigorous criteria. …”
Get full text

Based on Mendelian Randomization to Explore the Causal Relationship with Insomnia and Gut Microbiota by GUO Yumeng, CUI Yanglin, ZHANG Xianzhong

“…Methods Single nucleotide polymorphisms (SNPs) significantly associated with the relative abundance of 196 gut microorganisms were extracted as instrumental variables (IVs) according to predefined thresholds using pooled statistics of the gut microbiota from the largest available genome-wide meta-analysis of association studies conducted by the MiBioGen consortium (n=18 340). …”
Get full text

Causal Effect of Obstructive Sleep Apnea on Sick Sinus Syndrome: A Bidirectional Mendelian Randomization Study by Chen W, Pan W, Ling L, Jiang B, Zhang Y, Su X, Jiang T, Lin J

“…Effect estimates were computed through the utilization of inverse-variance weighting (IVW), MR-Egger, weighted median, maximum likelihood techniques, and sensitivity analyses were conducted using the Mendelian Randomization Pleiotropy Residual Sum and Outlier (MR-PRESSO) approaches.Results: Our MR analyses utilizing IVW (fixed effects) revealed a heightened susceptibility to SSS among individuals with genetically predisposed OSA (OR= 1.493; 95% CI, 1.120– 1.990; P= 0.006), utilizing a set of 7 single nucleotide polymorphisms as the instrumental variables. …”
Get full text

Liver enzyme and risk of vascular dementia: A univariable and multivariable Mendelian randomization of European descent by Jieyu Chen, Jianzhun Chen, Chunyu Liang, Chenxi Liu, Liu Jie, Bin Liu, Xinglong Yang

“…UVMR approaches such as inverse variance weighting (IVW), MR‐Egger, weighted median, simple mode, and weighted mode were used, with IVW as primary. …”
Get full text

Comprehensive Mendelian randomization analysis of low-density lipoprotein cholesterol and multiple cancers by Hengchang Liang, Chunling Tang, Yue Sun, Mingwei Wang, Tong Tong, Qinquan Gao, Hui Xie, Tao Tan

“…Methods We used gene variant data and disease data from the Genome-Wide Association Study (GWAS) database to assess the causal relationship between LDL-C and each cancer by Mendelian randomisation analysis methods such as inverse variance weighting and MR-Egger. Specifically, we selected Proprotein convertase subtilisin/kexin type 9 (PCSK9) and 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR), genes associated with LDL-C levels, as instrumental variables, extracted the corresponding single nucleotide polymorphism (SNP) data and analysed the associations of these SNPs with five cancers.In addition, sensitivity analyses and heterogeneity tests were performed to ensure the reliability of the results. …”
Get full text

A two-sample Mendelian randomization study of type 1 diabetes and the risk of 22 site-specific cancers by Mikiyas Amare Getu, Xianbin Zhang, Ying Ying, Peng Gong

“…Causal relationships were primarily evaluated through inverse-variance weighting-based analyses, supplemented by three additional methods: MR-Egger, weighted median, and mode-based estimate. …”
Get full text

Bone mineral density and sex hormone binding globulin as potential mediators of the causal effect of urolithiasis on osteoporosis risk: a Mendelian randomization by Jiawei Guo, Xinyu Chen, Xinping Yi, Yongqi Dou, Yongjiang Xiong, Tao Zhao

“…The primary approach to analysis was inverse variance weighting (IVW). In addition, we also used another osteoporosis data from UK biobank (UKB) to further verify the mediating role.ResultsWe discovered that there was a 14% increase in the incidence of OP in UL patients using the IVW approach. …”
Get full text

Genome-wide association study and genomic prediction of root system architecture traits in Sorghum (Sorghum bicolor (L.) Moench) at the seedling stage by Muluken Enyew, Mulatu Geleta, Kassahun Tesfaye, Amare Seyoum, Tileye Feyissa, Admas Alemu, Cecilia Hammenhag, Anders S. Carlsson

“…The sorghum panel was genotyped with 5,000 single nucleotide polymorphism (SNP) markers for use in the current GWAS and GP studies. …”
Get full text

Genetic Associations Between Specific Sleep-Related Phenotypes and Idiopathic Sudden Sensorineural Hearing Loss: A Mendelian Randomization Analysis by Li M, He J, Liang Y, Zou F, Gou C, Lv J, Zhang X, Li D, Yu Z

“…SRPs were from the UK Biobank and FinnGen database. The inverse variance weighted (IVW) method was utilized, followed by confirming the robustness and reliability using the MR Egger, weighted median, simple mode, and weighted mode. …”
Get full text

Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry. by Amidou N'Diaye, Gary K Chen, Cameron D Palmer, Bing Ge, Bamidele Tayo, Rasika A Mathias, Jingzhong Ding, Michael A Nalls, Adebowale Adeyemo, Véronique Adoue, Christine B Ambrosone, Larry Atwood, Elisa V Bandera, Lewis C Becker, Sonja I Berndt, Leslie Bernstein, William J Blot, Eric Boerwinkle, Angela Britton, Graham Casey, Stephen J Chanock, Ellen Demerath, Sandra L Deming, W Ryan Diver, Caroline Fox, Tamara B Harris, Dena G Hernandez, Jennifer J Hu, Sue A Ingles, Esther M John, Craig Johnson, Brendan Keating, Rick A Kittles, Laurence N Kolonel, Stephen B Kritchevsky, Loic Le Marchand, Kurt Lohman, Jiankang Liu, Robert C Millikan, Adam Murphy, Solomon Musani, Christine Neslund-Dudas, Kari E North, Sarah Nyante, Adesola Ogunniyi, Elaine A Ostrander, George Papanicolaou, Sanjay Patel, Curtis A Pettaway, Michael F Press, Susan Redline, Jorge L Rodriguez-Gil, Charles Rotimi, Benjamin A Rybicki, Babatunde Salako, Pamela J Schreiner, Lisa B Signorello, Andrew B Singleton, Janet L Stanford, Alex H Stram, Daniel O Stram, Sara S Strom, Bhoom Suktitipat, Michael J Thun, John S Witte, Lisa R Yanek, Regina G Ziegler, Wei Zheng, Xiaofeng Zhu, Joseph M Zmuda, Alan B Zonderman, Michele K Evans, Yongmei Liu, Diane M Becker, Richard S Cooper, Tomi Pastinen, Brian E Henderson, Joel N Hirschhorn, Guillaume Lettre, Christopher A Haiman

“…More than 180 single nucleotide polymorphisms (SNPs), identified mostly in populations of European descent, are associated with height. …”
Get full text

The causal relationships between body composition and heart failure: A two-sample mendelian randomization study by Chenxi Lu, Zhuang Guo, Zhuoran Wang, Ke Xu, Guiyuan Han, Ke Peng, Xiaoying Liu, Yichong Li, Yu Shi

“…We used genome-wide significant single nucleotide polymorphisms (SNPs) related to body composition from the UK Biobank, GIANT, and FinnGen as instrumental variables. …”
Get full text

Association Between Hypoxia‐Inducible Factor‐1α and Neurological Diseases: A Bidirectional Two‐Sample Mendelian Randomization Analysis by Jing Liang, Xiaoyan Du, Mengfei Wang, Hongqin Zheng, Yang Sun, Yi Lin

“…Methods Single‐nucleotide polymorphisms (SNPs) genetically representing plasma HIF‐1α were screened as instrumental variables (IVs). …”
Get full text

The Causal Relationship Between Gut Microbiomes, Inflammatory Mediators, and Traumatic Brain Injury in Europeans: Evidence from Genetic Correlation and Functional Mapping Annotatio... by Bingyi Song, Youjia Qiu, Zilan Wang, Yuchen Tao, Menghan Wang, Aojie Duan, Minjia Xie, Ziqian Yin, Zhouqing Chen, Chao Ma, Zhong Wang

“…Additionally, we utilized FUMA GWAS to map single-nucleotide polymorphisms to genes and conduct transcriptomic MR analysis. …”
Get full text

Nanoparticles in Plant Cryopreservation: Effects on Genetic Stability, Metabolic Profiles, and Structural Integrity in Bleeding Heart (Papaveraceae) Cultivars by Kulus D, Tymoszuk A, Kulpińska A, Dębska B, Michalska A, Nowakowska J, Wichrowska D, Wojnarowicz J, Szałaj U

“…As for the genetic analysis, SCoT markers identified polymorphisms in 11.5% of ‘Gold Heart’ plants, while RAPDs detected mutations in 1.9% of ‘Valentine’ specimens. …”
Get full text

Causal relationship between gut microbiota and hepatocellular carcinoma: a two-sample Mendelian randomization and case–control study by Liu Yang, Wei Wei, Yuekui Wang, Wentao Kuai, Liang Xu

“…Utilizing the MR-Egger regression, weighted median (WME), and weighted mode (WM) as supplemental methods for inverse variance weighting (IVW), the main basis was IVW. Additional sensitivity, pleiotropy, and heterogeneity tests were performed. …”
Get full text

Assessing the Causal Relationship Between Various Immune Cells and Attention Deficit Hyperactivity Disorder: Mendelian Randomization Study by Qian Ge, Zhongyan Li, Weijing Meng, Chen Cai, Mengdi Qiu, Yafei Liu, Haibo Zhu

“…It was discovered that single‐nucleotide polymorphisms (SNPs) are linked to ADHD. To evaluate the dependability of the results, we conducted sensitivity analysis (heterogeneity and pleiotropy) and employed supplementary MR techniques, such as the inverse variance weighted (IVW) and MR‐Egger. …”
Get full text

Leukocyte telomere length and lung function: a mendelian randomization study in European population by Shenyu Zhu, Shenyu Zhu, Wenlong Zheng, Dingyu Rao, Dingyu Rao, Zhixian Tang, Zhixian Tang, Xinhui Liao

“…The associated between the exposures and outcomes was assessed using inverse-variance weighted (IVW), MR-Egger, and weighted median methods. …”
Get full text